Asparagine in plants

Annals of Applied Biology

Volumn 150, Issue 1, 2007, Pages 1-26

  Lea, P J ^a   Sodek, L ^b   Parry, M A J ^c   Shewry, P R ^c   Halford, N G ^c  

^a LANCASTER UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c ROTHAMSTED RESEARCH   (United Kingdom)

Author keywords

Accumulation; Acrylamide; Asparagine; Food; Potato; Wheat

Indexed keywords

CARCINOGEN; FOOD; GENE EXPRESSION; PHYSIOLOGY; POLYMER; POTATO; SEED; SUGAR; THERMAL DECOMPOSITION; TOXIN; WHEAT;

SOLANUM TUBEROSUM; TRITICUM AESTIVUM;

EID: 33846675296     PISSN: 00034746     EISSN: 17447348     Source Type: Journal    
DOI: 10.1111/j.1744-7348.2006.00104.x     Document Type: Review

References (234)

1. Aidar M.P.M., Schmidt S., Moss G., Stewart G.R., Joly C.A. (2003) Nitrogen use strategies of neotropical rainforest trees in threatened Atlantic forest. Plant Cell and Environment, 26, 389-399.
2. Almeida J.P.F., Hartwig U.A., Frehner M., Nösberger J., Lüscher A. (2000) Evidence that P deficiency induces N feedback regulation of symbiotic nitrogen fixation in white clover (Trifolium repens L.). Journal of Experimental Botany, 51, 1289-1297.
3. Amancio S., Clarkson D.T., Diogo E., Lewis M., Santos H. (1997) Assimilation of nitrate and ammonium by sulphur deficient Zea mays cells. Plant Physiology and Biochemistry, 35, 41-48.
4. do Amarante L., Lima L.D., Sodek L. (2006) Growth and stress conditions cause similar changes in xylem amino acids for different legume species. Environmental and Experimental Botany, 58, 123-129.
5. Amrein T.M., Bachmann S., Noti A., Biedermann M., Barbosa M.F., Biedermann-Brem S., Grob K., Keiser A., Realini P., Escher F., Amado R. (2003) Potential of acrylamide formation, sugars, and free asparagine in potatoes: a comparison of cultivars and farming systems. Journal of Agricultural and Food Chemistry, 51, 5556-5560.
6. Arruda P., Da Silva W.J., Teixeira J.P.F. (1978) Protein and free amino acids in a high lysine maize double mutant. Phytochemistry, 17, 1217-1218.
7. Atkins C.A., Pate J.S., Sharkey P.J. (1975) Asparagine metabolism - key to the nitrogen nutrition of developing legume seeds. Plant Physiology, 56, 807-812.
8. Atkins C.A., Pate J.S., Peoples M.B., Joy K.W. (1983) Amino acid transport and metabolism in relation to the nitrogen economy of a legume leaf. Plant Physiology, 71, 841-848.
9. 2 and allopurinol. Plant Physiology, 86, 204-207.
10. Azevedo R.A., Arruda P., Turner W.L., Lea P.J. (1997) The biosynthesis and metabolism of the aspartate derived amino acids in higher plants. Phytochemistry, 46, 395-419.
11. Azevedo R.A., Damerval C., Lea P.J., Landry J., Bellato C.M., Meinhardt L.W., Le Guilloux M., Delhaye S., Toro A.A., Gaziola S.A., Varisi V.A., Gratão P.L. (2004) Genetic control of lysine metabolism in maize endosperm mutants. Functional Plant Biology, 31, 339-348.
12. Azevedo R.A., Lancien M., Lea P.J. (2006) The aspartic acid metabolic pathway, an exciting and essential pathway in plants. Amino Acids, 30, 143-162.
13. Baker J.M., Hawkins N.D., Ward J.L., Lovegrove A., Napier J.A., Shewry P.R., Beale M.H. (2006) A metabolomic study of substantial equivalence of field-grown genetically modified wheat. Plant Biotechnology Journal, 4, 381-392.
14. Baudet J., Huet J.-C., Jolivet E., Lesaint C., Mossé J., Pernollet J.-C. (1986) Changes in accumulation of seed nitrogen compounds in maize under conditions of sulphur deficiency. Physiologia Plantarum, 68, 608-614.
15. Becalski A., Lau B.P.-Y., Lewis D., Seaman S.W. (2003) Acrylamide in foods: occurrence, sources, and modeling. Journal of Agricultural and Food Chemistry, 51, 802-808.
16. Benavides M.P., Gallego S.M., Tomaro M.L. (2005) Cadmium toxicity in plants. Brazilian Journal of Plant Physiology, 17, 21-34.
17. Bencur P., Steinkellner H., Svoboda B., Mucha J., Strasser R., Kolarich D., Hann S., Kollensperger G., Glossl J., Altmann F., Mach L. (2005) Arabidopsis thaliana beta 1,2-xylosyltransferase: an unusual glycosyltransferase with the potential to act at multiple stages of the plant N-glycosylation pathway. Biochemical Journal, 388, 515-525.
18. Biedermann-Brem S., Noti A., Grob K., Imhof D., Bazzocco D., Pfefferle A. (2003) How much reducing sugar may potatoes contain to avoid excessive acrylamide formation during roasting and baking? European Food Research and Technology, 217, 369-373.
19. Borek D., Podkowinski J., Kisiel A., Jaskolski M. (1999) Isolation and characterization of cDNA encoding l-asparaginase from Lupinus luteus (Accession, AF112444). Plant Physiology, 119, 1568.
20. Borek D., Michalska K., Brzezinski K., Kisiel A., Podkowinski J., Bonthron D.T., Krowarsch D., Otlewski J., Jaskolski M. (2004) Expression, purification and catalytic activity of Lupinus luteus asparagine β-amidohydrolase and its Escherichia coli homolog. European Journal of Biochemistry, 271, 3215-3226.
21. Bottari F., Festa M.R. (1996) Asparagine as a ligand for cadmium (II). Lead (II) and zinc (II). Chemical Speciation and Bioavailability, 8, 75-83.
22. Brears T., Liu C., Knight T.J., Coruzzi G.M. (1993) Ectopic overexpression of asparagine synthetase in transgenic tobacco. Plant Physiology, 103, 1285-1290.
23. Brierley E.R., Bonner P.L.R., Cobb A.H. (1997) Aspects of amino acid metabolism in stored potato tubers (cv. Pentland Dell). Plant Science, 127, 17-24.
24. Bright S.W.J., Shewry P.R. (1983) Improvement of protein quality in cereals. CRC Critical Reviews in Plant Sciences, 1, 49-93.
25. Bruneau L., Chapman R., Marsolais F. (2006) Co-occurrence of both L-asparaginase subtypes in Arabidopsis: At3g16150 encodes a K+-dependent L-asparaginase. Planta, 224, 668-679.
26. Byers M., Miflin B.J., Smith S.J. (1983) A quantitative comparison of the extraction of protein fractions from wheat grain by different solvents, and of the polypeptide and amino acid composition of the alcohol-soluble proteins. Journal of the Science of Food and Agriculture, 34, 447-462.
27. Camargos L.S., Aguiar L.F., Azevedo R.A. (2004) Variation in the amino acid concentration during the development of Canavalia ensiformes. Biologia Plantarum, 48, 47-52.
28. Cañas R.A., de la Torre F., Cánovas F.M., Cantón F.R. (2006) High levels of asparagine synthetase in hypocotyls of pine seedlings suggest a role of the enzyme in re-allocation of seed-stored nitrogen. Planta, 224, 83-95.
29. Cantón F.R., Suárez M.F., Cánovas F.M. (2005) Molecular aspects of nitrogen mobilization and recycling in trees. Photosynthesis Research, 83, 265-278.
30. Capdevila A.M., Dure L. (1977) Developmental biochemistry of cottonseed embryogenesis and germination. Plant Physiology, 59, 268-273.
31. Carillo P., Mastrolonardo G., Nacca F., Fuggi A. (2005) Nitrate reductase in durum wheat seedlings as affected by nitrate nutrition and salinity. Functional Plant Biology, 32, 209-219.
32. Carvalho H.G., Lopes-Cardoso I.A., Lima L.M., Melo P.M., Cullimore J.V. (2003) Nodule-specific modulation of glutamine synthetase in transgenic Medicago truncatula leads to inverse alterations in asparagine synthetase expression. Plant Physiology, 133, 243-252.
33. Casado A., Caballero J.L., Franco A.R., Cárdenas J., Grant M.R., Muñoz-Blanco J. (1995) Molecular cloning of the gene encoding the L-asparaginase enzyme of Arabidopsis thaliana. Plant Physiology, 108, 1321-1322.
34. Chaffei C., Pageau K., Suzuki A., Gouia H., Ghorbel M.H., Masclaux-Daubresse C. (2004) Cadmium toxicity induced changes in nitrogen management in Lycopersicon esculentum leading to a metabolic safeguard through an amino acid storage strategy. Plant Cell Physiology, 45, 1681-1693.
35. Chang K.S., Farnden K.J. (1981) Purification and properties of asparaginase from Lupinus arboreus and Lupinus angustifolius. Archives of Biochemistry and Biophysics, 208, 49-58.
36. Chevalier C., Bourgeois E., Just D., Raymond P. (1996) Metabolic regulation of asparagine synthetase gene expression in maize (Zea mays L.) root tips. Plant Journal, 9, 1-11.
37. Chibnall A.C. (1939) Protein Metabolism in the Plant. New Haven, Connecticut: Yale University Press.
38. Chou K., Splittstoesser W.E. (1972) Changes in amino acid content and the metabolism of γ-aminobutyrate in Cucurbita moschata seedlings. Physiologia Plantarum, 26, 110-114.
39. Chuda Y., Ono H., Yada H., Ohara-Takada A., Matsuura-Endo C., Mori M. (2003) Effects of physiological changes in potato tubers (Solanum tuberosum L.) after low temperature storage on the level of acrylamide formed in potato chips. Bioscience, Biotechnology and Biochemistry, 67, 1188-1190.
40. Clarke S. (2003) Aging as a war between chemical and biochemical processes: protein methylation and the recognition of age-damaged proteins for repair. Ageing Research Reviews, 2, 263-285.
41. Coleman C.E., Larkins B.A. (1999) The prolamins of maize. In Seed Proteins, pp. 109-139. Eds P.R. Shewry and R. Casey. Dordrecht, the Netherlands: Kluwer Academic Publishers.
42. Colmer T.D., Epstein E., Dvorak J. (1995) Differential solute regulation in leaf blades of various ages in salt-sensitive wheat and a salt-tolerant wheat x Lophopyrum elongatum (Host) A. Löve amphiploid. Plant Physiology, 108, 1715-1724.
43. Costa G., Morel J.L. (1994) Water relations, gas exchange and amino acid content in Cd-treated lettuce. Plant Physiology and Biochemistry, 32, 561-570.
44. Costa G., Spitz R. (1997) Influence of cadmium on soluble carbohydrates, free amino acids, protein content of in vitro cultured Lupinus albus. Plant Science, 128, 131-140.
45. Damodaran M. (1932) The isolation of asparagines from an enzymic digest of edestin. Biochemical Journal, 26, 235-247.
46. Davies K.M., King G.A. (1993) Isolation and characterization of a cDNA clone for a harvest induced asparagine synthetase from Asparagus officinalis L. Plant Physiology, 102, 1337-1340.
47. Davies K.M., Seelye J.F., Irving D.E., Borst W.M., Hurst P.L., King G.A. (1996) Sugar regulation of harvest-related genes in asparagus. Plant Physiology, 111, 877-883.
48. Delauney A.J., Verma D.P.S. (1993) Proline biosynthesis and osmoregulation in plants. Plant Journal, 4, 215-223.
49. Delaville M. (1802) Sur les seves d'asperges et de choux. Annales de Chimie (Paris), 41, 298.
50. Dembinski E., Bany S. (1991) The amino acid pool of high and low protein rye inbred lines (Secale cereale L.). Journal of Plant Physiology, 138, 494-496.
51. Dembinski E., Wisniewska I., Zebrowski J., Raczynska-Bojanowska K. (1996) Negative regulation of asparagine synthetase in the leaves of maize seedling by light, benzyladenine and glucose. Physiologia Plantarum, 96, 66-70.
52. De Wilde T., De Meulenaer B., Mestdagh F., Govaert Y., Vandeburie S., Ooghe W., Fraselle S., Demeulemeester K., Van Peteghem C., Calus A., Degroodt J.M., Verhe R.A. (2005) Influence of storage practices on acrylamide formation during potato frying. Journal of Agricultural and Food Chemistry, 53, 6550-6557.
53. De Wilde T., De Meulenaer B., Mestdagh F., Govaert Y., Vandeburie S., Ooghe W., Fraselle S., Demeulemeester K., Van Peteghem C., Calus A., Degroodt J.M., Verhe R. (2006) Influence of fertilization on acrylamide formation during frying of potatoes harvested in 2003. Journal of Agricultural and Food Chemistry, 54, 404-408.
54. Dickson J.M., Vincze E., Grant M.R., Smith L.A., Rodber K.A., Farnden K.J., Reynolds P.H. (1992) Molecular cloning of the gene encoding developing seed L-asparaginase from Lupinus angustifolius. Plant Molecular Biology, 20, 333-336.
55. Dilworth M.F., Dure L. (1978) Developmental biochemistry of cotton seed embryogenesis and germination; Nitrogen flow from arginine to asparagine in germination. Plant Physiology, 61, 698-702.
56. Downs C.G., Somerfield S.D. (1997) Asparagine synthetase gene expression increases as sucrose declines in broccoli after harvest. New Zealand Journal of Crop and Horticultural Science, 25, 191-195.
57. Downs C.G., Somerfield S.D., Davey M.C. (1997) Cytokinin treatment delays senescence but not sucrose loss in harvested broccoli. Postharvest Biology and Technology, 11, 93-100.
58. Eason J.R., O'Donoghue E.M., King G.A., (1996) Asparagine synthesis and localization of transcripts for asparagine synthetase in tips of harvested asparagus spears. Journal of Plant Physiology, 149, 251-256.
59. Eason J.R., Johnston J.W., de Vré L., Sinclair B.K., King G.A. (2000) Amino acid metabolism in senescing Sandersonia aurantiaca flowers: cloning and characterization of asparagine synthetase and glutamine synthetase cDNAs. Australian Journal of Plant Physiology, 27, 389-396.
60. Elmore C.D., King E.E. (1978) Amino acid composition of germinating cotton seeds. Plant Physiology, 62, 531-535.
61. Eppendorfer W.H., Bille S.W. (1996). Free and total amino acid composition of edible parts of beans, kale, spinach, cauliflower and potatoes as influenced by nitrogen fertilisation and phosphorus and potassium deficiency. Journal of the Science of Food and Agriculture, 71, 449-458.
62. Ericsson A., Nordén L.G., Näsholm T., Walheim M. (1993) Mineral nutrient imbalances and arginine concentrations in needles of Picea abies L., Karst from two areas with different levels of airborne deposition. Trees - Structure and Function, 8, 67-74.
63. Escher P., Eiblmeier M., Hetzger I., Rennenberg H. (2004) Spatial and seasonal variation in amino compounds in the xylem sap of a mistletoe (Viscum album) and its hosts (Populus spp. and Abies alba). Tree Physiology, 24, 639-650.
64. Ferreira R.R., Varisi V.A., Meinhardt L.W., Lea P.J., Azevedo R.A. (2005) Are high-lysine cereal crops still a challenge? Brazilian Journal of Medical and Biological Research, 38, 985-994.
65. Ferreira R.R., Meinhardt L.W., Azevedo R.A. (2006) Lysine and threonine biosynthesis in sorghum seeds: characterisation of aspartate kinase and homoserine dehydrogenase isoenzymes. Annals of Applied Biology, 149, 77-86.
66. Fougère F., Le Rudulier D., Streeter J.G. (1991) Effects of salt stress on amino acid, organic acid, and carbohydrate composition of roots, bacteroids, and cytosol of alfalfa (Medicago sativa L.). Plant Physiology, 96, 1228-1236.
67. Fowden L. (1954) The nitrogen metabolism of groundnut plants: the role of γ-methyleneglutamine and γ-methyleneglutamic acid. Annals of Botany, 18, 417-440.
68. Fredriksson H., Tallving J., Rosén J., Åman P. (2004) Fermentation reduces free asparagine in dough and acrylamide content in bread. Cereal Chemistry, 81, 650-653.
69. Friedman M. (2003) Chemistry, biochemistry, and safety of acrylamide. A review. Journal of Agricultural and Food Chemistry, 51, 4504-4526.
70. 15N-labelled protein. Physiologia Plantarum, 61, 622-628.
71. Gálvez-Valdivieso G., Osuna D., Maldonado J.M., Pineda M., Aquilar M. (2005). Purification of a functional asparagine synthetase (PVAS2) from common bean (Phaseolus vulgaris), a protein predominantly found in root tissues. Plant Science, 168, 89-95.
72. - into the shoots. Journal of Experimental Botany, 56, 2365-2378.
73. Gilbert G.A., Gadush M.V., Wilson C., Madore M.A. (1998) Amino acid accumulation in sink and source tissues of Coleus blumei Benth., during salinity stress. Journal of Experimental Botany, 49, 107-114.
74. Gomes M.A., Sodek L. (1984) Allantoinase and asparaginase activities in maturing fruits of nodulated and nonnodulated soybeans. Physiologia Plantarum, 62, 105-109.
75. Grant M., Bevan M.W. (1994) Asparaginase gene expression is regulated in a complex spatial and temporal pattern in nitrogen-sink tissues. Plant Journal, 5, 695-704.
76. Gratão P.L., Polle A., Lea P.J., Azevedo R.A. (2005) Making the life of heavy metal-stressed plants a little easier. Functional Plant Biology, 32, 481-494.
77. Grob K., Biedermann M., Biedermann-Brem S., Noti A., Imhof D., Amrein T., Pfefferle A., Bazzocco D. (2003) French fries with less than 100 μg/kg acrylamide. A collaboration between cooks and analysts. European Food Research and Technology, 217, 185-194.
78. Haase N.U., Matthaus B., Vosmann K. (2004) Aspects of acrylamide formation in potato crisps. Journal of Applied Botany and Food Quality - Angewandte Botanik, 78, 144-147.
79. Hejazi M., Piotukh K., Mattow J., Deutzmann R., Volkmer-Engert R., Lockau W. (2002) Isoaspartyl dipeptidase activity of plant-type asparaginases. Biochemical Journal, 364, 129-136.
80. Herrera-Rodríguez M.B., Carrasco-Ballesteros S., Maldonado J.M., Pineda M., Aguilar M., Pérez-Vicente R. (2002) Three genes showing distinct regulatory patterns encode the asparagine synthetase of sunflower (Helianthus annuus). New Phytologist, 155, 33-45.
81. Herrera-Rodríguez M.B., Maldonado J.M., Pérez-Vicente R. (2004) Light and metabolic regulation of HAS1, HAS1.1 and HAS2, three asparagine synthetase genes in Helianthus annuus. Plant Physiology and Biochemistry, 42, 511-518.
82. Herrera-Rodríguez M.B., Maldonado J.M., Pérez-Vicente R. (2006) Role of asparagine and asparagine synthetase genes in sunflower (Helianthus annuus) germination and natural senescence. Journal of Plant Physiology, 163, 1061-1070.
83. 15N methods. Plant Physiology, 93, 495-503.
84. Hoff J.E., Jones C.M., Wilcox G.F., Castro M.D. (1977) The effect of nitrogen fertilization on the composition of the free amino acid pool of potato tubers. American Potato Journal, 48, 391-394.
85. Howarth J.R., Jacquet J.N., Doherty A., Jones H.D., Cannell M.E. (2005) Molecular genetic analysis of silencing in two lines of Triticum aestivum transformed with the reporter gene construct pAHC25. Annals of Applied Biology, 146, 311-320.
86. Huber T.A., Streeter J.G. (1984) Asparagine biosynthesis in soybean nodules. Plant Physiology, 74, 605-610.
87. Huber T.A., Streeter J.G. (1985) Purification and properties of asparagine synthetase from soybean root nodules. Plant Science, 42, 9-17.
88. Hughes C.A., Beard H.S., Matthews B.F. (1997) Molecular cloning and expression of two cDNA encoding asparagine synthetase in soybean. Plant Molecular Biology, 33, 301-311.
89. Hurst P.L., Clark C.J. (1993) Postharvest changes in ammonium, amino acids and enzymes of amino acid metabolism in asparagus spear tips. Journal of the Science of Food and Agriculture, 63, 465-471.
90. Hurst P.L., Boulton G., Lill R.E. (1998) Towards a freshness test for asparagus: spear tip asparagine content is strongly related to post-harvest accumulated heat-units. Food Chemistry, 61, 381-384.
91. IARC (1994) Acrylamide. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, 60, 389.
92. Ireland R.J., Joy K.W. (1981) Two routes for asparagine metabolism in Pisum sativum L. Planta, 151, 289-292.
93. Ireland R.J., Joy K.W. (1983a) Subcellular localization of asparaginase and asparagine aminotransferase in Pisum sativum leaves. Plant Physiology, 72, 1127-1129.
94. Ireland R.J., Joy K.W. (1983b) Purification and properties of an asparagine aminotransferase from Pisum sativum leaves. Archives of Biochemistry and Biophysics, 223, 291-296.
95. Irving D.E., Shungleton G.J., Hurst P.L. (2001) Expression of asparagine synthetase in response to carbohydrate supply in model callus cultures and shoot tips of asparagus (Asparagus officinalis L.). Journal of Plant Physiology, 158, 561-568.
96. Joy K.W. (1988) Ammonia, glutamine and asparagine: a carbon-nitrogen interface. Canadian Journal of Botany, 66, 2103-2109.
97. Joy K.W., Ireland R.J., Lea P.J. (1983) Asparagine synthesis in pea leaves and the occurrence of an asparagine synthetase inhibitor. Plant Physiology, 73, 165-168.
98. Jung M.Y., Choi D.S., Ju J.W. (2003) A novel technique for limitation of acrylamide formation in fried and baked corn chips and in French fries. Journal of Food Science, 68, 1287-1290.
99. Kato T. (1981) Major nitrogen compounds transported in xylem vessels from roots to top in citrus trees. Physiologia Plantarum, 52, 275-279.
100. Kern R., Chrispeels M.J. (1978) Influence of the axis on the enzymes of protein and amide metabolism in the cotyledons of mung bean seedlings. Plant Physiology, 62, 815-819.
101. Keys A.J. (2006) The re-assimilation of ammonia produced by photorespiration and the nitrogen economy of C-3 higher plants. Photosynthesis Research, 87, 165-175.
102. King C.A., Purcell L.C. (2005) Inhibition of nitrogen fixation in soybean is associated with elevated ureides and amino acids. Plant Physiology, 137, 1389-1396.
103. King G.A., O'Donoghue E.M. (1995) Unravelling senescence: new opportunities for delaying the inevitable in harvested fruit and vegetables. Trends in Food Science and Technology, 6, 385-389.
104. King J.E., Gifford D.J. (1997) Amino acid utilization in seeds of loblolly pine during germination and early seedling growth. Plant Physiology, 113, 1125-1135.
105. King G.A., Woollard D.C., Irving D.E., Borst W.M. (1990) Physiological changes in asparagus spear tips after harvest. Physiologia Plantarum, 80, 393-400.
106. Køie B., Doll H. (1979) Protein and carbohydrate components. I. Risø high lysine barley mutants. In Seed Protein Improvement in Cereals and Grain Legumes. Volume 1, pp. 205-215. Vienna, Austria: IAEA.
107. Kusaka M., Ohta M., Fujimura T. (2005) Contribution of inorganic components to osmotic adjustment and leaf folding for drought tolerance in pearl millet. Physiologia Plantarum, 125, 474-489.
108. Lam H.M., Peng S.S., Coruzzi G.M. (1994) Metabolic regulation of the gene encoding glutamine-dependent asparagine synthetase in Arabidopsis thaliana. Plant Physiology, 106, 1347-1357.
109. Lam H.M., Hsieh M.H., Coruzzi G. (1998) Reciprocal regulation of distinct asparagine synthetase genes by light and metabolites in Arabidopsis thaliana. Plant Journal, 16, 345-353.
110. Lea P.J., Fowden L. (1975) The purification and properties of glutamine-dependent asparagine synthetase isolated from Lupinus albus. Proceedings of the Royal Society of London B, 192, 13-26.
111. Lea P.J., Joy K. (1983) Amino acids interconversion in germinating seeds. In Recent Advances in Phytochemistry. Volume 17, pp. 77-109. Eds C. Nozolillo, P.J. Lea and F.A. Loewus. New York: Plenum Press.
112. Lea P.J., Miflin B.J. (2003) Glutamate synthase and the synthesis of glutamate in plants. Plant Physiology and Biochemistry, 41, 555-564.
113. Lea P.J., Fowden L., Miflin B.J. (1978) The purification and properties of asparaginase from Lupinus species. Phytochemistry, 17, 217-222.
114. Lerouge P., Cabanes-Macheteau M., Rayon C., Fischette-Lainé A.C., Gomord V., Faye L. (1998) N-glycoprotein biosynthesis in plants: recent developments and future trends. Plant Molecular Biology, 38, 31-48.
115. Lima J.D., Sodek L. (2003) N-stress alters aspartate and asparagine levels of xylem sap in soybean. Plant Science, 165, 649-656.
116. Limami A.M., Rouillon C., Glevarec G., Gallais A., Hirel B. (2002) Genetic and physiological analysis of germination efficiency in maize in relation to nitrogen metabolism reveals the importance of cytosolic glutamine synthetase. Plant Physiology, 130, 1860-1870.
117. Lin J.F., Wu S.H. (2004) Molecular events in senescing Arabidopsis leaves. Plant Journal, 39, 612-628.
118. Lough T.J., Chang K.S., Carne A., Monk B.C., Reynolds P.H.S., Farnden K.J.F. (1992a) L-asparaginase from developing seeds of Lupinus arboreus. Phytochemistry, 31, 1519-1527.
119. Lough T.J., Reddington B.D., Grant M.T., Hill D.F., Reynolds P.H.S., Farnden K.J.F. (1992b) The isolation and characterization of cDNA clone encoding L-asparaginase from developing seeds of lupin (Lupinus arboreus). Plant Molecular Biology, 19, 391-399.
120. Ma Y., Nelson O.E. (1975) Amino acid composition and storage proteins in two new high-lysine mutants in maize. Cereal Chemistry, 52, 412-419.
121. Malaguti D., Millard P., Wendler R., Hepburn A., Tagliavani M. (2001) Translocation of amino acids in the xylem of apple trees in spring as a consequence of both N remobilization and root uptake. Journal of Experimental Botany, 52, 1665-1671.
122. Malik N.S.A. (1982) Senescence in detached oat leaves. I. Changes in free amino acid levels. Plant Cell Physiology, 23, 49-57.
123. Mansfield J., Gebauer S., Dathe K., Ulbrich-Hofmann R. (2006) Secretory phospholipase A2 from Arabidopsis thaliana: insights into the three-dimensional structure and the amino acids involved in catalysis. Biochemistry, 45, 5687-5694.
124. Matsuura-Endo C., Ohara-Takada A., Chuda Y., Ono H., Yada H., Yoshida M., Kobayashi A., Tsuda S., Takigawa S., Noda T., Yamauchi H., Mori M. (2006) Effects of storage temperature on the contents of sugars and free amino acids in tubers from different potato cultivars and acrylamide in chips. Bioscience, Biotechnology and Biochemistry, 70, 1173-1180.
125. McKee H.S. (1962) Nitrogen Metabolism in Plants. Oxford: Clarendon Press.
126. Meiyalaghan S., Butler R.C., Wratten S.D., Conner A.J. (2006) An experimental approach to simulate transgene pyramiding for the deployment of cry genes to control potato tuber moth (Phthorimaea operculella). Annals of Applied Biology, 148, 231-238.
127. Michalska K., Bujacz G., Jaskolski M. (2006) Crystal structure of plant asparaginase. Journal of Molecular Biology, 360, 105-116.
128. Millard P. (1996) Ecophysiology of the internal cycling of nitrogen for tree growth. Journal of Plant Nutrition and Soil Science, 159, 1-10.
129. Millard P., Wendler R., Grassi G., Grelet G.A., Tagliavini M. (2006) Translocation of nitrogen in the xylem of field-grown cherry and poplar trees during remobilization. Tree Physiology, 26, 527-536.
130. Misra P.S., Mertz E.T., Glover D.V. (1975) Studies on corn proteins. VII. Free amino acid content of opaque-2 double mutants. Cereal Chemistry, 52, 844-848.
131. Møller M.G., Taylor C., Rasmussen S.K., Holm P.B. (2003) Molecular cloning and characterisation of two genes encoding asparagine synthetase in barley (Hordeum vulgare L.). Biochimica et Biophysica Acta, 1628, 123-132.
132. Mortensen J., Eriksen J., Nielsen J.D. (1993) Sulphur deficiency and amino acid composition in seeds and grass. Phyton - Annales Rei Botanicae, 32, 85-90.
133. Mothes K. (1926) Ein Beitrag zur Kenntnis des N-Stoffwechsels höherer Pflanzen. Planta, 1, 472.
134. Mothes K. (1940) Zur Biosythese der Säureamide Asparagin und Glutamin. Planta, 30, 726.
135. Mottram D.S., Wedzicha B.L., Dodson A.T. (2002) Acrylamide is formed in the Maillard reaction. Nature, 419, 448-449.
136. Mucci L.A., Dickman P.W., Steineck G., Adami H.-O., Augustsson K. (2003) Dietary acrylamide and cancer of the large bowel, kidney, and bladder: absence of an association in a population-based study in Sweden. British Journal of Cancer, 88, 84-89.
137. Murphy J.J., Dalby A. (1971) Changes in the protein fractions of developing normal and opaque-2 maize endosperm. Cereal Chemistry, 48, 336-349.
138. Murray D.R., Kennedy I.R. (1980) Changes in the activity of enzymes of nitrogen metabolism in seedcoats and cotyledons during embryo development in pea seeds. Plant Physiology, 66, 782-785.
139. Murray A.J.S., Blackwell R.D., Joy K.W., Lea P.J. (1987) Photorespiratory donors, aminotransferase specificity and photosynthesis in a mutant of barley deficient in serine-glyoxylate aminotransferase. Planta, 172, 106-113.
140. Muttucumaru N., Halford N.G., Elmore J.S., Dodson A.T., Parry M.A.J., Shewry P.R., Mottram D.S. (2006) The formation of high levels of acrylamide during the processing of flour derived from sulfate-deprived wheat. Journal of Agricultural and Food Chemistry, 54, 8951-8955.
141. Nahm M., Holst T., Matzarakis A., Mayer H., Rennenberg H., Gessler A. (2006) Soluble N compound profiles and concentrations in European beech (Fagus sylvatica L.) are influenced by local climate and thinning. European Journal of Forest Research, 125, 1-14.
142. Näsholm T. (1994) Removal of nitrogen during needle senescence in Scots pine (Pinus sylvestris). Oecologia, 99, 290-296.
143. Nikiforova V.J., Bielecka M., Gakiere B., Krueger S., Rinder J., Kempa S., Morcuende R., Scheible W.R., Hesse H., Hoefgen R. (2006) Effect of sulfur availability on the integrity of amino acid biosynthesis in plants. Amino Acids, 30, 173-183.
144. Nordin A., Uggla C., Näsholm T. (2001) Nitrogen forms in bark, wood and foliage of nitrogen-fertilized Pinus sylvestris. Tree Physiology, 21, 59-64.
145. Nozawa A., Ito M., Hayashi H., Watanabe A. (1999) Dark-induced expression of genes for asparagine synthetase and cytosolic glutamine synthetase in radish cotyledons is dependent on the growth stage. Plant Cell Physiology, 40, 942-948.
146. Oaks A., Ross D.W. (1984) Asparagine synthetase in Zea mays. Canadian Journal of Botany, 62, 68-73.
147. Ohara-Takada A., Matsuura-Endo C., Chuda Y., Ono H., Yada H., Yoshida M., Kobayashi A., Tsuda S., Takigawa S., Noda T., Yamauchi H., Mori M. (2005) Change in content of sugars and free amino acids in potato tubers under short-term storage at low temperature and the effect on acrylamide level after frying. Bioscience, Biotechnology and Biochemistry, 69, 1232-1238.
148. Olea F., Pérez-García A., Cantón F.R., Rivera M.E., Cañas R., Ávila C., Cazorla F.M., Cánovas F.M., de Vicente A. (2004) Up-regulation and localization of asparagine synthetase in tomato leaves infected by the bacterial pathogen Pseudomonas syringae. Plant Cell Physiology, 45, 770-780.
149. Olsson K., Svensson R., Roslund C.A. (2004) Tuber components affecting acrylamide formation and colour in fried potato: variation by variety, year, storage temperature and storage time. Journal of the Science of Food and Agriculture, 84, 447-458.
150. 3-N to nitrogenous compounds at the vegetative growth stage of potato plants. Soil Science and Plant Nutrition, 41, 699-708.
151. Osuna D., Gálvez G., Pineda M., Aguilar M. (1999) RT-PCR cloning, characterization and mRNA expression analysis of a cDNA encoding a type II asparagine synthetase in common bean. Biochimica et Biophysica Acta, 1445, 75-85.
152. Osuna D., Gálvez-Valdivieso G., Piedras P., Pineda M., Aguilar M. (2001) Cloning characterization and mRNA expression analysis of PVAS1, a type I asparagine synthetase gene from Phaseolus vulgaris. Planta, 213, 402-410.
153. Parry M.A.J., Flexas J., Medrano H. (2005) Prospects for crop production under drought: research priorities and future directions. Annals of Applied Biology, 147, 211-226.
154. Pate J.S. (1980) Transport and partitioning of nitrogenous solutes. Annual Review of Plant Physiology, 31, 313-340.
155. Pate J.S., Atkins C.A., Hamel K., McNeil D.L., Layzell D.B. (1979) Transport of organic solutes in phloem and xylem of a nodulated legume. Plant Physiology, 63, 1082-1088.
156. Pate J.S., Atkins C.A., Herridge D.F., Layzell D.B. (1981) Synthesis, storage, and utilization of amino compounds in white lupin (Lupinus albus L.). Plant Physiology, 67, 37-42.
157. 2 deficiency on transport and partitioning of C and N in a nodulated legume. Plant Physiology, 76, 59-64.
158. Peeters K.M.U., Van Laere A.J. (1992) Ammonium and amino acid metabolism in excised leaves of wheat (Triticum aestivum) senescing in the dark. Physiologia Plantarum, 84, 243-249.
159. Peoples M.B., Pate J.S., Atkins C.A. (1985) The effect of nitrogen source on transport and metabolism of nitrogen in fruiting plants of cowpea (Vigna unguiculata (L.) Walp). Journal of Experimental Botany, 36, 567-582.
160. Peoples M.B., Pate J.S., Atkins C.A., Bergersen F.J. (1986) Nitrogen nutrition and xylem sap composition of peanut (Arachis hypogaea L. cv Virginia Bunch). Plant Physiology, 82, 946-951.
161. Pérez-García A., Pereira S., Pissarra J., García Gutiérrez A., Cazorla F.M., Salema R., de Vicente A., Cánovas F.M. (1998) Cytosolic localization in tomato mesophyll cells of a novel glutamine synthetase induced in response to bacterial infection or phosphinothricin treatment. Planta, 206, 426-434.
162. Piotrowski M., Volmer J. (2006) Cyanide metabolism in higher plants: cyanoalanine hydratase is a NIT4 Homolog. Plant Molecular Biology, 61, 111-122.
163. Possingham J.V. (1956) The effect of mineral nutrition on the content of free amino acids and amides in tomato plants. I. A comparison of the effects of deficiencies of copper, zinc, manganese, iron and molybdenum. Australian Journal of Biological Sciences, 9, 539-551.
164. Prell J., Poole P. (2006) Metabolic changes of rhizobia in legume nodules. Trends in Microbiology, 14, 161-168.
165. Prianischnikov D.N. (1922) Ueber den Aufbau un Abbau des Asparagins in den Pflanzen. Bericht der Deutschen botanischen Gesellschaft, 40, 242.
166. Rabe E., Lovatt C.J. (1986) Increased arginine biosynthesis during phosphorus deficiency. Plant Physiology, 81, 774-779.
167. Rainbird R.M., Thorne J.H., Hardy R.W.F. (1984) Role of amides, amino acids and ureides in the nutrition of developing soybean seeds. Plant Physiology, 74, 329-334.
168. Rhodes D., Rich P.J., Brunk D.G. (1989) Amino acid metabolism of Lemna
169. Richards N.G., Schuster S.M. (1998) Mechanistic issues in asparagine synthetase catalysis. Advances in Enzymology and Related Areas of Molecular Biology, 72, 145-198.
170. Rognes S.E. (1975) Glutamine-dependent asparagine synthetase from Lupinus luteus. Phytochemistry, 14, 1975-1982.
171. Rognes S.E. (1980) Anion regulation of lupine asparagine synthetase: chloride activation of the glutamine-utilizing reactions. Phytochemistry, 19, 2287-2293.
172. Romagni J.G., Dayan F.E. (2000) Measuring asparagine synthetase activity in crude plant extracts. Journal of Agricultural and Food Chemistry, 48, 1692-1696.
173. Rozan P., Kuo Y.H., Lambein F. (2001) Amino acids in seeds and seedlings of the genus Lens. Phytochemistry, 58, 281-289.
174. Rufty T.W., MacKown C.T., Israel D.W. (1990) Phosphorus stress effects on the assimilation of nitrate. Plant Physiology, 94, 328-333.
175. Rufty T.W., Israel D.W., Volk R.J., Qiu J., Sa T. (1993) Phosphate regulation of nitrate assimilation in soybean. Journal of Experimental Botany, 44, 879-891.
176. Rydberg P., Eriksson S., Tareke E., Karlsson P., Ehrenberg L., Törnqvist M. (2003) Investigations of factors that influence the acrylamide content of heated foodstuffs. Journal of Agricultural and Food Chemistry, 51, 7012-7018.
177. Scarpari L.M., Meinhardt L.W., Mazzafera P., Pomella A.W.V., Schiavinato M.A., Cascardo J.C.M., Pereira G.A.G. (2005) Biochemical changes during the development of witches' broom: the most important disease of cocoa in Brazil caused by Crinipellis perniciosa. Journal of Experimental Botany, 56, 865-877.
178. 15N nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry. Plant Physiology, 131, 367-378.
179. Schmid M., Davison T.S., Henz S.R., Pape U.J., Demar M., Vingron M., Scholkopf B., Weigel D., Lohmann J.U. (2005) A gene expression map of Arabidopsis thaliana development. Nature Genetics, 37, 501-506.
180. Schneider S., Gessler A., Weber P., Von Sengbusch D., Hanemann U., Rennenberg H. (1996) Soluble N compounds in trees exposed to high loads of N: a comparison of spruce (Picea abies) and beech (Fagus sylvatica). New Phytologist, 134, 103-114.
181. Schulze E. (1898) Ueber den Umsatz der Eiweissstoffe in der lebenden Pflanze. Zeitschrift fur Physiologische Chemie, 24, 18-114.
182. Schwartz G., Mendel R.R. (2006) Molybdenum cofactor biosynthesis and molybdenum enzymes. Annual Review of Plant Biology, 57, 623-647.
183. Scott D.B., Farnden K.J.F., Robertson J.G. (1976) Ammonia assimilation in lupin nodules. Nature, 263, 703-705.
184. Seebauer J.R., Moose S.P., Fabbri B.J., Crossland L.D., Below F.E. (2004) Amino acid metabolism in maize earshoots. Implications for assimilate preconditioning and nitrogen signalling. Plant Physiology, 136, 4326-4334.
185. Sharma S.S., Dietz K.-J. (2006) The significance of amino acids and amino-derived molecules in plant responses and adaptation to heavy metal stress. Journal of Experimental Botany, 57, 711-726.
186. Shewry P.R., Jones H.D. (2005) Transgenic wheat: where do we stand after the first 12 years? Annals of Applied Biology, 147, 1-14.
187. Shewry P.R., Franklin J., Parmar S., Smith S.J., Miflin B.J. (1983) The effects of sulphur starvation on the amino acid and protein compositions of barley grain. Journal of Cereal Science, 1, 21-31.
188. Shewry P.R., Williamson M.S., Kreis M. (1987) Effects of mutant genes on the synthesis of storage components in developing barley endosperms. In Mutant Genes that Affect Plant Development, pp. 95-118. Eds H. Thomas and D. Grierson. Cambridge: Cambridge University Press.
189. Shi L., Twary S.N., Yoshioka H., Gregerson R.G., Miller S.S., Samac D.A., Grantt J.S., Unkefer P.J., Vance C.P. (1997) Nitrogen assimilation in alfalfa: isolation and characterization of an asparagine synthetase gene showing enhanced expression in root nodules and dark-adapted leaves. Plant Cell, 9, 1339-1356.
190. Shimizu M.M., Mazzafera P. (2000) Compositional changes of proteins and amino acids in germinating coffee seeds. Brazilian Archives of Biology and Technology, 43, 259-265.
191. Shimizu T., Matsuoka Y., Shirasawa T. (2005) Biological significance of isoaspartate and its repair system. Biological and Pharmaceutical Bulletin, 28, 1590-1596.
192. Sieciechowicz K.A., Ireland R.J. (1989a) Proteolysis and the diurnal decrease of asparaginase activity. Physiologia Plantarum, 76, 551-556.
193. Sieciechowicz K.A., Ireland R.J., (1989b) Isolation and properties of an asparaginase from leaves of Pisum sativum. Phytochemistry, 28, 2275-2279.
194. Sieciechowicz K.A., Ireland R.J., Joy K.W. (1985) Diurnal variation of asparaginase in developing pea leaves. Plant Physiology, 77, 506-508.
195. Sieciechowicz K.A., Ireland R.J., Joy K.W. (1988a) Diurnal changes in asparaginase activity in pea leaves II. Regulation of activity. Journal of Experimental Botany, 39, 707-721.
196. Sieciechowicz K.A., Joy K.W., Ireland R.J. (1988b) Diurnal changes in asparaginase activity in pea leaves I. The requirement for light for increased activity. Journal of Experimental Botany, 39, 695-706.
197. Sieciechowicz K.A., Joy K.W., Ireland R.J. (1988c) The metabolism of asparagine in plants. Phytochemistry, 27, 663-671.
198. Silva E.M., Simon P.W. (2005) Genetic, physiological and environmental factors affecting acrylamide concentration in fried potato products. In Chemistry and Safety of Acrylamide in Food, pp. 371-386 Eds R. Friedman and D. Mottram. New York: Springer Science-Media Inc.
199. Smith P.M.C., Atkins C.A. (2002) Purine biosynthesis. Big in cell division, even bigger in nitrogen assimilation. Plant Physiology, 128, 793-802.
200. Smirnoff N., Stewart G.R. (1987) Nitrogen assimilation and zinc toxicity to zinc-tolerant and non-tolerant clones of Deschampsia cespitosa (L.) Beauv. New Phytologist, 107, 671-680.
201. Snapp S.S., Vance C.P. (1986) Asparagine biosynthesis in alfalfa (Medicago sativa L.) root nodules. Plant Physiology, 82, 390-395.
202. Sodek L., Lea P.J. (1993) Asparaginase from the testa of developing lupin and pea seeds. Phytochemistry, 34, 51-56.
203. Sodek L., Wilson C.M. (1971) Amino acid composition of proteins isolated from normal, opaque-2 and floury-2 corn endosperms by a modified Osborne procedure. Journal of Agricultural and Food Chemistry, 19, 1144-1150.
204. Sodek L., Lea P.J., Miflin B.J. (1980) Distribution and properties of a potassium-dependent asparaginase isolated from developing seeds of Pisum sativum and other plants. Plant Physiology, 65, 22-26.
205. Stadler R.H., Blank I., Varga N., Robert F., Hau J., Guy P.A., Robert M.-C., Riediker S. (2002) Acrylamide from Maillard reaction products. Nature, 419, 449-450.
206. Stewart G.R., Larher F. (1980) Accumulation of amino acids and related compounds in relation to environmental stress. In The Biochemistry of Plants. Volume 5, pp. 609-635. Ed B.J. Miflin. London: Academic Press.
207. Streeter J.G. (1973) In vivo and in vitro studies on asparagine biosynthesis in soybean seedlings. Archives of Biochemistry and Biophysics, 157, 613-624.
208. Surdyk N., Rosen J., Andersson R., Aman P. (2004) Effects of asparagine, fructose, and baking conditions on acrylamide content in yeast-leavened wheat bread. Journal of Agricultural and Food Chemistry, 52, 2047-2051.
209. Ta T.-C., Faris M.A., Macdowall F.D.H. (1986) Pathways of nitrogen metabolism in nodules of alfalfa (Medicago sativa L.). Plant Physiology, 80, 1002-1005.
210. Tareke E., Rydberg P., Karlsson P., Eriksson S., Törnqvist M. (2002) Analysis of acrylamide, a carcinogen formed in heated foodstuffs. Journal of Agricultural and Food Chemistry, 50, 4998-5006.
211. Taubert D., Harlfinger S., Henkes L., Berkels R., Schomig E. (2004) Influence of processing parameters on acrylamide formation during frying of potatoes. Journal of Agricultural and Food Chemistry, 52, 2735-2739.
212. Thomas H. (1978) Enzymes of nitrogen mobilisation in detached leaves of Lolium temulentum during senescence. Planta, 142, 161-169.
213. Thum K.E., Shasha D.E., Lejay L.V., Coruzzi G.M. (2003) Light- and carbon-signaling pathways: modeling circuits of interactions. Plant Physiology, 132, 440-452.
214. Tonin G.S., Sodek L. (1990) Asparaginase, allantoinase and glutamine synthetase in soybean cotyledons grown in vitro. Phytochemistry, 29, 2829-2831.
215. Tromp J., Ovaa J.C. (1971) Phloem translocation of nitrogen in apple. Physiologia Plantarum, 25, 407-413.
216. Tromp J., Ovaa J.C. (1976) Effect of time of nitrogen application on amino-nitrogen composition of roots and xylem sap of apple. Physiologia Plantarum, 37, 29-34.
217. Tsai F.-Y., Coruzzi G.M. (1990) Dark-induced and organ-specific expression of two asparagine synthetase genes in Pisum sativum. EMBO Journal, 9, 323-332.
218. Tsai F.-Y., Coruzzi G.M. (1991) Light represses transcription of asparagine synthetase genes in photosynthetic and non-photosynthetic organs of plants. Molecular Cell Biology, 11, 4966-4972.
219. Vauquelin L.N., Robiquet P.J. (1806) The discovery of a new plant principle in Asparagus sativus. Annales de Chimie (Paris), 57, 88-93.
220. Verdoy D., Coba de la Peña T., Redono F.J., Luca M.M., Pueyo J.J. (2006) Transgenic Medicago truncatula plants that accumulate proline display nitrogen-fixing activity with enhanced tolerance to osmotic stress. Plant Cell Physiology, 29, 1913-1923.
221. Vickery H.B., Pucher G.W., Wakeman A.J., Leavenworth C.S. (1937) Chemical changes that occur in leaves during culture in light and darkness. Connecticut Agricultural Experimental Station Bulletin, 399.
222. Vivanti V., Finotti E., Friedman M. (2006) Level of acrylamide precursors asparagine, fructose, glucose, and sucrose in potatoes sold at retail in Italy and in the United States. Journal of Food Science, 71, C81-C85.
223. Wang H.B., Liu D.C., Sun J.Z., Zhang A.M. (2005) Asparagine synthetase gene TaASN1 from wheat is up-regulated by salt stress, osmotic stress and ABA. Journal of Plant Physiology, 162, 81-89.
224. Waterhouse R.N., Smyth A.J., Massonneau A., Prosser I.M., Clarkson D.T. (1996) Molecular cloning and characterization of asparagine synthetase from Lotus japonicus: dynamics of asparagine synthesis in N-sufficient conditions. Plant Molecular Biology, 30, 883-897.
225. White M.C., Baker F.D., Chaney R.L., Decker A.M. (1981) Metal complexation in xylem fluid 2. Theoretical equilibrium model and computational computer program. Plant Physiology, 67, 301-310.
226. Wicklund T., Østlie H., Lothe O., Knutsen S.H., Bråthen E., Kita A. (2006) Acrylamide in potato crisp - the effect of raw material and processing. LWT - Food Science and Technology, 39, 571-575.
227. Winichayakul S., Moyle R.L., Coupe S.A., Davies K.M., Farnden K.J.F. (2004a) Analysis of the asparagus (Asparagus officinalis) asparagine synthetase gene promoter identifies evolutionarily conserved cis-regulatory elements that mediate Suc-repression. Functional Plant Biology, 31, 63-72.
228. Winichayakul S., Moyle R.L., Ryan D.J., Farnden K.J.F., Davies K.M., Coupe S.A. (2004b) Distinct cis-elements in the Asparagus officinalis asparagine synthetase promoter respond to carbohydrate and senescence signals. Functional Plant Biology, 31, 573-582.
229. Winkler U., Schön W.J. (1980) Amino acid composition of the kernel proteins in barley resulting from nitrogen fertilization at different stages of development. Journal of Agronomy and Crop Science, 149, 503-512.
230. Wong H.-K., Chan H.-K., Coruzzi G.M., Lam H.-M. (2004) Correlation of ASN2 gene expression in ammonium metabolism in Arabidopsis. Plant Physiology, 134, 332-338.
231. Yemm E.W. (1950) Respiration of barley plants IV. Protein catabolism and the formation of amides in starving leaves. Proceedings of the Royal Society of London B, 136, 632-649.
232. Zhao F.J., Hawkesford M.J., Warrilow A.G.S., McGrath S.P., Clarkson D.T. (1996) Responses of two wheat varieties to sulphur addition and diagnosis of sulphur deficiency. Plant and Soil, 181, 317-327.
233. Zhao F.J., Hawkesford M.J., McGrath S.P. (1999) Sulphur assimilation and effects on yield and quality of wheat. Journal of Cereal Science, 30, 1-17.
234. Zyzak D.V., Sanders R.A., Stojanovic M., Tallmadge D.H., Loye Eberhart B., Ewald D.K., Gruber D.C., Morsch T.R., Strothers M.A., Rizzi G.P., Villagran M.D. (2003) Acrylamide formation mechanism in heated foods. Journal of Agricultural Food Chemistry, 51, 4782-4787.