Enhanced contractile response to thrombin in the pregnant rat myometrium

British Journal of Pharmacology

Volumn 131, Issue 8, 2000, Pages 1619-1628

  Shintani, Yoshinobu ^a   Hirano, Katsuya ^a   Nishimura, Junji ^a   Nakano, Hitoo ^a   Kanaide, Hideo ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Myometrial contraction; Pregnancy; Protease activated receptor; Rat; Thrombin

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; DILTIAZEM; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN;

ANIMAL TISSUE; ARTICLE; DRUG EFFECT; FLUOROMETRY; HEMOSTASIS; HORMONAL REGULATION; MECHANICAL STRESS; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN DOMAIN; RAT; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE CONTRACTION; UTERUS CONTRACTILITY;

EID: 0034527759     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703729     Document Type: Article

References (55)

1. Hemeoxygenase-1 inhibits human myometrial contractility via carbon monoxide and is upregulated by progesterone during pregnancy
2. Ligand cross-reactivity within the protease-activated receptor family
3. Inositol, 1,4,5-triphosphate and protein kinase C are involved in thrombin- and trap-induced vascular smooth muscle contraction
4. G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly
5. Differential sensitivity to nickel and SK&F96365 of second messenger-operated and receptor-operated calcium channels in rat submandibular ductal cells
6. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
7. Bronchoconstrictor effect of thrombin and thrombin receptor activating peptide in guinea-pigs in vivo
8. Protease-activated receptors: Sentries for inflammation?
9. Protease-activated receptors mediate apamin-sensitive relaxation of mouse and guinea-pig gastrointestinal smooth muscle
10. Galpha 12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac
11. Role of the thrombin receptor in development and evidence for a second receptor
12. How the protease thrombin talks to cells
13. Thrombin receptor function and cardiovascular disease
14. Synergism between the contractile effect of epidermal growth factor and that of des-Arg9-bradykinin or of alpha-thrombin in rabbit aortic rings
15. Proteinase-activated receptors: Novel mechanisms of signaling by serine proteases
16. Relationships among sex steroids, oxytocin, and their receptors in the rat uterus during late gestation and at parturition
17. Correlation between oxytocin receptor concentration and responsiveness to oxytocin in pregnant rat myometrium: Effects of ovarian steroids
18. Mode of action of thrombin in the rabbit aorta
19. Cellular consequences of thrombin-receptor activation
20. Up-regulation of oxytocin receptors in rabbit amnion by glucocorticoids: Potentiation by cyclic adenosine 3′,5′-monophosphate
21. Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction
22. Protease-activated receptor 3 is a second thrombin receptor in humans
23. Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin
24. 2+ in pregnant rat myometrium
25. Gestational changes in oxytocin- and endothelin-1-induced contractility of pregnant rat myometrium
26. Gestational changes in mechanical properties of skinned muscle tissues of human myometrium
27. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
28. A dual thrombin receptor system for platelet activation
29. i in smooth muscle strips using front-surface fluorimetry
30. Expression of oxytocin receptor in human pregnant myometrium
31. Stretching cardiac myocytes stimulates protooncogene expression
32. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation
33. Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor
34. PAR3 is a cofactor for PAR4 activation by thrombin
35. Mechanisms of galanin-induced contraction in the rat myometrium
36. Molecular cloning of a potential proteinase activated receptor
37. Pregnancy increases ET-1-induced contraction and changes receptor subtypes in uterine smooth muscle in humans
38. Regulation of uterine smooth muscle function during gestation
39. Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue
40. Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function
41. Mechanisms underlying neurokinin A-induced contraction of the pregnant rat myometrium
42. Regulation of oxytocin receptor concentration in rat uterine explants by estrogen and progesterone
43. PAR1 thrombin receptor-G protein interactions
44. Contribution of sarcoplasmic reticular calcium to smooth muscle contractile activation: Gestational dependence in isolated rat uterus
45. Contractile actions of thrombin receptor-derived polypeptides in human umbilical and placental vasculature: Evidence for distinct receptor systems
46. Thrombin receptor-mediated vascular relaxation differentiated by a receptor antagonist and desensitization
47. Comparison of effects of oxytocin and prostaglandin F2-alpha on circular and longitudinal myometrium from the pregnant rat
48. Up-regulation of oxytocin receptors in porcine endometrium by adenosine 3′,5′-monophosphate
49. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
50. 2+ pool depletion in thapsigargin-resistant cells
51. Responses of aortic smooth muscle to thrombin and thrombin analogues
52. Uterine contraction and physiological mechanisms of modulation
53. Cloning and characterization of human protease-activated receptor 4
54. Actions of thrombin and thrombin receptor peptide analogues in gastric and aortic smooth muscle: Development of bioassays for structure-activity studies
55. Molecular cloning of the rat vascular smooth muscle thrombin receptor. Evidence for in vitro regulation by basic fibroblast growth factor