-
1
-
-
0035338993
-
Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans
-
Hotchkiss RS, Tinsley KW, Swanson PE, Schmieg RE Jr, Hui JJ, Chang KC, et al. Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol. 2001;166:6952-63.
-
(2001)
J Immunol
, vol.166
, pp. 6952-6963
-
-
Hotchkiss, R.S.1
Tinsley, K.W.2
Swanson, P.E.3
Schmieg Jr, R.E.4
Hui, J.J.5
Chang, K.C.6
-
2
-
-
0037426726
-
The pathophysiology and treatment of sepsis
-
Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med. 2003;348:138-50.
-
(2003)
N Engl J Med
, vol.348
, pp. 138-150
-
-
Hotchkiss, R.S.1
Karl, I.E.2
-
3
-
-
23044477087
-
Leukocyte apoptosis and its significance in sepsis and shock
-
Wesche DE, Lomas-Neira JL, Perl M, Chung CS, Ayala A. Leukocyte apoptosis and its significance in sepsis and shock. J Leukoc Biol. 2005;78:325-37.
-
(2005)
J Leukoc Biol
, vol.78
, pp. 325-337
-
-
Wesche, D.E.1
Lomas-Neira, J.L.2
Perl, M.3
Chung, C.S.4
Ayala, A.5
-
4
-
-
17044413706
-
Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways
-
Hotchkiss RS, Osmon SB, Chang KC, Wagner TH, Coopersmith CM, Karl IE. Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J Immunol. 2005;174:5110-8.
-
(2005)
J Immunol
, vol.174
, pp. 5110-5118
-
-
Hotchkiss, R.S.1
Osmon, S.B.2
Chang, K.C.3
Wagner, T.H.4
Coopersmith, C.M.5
Karl, I.E.6
-
5
-
-
14844343217
-
Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure
-
Felmet KA, Hall MW, Clark RS, Jaffe R, Carcillo JA. Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure. J Immunol. 2005;174:3765-72.
-
(2005)
J Immunol
, vol.174
, pp. 3765-3772
-
-
Felmet, K.A.1
Hall, M.W.2
Clark, R.S.3
Jaffe, R.4
Carcillo, J.A.5
-
6
-
-
85047692486
-
Spleen depletion in neonatal sepsis and chorioamnionitis
-
Toti P, de Felice C, Occhini R, Schuerfeld K, Stumpo M, Epistolato MC, et al. Spleen depletion in neonatal sepsis and chorioamnionitis. Am J Clin Pathol. 2004;122:765-71.
-
(2004)
Am J Clin Pathol
, vol.122
, pp. 765-771
-
-
Toti, P.1
de Felice, C.2
Occhini, R.3
Schuerfeld, K.4
Stumpo, M.5
Epistolato, M.C.6
-
7
-
-
6444244641
-
Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome
-
Le Tulzo Y, Pangault C, Gacouin A, Guilloux V, Tribut O, Amiot L, et al. Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome. Shock. 2002;18:487-94.
-
(2002)
Shock
, vol.18
, pp. 487-494
-
-
Le Tulzo, Y.1
Pangault, C.2
Gacouin, A.3
Guilloux, V.4
Tribut, O.5
Amiot, L.6
-
8
-
-
0030739250
-
-
Hotchkiss RS, Swanson PE, Cobb JP, Jacobson A, Buchman TG, Karl IE. Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit Care Med. 1997;25:1298-307.
-
Hotchkiss RS, Swanson PE, Cobb JP, Jacobson A, Buchman TG, Karl IE. Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit Care Med. 1997;25:1298-307.
-
-
-
-
9
-
-
16644390415
-
Increased lymphoid tissue apoptosis in baboons with bacteremic shock
-
Efron PA, Tinsley K, Minnich DJ, Monterroso V, Wagner J, Lainee P, et al. Increased lymphoid tissue apoptosis in baboons with bacteremic shock. Shock. 2004;21:566-71.
-
(2004)
Shock
, vol.21
, pp. 566-571
-
-
Efron, P.A.1
Tinsley, K.2
Minnich, D.J.3
Monterroso, V.4
Wagner, J.5
Lainee, P.6
-
10
-
-
4043053773
-
Pathogenesis of filoviral haemorrhagic fevers
-
Mahanty S, Bray M. Pathogenesis of filoviral haemorrhagic fevers. Lancet Infect Dis. 2004;4:487-98.
-
(2004)
Lancet Infect Dis
, vol.4
, pp. 487-498
-
-
Mahanty, S.1
Bray, M.2
-
11
-
-
0032907635
-
Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients
-
Baize S, Leroy EM, Georges-Courbot MC, Capron M, Lansoud-Soukate J, Debre P, et al. Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients. Nat Med. 1999;5:423-6.
-
(1999)
Nat Med
, vol.5
, pp. 423-426
-
-
Baize, S.1
Leroy, E.M.2
Georges-Courbot, M.C.3
Capron, M.4
Lansoud-Soukate, J.5
Debre, P.6
-
12
-
-
4544228226
-
Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: Cellular responses, virus load, and nitric oxide levels
-
Sanchez A, Lukwiya M, Bausch D, Mahanty S, Sanchez AJ, Wagoner KD, et al. Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels. J Virol. 2004;78:10370-7.
-
(2004)
J Virol
, vol.78
, pp. 10370-10377
-
-
Sanchez, A.1
Lukwiya, M.2
Bausch, D.3
Mahanty, S.4
Sanchez, A.J.5
Wagoner, K.D.6
-
13
-
-
4544293451
-
Depletion of peripheral blood T lymphocytes and NK cells during the course of Ebola hemorrhagic fever in cynomolgus macaques
-
Reed DS, Hensley LE, Geisbert JB, Jahrling PB, Geisbert TW. Depletion of peripheral blood T lymphocytes and NK cells during the course of Ebola hemorrhagic fever in cynomolgus macaques. Viral Immunol. 2004;17:390-400.
-
(2004)
Viral Immunol
, vol.17
, pp. 390-400
-
-
Reed, D.S.1
Hensley, L.E.2
Geisbert, J.B.3
Jahrling, P.B.4
Geisbert, T.W.5
-
14
-
-
0035659667
-
Pathogenesis of experimental Ebola Zaire virus infection in BALB/c mice
-
Gibb TR, Bray M, Geisbert TW, Steele KE, Kell WM, Davis KJ, et al. Pathogenesis of experimental Ebola Zaire virus infection in BALB/c mice. J Comp Pathol. 2001;125:233-42.
-
(2001)
J Comp Pathol
, vol.125
, pp. 233-242
-
-
Gibb, T.R.1
Bray, M.2
Geisbert, T.W.3
Steele, K.E.4
Kell, W.M.5
Davis, K.J.6
-
15
-
-
0034006617
-
Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses
-
Geisbert TW, Hensley LE, Gibb TR, Steele KE, Jaax NK, Jahrling PB. Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses. Lab Invest. 2000;80:171-86.
-
(2000)
Lab Invest
, vol.80
, pp. 171-186
-
-
Geisbert, T.W.1
Hensley, L.E.2
Gibb, T.R.3
Steele, K.E.4
Jaax, N.K.5
Jahrling, P.B.6
-
16
-
-
0036569530
-
Anthrax as a biological weapon, 2002: Updated recommendations for management
-
Inglesby TV, O'Toole T, Henderson DA, Bartlett JG, Ascher MS, Eitzen E, et al. Anthrax as a biological weapon, 2002: updated recommendations for management. JAMA. 2002;287:2236-52.
-
(2002)
JAMA
, vol.287
, pp. 2236-2252
-
-
Inglesby, T.V.1
O'Toole, T.2
Henderson, D.A.3
Bartlett, J.G.4
Ascher, M.S.5
Eitzen, E.6
-
17
-
-
0035039617
-
Quantitative pathology of inhalational anthrax I: Quantitative microscopic findings
-
Grinberg LM, Abramova FA, Yampolskaya OV, Walker DH, Smith JH. Quantitative pathology of inhalational anthrax I: quantitative microscopic findings. Mod Pathol. 2001;14:482-95.
-
(2001)
Mod Pathol
, vol.14
, pp. 482-495
-
-
Grinberg, L.M.1
Abramova, F.A.2
Yampolskaya, O.V.3
Walker, D.H.4
Smith, J.H.5
-
18
-
-
36749009663
-
Anthrax lethal toxin-mediated killing of human and murine dendritic cells impairs the adaptive immune response
-
Alileche A, Serfass ER, Muehlbauer SM, Porcelli SA, Brojatsch J. Anthrax lethal toxin-mediated killing of human and murine dendritic cells impairs the adaptive immune response. PLoS Pathog. 2005;1:e19.
-
(2005)
PLoS Pathog
, vol.1
-
-
Alileche, A.1
Serfass, E.R.2
Muehlbauer, S.M.3
Porcelli, S.A.4
Brojatsch, J.5
-
19
-
-
0034600229
-
Plague as a biological weapon: Medical and public health management. Working Group on Civilian Biodefense
-
Inglesby TV, Dennis DT, Henderson DA, Bartlett JG, Ascher MS, Eitzen E, et al. Plague as a biological weapon: medical and public health management. Working Group on Civilian Biodefense. JAMA. 2000;283:2281-90.
-
(2000)
JAMA
, vol.283
, pp. 2281-2290
-
-
Inglesby, T.V.1
Dennis, D.T.2
Henderson, D.A.3
Bartlett, J.G.4
Ascher, M.S.5
Eitzen, E.6
-
20
-
-
25444476788
-
Yersinia outer proteins: Role in modulation of host cell signaling responses and pathogenesis
-
Viboud GI, Bliska JB. Yersinia outer proteins: role in modulation of host cell signaling responses and pathogenesis. Annu Rev Microbiol. 2005;59:69-89.
-
(2005)
Annu Rev Microbiol
, vol.59
, pp. 69-89
-
-
Viboud, G.I.1
Bliska, J.B.2
-
21
-
-
29144515366
-
Progression of primary pneumonic plague: A mouse model of infection, pathology, and bacterial transcriptional activity
-
Lathem WW, Crosby SD, Miller VL, Goldman WE. Progression of primary pneumonic plague: a mouse model of infection, pathology, and bacterial transcriptional activity. Proc Natl Acad Sci U S A. 2005;102:17786-91.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 17786-17791
-
-
Lathem, W.W.1
Crosby, S.D.2
Miller, V.L.3
Goldman, W.E.4
-
22
-
-
1042266623
-
Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH
-
Alonso A, Bottini N, Bruckner S, Rahmouni S, Williams S, Schoenberger SP, et al. Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH. J Biol Chem. 2004;279:4922-8.
-
(2004)
J Biol Chem
, vol.279
, pp. 4922-4928
-
-
Alonso, A.1
Bottini, N.2
Bruckner, S.3
Rahmouni, S.4
Williams, S.5
Schoenberger, S.P.6
-
23
-
-
17844375136
-
Kinetics of disease progression and host response in a rat model of bubonic plague
-
Sebbane F, Gardner D, Long D, Gowen BB, Hinnebusch BJ. Kinetics of disease progression and host response in a rat model of bubonic plague. Am J Pathol. 2005;166:1427-39.
-
(2005)
Am J Pathol
, vol.166
, pp. 1427-1439
-
-
Sebbane, F.1
Gardner, D.2
Long, D.3
Gowen, B.B.4
Hinnebusch, B.J.5
-
24
-
-
0033120115
-
Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis
-
Hotchkiss RS, Swanson PE, Knudson CM, Chang KC, Cobb JP, Osborne DF, et al. Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol. 1999;162:4148-56.
-
(1999)
J Immunol
, vol.162
, pp. 4148-4156
-
-
Hotchkiss, R.S.1
Swanson, P.E.2
Knudson, C.M.3
Chang, K.C.4
Cobb, J.P.5
Osborne, D.F.6
-
25
-
-
0042333417
-
Over-expression of Bcl-2 provides protection in septic mice by a trans effect
-
Iwata A, Stevenson VM, Minard A, Tasch M, Tupper J, Lagasse E, et al. Over-expression of Bcl-2 provides protection in septic mice by a trans effect. J Immunol. 2003;171:3136-41.
-
(2003)
J Immunol
, vol.171
, pp. 3136-3141
-
-
Iwata, A.1
Stevenson, V.M.2
Minard, A.3
Tasch, M.4
Tupper, J.5
Lagasse, E.6
-
26
-
-
2942527148
-
Akt decreases lymphocyte apoptosis and improves survival in sepsis
-
Bommhardt U, Chang KC, Swanson PE, Wagner TH, Tinsley KW, Karl IE, et al. Akt decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol. 2004;172:7583-91.
-
(2004)
J Immunol
, vol.172
, pp. 7583-7591
-
-
Bommhardt, U.1
Chang, K.C.2
Swanson, P.E.3
Wagner, T.H.4
Tinsley, K.W.5
Karl, I.E.6
-
27
-
-
0034908235
-
Inhibition of Fas signaling prevents hepatic injury and improves organ blood flow during sepsis
-
Chung CS, Yang S, Song GY, Lomas J, Wang P, Simms HH, et al. Inhibition of Fas signaling prevents hepatic injury and improves organ blood flow during sepsis. Surgery. 2001;130:339-45.
-
(2001)
Surgery
, vol.130
, pp. 339-345
-
-
Chung, C.S.1
Yang, S.2
Song, G.Y.3
Lomas, J.4
Wang, P.5
Simms, H.H.6
-
28
-
-
27144512743
-
In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice
-
Wesche-Soldato DE, Chung CS, Lomas-Neira J, Doughty LA, Gregory SH, Ayala A. In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. Blood. 2005;106:2295-301.
-
(2005)
Blood
, vol.106
, pp. 2295-2301
-
-
Wesche-Soldato, D.E.1
Chung, C.S.2
Lomas-Neira, J.3
Doughty, L.A.4
Gregory, S.H.5
Ayala, A.6
-
29
-
-
33745316012
-
Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis
-
Schwulst SJ, Grayson MH, Dipasco PJ, Davis CG, Brahmbhatt TS, Ferguson TA, et al. Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol. 2006;177:557-65.
-
(2006)
J Immunol
, vol.177
, pp. 557-565
-
-
Schwulst, S.J.1
Grayson, M.H.2
Dipasco, P.J.3
Davis, C.G.4
Brahmbhatt, T.S.5
Ferguson, T.A.6
-
30
-
-
33645988546
-
TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo
-
Hotchkiss RS, McConnell KW, Bullok K, Davis CG, Chang KC, Schwulst SJ, et al. TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J Immunol. 2006;176:5471-7.
-
(2006)
J Immunol
, vol.176
, pp. 5471-5477
-
-
Hotchkiss, R.S.1
McConnell, K.W.2
Bullok, K.3
Davis, C.G.4
Chang, K.C.5
Schwulst, S.J.6
-
31
-
-
22144498421
-
Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor
-
Weaver JG, Tarze A, Moffat TC, Lebras M, Deniaud A, Brenner C, et al. Inhibition of adenine nucleotide translocator pore function and protection against apoptosis in vivo by an HIV protease inhibitor. J Clin Invest. 2005;115:1828-38.
-
(2005)
J Clin Invest
, vol.115
, pp. 1828-1838
-
-
Weaver, J.G.1
Tarze, A.2
Moffat, T.C.3
Lebras, M.4
Deniaud, A.5
Brenner, C.6
-
32
-
-
0033431682
-
Prevention of lymphocyte cell death in sepsis improves survival in mice
-
Hotchkiss RS, Tinsley KW, Swanson PE, Chang KC, Cobb JP, Buchman TG, et al. Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci U S A. 1999;96:14541-6.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 14541-14546
-
-
Hotchkiss, R.S.1
Tinsley, K.W.2
Swanson, P.E.3
Chang, K.C.4
Cobb, J.P.5
Buchman, T.G.6
-
33
-
-
5944251623
-
Caspase inhibitors improve survival in sepsis: A critical role of the lymphocyte
-
Hotchkiss RS, Chang KC, Swanson PE, Tinsley KW, Hui JJ, Klender P, et al. Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat Immunol. 2000;1:496-501.
-
(2000)
Nat Immunol
, vol.1
, pp. 496-501
-
-
Hotchkiss, R.S.1
Chang, K.C.2
Swanson, P.E.3
Tinsley, K.W.4
Hui, J.J.5
Klender, P.6
-
34
-
-
3643052918
-
-
Chung CS, Xu YX, Wang W, Chaudry IH, Ayala A. Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis? Arch Surg. 1998;133:1213-20.
-
Chung CS, Xu YX, Wang W, Chaudry IH, Ayala A. Is Fas ligand or endotoxin responsible for mucosal lymphocyte apoptosis in sepsis? Arch Surg. 1998;133:1213-20.
-
-
-
-
35
-
-
27144431943
-
Selecting and screening recombinant antibody libraries
-
Hoogenboom HR. Selecting and screening recombinant antibody libraries. Nat Biotechnol. 2005;23:1105-16.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1105-1116
-
-
Hoogenboom, H.R.1
-
36
-
-
1642500084
-
Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics
-
Methot N, Huang J, Coulombe N, Vaillancourt JP, Rasper D, Tam J, et al. Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics. J Exp Med. 2004;199:199-207.
-
(2004)
J Exp Med
, vol.199
, pp. 199-207
-
-
Methot, N.1
Huang, J.2
Coulombe, N.3
Vaillancourt, J.P.4
Rasper, D.5
Tam, J.6
-
37
-
-
2542457495
-
Inflammatory caspases: Linking an intracellular innate immune system to autoinflammatory diseases
-
Martinon F, Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell. 2004;117:561-74.
-
(2004)
Cell
, vol.117
, pp. 561-574
-
-
Martinon, F.1
Tschopp, J.2
-
38
-
-
0037383849
-
Caspase activation is not death
-
Perfettini JL, Kroemer G. Caspase activation is not death. Nat Immunol. 2003;4:308-10.
-
(2003)
Nat Immunol
, vol.4
, pp. 308-310
-
-
Perfettini, J.L.1
Kroemer, G.2
-
39
-
-
18544383460
-
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
-
Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, Siegel RM, et al. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature. 2002;419:395-9.
-
(2002)
Nature
, vol.419
, pp. 395-399
-
-
Chun, H.J.1
Zheng, L.2
Ahmad, M.3
Wang, J.4
Speirs, C.K.5
Siegel, R.M.6
-
40
-
-
0037386245
-
Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2
-
Cauwels A, Janssen B, Waeytens A, Cuvelier C, Brouckaert P. Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2. Nat Immunol. 2003;4:387-93.
-
(2003)
Nat Immunol
, vol.4
, pp. 387-393
-
-
Cauwels, A.1
Janssen, B.2
Waeytens, A.3
Cuvelier, C.4
Brouckaert, P.5
|