Inhibitory mode of 2-acetoxyphenyl alkyl sulfides against COX-1 and COX-2: QSAR analyses

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 20, 2006, Pages 5280-5284

  Jain, Hemant Kumar ^a   Mourya, V K ^b   Agrawal, R K ^a  

^a DR H S GOUR UNIVERSITY   (India)

^b GOVERNMENT COLLEGE OF PHARMACY   (India)

Author keywords

Acetoxyphenyl alkyl sulfide; COX 1 and COX 2 inhibitor; QSAR

Indexed keywords

5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; CARBONYL DERIVATIVE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FURANONE DERIVATIVE; IMIDAZOLE DERIVATIVE; INDOMETACIN DERIVATIVE; ISOXAZOLE DERIVATIVE; MECLOFENAMIC ACID; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PYRAZOLE DERIVATIVE; THIOPHENE DERIVATIVE;

ARTICLE; CHEMICAL BOND; DRUG DESIGN; DRUG SELECTIVITY; ENZYME INHIBITION; LIPOPHILICITY; MOLECULAR WEIGHT; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ACETIC ACIDS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES;

EID: 33748329448     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.002     Document Type: Article

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