Elevated transforming growth factor β2 enhances apoptosis and contributes to abnormal outflow tract and aortic sac development in retinoic X receptor α knockout embryos

Development

Volumn 129, Issue 3, 2002, Pages 733-746

  Kubalak, Steven W ^a   Hutson, D Reneé ^a   Scott, Karen K ^a   Shannon, Rebecca A ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Apoptosis; Outflow tract; Retinoid X receptor; TGF 2; Whole mouse culture

Indexed keywords

BROXURIDINE; CASPASE; RETINOID X RECEPTOR; RETINOID X RECEPTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA2; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AORTA ANOMALY; AORTOPULMONARY SEPTAL DEFECT; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; EMBRYO; GENE MUTATION; HETEROZYGOSITY; KNOCKOUT MOUSE; LETHALITY; MOLECULAR BIOLOGY; MORPHOGENESIS; MOUSE; NICK END LABELING; NONHUMAN; NULL ALLELE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; WILD TYPE;

ANIMALS; AORTA; APOPTOSIS; CARDIOVASCULAR ABNORMALITIES; HEART; HETEROZYGOTE; MICE; MICE, TRANSGENIC; ORGAN CULTURE TECHNIQUES; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2;

ANIMALIA;

EID: 0036337353     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Differential gene expression of TGF-beta isoforms and TGF-beta receptors during the first trimester of pregnancy at the human maternal-fetal interface
2. PPAR gamma is required for placental, cardiac, and adipose tissue development
3. Morphogenetic considerations on congenital malformations of the outflow tract. Part 1: Common arterial trunk and tetralogy of Fallot
4. Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice
5. Developmental abnormalities in cultured mouse embryos deprived of retinoic acid by inhibition of yolk-sac retinol binding protein synthesis
6. Ventricular muscle-restricted targeting of the RXRα gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis
7. Transcriptional regulation by transforming growth factor beta of the expression of retinoic acid and retinoid X receptor genes in osteoblastic cells is mediated through AP-1
8. Transcriptional regulation during cardiac growth and development
9. Dissection and culture of postimplantation embryos
10. The development of the myocardium and endocardium in mouse embryos
11. The murine transforming growth factor-beta precursor
12. Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci
13. Selective regulation of cardiomyocyte gene expression and cardiac morphogenesis by retinoic acid
14. RNA and protein localisations of TGFβ2 in the early mouse embryo suggest an involvement in cardiac development
15. -/- mice
16. Fashioning the vertebrate heart: Earliest embryonic decisions
17. Myosin light chain 2a and 2v identifies the embryonic outflow tract myocardium in the developing rodent heart
18. Persistant truncus arteriosus in the Splotch mouse
19. TGF beta 2 mRNA expression and pregnancy failure in mice
20. RXRα deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice
21. Down-regulation of atrial markers during cardiac chamber morphogenesis is cell-autonomous in murine embryos
22. Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and cardiac chamber morphogenesis
23. TGFβ2 in embryos with inborn anomalies: Effect of maternal immunopotentiation
24. Differential regulation of the expression of transforming growth factor-β mRNAs by growth factors and retinoic acid in chicken embryo chondrocytes, myocytes, and fibroblasts
25. Genetic analysis of RXRα developmental function: Convergence of RXR and RAR signaling pathways in heart and eye morphogenesis
26. Vitamin A deficiency and mutations of RXR-Alpha, RXR-Beta and RAR-Alpha lead to early differentiation of embryonic ventricular cardiomyocytes
27. Neural Crest and Cardiovascular Patterning
28. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors
29. Expression of type XVII collagen alpha-1 chain mRNA in the mouse heart
30. Retinoids in Heart Development
31. Chamber specification of atrial myosin light chain-2 expression precedes septation during cardiogenesis
32. Formation of the tricuspid valve in the human heart
33. Retinoic acid embryopathy
34. Maternal rescue of transforming growth factor-β1 null mice
35. Structural development of endocardial cushions
36. TGFβ2 activation status during cardiac morphogenesis
37. Murine transforming growth factor-β2 cDNA sequence and expression in adult tissues and embryos
38. Development of trophoblast and placenta of the mouse. A reinvestigation with regard to the in vitro culture of mouse trophoblast and placenta
39. Pathogenesis of persistent truncus arteriosus and dextroposed aorta in the chick embryo after neural crest ablation
40. Role of cell death in conal ridges of the developing human heart
41. Late fetal development of retinoic acid induced transposition of the great arteries
42. Neural crest cells in outflow tract septation of the embryonic chicken heart: Differentiation and apoptosis
43. Apoptosis in cardiac development
44. DLX-2, MASH-1 and MAP-2 expression and bromodeoxyuridine incorporation define molecularly distinct cell populations in the embryonic mouse forebrain
45. Epithelial-mesenchymal cell transformation in the embryonic heart can be mediated, in part, by transforming growth factor β
46. Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor β3
47. TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes
48. Defects of the chorioallantoic placenta in mouse RXRalpha null fetuses
49. Transforming growth factor-beta(1), -beta(2), -beta(3) and their type I and II receptors in human term placenta
50. Retinoic acid directs cardiac laterality and the expression of early markers of precardiac asymmetry
51. Retinoids and their receptors in vertebrate embryogenesis
52. RXRα mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis
53. Postimplantation mouse development: Whole embryo culture and micro-manipulation
54. Retinoic acid-induced heart malformations in the hamster
55. The RXRalpha gene functions in a non-cell-autonomous manner during mouse cardiac morphogenesis
56. Retinoid-induced limb defects 2: Involvement of TGF-β2 in retinoid-induced inhibition of limb bud development
57. Myocardialization of the cardiac outflow tract
58. Programmed cell death in the developing heart
59. Conotruncal anomalies in the Trisomy 16 mouse: An immunohistochemical analysis with emphasis on the involvement of neural crest
60. Developmental remodeling and shortening of the cardiac outflow tract involves myocyte programmed cell death
61. Formation of the atrioventricularseptal structures in the normal mouse
62. The development of the atrioventricular junction in the human heart
63. Aortic-arch and cardiac anomolies in offspring of vitamin A deficient rats
64. An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation
65. Identification of 1 alpha,25-dihydroxyvitamin D3 response elements in the human transforming growth factor beta 2 gene
66. Normal development of the outflow tract in the rat