Bioinformatic identification of tandem repeat antigens of the Leishmania donovani complex

Infection and Immunity

Volumn 75, Issue 2, 2007, Pages 846-851

  Goto, Yasuyuki ^a   Coler, Rhea N ^a   Reed, Steven G ^a  

^a INFECTIOUS DISEASE RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIGEN; PARASITE ANTIGEN;

ANTIBODY RESPONSE; ANTIGENICITY; ARTICLE; BIOINFORMATICS; GENE SEQUENCE; LEISHMANIA DONOVANI; LEISHMANIA INFANTUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE DATABASE; SUDAN; TANDEM REPEAT; VISCERAL LEISHMANIASIS;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; COMPUTATIONAL BIOLOGY; ENZYME-LINKED IMMUNOSORBENT ASSAY; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; SUDAN; TANDEM REPEAT SEQUENCES;

EID: 33846833611     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01205-06     Document Type: Article

References (37)

1. Araoz, R., N. Honore, S. Cho, J. P. Kim, S. N. Cho, M. Monot, C. Demangel, P. J. Brennan, and S. T. Cole. 2006. Antigen discovery: a postgenomic approach to leprosy diagnosis. Infect. Immun. 74:175-182.
2. Benson, G. 1999. Tandem repeats finder: a program to analyze DNA sequences. Nucleic Acids Res. 27:573-580.
3. Bern, C., S. N. Jha, A. B. Joshi, G. D. Thakur, and M. B. Bista. 2000. Use of the recombinant K39 dipstick test and the direct agglutination test in a setting endemic for visceral leishmaniasis in Nepal. Am. J. Trop. Med. Hyg. 63:153-157.
4. Berriman, M., E. Ghedin, C. Hertz-Fowler, G. Blandin, H. Renauld, D. C. Bartholomeu, N. J. Lennard, E. Caler, N. E. Hamlin, B. Haas, U. Bohme, L. Hannick, M. A. Aslett, J. Shallom, L. Marcello, L. Hou, B. Wickstead, U. C. Alsmark, C. Arrowsmith, R. J. Atkin, A. J. Barron, F. Bringaud, K. Brooks, M. Carrington, I. Cherevach, T. J. Chillingworth, C. Churcher, L. N. Clark, C. H. Corton, A. Cronin, R. M. Davies, J. Doggett, A. Djikeng, T. Feldblyum, M. C. Field, A. Fraser, I. Goodhead, Z. Hance, D. Harper, B. R. Harris, H. Hauser, J. Hosteller, A. Ivens, K. Jagels, D. Johnson, J. Johnson, K. Jones, A. X. Kerhornou, H. Koo, N. Larke, S. Landfear, C. Larkin, V. Leech, A. Line, A. Lord, A. Macleod, P. J. Mooney, S. Moule, D. M. Martin, G. W. Morgan, K. Mungall, H. Norbertczak, D. Ormond, G. Pai, C. S. Peacock, J. Peterson, M. A. Quail, E. Rabbinowitsch, M. A. Rajandream, C. Reitter, S. L. Salzberg, M. Sanders, S. Schobel, S. Sharp, M. Simmonds, A. J. Simpson, L. Tallon, C. M. Turner, A. Tait, A. R. Tivey, S. Van Aken, D. Walker, D. Wanless, S. Wang, B. White, O. White, S. Whitehead, J. Woodward, J. Wortman, M. D. Adams, T. M. Embley, K. Gull, E. Ullu, J. D. Barry, A. H. Fairlamb, F. Opperdoes, B. G. Barrell, J. E. Donelson, N. Hall, C. M. Fraser, et al. 2005. The genome of the African trypanosome Trypanosoma brucei. Science 309:416-422.
5. Bhatia, A., N. S. Daifalla, S. Jen, R. Badaro, S. G. Reed, and Y. A. Skeiky. 1999. Cloning, characterization, and serological evaluation of K9 and K26: two related hydrophilic antigens of Leishmania chagasi. Mol. Biochem. Parasitol. 102:249-261.
6. Bhatia, V., M. Sinha, B. Luxon, and N. Garg. 2004. Utility of the Trypanosoma cruzi sequence database for identification of potential vaccine candidates by in silico and in vitro screening. Infect. Immun. 72:6245-6254.
7. Burns, J. M., Jr., W. G. Shreffler, D. R. Benson, H. W. Ghalib, R. Badaro, and S. G. Reed. 1993. Molecular characterization of a kinesin-related antigen of Leishmania chagasi that detects specific antibody in African and American visceral leishmaniasis. Proc. Natl. Acad. Sci. USA 90:775-779.
8. Burns, J. M., Jr., W. G. Shreffler, D. E. Rosman, P. R. Sleath, C. J. March, and S. G. Reed. 1992. Identification and synthesis of a major conserved antigenic epitope of Trypanosoma cruzi. Proc. Natl. Acad. Sci. USA 89:1239-1243.
9. Coppel, R. L., A. F. Cowman, R. F. Anders, A. E. Bianco, R. B. Saint, K. R. Lingelbach, D. J. Kemp, and G. V. Brown. 1984. Immune sera recognize on erythrocytes Plasmodium falciparum antigen composed of repeated amino acid sequences. Nature 310:789-792.
10. Cowman, A. F., R. B. Saint, R. L. Coppel, G. V. Brown, R. F. Anders, and D. J. Kemp. 1985. Conserved sequences flank variable tandem repeats in two S-antigen genes of Plasmodium falciparum. Cell 40:775-783.
11. Dame, J. B., J. L. Williams, T. F. McCutchan, J. L. Weber, R. A. Wirtz, W. T. Hockmeyer, W. L. Maloy, J. D. Haynes, I. Schneider, D. Roberts, et al. 1984. Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum. Science 225:593-599.
12. de Andrade, C. R., L. V. Kirchhoff, J. E. Donelson, and K. Otsu. 1992. Recombinant Leishmania Hsp90 and Hsp70 are recognized by sera from visceral leishmaniasis patients but not Chagas' disease patients. J. Clin. Microbiol. 30:330-335.
13. Dillon, D. C., C. H. Day, J. A. Whittle, A. J. Magill, and S. G. Reed. 1995. Characterization of a Leishmania tropica antigen that detects immune responses in Desert Storm viscerotropic leishmaniasis patients. Proc. Natl. Acad. Sci. USA 92:7981-7985.
14. Gardner, M. J., N. Hall, E. Fung, O. White, M. Berriman, R. W. Hyman, J. M. Carlton, A. Pain, K. E. Nelson, S. Bowman, I. T. Paulsen, K. James, J. A. Eisen, K. Rutherford, S. L. Salzberg, A. Craig, S. Kyes, M. S. Chan, V. Nene, S. J. Shallom, B. Suh, J. Peterson, S. Angiuoli, M. Pertea, J. Allen, J. Selengut, D. Haft, M. W. Mather, A. B. Vaidya, D. M. Martin, A. H. Fairlamb, M. J. Fraunholz, D. S. Roos, S. A. Ralph, G. I. McFadden, L. M. Cummings, G. M. Subramanian, C. Mungall, J. C. Venter, D. J. Carucci, S. L. Hoffman, C. Newbold, R. W. Davis, C. M. Fraser, and B. Barrell. 2002. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419:498-511.
15. Ghedin, E., W. W. Zhang, H. Charest, S. Sundar, R. T. Kenney, and G. Matlashewski. 1997. Antibody response against a Leishmania donovani amastigote-stage-specific protein in patients with visceral leishmaniasis. Clin. Diagn. Lab. Immunol. 4:530-535.
16. 16. Goto, Y., R. N. Coler, J. Guderian, R. Mohamath, and S. G. Reed. 2006. Cloning, characterization, and serodiagnostic evaluation of Leishmania infantum tandem repeat proteins. Infect. Immun. 74:3939-3945.
17. Gruber, A., and B. Zingales. 1993. Trypanosoma cruzi: characterization of two recombinant antigens with potential application in the diagnosis of Chagas' disease. Exp. Parasitol. 76:1-12.
18. Hertz-Fowler, C., C. S. Peacock, V. Wood, M. Aslett, A. Kerhornou, P. Mooney, A. Tivey, M. Berriman, N. Hall, K. Rutherford, J. Parkhill, A. C. Ivens, M. A. Rajandream, and B. Barrell. 2004. GeneDB: a resource for prokaryotic and eukaryotic organisms. Nucleic Acids Res. 32:D339-D343.
19. Ibanez, C. F., J. L. Affranchino, R. A. Macina, M. B. Reyes, S. Leguizamon, M. E. Camargo, L. Aslund, U. Pettersson, and A. C. Frasch. 1988. Multiple Trypanosoma cruzi antigens containing tandemly repeated amino acid sequence motifs. Mol. Biochem. Parasitol. 30:27-33.
20. Ivens, A. C., C. S. Peacock, E. A. Worthey, L. Murphy, G. Aggarwal, M. Berriman, E. Sisk, M. A. Rajandream, E. Adlem, R. Aert, A. Anupama, Z. Apostolou, P. Attipoe, N. Bason, C. Bauser, A. Beck, S. M. Beverley, G. Bianchettin, K. Borzym, G. Bothe, C. V. Bruschi, M. Collins, E. Cadag, L. Ciarloni, C. Clayton, R. M. Coulson, A. Cronin, A. K. Cruz, R. M. Davies, J. De Gaudenzi, D. E. Dobson, A. Duesterhoeft, G. Fazelina, N. Fosker, A. C. Frasch, A. Fraser, M. Fuchs, C. Gabel, A. Goble, A. Goffeau, D. Harris, C. Hertz-Fowler, H. Hubert, D. Horn, Y. Huang, S. Klages, A. Knights, M. Kube, N. Larke, L. Litvin, A. Lord, T. Louie, M. Marra, D. Masuy, K. Matthews, S. Michaeli, J. C. Mottram, S. Muller-Auer, H. Munden, S. Nelson, H. Norbertczak, K. Oliver, S. O'Neil, M. Pentony, T. M. Pohl, C. Price, B. Purnelle, M. A. Quail, E. Rabbinowitsch, R. Reinhardt, M. Rieger, J. Rinta, J. Robben, L. Robertson, J. C. Ruiz, S. Rutter, D. Saunders, M. Schafer, J. Schein, D. C. Schwartz, K. Seeger, A. Seyler, S. Sharp, H. Shin, D. Sivam, R. Squares, S. Squares, V. Tosato, C. Vogt, G. Volckaert, R. Wambutt, T. Warren, H. Wedler, J. Woodward, S. Zhou, W. Zimmermann, D. F. Smith, J. M. Blackwell, K. D. Stuart, B. Barrell, et al. 2005. The genome of the kinetoplastid parasite, Leishmania major. Science 309:436-442.
21. Kemp, D. J., R. L. Coppel, and R. F. Anders. 1987. Repetitive proteins and genes of malaria. Annu. Rev. Microbiol. 41:181-208.
22. Koenen, M., A. Scherf, O. Mercereau, G. Langsley, L. Sibilli, P. Dubois, L. Pereira da Suva, and B. Muller-Hill. 1984. Human antisera detect a Plasmodium falciparum genomic clone encoding a nonapeptide repeat. Nature 311:382-385.
23. Kotera, Y., J. D. Fontenot, G. Pecher, R. S. Metzgar, and O. J. Finn. 1994. Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients. Cancer Res. 54:2856-2860.
24. Mollick, J. A., F. S. Hodi, R. J. Soiffer, L. M. Nadler, and G. Dranoff. 2003. MUC1-like tandem repeat proteins are broadly immunogenic in cancer patients. Cancer Immun. 3:3.
25. Pain, A., H. Renauld, M. Berriman, L. Murphy, C. A. Yeats, W. Weir, A. Kerhornou, M. Aslett, R. Bishop, C. Bouchier, M. Cochet, R. M. Coulson, A. Cronin, E. P. de Villiers, A. Fraser, N. Fosker, M. Gardner, A. Goble, S. Griffiths-Jones, D. E. Harris, F. Katzer, N. Larke, A. Lord, P. Maser, S. McKellar, P. Mooney, F. Morton, V. Nene, S. O'Neil, C. Price, M. A. Quail, E. Rabbinowitsch, N. D. Rawlings, S. Rutter, D. Saunders, K. Seeger, T. Shah, R. Squares, S. Squares, A. Tivey, A. R. Walker, J. Woodward, D. A. Dobbelaere, G. Langsley, M. A. Rajandream, D. McKeever, B. Shiels, A. Tait, B. Barrell, and N. Hall. 2005. Genome of the host-cell transforming parasite Theileria annulata compared to T. parva. Science 309:131-133.
26. Reece, S. T., G. Ireton, R. Mohamath, J. Guderian, W. Goto, R. Gelber, N. Groathouse, J. Spencer, P. Brennan, and S. G. Reed. 2006. ML0405 and ML2331 are antigens of Mycobacterium leprae with potential for diagnosis of leprosy. Clin. Vaccine Immunol. 13:333-340.
27. Reed, S. G. 1996. Diagnosis of leishmaniasis. Clin. Dermatol. 14:471-478.
28. Reeder, J. C., and G. V. Brown. 1996. Antigenic variation and immune evasion in Plasmodium falciparum malaria. Immunol. Cell Biol. 74:546-554.
29. Schofield, L. 1991. On the function of repetitive domains in protein antigens of Plasmodium and other eukaryotic parasites. Parasitol. Today 7:99-105.
30. Singh, S., and R. Sivakumar. 2003. Recent advances in the diagnosis of leishmaniasis. J. Postgrad. Med. 49:55-60.
31. Skeiky, Y. A., D. R. Benson, M. Elwasila, R. Badaro, J. M. Burns, Jr., and S. G. Reed. 1994. Antigens shared by Leishmania species and Trypanosoma cruzi: immunological comparison of the acidic ribosomal P0 proteins. Infect. Immun. 62:1643-1651.
32. Stahl, H. D., P. E. Crewther, R. F. Anders, G. V. Brown, R. L. Coppel, A. E. Bianco, G. F. Mitchell, and D. J. Kemp. 1985. Interspersed blocks of repetitive and charged amino acids in a dominant immunogen of Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 82:543-547.
33. Sundar, S., R. Maurya, R. K. Singh, K. Bharti, J. Chakravarty, A. Parekh, M. Rai, K. Kumar, and H. W. Murray. 2006. Rapid, noninvasive diagnosis of visceral leishmaniasis in India: comparison of two immunochromatographic strip tests for detection of anti-K39 antibody. J. Clin. Microbiol. 44:251-253.
34. Sundar, S., and M. Rai. 2002. Laboratory diagnosis of visceral leishmaniasis. Clin. Diagn. Lab. Immunol. 9:951-958.
35. Sundar, S., S. G. Reed, V. P. Singh, P. C. Kumar, and H. W. Murray. 1998. Rapid accurate field diagnosis of Indian visceral leishmaniasis. Lancet 351: 563-565.
36. Vergara, U., M. Lorca, C. Veloso, A. Gonzalez, A. Engstrom, L. Aslund, U. Pettersson, and A. C. Frasch. 1991. Assay for detection of Trypanosoma cruzi antibodies in human sera based on reaction with synthetic peptides. J. Clin. Microbiol. 29:2034-2037.
37. Zijlstra, E. E., Y. Nur, P. Desjeux, E. A. Khalil, A. M. El-Hassan, and J. Groen. 2001. Diagnosing visceral leishmaniasis with the recombinant K39 strip test: experience from the Sudan. Trop. Med. Int. Health 6:108-113.