Biochemistry of visual pigment regeneration: The Friedenwald lecture

Investigative Ophthalmology and Visual Science

Volumn 41, Issue 2, 2000, Pages 337-348

  Saari, John C ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROLASE; RHODOPSIN; TRANSDUCIN; VISUAL PIGMENT;

CELL REGENERATION; CONFERENCE PAPER; HYPOTHESIS; PHOTORECEPTOR; PIGMENT EPITHELIUM; PIGMENTATION; PRIORITY JOURNAL; REGENERATION; RETINA ROD;

ANIMALS; AWARDS AND PRIZES; BIOCHEMISTRY; CONES (RETINA); FLORIDA; HUMANS; MICE; NIGHT BLINDNESS; OPHTHALMOLOGY; PHOTOTRANSDUCTION; PIGMENT EPITHELIUM OF EYE; REGENERATION; RETINAL PIGMENTS; RETINOIDS; RODS (RETINA); SOCIETIES, SCIENTIFIC;

EID: 0033960296     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (118)

1. Kühne W. Chemische vorgänge in der netzhaut. In: Hermann L, ed. Handbuch der Physiologie, Leipzig: Vogel; 1879:235-342. English translation taken from Vision Res, 1977;17:1269-1316.
2. Kühne W. Chemische vorgänge in der netzhaut. In: Hermann L, ed. Handbuch der Physiologie, Leipzig: Vogel; 1879:235-342. English translation taken from Vision Res, 1977;17:1269-1316.
3. Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K. Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. J Biol Chem. 1998;273:21790-21799.
4. Ruiz A, Winston A, Lim Y-H, Gilbert BA, Rando RR, Bok D. Molecular and biochemical characterization of lecithin retinol acyltransferase. J Biol Chem. 1999;274:3834-3841.
5. Simon A, Hellman U, Wernstedt C, Eriksson U. The retinal pigment epithelial-specific 11-cis-retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases. J Biol Chem. 1995;270:1107-1112.
6. Alpern M. Rhodopsin kinetics in the human eye. J Physiol. 1971; 217:447-471.
7. Rushton WAH. Dark-adaptation and the regeneration of rhodopsin. J Physiol. 1961;156:166-178.
8. Rushton WAH. The Ferrier Lecture, 1962. Visual adaptation. Proc R Soc Lond B Biol Sci. 1965;162:20-46.
9. Schoenlein RW, Peteanu LA, Mathies RA, Shank CV. The first step in vision: femtosecond isomerization of rhodopsin. Science. 1991; 254:412-415.
10. Alpern M, Masseidvaag F, Ohba N. The kinetics of cone visual pigments in man. Vision Res. 1971;11:539-549.
11. Lamb TD. Dark adaptation: a re-examination. In: Hess RF, Sharpe LT, Nordby K, eds. Night Vision. Basic, Clinical and Applied Aspects. Cambridge, UK: Cambridge University Press; 1990:177-222.
12. Leibrock CS, Reuter R, Lamb TD. Molecular basis of dark adaptation in rod photoreceptors. Eye. 1998;12:511-520.
13. Buczylko J, Saari JC, Crouch RK, Palczcwski K. Mechanisms of opsin activation. J Biol Chem. 1996;271:20621-20630.
14. Fain GL, Lisman JE. Photoreceptor degeneration in vitamin A deprivation and retinitis pigmentosa: the equivalent light hypothesis. Exp Eye Res. 1993;57:335-340.
15. Fain GL, Matthews HR, Cornwall MC. Dark adaptation in vertebrate photoreceptors. Trends Neurosci. 1996;19:502-507.
16. Jin J, Crouch RK, Corson DW, Katz BM, MacNichol EF, Cornwall MC. Noncovalent occupancy of the retinal-binding pocket of opsin diminishes bleaching adaptation of retinal cones. Neuron. 1993;11:513-522.
17. Rao VR, Cohen GB, Oprian DD. Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness. Nature. 1994;367:639-642.
18. Boll F. Zur anatomie und physiologie der retina. Monatsber Akad Wissensch, Berlin. 1876;23:783-787.
19. Boll F. Zur anatomie und physiologic der retina. Arch Anat Physiol Abstr. 1877:4-35. English translation taken from Vision Res. 1977;17:1253-1264.
20. Boll F. Zur anatomie und physiologic der retina. Arch Anat Physiol Abstr. 1877:4-35. English translation taken from Vision Res. 1977;17:1253-1264.
21. Kühne W. Uber den sehpurpur. Untersuch Physiol Instit Univ Heidelberg. 1877;1:1-14.
22. Marmor MF, Martin AB. 100 years of the visual cycle. Surv Ophthalmol. 1978;22:279-285.
23. Wald G. Carotenoids and the vitamin A cycle in vision. Nature. 1934;134:65.
24. Dowling JE. Chemistry of visual adaptation in the rat. Nature. 1960;168:114-118.
25. Bridges CDB. Vitamin A and the role of the pigment epithelium during bleaching and regeneration of rhodopsin in the frog eye. Exp Eye Res. 1976;22:435-455.
26. Zimmerman WF. The distribution and proportions of vitamin A compounds during the visual cycle in the rat. Vision Res. 1974; 14:795-802.
27. Bernstein PS, Law WC, Rando RR. Isomerization of all-trans-retinoids to 11-cis-retinoids in vitro. Proc Natl Acad Sci USA., 1987;84:1849-1853.
28. Rando RR. Polyenes and vision. Chem Biol. 1996;3:255-262.
29. Mata NL, Tsin ATC. Distribution of 11-cis-LRAT, 11-cis-RD and 11-cis-REH in bovine retinal pigment epithelium membranes. Biochim Biophys Acta. 1998;1394:16-22.
30. Sun H, Molday RS, Nathans J. Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specinc ATP-binding cassette transporter responsible for Stargardt disease. J Biol Chem. 1999;274:8269-8281.
31. Weng J, Mata NL, Azarian SM, Tzekov RT, Birch DG, Travis GH. Insights into the function of rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in aber knock-out mice. Cell. 1999;98:13-23.
32. Bok D. Processing and transport of retinoids by the retinal pigment epithelium. Eye. 1990;4:326-332.
33. Crouch RK, Chader GJ, Wiggert B, Pepperberg DR. Retinoids and the visual process. Photochem Photobiol. 1996;64:613-621.
34. Pepperberg DR, Okajima T-IL, Wiggert B, Ripps H, Crouch K, Chader GJ. Interphotoreceptor retinoid-binding protein (IRBP): molecular biology and physiological role in the visual cycle of rhodopsin. Mol Neurobiol. 1993;1993:7:61-84.
35. Saari JC. Retinoids in photosensitive systems In: Sporn MB, Roberts AH, Goodman DS, eds. The Retinoids: Biology, Chemistry, and Medicine. 2nd ed. New York: Raven Press; 1994:351-385.
36. Wald G. Molecular basis of visual excitation. Science. 1968;162: 230-239.
37. Bok D, Ong DE, Chytil F. Immunocytochemical localization of cellular retinol binding protein in the rat retina. Invest Ophthalmol Vis Sci. 1984;25:877-883.
38. Bunt-Milam AH, Saari JC. Immunocytochemical localization of two retinoid-binding proteins in vertebrate retina. J Cell Biol. 1983;97:703-712.
39. Saari JC, Bunt-Milam AH, Bredberg DL, Garwin GG. Properties and immunocytochemical localization of three retinoid-binding proteins from bovine retina. Vision Res. 1984;24:1595-1603.
40. Perlman I. Kinetics of bleaching and regeneration of rhodopsin in abnormal (RCS) and normal albino rats in vivo. J Physiol. 1978; 278:141-159.
41. Yoshikami S, Noll GN. Isolated retinas synthesize visual pigments from retinol congeners delivered by liposomes. Science. 1978; 200:1393-1395.
42. Saari JC, Garwin GG, Van Hooser JP, Palczewski K. Reduction of all-trans-retinal limits regeneration of visual pigment in mice. Vision Res. 1998;38:1325-1333.
43. Perlman JI, Nodes HR, Pepperberg DR. Utilization of retinoids in the bullfrog retina. J Gen Physiol. 1982;80:885-913.
44. Ohguro H, Van Hooser JP, Milam AH, Palczewski K. Rhodopsin phosphorylation and dephosphorylation in vivo. J Biol Chem. 1995;270:14259-14262.
45. Ostroy SE, Gaitatzes CG, Friedmann AL. Hypoxia inhibits rhodopsin regeneration in the excised mouse eye. Invest Ophthalmol Vis. Sci. 1993;34:447-452.
46. Palczewski K, Van Hooser JP, Garwin GG, Saari JC. Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. Biochemistry. 1999;39: 12012-12019.
47. Hubbard R. Retinene isomerase. J Gen Physiol. 1956;39:935-962.
48. Rando RR, Chang A. Studies on the catalyzed interconversions of vitamin A derivatives. J Am Chem Soc. 1983;105:2879-2882.
49. Deigner PS, Law WC, Canada FJ, Rando RR. Membranes as the energy source in the endergonic transformation of vitamin A to 11-cis-retinol. Science. 1989;244:968-971.
50. Ames A III, Gurian BS. Effects of glucose and oxygen deprivation on function of isolated mammalian retina. J Neurophysiol. 1963; 26:617-634.
51. Futterman S. The role of reduced triphosphopyridine nucleotide in the visual cycle. J Biol Chem. 1963;238:1145-1150.
52. Lion F, Rotmans JP, Daemen FJM, Bonting SL. Biochemical aspects of the visual process, XXVII: Stereospecificity of ocular retinol dehydrogenases and the visual cycle. Biochim Biophys Acta. 1975;384:283-292.
53. Pandolfi PP, Sonati F, Rivi R, Mason P, Grosveld F, Luzatto L. Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress. EMBO J. 1995;14:5209-5215.
54. Stanton RC, Seifter JL, Boxer DC, Zimmerman E, Cantley LC. Rapid release of bound glucose-6-phosphate dehydrogenase by growth factors. J Biol Chem. 1991;266:12442-12448.
55. Tian W-N, Braunstaein LD, Pang J, et al. Importance of glucose-6-phosphate dehydrogenase activity for cell growth. J Biol Chem. 1998;273:10609-10617.
56. Hsu S-C, Molday RS. Glucose metabolism in photoreceptor outer segments: its role in phototransduction and in NADPH-requiring reactions. J Biol Chem. 1994;269:17954-17959.
57. Matchinsky FM. Quantitative histochemistry of nicotinamide adenine nucleotides in retina of monkey and rabbit. J Neurochem. 1968;15:643-657.
58. Aguiar E, Cheng H-M, Lam DM-K. Real-time hexose monophosphate shunt activity in light- and dark-adapted rabbit retinas. Ophthalmic Res. 1987;19:290-302.
59. Papermaster DS, Schneider BG, Zorn MA, Kraehenbuhl JP. Immunocytochemical localization of a large intrinsic membrane protein to the incisures and margins of frog rod outer segment disks. J Cell Biol. 1978;78:415-425.
60. Illing M, Molday LL, Molday RS. The 220-kDa rim protein of retinal rod outer segments is a member of the AHC transporter super-family. J Biol Chem. 1997;272:10303-10310.
61. Thomson JL, Brzeski H, Dunbar B, et al. Photoreceptor rim protein: partial sequences of cDNA show a high degree of similarity to ABC transporters. Curr Eye Res. 1997;16:741-745.
62. Saari JC, Bredberg DL. Lecithin:retinol acyltransferase in retinal pigment epithelial microsomes. J Biol Chem. 1989;264:8636-8640.
63. Barry RJ, Canada FJ, Rando RR. Solubilization and partial purification of retinyl ester synthetase and retinoid isomerase from bovine ocular pigment epithelium. J Biol Chem. 1989;264:9231-9238.
64. Palczewski K. GTP-binding-coupled receptor kinases: two mechanistic models. Eur J Biochem. 1997;248:261-269.
65. Palczewski K. Structure and functions of arrestins. Protein Sci. 1994;3:1355-1361.
66. Hofmann KP, Pulvermüller A, Buczylko J. Van Hooser JP, Palczewski K. The role of arrestin and retinoids in the regeneration pathway of rhodopsin. J Biol Chem. 1992;267:15701-15706.
67. Palczewski K, Jager S, Buczylko J, et al. Rod outer segment retinol dehydrogenase: substrate specificity and role in phototransduction. Biochemistry. 1994;33:13741-13750.
68. Adler AJ, Stafford III WF, Slayter HS. Size and shape of bovine interphotoreceptor retinoid-binding protein by electron microscopy and hydrodynamic analysis. J Biol Chem. 1987;262:13198-13203.
69. Chen Y, Saari JC, Noy N. Interactions of all-trans-retinol and long-chain fatty acids with interphotoreceptor retinoid-binding protein. Biochemistry. 1993;32:11311-11318.
70. Lai YL, Wiggert B, Liu YP, Chader GJ. Interphotoreceptor retinol-binding proteins: possible transport vehicles between compartments of the retina. Science. 1982;298:848-849.
71. Saari JC, Teller DC, Crabb JW, Bredberg D. Properties of an interphotoreceptor retinoid-binding protein from bovine retina. J Biol Chem. 1985;265:195-201.
72. Fong S-L, Liou GI, Landers RA, Alvarez RA, Bridges CD. Purification and characterization of a retinol-binding glycoprotein synthesized and secreted by bovine neural retina. J Biol Chem. 1984;259:6534-6542.
73. Adler AJ, Spencer SA. Effect of light on endogenous ligands carried by interphotoreceptor retinoid-binding protein. Exp Eye Res. 1991;53:337-346.
74. Bunt-Milam AH, Saari JC, Klock IH, Garwin GG. Zonulae adherentes pore size in the external limiting membrane of the rabbit retina. Invest Ophthalmol Vis Sci. 1985;26:1377-1380.
75. Pfeffer B, Wiggert B, Lee L, Zonnenberg B, Newsome D, Chader G. The presence of a soluble interphotoreceptor retinol-hinding protein (IRBP) in the retinal interphotoreceptor space. J Cell Physiol. 1983;117:333-341.
76. Lion GI, Fei Y, Peachey NS, et al. Early onset photoreceptor abnormalities induced by targeted disruption of the interphotoreceptor retinoid-binding protein gene. J Neurosci. 1998;18: 4511-4520.
77. Carlson A, Bok D. Promotion of release of 11-cis-retinal from cultured retinal pigment epithelium by interphotoreceptor retinoid-hinding protein. Biochemistry. 1992;31:9056-9062.
78. Carlson A, Bok D. Polarity of 11-cis retinal release from cultured retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1999;40: 533-537.
79. Okajima T-IL, Pepperberg DR, Ripps H, Wiggert B, Chader GJ. Interphotoreceptor retinoid-binding protein promotes rhodopsin regeneration in toad photoreceptors. Proc Natl Acad Sci USA. 1990;87:6907-6911.
80. Adler AJ, Evans CD, Stafford WF III. Molecular properties of bovine interphotoreceptor retinol-binding protein. J Biol Chem. 1985;260:4850-4855.
81. Redmond TM, Wiggert B, Robey FA, et al. Isolation and characterization of monkey interphotoreceptor retinoid-binding protein, a unique extracellular matrix component of the retina. Biochemistry. 1985;24:787-793.
82. Ho M-TP, Massey JB, Pownall HJ, Anderson RE, Hollyfield JG. Mechanism of vitamin A movement between rod outer segments, interphotoreceptor retinoid-binding protein, and liposomes. J Biol Chem. 1989;264:928-935.
83. Crouch RK, Hazard ES, Lind T, Wiggert B, Chader G, Corson DW. Interphotoreceptor retinoid-binding protein and alpha-tocopherol preserve the isomeric and oxidation state of retinol. Photochem Photobiol. 1992;56:251-252.
84. Redmond TM, Yu S, Lee E. et al. Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat Gen. 1998;20:344-351.
85. Sun H, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J. Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium. Proc Natl Acad Sci USA. 1997;94:9893-9898.
86. Shen D, Jiang M, Hao W, Tao L, Salazar M, Fong HKW. A human opsin-related gene that encodes a retinaldehyde-binding protein. Biochemistry. 1994;33:13117-13125.
87. Schuster VL. Molecular mechanisms of prostaglandin transport. Annu Rev Physiol. 1998;60:221-242.
88. Das SR, Bhardwaj N, Kjeldbye H, Gouras P. Muller cells of chicken retina synthesize 11-cis-retinol. Biochem J. 1992;285: 907-913.
89. Kemp CM, Jacobson SG, Roman AJ, Sung CH, Nathans J. Abnormal rod dark adaptation in autosomal dominant retinitis pigmentosa with proline-23-histidine rhodopsin mutation. Am J Ophthalmol. 1992;15:165-174.
90. Ripps H, Brin KP, Weale RA. Rhodopsin and visual threshold in retinitis pigmentosa. Invest Ophthalmol Vis Sci. 1978;17:735-745.
91. Sieving PA, Richards JE, Naarendorp F, Bingham EL, Scott K, Alpern M. Dark-light: model for nightblindness from the human rhodopsin Gly-90-Asp mutation. Proc Natl Acad Sci USA. 1995; 92:880-884.
92. Rao VR, Oprian DD. Activating mutations of rhodopsin and other G protein-coupled receptors. Annu Rev Biophys Biomol Struct. 1996;25:287-314.
93. Dryja TP, Hahn LB, Reboul T, Arnaud B. Missense mutation in the gene encoding the a subunit of rod transducin in the Nougaret form of congenital stationary night blindness. Nat Gen. 1996;13: 358-360.
94. Fuchs S, Hakazawa M, Maw M, Tamai M, Oguchi Y, Gal A. A homozygous 1-base pair deletion in the arrestin gene is a frequent cause of Oguchi disease in Japanese. Nat Gen 1995; 10:360-362.
95. Yamamoto S, Sippel KC, Berson EL, Dryja TP. Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. Nat Gen. 1997;15:175-178.
96. Allikmets R, Singh N, Sun H, et al. et al. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet. 1997;15:236-245.
97. Gu S-M, Thompson DA, Srisailapathy Srikumari CR, et al. Mutations in RPE65 cause autosomal recessive childhood onset severe retinal dystrophy. Nat Genet. 1997;17:194-197.
98. Marlhens F, Bareil C, Griffoin J-M, et al. Mutations in RPE65 cause Leber's congenital amaurosis. Nat Genet. 1997;17:139-141.
99. Yamamoto H., Simon A, Eriksson U, Harris E, Berson EL, and Dryja TP. Mutations in the gene encoding 11-cis-retinol dehydrogenase (RDH1) in patients with fundus albipunctatus. Nature Genetics. 1999;22:188-191.
100. Carr RE. Abnormalities of cone and rod function. In: Ryan SJ, Ogden TE, Shachat AP, eds. Retina. 2nd ed. Vol 1. St Louis: Mosby; 1994:502-514.
101. Carr RE, Ripps H. Rhodopsin kinetics and rod adaptation in Oguchi's disease. Invest Ophthalmol Vis Sci. 1967;6:426-436.
102. Ripps H. Night blindness revisited: from man to molecules. Invest Ophthalmol Vis Sci. 1982;23:588-609.
103. Saari JC, Bredberg DL. Photochemistry and stereoselectivity of cellular retinaldehyde-binding protein from bovine retina. J Biol Chem. 1987;262:7618-7622.
104. Saari JC, Bredberg L, Garwin GG. Identification of the endogenous retinoids associated with three cellular retinoid-binding proteins from bovine retina and retinal pigment epithelium. J Biol Chem. 1982;257:13329-13333.
105. Saari JC, Bredberg DL, Noy N. Control of substrate flow at a branch in the visual cycle. Biochemistry. 1994;33:3106-3112.
106. Stecher H, Gelb MH, Saari JC, Palczewski K. Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein. J Biol Chem. 1999;274:8577-8585.
107. Winston AE, Rando RR. Regulation of isomerohydrolase activity in the visual cycle. Biochemistry. 1998;37:2044-2050.
108. Kennedy BN, Huang J, Saari JC, Crabb JW. Molecular characterization of the mouse gene encoding cellular retinaldehyde-binding protein. Mol Vis. 1998;4:14-21.
109. Maw, MA, Kennedy B, Knight A, et al. Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa. Nat Gen. 1997;17:198-200.
110. Morimura H, Berson EL, Dryja TP. Recessive mutations in the RLBP1 gene encoding cellular retinaldehyde-binding protein in a form of retinitis punctata albescens. Invest Ophthalmot Vis Sci. 1999;40:1000-1004.
111. Burstedl MSI, Sandgren O, Holmgren G, Forsman-Semb K. Bothnia dystrophy caused by mutations in the cellular retinaldehyde-binding protein gene (RLBP1) on chromosome 15q26. Invest Ophthalmol Vis Sci. 1999;40:995-1000.
112. Mangelsdorf DJ, Umesono K, Evans RE. The retinoid receptors. In: Sporn MB, Roberts AB, Goodman DS, eds. The Retinoids: Biology, Chemistry, and Medicine. 2nd ed. New York: Raven Press; 1994:319-349.
113. Jones GJ, Crouch RK, Wiggert B, Cornwall MC, Chader GJ. Retinoid requirements for recovery of sensitivity after visual-pigment bleaching in isolated photoreceptors. Proc Natl Acad Sci USA. 1989;86:9606-9610.
114. Goldstein EB. Early receptor potential of the isolated frog (Rana pipiens) retina. Vision Res. 1967;7:837-845.
115. Goldstein EB. Cone pigment regeneration in the isolated frog retina. Vision Res. 1970;10:1065-1068.
116. Goldstein EB, Wolf BM. Regeneration of the green-rod pigment in the isolated frog retina. Vision Res. 1973;13:527-534.
117. Cone RA. Early receptor potential of the vertebrate eye. Nature. 1964;204:736-739.
118. Cone RA, Cobbs WH III. Rhodopsin cycle in the living eye of the rat. Nature. 1969;221:820-822.