Expression and function of protease-activated receptor 4 in human myometrium

American Journal of Obstetrics and Gynecology

Volumn 196, Issue 2, 2007, Pages 169.e1-169.e6

  Allen, Nicholas M ^a   O'Brien, Margaret ^a   Friel, Anne M ^a   Smith, Terry J ^a   Morrison, John J ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

myometrium; pregnancy preterm labor; protease activated receptor thrombin

Indexed keywords

ALANYLTYROSYLPROLYLGLYCYLLYSYLPHENYLALANINAMIDE; AMIDE; AMINO ACID RECEPTOR BLOCKING AGENT; MESSENGER RNA; PROTEINASE ACTIVATED RECEPTOR 4; THREONYLCYSTEINYLTYROSYLPROLYLGLYCYLLYSYLPHENYLALANINAMIDE; THROMBIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANALYTIC METHOD; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; MUSCLE ISOMETRIC CONTRACTION; MYOMETRIUM; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UTERUS CONTRACTILITY;

EID: 33846922348     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2006.09.027     Document Type: Article

References (24)

1. Dery O., Corvera C.U., Steinhoff M., and Bunnett N.W. Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases. Am J Physiol 274 (1998) 1429-1452
2. Vergnolle N. Proteinase-activated receptors-novel signals for gastrointestinal pathophysiology. Aliment Pharmacol Ther 14 (2000) 257-266
3. Vergnolle N., Wallace J.L., Bunett N.W., and Hollenberg M.D. Protease-activated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol Sci 3 (2001) 146-151
4. Coughlin S.R. How the protease thrombin talks to cells. Proc Natl Acad Sci U S A 96 (1999) 11023-11027
5. Coughlin S.R. Thrombin signaling and protease-activated receptors. Nature 407 (2000) 258-264
6. Elovitz M.A., Saunders T., Ascher-Landsberg J., and Phillippe M. Effects of thrombin on myometrial contractions in vitro and in vivo. Am J Obstet Gynecol 183 (2000) 799-804
7. Phillipe M., Elovitz M., and Saunders T. Thrombin-stimulated uterine contractions in the pregnant and non-pregnant rat. J Soc Gynecol Invest 8 (2001) 260-265
8. Shintani Y., Hirano K., Nishimura J., Nakano H., and Kanaide H. Enhanced contractile response to thrombin in the pregnant rat myometrium. Br J Pharmacol 131 (2000) 1619-1628
9. Shintani Y., Hirano K., Nakayama T., Nishimura J., Nakano H., and Kanaide H. Mechanism of trypsin-induced contraction in the rat myometrium: the possible involvement of a novel member of protease-activated receptor. Br J Pharmacol 133 (2001) 1276-1285
10. O'Sullivan C.J., Allen N.M., O'Loughlin A.J., Friel A.M., and Morrison J.J. Thrombin and PAR1-activating peptide: effects on human uterine contractility in vitro. Am J Obstet Gynecol 190 (2004) 1098-1105
11. Xu W.F., Andersen H., Whitmore T.E., et al. Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci U S A 95 (1998) 6642-6646
12. Macfarlane S.R., Seatter M.J., Kanke T., Hunter G.D., and Plevin R. Proteinase-activated receptors. Pharmacol Rev 53 (2001) 245-282
13. Kahn M.L., Zheng Y.W., Huang W., et al. A dual thrombin receptor system for platelet activation. Nature 394; (1998) 13690-13694
14. Chomczynski P. A Reagent for single-step simultaneous isolation of RNA. BioTechniques 15 (1993) 532-536
15. Asokananthen N., Graham P.T., Fink J., et al. Activation of protease-activated receptor (PAR-1), PAR-2 and PAR-4 stimulates Il-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. J Immunol 168 (2002) 3577-3585
16. O'Brien M., Morrison J.J., and Smith T.J. Investigation of thrombin receptor expression in human myometrium and in primary myometrial smooth muscle cells. J Soc Gynecol Investig 11 (2004) 78A
17. Dennedy M.C., Friel A.M., Houlihan D.D., Broderick V., Smith T.J., and Morrison J.J. Cannabinoids and the human uterus during pregnancy. Am J Obstet Gynecol 190 (2004) 2-9
18. Hirano K., and Kanaide H. Role of protease-activated receptors in the vascular system. J Atheroscler Thromb 10 (2003) 211-225
19. Mule F., Pizzuti R., Capparelli A., and Vergnolle N. Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon. Gut 53 (2004) 229-234
20. D'Andrea M.R., Saban M.R., Nguyen N.B., Andrade-Gordon P., and Saban R. Expression of protease-activated receptor-1, -2, -3, and -4 in control and experimentally inflamed mouse bladder. Am J Pathol 162 (2003) 907-923
21. Wu C.C., Hwang T.L., Liao C.H., Kuo S.C., Lee F.Y., and Teng C.M. The role of PAR4 in thrombin-induced thromboxane production in human platelets. Thromb Haemost 90 (2003) 299-308
22. Kataoka H., Hamilton J.R., McKemy D.D., et al. Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood 102 (2003) 3224-3231
23. Jerius H., Beall A., Woodrum D., Epstein A., and Brophy C. Thrombin-induced vasospasm: cellular signaling mechanisms. Surgery 123 (1998) 46-50
24. Hollenberg M.D., Mahmoud S., Sandhu S., Houle S., and Vergnolle N. Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br J Pharmacol 143 (2004) 443-454