MUC1-like tandem repeat proteins are broadly immunogenic in cancer patients

Cancer Immunity

Volumn 3, Issue , 2003, Pages 1-17

  Mollick, Joseph A ^a,c   Hodi, F Stephen ^a,b   Soiffer, Robert J ^a,b   Nadler, Lee M ^a,b   Dranoff, Glenn ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cultured tumor cells; Human; Melanoma; SEREX; Serologic tests; Tumor antigen

Indexed keywords

ANTISERUM; ARF PROTEIN; CELL ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR RECEPTOR; MUCIN 1; OPIOID GROWTH FACTOR RECEPTOR; OPIOID GROWTH FACTOR RECEPTOR ALTERNATIVE READING FRAME; PROTEIN ANTIBODY; SYNTHETIC PEPTIDE; TUMOR ANTIGEN; TUMOR CELL VACCINE; UNCLASSIFIED DRUG;

ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIGEN DETECTION; ARTICLE; BIOENGINEERING; BREAST CANCER; CANCER PATIENT; CANCER SURVIVAL; CELL FRACTIONATION; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPLASM; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOGENICITY; LUNG CANCER; MELANOMA; METASTASIS; OVARY CANCER; PROSTATE CANCER; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN POLYMORPHISM; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SERUM; SURVIVAL TIME; TANDEM REPEAT; TUMOR CELL; VACCINATION;

EID: 3042820772     PISSN: 14249634     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Boon T, van der Bruggen P. Human tumor antigens recognized by T lymphocytes. J Exp Med 1996; 183: 725-729. (PMID: 8642276)
2. Cox AL, Skipper J, Chen Y, Henderson RA, Darrow TL, Shabanowitz J, Engelhard VH, Hunt DF, Slingluff CL Jr. Identification of a peptide recognized by five melanoma-specific human cytotoxic T cell lines. Science 1994; 264: 716-719. (PMID: 7513441)
3. Sahin U, Tureci O, Schmitt H, Cochlovius B, Johannes T, Schmits R, Stenner F, Luo G, Schobert I, Pfreundschuh M. Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci USA 1995; 92: 11810-11813. (PMID: 8524854)
4. Chen YT, Scanlan MJ, Sahin U, Tureci O, Gure AO, Tsang S, Williamson B, Stockert E, Pfreundschuh M, Old LJ. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc Natl Acad Sci USA 1997; 94: 1914-1918. (PMID: 9050879)
5. Jager D, Stockert E, Scanlan MJ, Gure AO, Jager E, Knuth A, Old LJ, Chen YT. Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene. Cancer Res 1999; 59: 6197-6204. (PMID: 10626813)
6. von Mensdorff-Pouilly S, Snijdewint FG, Verstraeten AA, Verheijen RH, Kenemans P. Human MUC1 mucin: a multifaceted glycoprotein. Int J Biol Markers 2000; 15: 343-356. (PMID: 11192832)
7. von Mensdorff-Pouilly S, Verstraeten AA, Kenemans P, Snijdewint FG, Kok A, Van Kamp GJ, Paul MA, Van Diest PJ, Meijer S, Hilgers J. Survival in early breast cancer patients is favorably influenced by a natural humoral immune response to polymorphic epithelial mucin. J Clin Oncol 2000; 18: 574-583. (PMID: 10653872)
8. Soiffer R, Lynch T, Mihm M, Jung K, Rhuda C, Schmollinger JC, Hodi FS, Liebster L, Lam P, Mentzer S, Singer S, Tanabe KK, Cosimi AB, Duda R, Sober A, Bhan A, Daley J, Neuberg D, Parry G, Rokovich J, Richards L, Drayer J, Berns A, Clift S, Cohen LK, Mulligan RC, Dranoff G. Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc Natl Acad Sci USA 1998; 95: 13141-13146. (PMID: 9789055)
9. Zagon IS, Smith JP, Conter R, McLaughlin PJ. Identification and characterization of opioid growth factor receptor in human pancreatic adenocarcinoma. Int J Mol Med 2000; 5: 77-84. (PMID: 10601579)
10. Zagon IS, Verderame MF, Allen SS, McLaughlin PJ. Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans. Brain Res 2000; 856: 75-83. (PMID: 10677613)
11. Siddiqui J, Abe M, Hayes D, Shani E, Yunis E, Kufe D. Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen. Proc Natl Acad Sci USA, 1988; 85: 2320-2323. (PMID: 2895474)
12. Gendler SJ, Lancaster CA, Taylor-Papadimitriou J, Duhig T, Peat N, Burchell J, Pemberton L, Lalani EN, Wilson D. Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J Biol Chem 1990; 265: 15286-15293. (PMID: 1697589)
13. Fontenot JD, Gatewood JM, Mariappan SV, Pau CP, Parekh BS, George JR, Gupta G. Human immunodeficiency virus (HIV) antigens: structure and serology of multivalent human mucin MUC1-HIV V3 chimeric proteins. Proc Natl Acad Sci USA 1995; 92: 315-319. (PMID: 7816840)
14. Fontenot JD, Mariappan SV, Catasti P, Domenech N, Finn OJ, Gupta G. Structure of a tumor associated antigen containing a tandemly repeated immunodominant epitope. J Biomol Struct Dyn 1995; 13: 245-260. (PMID: 8579785)
15. Fontenot JD, Finn OJ, Dales N, Andrews PC, Montelaro RC. Synthesis of large multideterminant peptide immunogens using a polyproline beta-turn helix motif. Pept Res 1993; 6: 330-336. (PMID: 8292850)
16. Quelle DE, Zindy F, Ashmun RA, Sherr CJ. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 1995; 83: 993-1000. (PMID: 8521522)
17. Mollick J. Unpublished observation.
18. Snijdewint FG, von Mensdorff-Pouilly S, Karuntu-Wanamarta AH, Verstraeten AA, van Zanten-Przybysz I, Hummel P, Nijman HW, Kenemans P, Hilgers J. Cellular and humoral immune responses to MUC1 mucin and tandem-repeat peptides in ovarian cancer patients and controls. Cancer Immunol Immunother 1999; 48: 47-55. (PMID: 10235488)
19. Wu CJ, Yang XF, McLaughlin S, Neuberg D, Canning C, Stein B, Alyea EP, Soiffer RJ, Dranoff G, Ritz J. Detection of a potent humoral response associated with immune-induced remission of chronic myelogenous leukemia. J Clin Invest 2000; 106: 705-714. (PMID: 10974024)
20. Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ. Characterization of human colon cancer antigens recognized by autologous antibodies. Int J Cancer 1998; 76: 652-658. (PMID: 9610721)
21. Mayrand SM, Green WR. Non-traditionally derived CTL epitopes: exceptions that prove the rules? Immunol Today 1998; 19: 551-556. (PMID: 9864945)
22. Wang RF, Parkhurst MR, Kawakami Y, Robbins PF, Rosenberg SA. Utilization of an alternative open reading frame of a normal gene in generating a novel human cancer antigen. J Exp Med 1996; 183: 1131-1140. (PMID: 8642255)
23. Rimoldi D, Rubio-Godoy V, Dutoit V, Lienard D, Salvi S, Guillaume P, Speiser D, Stockert E, Spagnoli G, Servis C, Cerottini JC, Lejeune F, Romero P, Valmori D. Efficient simultaneous presentation of NY-ESO-1/LAGE-1 primary and nonprimary open reading frame-derived CTL epitopes in melanoma. J Immunol 2000; 165: 7253-7261. (PMID: 11120859)
24. Wang RF, Johnston SL, Zeng G, Topalian SL, Schwartzentruber DJ, Rosenberg SA. A breast and melanoma-shared tumor antigen: T cell responses to antigenic peptides translated from different open reading frames. J Immunol 1998; 161: 3598-3606. (PMID: 9759882)
25. Aarnoudse CA, van den Doel PB, Heemskerk B, Schrier PI. Interleukin-2-induced, melanoma-specific T cells recognize CAMEL, an unexpected translation product of LAGE-1. Int J Cancer 1999; 82: 442-448. (PMID: 10399963)
26. Shichijo S, Nakao M, Imai Y, Takasu H, Kawamoto M, Niiya F, Yang D, Toh Y, Yamana H, Itoh K. A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes. J Exp Med 1998; 187: 277-288. (PMID: 9449708)
27. Ronsin C, Chung-Scott V, Poullion I, Aknouche N, Gaudin C, Triebel F. A non-AUG-defined alternative open reading frame of the intestinal carboxyl esterase mRNA generates an epitope recognized by renal cell carcinoma-reactive tumor-infiltrating lymphocytes in situ. J Immunol 1999; 163: 483-490. (PMID: 10384152)
28. Sachs AB, Sarnow P, Hentze MW. Starting at the beginning, middle, and end: translation initiation in eukaryotes. Cell 1997; 89: 831-838. (PMID: 9200601)
29. Larsen B, Peden J, Matsufuji S, Matsufuji T, Brady K, Maldonado R, Wills NM, Fayet O, Atkins JF, Gesteland RF. Upstream stimulators for recoding. Biochem Cell Biol 1995; 73: 1123-1129. (PMID: 8722029)
30. Dropcho EJ, Chen YT, Posner JB, Old LJ. Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration. Proc Natl Acad Sci USA 1987; 84: 4552-4556. (PMID: 3474619)
31. Chen YT, Gure AO, Tsang S, Stockert E, Jager E, Knuth A, Old LJ. Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library. Proc Natl Acad Sci USA 1998; 95: 6919-6923. (PMID: 9618514)
32. Fehr T, Skrastina D, Pumpens P, Zinkernagel RM. T cell-independent type I antibody response against B cell epitopes expressed repetitively on recombinant virus particles. Proc Natl Acad Sci USA 1998; 95: 9477-9481. (PMID: 9689105)
33. Spicer AP, Rowse GJ, Lidner TK, Gendler SJ. Delayed mammary tumor progression in Muc-1 null mice. J Biol Chem 1995; 270: 30093-30101. (PMID: 8530414)
34. Agrawal B, Krantz MJ, Parker J, Longenecker B. M. Expression of MUC1 mucin on activated human T cells: implications for a role of MUC1 in normal immune regulation. Cancer Res 1998; 58: 4079-4081. (PMID: 9751614)
35. Treon SP, Mollick JA, Urashima M, Teoh G, Chauhan D, Ogata A, Raje N, Hilgers JH, Nadler L, Belch AR, Pilarski LM, Anderson KC. Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone. Blood 1999; 93: 1287-1298. (PMID: 9949172)
36. Dent GA, Civalier CJ, Brecher ME, Bentley SA. MUC1 expression in hematopoietic tissues. Am J Clin Pathol 1999; 111: 741-747. (PMID: 10361508)
37. Schol DJ, Meulenbroek MF, Snijdewint FG, von Mensdorff-Pouilly S, Verstraeten RA, Murakami F, Kenemans P, Hilgers J. 'Epitope fingerprinting' using overlapping 20-mer peptides of the MUC1 tandem repeat sequence. Tumour Biol 1998; 19 Suppl 1: 35-45. (PMID: 9422087)
38. Price MR, Rye PD, Petrakou E, Murray A, Brady K, Imai S, Haga S, Kiyozuka Y, Schol D, Meulenbroek MFA, Snijdewint FGM, von Mensdorff-Pouilly S, Verstraeten RA, Kenemans P, Blockzjil A, Nilsson K, Nilsson O, Reddish M, Suresh MR, Koganty RR, Fortier S, Baronic L, Berg A, Longenecker MB, Hilkens J, Boer M, Karanikas V, McKenzie IFC, Galanina OE, Simeoni LA, Ter-Grigoryan AG, Belyanchikov IM, Bovin NV, Cao Y, Karsten U, Dai J, Allard WJ, Davis G, Yeung KK, Hanisch FG, Lloyd KO, Kudryashov V, Sikut R, Sikut A, Zhang K, Baeckström D, Hansson GC, Reis CA, Hassan H, Bennett EP, Claussen H, Norum L, Varaas T, Kierulf B, Nustad K, Ciborowski P, Konitzki WM, Magarian-Blander J, Finn OJ, Hilgers J. Summary report on the ISOBM TD-4 Workshop: analysis of 56 monoclonal antibodies against the MUC1 mucin. San Diego, Calif., November 17-23, 1996. Tumour Biol 1998; 19 Suppl 1: 1-20. (PMID: 9422084)
39. Abmayr SM, Workman JL. Preparation of Nuclear and Cytoplasmic Extracts from Mammalian Cells. In: Ausubel FA, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K, editors. Current Protocols in Molecular Biology. New York (NY): John Wiley & Sons; 1993. p. 12.11.11-12.11.19.