Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases

Handbook of Experimental Pharmacology

Volumn 178, Issue , 2007, Pages 511-524

  Metzger, D ^a   Chambon, P ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Adipocytes; Cre recombinase; Eye; Heart; Keratinocytes; Liver; Prostate; RXR

Indexed keywords

RETINOID X RECEPTOR;

ADIPOCYTE; ANIMAL; CYTOLOGY; DISEASE MODEL; HEART MUSCLE CELL; HUMAN; LIVER CELL; METABOLISM; MOUSE; MUTAGENESIS; REVIEW;

ADIPOCYTES; ANIMALS; DISEASE MODELS, ANIMAL; HEPATOCYTES; HUMANS; MICE; MUTAGENESIS; MYOCYTES, CARDIAC; RETINOID X RECEPTORS;

EID: 33846913237     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-540-35109-2_21     Document Type: Article

References (54)

1. Aboseif S, Shinohara K, Borirakchanyavat S, Deirmenjian J, Carroll PR (1997) The effect of cryosurgical ablation of the prostate on erectile function. Br J Urol 80:918-922
2. Bok D (1993) The retinal pigment epithelium: a versatile partner in vision. J Cell Sci Suppl 17:189-195
3. Bok D (2002) New insights and new approaches toward the study of age-related macular degeneration. Proc Natl Acad Sci U S A 99:14619-14621
4. Chambon P (1994) The retinoid signaling pathway: molecular and genetic analyses. Semin Cell Biol 5:115-125
5. Chambon P (2005) The nuclear receptor superfamily: a personal retrospect on the first two decades. Mol Endocrinol 19:1418-1428
6. Chen J, Kubalak SW, Chien KR (1998) Ventricularmuscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chambermorphogenesis. Development 125:1943-1949
7. Chopra DP, Wilkoff LJ (1977) Reversal by vitamin A analogues (retinoids) of hyperplasia induced by N-methyl-N'-nitro-N-nitrosoguanidine in mouse prostate organ cultures. J Natl Cancer Inst 58:923-930
8. Dahiya R, Park H D, Cusick J, Vessella RL, Fournier G, Narayan P (1994) Inhibition of tumorigenicpotentialandprostate-specificantigen expressioninLNCaPhumanprostate cancer cell line by 13-cis-retinoic acid. Int J Cancer 59:126-132
9. De Vos S, DawsonMI, Holden S, Le T,Wang A, Cho SK, Chen DL, Koeffler HP (1997) Effects of retinoid X receptor-selective ligands on proliferation of prostate cancer cells. Prostate 32:115-121
10. Dyson E, Sucov HM, Kubalak SW, Schmid-Schonbein GW, DeLano FA, Evans RM, Ross J, Jr., and Chien KR (1995) Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha-/-mice. Proc Natl Acad Sci U S A 92:7386-7390
11. Evans RM (2005) The nuclear receptor superfamily: a rosetta stone for physiology. Mol Endocrinol 19:1429-1438
12. Fasshauer M, and Paschke R (2003) Regulation of adipocytokines and insulin resistance. Diabetologia 46:1594-1603
13. Fisher GJ, and Voorhees JJ (1996) Molecular mechanisms of retinoid actions in skin. Faseb J 10:1002-1013
14. Fuchs E (1997) Keith RPorter Lecture 1996. Of mice and men: genetic disorders of the cytoskeleton. Mol Biol Cell 8:189-203
15. Grondona JM, Kastner P, Gansmuller A, Decimo D, Chambon P, Mark M (1996) Retinal dysplasia and degeneration in RARbeta2/RARgamma2 compound mutant mice. Development 122:2173-2188
16. Gruber PJ, Kubalak SW, Pexieder T, Sucov HM, Evans RM, Chien KR (1996) RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice. J Clin Invest 98:1332-1343
17. Hardy MH (1992) The secret life of the hair follicle. Trends Genet 8:55-61
18. Hsing AW, Comstock GW, Abbey H, Polk BF (1990) Serologic precursors of cancer. Retinol, carotenoids, and tocopherol and risk of prostate cancer. J Natl Cancer Inst 82:941-946
19. Huang J, PowellWC,KhodavirdiAC,Wu J,MakitaT, CardiffRD, CohenMB, SucovHM,Roy-Burman P (2002) Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoidXreceptor alpha allele in the prostate epithelium. CancerRes 62:4812-4819
20. HuangW,Ma K, Zhang J, Qatanani M, Cuvillier J, Liu J, Dong B, Huang X,Moore DD (2006) Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science 312:233-236
21. Imai T, Jiang M, Chambon P, Metzger D (2001a) Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifeninducible chimeric Cre recombinase (Cre-ERT2) in adipocytes. Proc Natl Acad Sci U S A 98:224-228
22. Imai T, Jiang M, Kastner P, Chambon P, Metzger D (2001b) Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity. Proc Natl Acad Sci U S A 98:4581-4586
23. Imai T, Takakuwa R,Marchand S, Dentz E, Bornert JM,Messaddeq N,Wendling O,Mark M, Desvergne B,WahliWet al (2004) Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A 101:4543-4547
24. Kastner P, Grondona JM,MarkM, Gansmuller A, LeMeurM, Decimo D, Vonesch JL, Dolle P, Chambon P (1994) Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell 78:987-1003
25. Kastner P, Mark M, Chambon P (1995) Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell 83:859-869
26. Kastner P, Mark M, Leid M, Gansmuller A, Chin W, Grondona JM, Decimo D, KrezelW, Dierich A, Chambon P (1996) Abnormal spermatogenesis in RXR beta mutant mice. Genes Dev 10:80-92
27. Krezel W, Dupe V, Mark M, Dierich A, Kastner P, Chambon P (1996) RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta-/-/RXR gamma-/-mutant mice are viable. Proc Natl Acad Sci U S A 93:9010-9014
28. Kubalak SW, Hutson DR, Scott KK, Shannon RA (2002) Elevated transforming growth factor beta2 enhances apoptosis and contributes to abnormal outflow tract and aortic sac development in retinoic X receptor alpha knockout embryos. Development 129:733-746
29. Lasnitzki I, Goodman DS (1974) Inhibition of the effects of methylcholanthrene on mouse prostate in organ culture by vitamin A and its analogs. Cancer Res 34:1564-1571
30. Li M, Indra AK, Warot X, Brocard J, Messaddeq N, Kato S, Metzger D, Chambon P (2000) Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis. Nature 407:633-636
31. Li M, Chiba H,Warot X, Messaddeq N, Gerard C, Chambon P,Metzger D (2001) RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations. Development 128:675-688
32. Li M, Messaddeq N, Teletin M, Pasquali JL, Metzger D, Chambon P (2005) Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. Proc Natl Acad Sci U S A 102:14795-14800
33. Li M, Hener P, Zhikun Z, Kato P, Metzger D, Chambon P (2006) Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A 103:11736-11741
34. LohnesD, Kastner P, Dierich A,MarkM, LeMeurM, Chambon P (1993) Function of retinoic acid receptor gamma in the mouse. Cell 73:643-658
35. Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub MP, LeMeur M, Chambon P (1993) High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci U S A 90:7225-7229
36. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P,Mark M, Chambon P, Evans RM (1995) The nuclear receptor superfamily: the second decade. Cell 83:835-839
37. McBee JK, Palczewski K, Baehr W, Pepperberg DR (2001) Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Prog Retin Eye Res 20:469-529
38. Mendelsohn C, Mark M, Dolle P, Dierich A, Gaub MP, Krust A, Lampron C, Chambon P (1994) Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal. Dev Biol 166:246-258
39. Merki E, Zamora M, Raya A, Kawakami Y,Wang J, Zhang X, Burch J, KubalakSW, Kaliman P, Belmonte JC et al (2005) Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A 102:18455-18460
40. Mori M,MetzgerD, Picaud S,Hindelang C, SimonuttiM, Sahel J, Chambon P,MarkM (2004) Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium. Am J Pathol 164:701-710
41. Nguyen-Legros J,HicksD (2000) Renewal of photoreceptor outer segments and their phagocytosis by the retinal pigment epithelium. Int Rev Cytol 196:245-313
42. Paus R, Cotsarelis G (1999) The biology of hair follicles. N Engl J Med 341:491-497
43. PollardM, Luckert PH, SpornMB (1991) Prevention of primary prostate cancer in Lobund-Wistar rats by N-(4-hydroxyphenyl) retinamide. Cancer Res 51:3610-3611
44. ReichmanME,HayesRB,ZieglerRG, SchatzkinA,TaylorPR,Kahle LL, Fraumeni JF Jr (1990) Serum vitamin A and subsequent development of prostate cancer in the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. Cancer Res 50:2311-2315
45. Roy-BurmanP,WuH, PowellWC,Hagenkord J,CohenMB (2004) Genetically definedmouse models that mimic natural aspects of human prostate cancer development. Endocr Relat Cancer 11:225-254
46. Saari JC (2000) Biochemistry of visual pigment regeneration: the Friedenwald lecture. Invest Ophthalmol Vis Sci 41:337-348
47. Seo R,McGuireM, Chung M, BushmanW (1997) Inhibition of prostate ductal morphogenesis by retinoic acid. J Urol 158:931-935
48. Subbarayan V,Mark M,Messadeq N, Rustin P, Chambon P, and Kastner P (2000) RXRalpha overexpression in cardiomyocytes causes dilated cardiomyopathy but fails to rescue myocardial hypoplasia in RXRalpha-null fetuses. J Clin Invest 105:387-394
49. SucovHM, Dyson E, Gumeringer CL, Price J, Chien KR, EvansRM (1994) RXR alphamutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev 8:1007-1018
50. Tontonoz P,Hu E, SpiegelmanBM (1994) Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 79:1147-1156
51. Tran CM, SucovHM (1998) TheRXRalpha gene functions in a non-cell-autonomousmanner during mouse cardiac morphogenesis. Development 125:1951-1956
52. Wan YJ, An D, Cai Y, Repa JJ, Hung-Po Chen T, Flores M, Postic C,MagnusonMA, Chen J, Chien KR et al (2000a) Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver. Mol Cell Biol 20:4436-4444
53. Wan YJ, Cai Y, LungoW, Fu P, Locker J, French S, SucovHM (2000b) Peroxisomeproliferatoractivated receptor alpha-mediated pathways are altered in hepatocyte-specific retinoid X receptor alpha-deficient mice. J Biol Chem 275:28285-28290
54. Wilson JG, Roth CB, Warkany J (1953) An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation. Am J Anat 92:189-217