Regulatory mechanisms and functions of MAP kinase signaling pathways

IUBMB Life

Volumn 58, Issue 5-6, 2006, Pages 312-317

  Imajo, Masamichi ^a   Tsuchiya, Yoshiki ^a   Nishida, Eisuke ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

ERK1 2; ERK5; Growth factor signaling; JNK; p38; Signal transduction

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATASE; SCAFFOLD PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

BIOCHEMICAL COMPOSITION; CELL COMPARTMENTALIZATION; CELL FUNCTION; CONFERENCE PAPER; DISEASE COURSE; ENZYME REGULATION; ENZYME SPECIFICITY; GENE CONTROL; GENETIC VARIABILITY; HUMAN; MAMMAL; NERVE CELL DIFFERENTIATION; NIDATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATOR GENE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES;

EID: 33745080013     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1080/15216540600746393     Document Type: Conference Paper

References (46)

1. Nishida, E., and Gotoh, Y. (1993) The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem. Sci. 18, 128-131.
2. Chang, L., and Karin, M. (2001) Mammalian MAP kinase signalling cascades. Nature 410, 37-40.
3. Pearson, G., Robinson, F., Beers, G. T., Xu, B. E., Karandikar, M., Berman, K., and Cobb, M. H. (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22, 153-183.
4. Tanoue, T., Adachi, M., Moriguchi, T., and Nishida, E. (2000) A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nat. Cell Biol. 2, 110-116.
5. Morrison, D. K., and Davis, R. J. (2003) Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Ann. Rev. Cell Dev. Biol. 19, 91-118.
6. Whitmarsh, A. J., Cavanagh, J., Tournier, C., Yasuda, J., and Davis, R. J. (1998) A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 281, 1671-1674.
7. Jaeschke, A., Czech, M. P., and Davis, R. J. (2004) An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev. 18, 1976-1980.
8. Nguyen, A., Burack, W. R., Stock, J. L., Kortum, R., Chaika, O. V., Afkarian, M., Muller, W. J., Murphy, K. M., Morrison, D. K., Lewis, R. E., McNeish, J., and Shaw, A. S. (2002) Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol. Cell. Biol. 22, 3035-3045.
9. Lozano, J., Xing, R., Cai, Z., Jensen, H. L., Trempus, C., Mark, W., Cannon, R., and Kolesnick, R. (2003) Deficiency of kinase suppressor of Rasl prevents oncogenic Ras signaling in mice. Cancer Res. 63, 4232-4238.
10. Takekawa, M., Maeda, T., and Saito, H. (1998) Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways. EMBO J. 17, 4744-4752.
11. Ogata, M., Oh-hora, M., Kosugi, A., and Hamaoka, T. (1999) Inactivation of mitogen-activated protein kinases by a mammalian tyrosine-specific phosphatase, PTPBR7. Biochem. Biophys. Res. Commun. 256, 52-56.
12. Avdi, N. J., Malcolm, K. C., Nick, J. A., and Worthen, G. S. (2002) A role for protein phosphatase-2A in p38 mitogen-activated protein kinase-mediated regulation of the c-Jun NH2-terminal kinase pathway in human neutrophils. J. Biol. Chem. 277, 40687-40696.
13. Zhou, B., Wang, Z. X., Zhao, Y., Brautigan, D. L., and Zhang, Z. Y. (2002) The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases. J. Biol. Chem. 277, 31818-31825.
14. Camps, M., Nichols, A., and Arkinstall, S. (2000) Dual specificity phosphatases: a gene family for control of MAP kinase function. FASEB J. 14, 6-16.
15. Camps, M., Nichols, A., Gillieron, C., Antonsson, B., Muda, M., Chabert, C., Boschert, U., and Arkinstall, S. (1998) Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase. Science 280, 1262-1265.
16. Fjeld, C. C., Rice, A. E., Kim, Y., Gee, K. R., and Denu, J. M. (2000) Mechanistic basis for catalytic activation of mitogen-activated protein kinase phosphatase 3 by extracellular signal-regulated kinase. J. Biol. Chem. 275, 6749-6757.
17. Farooq, A., Chaturvedi, G., Mujtaba, S., Plotnikova, O., Zeng, L., Dhalluin, C., Ashton, R., and Zhou, M.-M. (2001) Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2. Mol. Cell 7, 387-399.
18. Keyse, S. M., and Emslie, E. A. (1992) Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase. Nature 359, 644-647.
19. Zheng, C. F., and Guan, K. L. (1993) Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase. J. Biol. Chem. 268, 16116-16119.
20. Eblaghie, M. C., Lunn, J. S., Dickinson, R. J., Munsterberg, A. E., Sanz-Ezquerro, J. J., Farrell, E. R., Mathers, J., Keyse, S. M., Storey, K., and Tickle, C. (2003) Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos. Curr. Biol. 13, 1009-1018.
21. Kawakami, Y., Rodriguez-Leon, J., Koth, C. M., Buscher, D., Itoh, T., Raya, A., Ng, J. K., Esteban, C. R., Takahashi, S., Henrique, D., Schwarz, M.-F., Asahara, H., and Izpisua Belmonte, J. C. (2003) MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb. Nat. Cell Biol. 5, 513-519.
22. Smith, T. G., Sweetman, D., Patterson, M., Keyse, S. M., and Munsterberg, A. (2005) Feedback interactions between MKP3 and ERK MAP kinase control scleraxis expression and the specification of rib progenitors in the developing chick somite. Development 132, 1305-1314.
23. Fukuda, M., Gotoh, I., Gotoh, Y., and Nishida, E. (1996) Cytoplasmic localization of mitogen-activated protein kinase kinase directed by its NH2-terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signal. J. Biol. Chem. 271, 20024-20028.
24. Khokhlatchev, A. V., Canagarajah, B., Wilsbacher, J., Robinson, M., Atkinson, M., Goldsmith, E., and Cobb, M. H. (1998) Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell 93, 605-615.
25. Adachi, M., Fukuda, M., and Nishida, E. (1999) Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer. EMBO J. 18, 5347-5358.
26. Matsubayashi, Y., Fukuda, M., and Nishida, E. (2001) Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells. J. Biol. Chem. 276, 41755-41760.
27. Whitehurst, A. W., Wilsbacher, J. L., You, Y., Luby-Phelps, K., Moore, M. S., and Cobb, M. H. (2002) ERK2 enters the nucleus by a carrier-independent mechanism. Proc. Natl. Acad. Sci. USA 99, 7496-7501.
28. Cavigelli, M., Dolfi, F., Claret, F. X., and Karin, M. (1995) Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO J. 14, 5957-5964.
29. Cheng, H. L., and Feldman, E. L. (1998) Bidirectional regulation of p38 kinase and c-Jun N-terminal protein kinase by insulin-like growth factor-I. J. Biol. Chem. 273, 14560-14565.
30. Kondoh, K., Terasawa, K., Morimoto, H., and Nishida, E. (2006) Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms. Mol. Cell. Biol. 26, 1679-1690.
31. Tsang, M., Friesel, R., Kudoh, T., and Dawid, I. B. (2002) Identification of Sef, a novel modulator of FGF signalling. Nat. Cell Biol. 4, 165-169.
32. Furthauer, M., Lin, W., Ang, S.-L., Thisse, B., and Thisse, C. (2002) Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. Nat. Cell Biol. 4, 170-174.
33. Kovalenko, D., Yang, X., Nadeau, R. J., Harkins, L. K., and Friesel, R. (2003) Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation. J. Biol. Chem. 278, 14087-14091.
34. Xiong, S., Zhao, Q., Rong, Z., Huang, G., Huang, Y., Chen, P., Zhang, S., Liu, L., and Chang, Z. (2003) hSef inhibits PC-12 cell differentiation by interfering with Ras-mitogen-activated protein kinase MAPK signaling. J. Biol. Chem. 278, 50273-50282.
35. Torii, S., Kusakabe, M., Yamamoto, T., Maekawa, M., and Nishida, E. (2004) Sef is a spatial regulator for Ras/MAP kinase signaling. Dev. Cell 7, 33-44.
36. Maekawa, M., Yamamoto, T., Tanoue, T., Yuasa, Y., Chisaka, O., and Nishida, E. (2005) Requirement of the MAP kinase signaling pathways for mouse preimplantation development. Development 132, 1773-1783.
37. Aguirre, V., Uchida, T., Yenush, L., Davis, R., and White, M. F. (2000) The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307. J. Biol. Chem. 275, 9047-9054.
38. Aguirre, V., Werner, E. D., Giraud, J., Lee, Y. H., Shoelson, S. E., and White, M. F. (2002) Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J. Biol. Chem. 277, 1531-1537.
39. Hirosumi, J., Tuncman, G., Chang, L., Gorgun, C. Z., Uysal, K. T., Maeda, K., Karin, M., and Hotamisligil, G. S. (2002) A central role for JNK in obesity and insulin resistance. Nature 420, 333-336.
40. Lee, Y. H., Giraud, J., Davis, R. J., and White, M. F. (2003) c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J. Biol. Chem. 278, 2896-2902.
41. Regan, C. P., Li, W., Boucher, D. M., Spatz, S., Su, M. S., and Kuida, K. (2002) Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc. Natl. Acad. Sci. USA 99, 9248-9253.
42. Sohn, S. J., Sarvis, B. K., Cado, D., and Winoto, A. (2002) ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression. J. Biol. Chem. 277, 43344-43351.
43. Yan, L., Carr, J., Ashby, P., Murry-Tait, V., Thompson, C., and Arthur, J. S. (2003) Knockout of ERK5 causes multiple defects in placental and embryonic development. BMC Dev. Biol. 3, 11.
44. Wang, X., Merritt, A. J., Seyfried, J., Guo, C., Papadakis, E. S., Finegan, K. G., Kayahara, M., Dixon, J., Boot-Handford, R. P., Cartwright, E. J., Mayer, U., and Tournier, C. (2005) Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/Myocyte enhancer factor 2 cell survival pathway. Mol. Cell. Biol. 25, 336-345.
45. Hayashi, M., Kim, S. W., Imanaka-Yoshida, K., Yoshida, T., Abel, E. D., Eliceiri, B., Yang, Y., Ulevitch, R. J., and Lee, J. D. (2004) Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J. Clin. Invest. 113, 1138-1148.
46. Nishimoto, S., Kusakabe, M., and Nishida, E. (2005) Requirement of the MEK5-ERK5 pathway for neural differentiation in Xenopus embryonic development. EMBO Rep. 6, 1064-1069.