TRPC channels: Interacting proteins

Handbook of Experimental Pharmacology

Volumn 179, Issue , 2007, Pages 559-574

  Kiselyov, K ^a   Shin, D M ^b   Kim, J Y ^c   Yuan, J P ^c   Muallem, S ^c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b Yonsei University College of Dentistry   (South Korea)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Homer; Junctate; Receptor induced Ca2+ influx; Scaffold proteins; TRP channels

Indexed keywords

PROTEIN; RECOMBINANT PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL C;

ANIMAL; BIOTRANSFORMATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMALS; BIOTRANSFORMATION; GENE EXPRESSION REGULATION; HUMANS; PROTEINS; RECOMBINANT PROTEINS; TRPC CATION CHANNELS;

EID: 33846912245     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-540-34891-7_33     Document Type: Article

References (102)

1. AllenPB, Ouimet CC,GreengardP(1997) Spinophilin, anovel protein phosphatase 1 binding protein localized to dendritic spines. Proc Natl Acad Sci U S A 94:9956
2. Berridge MJ (2001) The versatility and complexity of calcium signalling. Novartis Found Symp 239:52
3. Bezprozvanny I (2005) The inositol 1,4,5-trisphosphate receptors. Cell Calcium 38:261
4. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE (2004) Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol 6:709
5. Bosanac I, Yamazaki H, Matsu-Ura T, Michikawa T, Ikura K, Mikoshiba M (2005) Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor. Mol Cell 17:193
6. Boulay G, Zhu X, Peyton M, Jiang M, Hurst R, Stefani E, Birnbaumer L (1997) Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein. J Biol Chem 272:29672
7. Boulay G, Brown DM, Qin N, Jiang M, Dietrich A, Zhu MX, Chen Z, Birnbaumer M, Mikoshiba K, Birnbaumer L (1999) Modulation of Ca(2+) entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. Proc Natl Acad Sci U S A 96:14955
8. Brakeman PR, Lanahan AA, O'Brien R, Roche K, Barnes CA, Huganir RL,Worley PF (1997) Homer: aprotein that selectively binds metabotropic glutamate receptors.Nature 386:284
9. Brazer SC, Singh BB, Liu X, SwaimW,Ambudkar IS (2003) Caveolin-1 contributes to assembly of store-operated Ca2+ influx channels by regulating plasma membrane localization of TRPC1. J Biol Chem 278:27208
10. CatterallWA (2000) Structure and regulation of voltage-gated Ca2+ channels. Annu Rev Cell Dev Biol 16:521
11. Chevesich J, Kreuz AJ, Montell C (1997) Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex. Neuron 18:95
12. Delmas P, Wanaverbecq N, Abogadie FC, Mistry M, Brown DA (2002) Signaling microdomains define the specificity of receptor-mediated InsP(3) pathways in neurons. Neuron 34:209
13. DietrichA,Mederos YSM, GollaschM, GrossV, StorchU,Dubrovska G, Obst M, YildirimE, Salanova B, Kalwa H, Essin K, Pinkenburg O, Luft FC, Gudermann T, Birnbaumer L (2005) Increased vascular smooth muscle contractility in TRPC6?/? mice. Mol Cell Biol 25:6980
14. Dolmetsch RE, Xu K, Lewis RS (1998) Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392:933
15. EhrengruberMU, Kato A, Inokuchi K,Hennou S (2004)Homer/Vesl proteins and their roles in CNS neurons. Mol Neurobiol 29:213
16. Fagni L,Worley PF, Ango F (2002) Homer as both a scaffold and transduction molecule. Sci STKE 2002:RE8
17. Fasolato C, Nilius B (1998) Store depletion triggers the calcium release-activated calcium current (ICRAC) in macrovascular endothelial cells: a comparison with. Jurkat and embryonic kidney cell lines. Pflugers Arch 436:69
18. Feske S, Prakriya M, Rao A, LewisRS (2005)Asevere defect inCRACCa2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients. J Exp Med 202:651
19. Freichel M, Suh SH, Pfeifer A, Schweig U, Trost C,Weissgerber P, Biel M, Philipp S, Freise D, Droogmans G, Hofmann F, Flockerzi V, Nilius B (2001) Lack of an endothelial storeoperated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4?/? mice. Nat Cell Biol 3:121
20. Fujiyama K, Kajii Y, Hiraoka S, Nishikawa T (2003) Differential regulation by stimulants of neocortical expression ofmrt1, arc, and homer1amRNAin the rats treatedwith repeated methamphetamine. Synapse 49:143
21. Goel M, Sinkins WG, Schilling WP (2002) Selective association of TRPC channel subunits in rat brain synaptosomes. J Biol Chem 277:48303
22. Goel M, SinkinsW,Keightley A, KinterM, SchillingWP(2005) Proteomic analysis of TRPC5-and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Pflugers Arch 451:87
23. Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (2003) TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci 6:837
24. Gudermann T, Hofmann T, Mederos y Schnitzler M, Dietrich A (2004) Activation, subunit composition and physiological relevance of DAG-sensitive TRPC proteins. Novartis Found Symp 258:103
25. Guerini D, Coletto L, Carafoli E (2005) Exporting calcium from cells. Cell Calcium 38:281
26. Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, Mizutani A, Mikoshiba K (2004) Regulation of TRPC6 channel activity by tyrosine phosphorylation. J Biol Chem 279:18887
27. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397:259
28. Hong CS,Kwak YG, Ji JH, ChaeSW,Kim doH(2001)Molecular cloning and characterization of mouse cardiac junctate isoforms. Biochem Biophys Res Commun 289:882
29. Jahn R, Lang T, Sudhof TC (2003) Membrane fusion. Cell 112:519
30. Kane JK, Hwang Y, Konu O, Loughlin SE, Leslie FM, Li MD (2005) Regulation of Homer and group I metabotropic glutamate receptors by nicotine. Eur J Neurosci 21:1145
31. Kim MT, Kim BJ, Lee JH, Kwon SC, Yeon DS, Yang DK, So I, Kim KW (2005) Involvement of calmodulin and myosin light chain kinase in the activation of mTRPC5 expressed in HEK cells. Am J Physiol Cell Physiol 290:C1031-C1040
32. Kim SJ, Kim YS, Yuan JP, Petralia RS,Worley PF, Linden DJ (2003) Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Nature 426:285
33. Kiselyov K,Xu X,Mozhayeva G,KuoT, Pessah I, MigneryG,Zhu X,Birnbaumer L,Muallem S (1998) Functional interaction between InsP3 receptors and store-operated Htrp3 channels. Nature 396:478
34. Kiselyov K, Mignery GA, Zhu MX, Muallem S (1999) The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels. Mol Cell 4:423
35. Kiselyov KI, Shin DM, Wang Y, Pessah IN, Allen PD, Muallem S (2000) Gating of storeoperated channels by conformational coupling to ryanodine receptors. Mol Cell 6:421
36. KrizW(2005) TRPC6-a new podocyte gene involved in focal segmental glomerulosclerosis. Trends Mol Med 11:527
37. Liou J, Kim ML, Do HeoW, Jones JT,Myers JW, Ferrell JE Jr,Meyer T (2005) STIM is a Ca(2+) sensor essential for Ca(2+)-store-depletion-triggered Ca(2+) influx. Curr Biol 15:1235
38. MP, Cayouette S, Lepage PK, Bernier CL, Francoeur N, St-Hilaire M, Pinard M, BoulayG(2005a)MxA,amemberof thedynaminsuperfamily, interactswith the ankyrinlike repeat domain of TRPC. J Biol Chem 280:19393-19400
39. Lussier MP, Cayouette S, Lepage PK, Bernier CL, Francoeur N, St-Hilaire M, Pinard M, Boulay G (2005b) MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC. J Biol Chem 280:19393
40. Ma HT, Venkatachalam K, Li HS, Montell C, Kurosaki T, Patterson RL, Gill DL (2001) Assessment of the role of the inositol 1,4,5-trisphosphate receptor in the activation of transient receptor potential channels and store-operated Ca2+ entry channels. J Biol Chem 276:18888
41. McAvoy T, Allen PB, Obaishi H, Nakanishi H, Takai Y, Greengard P, Nairn AC, Hemmings HC Jr (1999) Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation. Biochemistry 38:12943
42. Mery L, Strauss B, Dufour JF, Krause KH, Hoth M (2002) The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells. J Cell Sci 115:3497
43. Miletic G, Miyabe T, Gebhardt KJ, Miletic V (2005) Increased levels of Homer1b/c and Shank1a in the post-synaptic density of spinal dorsal horn neurons are associated with neuropathic pain in rats. Neurosci Lett 386:189
44. Nakanishi H, Obaishi H, Satoh A, Wada M, Mandai K, Satoh K, Nishioka H, Matsuura Y, Mizoguchi A, Takai Y (1997) Neurabin: a novel neural tissue-specific actin filamentbinding protein involved in neurite formation. J Cell Biol 139:951
45. Nelson SE,Duricka DL, Campbell K, Churchill L,Krueger JM (2004)Homer1a and 1bc levels in the rat somatosensory cortex vary with the time of day and sleep loss. Neurosci Lett 367:105
46. Obukhov AG, Nowycky MC (2004) TRPC5 activation kinetics are modulated by the scaffoldingprotein ezrin/radixin/moesin-binding phosphoprotein-50 (EBP50). JCellPhysiol 201:227
47. Odell AF, Scott JL, Van Helden DF (2005) Epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4. J Biol Chem 280:37974
48. Olson PA, Tkatch T, Hernandez-Lopez S, Ulrich S, Ilijic E, Mugnaini E, Zhang H, Bezprozvanny I, Surmeier DJ (2005) G-protein-coupled receptor modulation of striatal CaV1.3 L-type Ca2+ channels is dependent on a Shank-binding domain. J Neurosci 25:1050
49. Orrenius S, Zhivotovsky B,Nicotera P (2003) Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 4:552
50. Parekh AB, Putney JW Jr (2005) Store-operated calcium channels. Physiol Rev 85:757
51. Paria BC, Vogel SM, Ahmmed GU, Alamgir S, Shroff J,Malik AB, Tiruppathi C (2004) Tumor necrosis factor-alpha-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeability. Am J Physiol Lung Cell Mol Physiol 287:L1303
52. PaschenW,Mengesdorf T (2003) Conditions associatedwith ER dysfunction activate homer 1a expression. J Neurochem 86:1108
53. Patterson RL, van Rossum DB, Ford DL, Hurt KJ, Bae SS, Suh PG, Kurosaki T, Snyder SH, Gill DL (2002) Phospholipase C-gamma is required for agonist-induced Ca2+ entry. Cell 111:529
54. Praefcke GJ, McMahon HT (2004) The dynamin superfamily: universal membrane tubulation and fission molecules?. Nat Rev Mol Cell Biol 5:133
55. PutneyJWJr, Broad LM, Braun FJ, Lievremont JP, BirdGS (2001)Mechanisms of capacitative calcium entry. J Cell Sci 114:2223
56. Rao JN, Platoshyn O, Golovina VA, Liu L, Zou T, Marasa BS, Turner DJ, J XJY, Wang JY (2005) TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after wounding. Am J Physiol Gastrointest Liver Physiol 290:G782-G792
57. Reiser J, Polu KR, Moller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, ClaphamDE,PollakMR(2005)TRPC6is a glomerular slit diaphragm-associatedchannel required for normal renal function. Nat Genet 37:739
58. Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O, Kozak JA, Wagner SL, Cahalan MD, Velicelebi G, Stauderman KA (2005) STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol 169:435
59. Sala C, Roussignol G, Meldolesi J, Fagni L (2005) Key role of the postsynaptic density scaffold proteins Shank and Homer in the functional architecture of Ca2+ homeostasis at dendritic spines in hippocampal neurons. J Neurosci 25:4587
60. Sampieri A,Diaz-MunozM, Antaramian A,Vaca L (2005) The foot structure fromthe type 1 ryanodine receptor is required for functional coupling to store-operated channels. J Biol Chem 280:24804
61. Satoh A, Nakanishi H, Obaishi H, Wada M, Takahashi K, Satoh K, Hirao K, Nishioka H, Hata Y,Mizoguchi A, Takai Y (1998) Neurabin-II/spinophilin. An actin filament-binding protein with one pdz domain localized at cadherin-based cell-cell adhesion sites. J Biol Chem 273:3470
62. Schilling WP, Goel M (2004) Mammalian TRPC channel subunit assembly. Novartis Found Symp 258:18
63. Scott K, Sun Y, Beckingham K, Zuker CS (1997) Calmodulin regulation of Drosophila lightactivated channels and receptor function mediates termination of the light response in vivo. Cell 91:375
64. Shi J, Mori E, Mori Y, Mori M, Li J, Ito Y, Inoue R (2004) Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol 561:415
65. Shimizu S, Yoshida T, Wakamori M, Ishii M, Okada T, Takahashi M, Seto M, Sakurada K, KiuchiY,MoriY(2005)Ca2+/calmodulin dependentmyosin light chainkinase is essential for activation of TRPC5 channels expressed in HEK293 cells. J Physiol 570:219-235
66. Singh BB, Liu X, Tang J, Zhu MX, Ambudkar IS (2002) Calmodulin regulates Ca(2+)-dependent feedback inhibition of store-operated Ca(2+) influx by interaction with a site in the C terminus of TrpC1. Mol Cell 9:739
67. Singh BB, Lockwich TP, Bandyopadhyay BC, Liu X, Bollimuntha S, Brazer SC, Combs C, DasS,LeendersAG, ShengZH,KnepperMA,AmbudkarSV,Ambudkar IS (2004)VAMP2-dependent exocytosis regulates plasma membrane insertion of TRPC3 channels and contributes to agonist-stimulated Ca2+ influx. Mol Cell 15:635
68. Soboloff J, Spassova M, Xu W, He LP, Cuesta N, Gill DL (2005) Role of endogenous TRPC6 channels in Ca2+ signal generation in A7r5 smooth muscle cells. J Biol Chem 280:39786
69. Spassova MA, Soboloff J, He LP, Xu W, Dziadek MA, Gill DL (2006) STIM1 has a plasma membrane role in the activation of store-operated Ca2+ channels. Proc Natl Acad Sci U S A 103:4040
70. Stamboulian S, Moutin MJ, Treves S, Pochon N, Grunwald D, Zorzato F, De Waard M, Ronjat M, Arnoult C (2005) Junctate, an inositol 1,4,5-triphosphate receptor associated protein, ispresent inrodent spermandbindsTRPC2andTRPC5butnotTRPC1channels. Dev Biol 286:326
71. Stiber JA, Tabatabaei N, Hawkins AF, Hawke T,Worley PF,Williams RS, Rosenberg P (2005) Homer modulates NFAT-dependent signaling during muscle differentiation. Dev Biol 287:213
72. Strubing C, Krapivinsky G, Krapivinsky L, Clapham DE (2001) TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29:645
73. Sutton KA, Jungnickel MK, Wang Y, Cullen K, Lambert S, Florman HM (2004) Enkurin is a novel calmodulin and TRPC channel binding protein in sperm. Dev Biol 274:426
74. Sweeney M, Yu Y, Platoshyn O, Zhang S,McDaniel SS, Yuan JX (2002) Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol 283:L144
75. Tang J, Lin Y, Zhang Z, Tikunova S, Birnbaumer L, ZhuMX (2001) Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. J Biol Chem 276:21303
76. Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, Zhu MX (2000) Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein NHERF. J Biol Chem 275:37559
77. Thebault S, Zholos A, Enfissi A, Slomianny C, Dewailly E, Roudbaraki M, Parys J, Prevarskaya N (2005) Receptor-operated Ca(2+) entry mediated by TRPC3/TRPC6 proteins in rat prostate smooth muscle (PS1) cell line. J Cell Physiol 290:C1060-C1066
78. Trebak M, Bird GS,McKay RR, Putney JW Jr (2002) Comparison of human TRPC3 channels inreceptor-activatedandstore-operatedmodes.Differential sensitivity to channel blockers suggests fundamental differences in channel composition. J Biol Chem 277:21617
79. Treves S, Feriotto G, Moccagatta L, Gambari R, Zorzato F (2000) Molecular cloning, expression, functional characterization, chromosomal localization, and gene structure of junctate, a novel integral calcium binding protein of sarco(endo)plasmic reticulum membrane. J Biol Chem 275:39555
80. Treves S, Franzini-Armstrong C, Moccagatta L, Arnoult C, Grasso C, Schrum A, Ducreux S, ZhuMX, Mikoshiba K, Girard T, Smida-Rezgui S, RonjatM, Zorzato F (2004) Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion. J Cell Biol 166:537
81. Tsunoda S, Sierralta J, Sun Y, Bodner R, Suzuki E, Becker A, Socolich M, Zuker CS (1997) A multivalent PDZ-domain protein assembles signalling complexes in a G-proteincoupled cascade. Nature 388:243
82. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (1998) Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21:717
83. van Rossum DB, Patterson RL, Sharma S, Barrow RK, Kornberg M, Gill DL, Snyder SH (2005) Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain. Nature 434:99
84. Vazquez G, Lievremont JP, St JBG, Putney JW Jr (2001) Human Trp3 forms both inositol trisphosphate receptor-dependent and receptor-independent store-operated cation channels in DT40 avian B lymphocytes. Proc Natl Acad Sci U S A 98:11777
85. Venkatachalam K,MaHT, FordDL, GillDL(2001) Expressionof functional receptor-coupled TRPC3 channels in DT40 riple receptor InsP3 knockout cells. J Biol Chem 276:33980
86. Venkatachalam K, Zheng F, Gill DL (2003) Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C. J Biol Chem 278:29031
87. Venkatachalam K, Zheng F, Gill DL (2004) Control of TRPC and store-operated channels by protein kinase C. Novartis Found Symp 258:172
88. Wang GX, PooMM(2005) Requirement of TRPC channels in netrin-1-induced chemotropic turning of nerve growth cones. Nature 434:898
89. Wang X, Zeng W, Soyombo AA, Tang W, Ross EM, Barnes AP, Milgram SL, Penninger JM, Allen PB, Greengard P, Muallem S (2005) Spinophilin regulates Ca(2+) signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-proteincoupled receptors. Nat Cell Biol 7:405-411
90. Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF, Daskalakis N, Kwan SY, Ebersviller S, Burchette JL, Pericak-Vance MA, Howell DN, Vance JM, Rosenberg PB (2005) A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 308:1801
91. Wu X, Babnigg G, Villereal ML (2000) Functional significance of human trp1 and trp3 in store-operated Ca(2+) entry in HEK-293 cells. Am J Physiol Cell Physiol 278:C526
92. Wu X, Babnigg G, Zagranichnaya T, Villereal ML (2002) The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells. J Biol Chem 277:13597
93. Wu X, Zagranichnaya TK, Gurda GT, Eves EM, Villereal ML (2004) A TRPC1/TRPC3-mediated increase in store-operated calcium entry is required for differentiation of H19-7 hippocampal neuronal cells. J Biol Chem 279:43392
94. Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Ruggiero A, Lanahan AA, Wenthold RJ, Worley PF (1998) Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related synaptic proteins. Neuron 21:707
95. Xiao B, Tu JC, Worley PF (2000) Homer: a link between neural activity and glutamate receptor function. Curr Opin Neurobiol 10:370
96. Yamamoto K, Sakagami Y, Sugiura S, Inokuchi K, Shimohama S, Kato N (2005) Homer 1a enhances spike-induced calcium influx via L-type calcium channels in neocortex pyramidal cells. Eur J Neurosci 22:1338
97. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (2003) Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114:777
98. Zagranichnaya TK, Wu X, Villereal ML (2005) Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. J Biol Chem 280:29559
99. Zhang SL, Yu Y, Roos J, Kozak JA, Deerinck TJ, Ellisman MH, Stauderman KA, Cahalan MD (2005) STIM1 is a Ca2+ sensor that activates CRAC channels and migrates fromthe Ca2+ store to the plasma membrane. Nature 437:902
100. ZhangZ, Tang J, TikunovaS, Johnson JD,ChenZ,QinN,DietrichA,Stefani E, BirnbaumerL, Zhu MX (2001) Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin froma common binding domain. Proc Natl Acad Sci U S A 98:3168
101. Zhu MH, Chae M, Kim HJ, Lee YM, Kim MJ, Jin NG, Yang DK, So I, Kim KW (2005) Desensitization of canonical transient receptor potential channel 5 by protein kinase C. Am J Physiol Cell Physiol 289:C591
102. Zhu MX (2005) Multiple roles of calmodulin and other Ca(2+)-binding proteins in the functional regulation of TRP channels. Pflugers Arch 451:105