Pathophysiology of epilepsy;Pathophysiologie der epilepsie

Klinische Neurophysiologie

Volumn 37, Issue 4, 2006, Pages 216-224

  Köhling, Rüdiger ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Bursting; Epilepsy; GABA; Ih; Im; Neuronal excitability; NMDA; Persistent sodium current; Sprouting; Synaptic plasticity

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID;

ARTICLE; EPILEPSY; GAP JUNCTION; HEREDITY; MEDICAL RESEARCH; MORPHOLOGY; PATHOPHYSIOLOGY;

EID: 33846648822     PISSN: 14340275     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-951902     Document Type: Article

References (62)

1. Avoli M, Louvel J, Pumain R, Köhling R. Cellular and molecular mechanisms of epilepsy in the human brain. Prog Neurobiol 2005; 77: 166-200
2. 2+ Channel causes a long-lasting modification of neuronal firing mode after status epilepticus. J Neurosci 2002; 22: 3645-3655
3. 2+ currents in acutely isolated human hippocampal granule cells. Am Physiol Society 1996; Vol: 1-12
4. 2+ currents in epilepsy. Epilepsy Res 1998; 32: 321-332
5. 2+-dependent intrinsic bursting in the rat pilocarpine model of temporal lobe epilepsy. Journal of Physiology-London 2001; 532: 205-216
6. Khosravani H, Altier C, Simms B et al. Gating effects of mutations in the Cav3.2 T-type calcium channel associated with childhood absence epilepsy. J Biol Chem 2004; 279: 9681-9684
7. Reckziegel G, Beck H, Schramm J, Elger CE, Urban BW. Properties of voltage-dependent sodium channels (INa) in isolated human hippocampal neurones. 1998
8. Vreugdenhil M, Hoogland G, Veelen CW van, Wadman WJ. Persistent sodium current in subicular neurons isolated from patients with temporal lobe epilepsy. Eur J Neurosci 2004; 19: 2769-2778
9. Chen K, Aradi I, Thon N, Eghbal-Ahmadi M, Baram TZ, Soltesz I. Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nat Med 2001; 7: 331-337
10. h is associated with enhanced excitability and absence epilepsy. Eur J Neurosci 2004; 19: 3048-3058
11. Bender RA, Soleymani SV, Brewster AL et al. Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. J Neurosci 2003; 23: 6826-6836
12. Yue C, Yaari Y. KCNQ/M channels control spike after depolarization and burst generation in hippocampal neurons. J Neurosci 2004; 24: 4614-4624
13. Biervert C, Schroeder BC, Kubisch C et al. A potassium channel mutation in neonatal human epilepsy. Science 1998; 279: 403-406
14. Prince DA. Neurophysiology of Epilepsy. Ann Rev Neurosci 1978; 1: 395-415
15. Köhr G, Koninck Y De, Mody I. Properties of NMDA receptor channels in neurons acutely isolated from epileptic (kindled) rats. J Neurosci 1993; 13: 3612-3627
16. Isokawa M, Levesque MF. Increased NMDA responses and dendritic degeneration in human epileptic hippocampal neurons in slices. Neurosci Lett 1991; 132: 212-216
17. Isokawa M, Levesque M, Fried I, Engel J. Glutamate currents in morphologically identified human dentate granule cells in temporal lobe epilepsy. J Neurophysiol 1997; 77: 3355-3369
18. Mathern GW, Pretorius JK, Mendoza D, Lozada A, Kornblum HI. Hippocampal AMPA and NMDA mRNA levels correlate with aberrant fascia dentata mossy fiber sprouting in the pilocarpine model of spontaneous limbic epilepsy. J Neurosci Res 1998; 54: 734-753
19. Mathern GW, Pretorius JK, Kornblum HI et al. Human hippocampal AMPA and NMDA mRNA levels in temporal lobe epilepsy patients. Brain 1997; 120: 1937-1959
20. Avoli M, Olivier A. Electrophysiological properties and synaptic responses in the deep layers of the human epileptogenic neocortex in vitro. J Neurophysiol 1989; 61, 3: 589-606
21. Kortenbruck G, Berger E, Speckmann E-J, Musshoff U. RNA Editing at the Q/R Site for the Glutamate Receptor Subunits GLUR2, GLUR5 and GLUR6 in Hippocampus and Temporal Cortex from Epileptic Patients. Neurobiology of Disease 2001; 8: 459-468
22. Dietrich D, Kral T, Clusmann H, Friedl M, Schramm J. Reduced function of L-AP4-sensitive metabotropic glutamate receptors in human epileptic sclerotic hippocampus. Eur J Neurosci 1999; 11: 1109-1113
23. Whittington MA, Traub RD, Jefferys JGR. Erosion of inhibition contributes to the progression of low magnesium bursts in rat hippocampal slices. J Physiol (Lond) 1995; 486: 723-734
24. Sloviter RS. Permanently altered hippocampal structure, excitability, and inhibition after experimental status epilepticus in the rat: The "Dormant Basket Cell" hypothesis and its possible relevance to temporal lobe epilepsy. Hippocampus 1991; 1: 41-66
25. McDonald JW, Garofalo EA, Hood T et al. Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy. Ann Neurol 1991; 29, 5: 529-541
26. Johnson EW, Lanerolle NC De, Kim JH et al. "Central" and "peripheral" benzodiazepine receptors: opposite changes in human epileptogenic tissue. Neurology 1992; 42: 811-815
27. Houser CR, Miyashiro JE, Swartz BE, Walsh CO, Rich JR, Delgado-Escueta AV. Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy. The Journal of Neuroscience 1990; 10: 267-282
28. Arellano JI, Munoz A, Ballesteros-Yanez I, Sola RG, DeFelipe J. Histopathology and reorganization of chandelier cells in the human epileptic sclerotic hippocampus. Brain 2004; 127: 45-64
29. A receptor-mediated inhibitory post-synaptic currents in dentate granule cells in epileptic hippocampus. J Neurophysiol 1996; 75: 1901-1908
30. Palma E, Ragozzino DA, Angelantonio S Di et al. Phosphatase inhibitors remove the run-down of γ-aminobutyric acid type A receptors in the human epileptic brain. PNAS 2004; 101: 10183-10188
31. Babb TL, Pretorius JK, Kupfer WR, Crandall PH. Glutamate decarboxylase-immunoreactive neurons are preserved in human epileptic hippocampus. The Journal of Neuroscience 1989; 9: 2562-2574
32. Bernard C, Esclapez M, Hirsch JC, Ben Ari Y. Interneurones are not so dormant in temporal lobe epilepsy: a critical reappraisal of the dormant basket cell hypothesis. Epilepsy Res 1998; 32: 93-103
33. Koch UR, Musshoff U, Pannek HW et al. Intrinsic excitability, synaptic potentials, and short-term plasticity in human epileptic neocortex. J Neurosci Res 2005; 80: 715-726
34. McCormick DA. GABA as an Inhibitory Neurotransmitter in Human Cerebral Cortex. Journal of neurophysiology 1989; 62: 1018-1027
35. Cohen I, Navarro V, Clemenceau S, Baulac M, Miles R. On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science 2002; 298: 1418-1421
36. A receptor-mediated oscillations. J Neurosci 2000; 20: 6820-6829
37. - co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 1999; 397: 251-255
38. -extrusion. The Journal of Cell Biology 2002; 159: 747-752
39. Köhling R, Lücke A, Straub H et al. Spontaneous sharp waves in human neocortical slices excised from epileptic patients. Brain 1998; 121: 1073-1087
40. Khalilov I, Holmes GL, Yehezkel B-A. In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures. Nature Neurosci 2003; 6: 1079-1085
41. Boison D. Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies. Neuroscientist 2005; 11: 25-36
42. Glass IM, Faull RLM, Bullock JY et al. Loss of A1 adenosine receptors in human temporal lobe epilepsy. Brain Res 1996; 710: 56-68
43. Naus CC, Bechberger JF, Paul DL. Gap junction gene expression in human seizure disorder. Exp Neurol 1991; 111: 198-203
44. 2+) in rat hippocampal slices depends on gap junctional coupling. Neuroscience 2001; 105: 579-587
45. Carlen PL, Skinner F, Zhang L, Naus C, Kushnir M, Velazquez JLP. The role of gap junctions in seizures. Brain Res Rev 2000; 32: 235-241
46. Wallraff A, Köhling R, Heinemann U, Theis M, Willecke K, Steinhauser C. The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus. J Neurosci 2006; 26: 5438-5447
47. Isokawa M. Remodeling dendritic spines of dentate granule cells in temporal lobe epilepsy patients and the rat pilocarpine model. Epilepsia 2000; 41, Suppl 6: S14-S17
48. Blümcke I, Schewe JC, Normann S et al. Increase of nestin-immunoreactive neural precursor cells in the dentate gyrus of pediatric patients with early-onset temporal lobe epilepsy. Hippocampus 2001; 11: 311-321
49. Blümcke I, Beck H, Lie AA, Wiestler OD. Molecular neuropathology of human mesial temporal lobe epilepsy. Epilepsy Res 1999; 36: 205-223
50. Haas CA, Dudeck O, Kirsch M et al. Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. J Neurosci 2002; 22: 5797-5802
51. Biervert C, Schroeder BC, Kubisch C et al. A potassium channel mutation in neonatal human epilepsy. Science 1998; 279: 403-406
52. Escayg A, MacDonald BT, Meisler MH et al. Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+ 2. Nat Genet 2000; 24: 343-345
53. Escayg A, Heils A, MacDonald BT, Haug K, Sander T, Meisler MH. A novel SCN1A mutation associated with generalized epilepsy with febrile seizures plus - and prevalence of variants in patients with epilepsy. Am J Hum Genet 2001; 68: 866-873
54. +-channel beta1 subunit gene SCN1B. Nat Genet 1998; 19: 366-370
55. A receptor dysfunction in epilepsy: a mutation in the gamma2-subunit gene. Nature Genet 2001; 28: 46-48
56. Phillips HA, Favre I, Kirkpatrick M et al. CHRNB2 is the second acetyl-choline receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy. Am J Hum Genet 2001; 68: 225-231
57. Steinlein OK, Mulley JC, Propping P et al. A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nat Genet 1995; 11: 201-203
58. Steinlein OK. Genes and mutations in idiopathic epilepsy. Am J Med Genet 2001; 106: 139-145
59. Aracri P, Colombo E, Mantegazza M et al. Layer-specific properties of the persistent sodium current in sensorimotor cortex. J Neurophysiol 2006; 95: 3460-3468
60. Robinson RB, Siegelbaum SA. Hyperpolarization-activated cation currents: from molecules to physiological function. Annu Rev Physiol 2003; 65: 453-480
61. Jentsch TJ. Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev Neurosci 2000; 1: 21-30
62. Kullmann DM, Asztely F, Walker MC. The role of mammalian ionotropic receptors in synaptic plasticity: LTP, LTD and epilepsy. Cell Mol Life Sci 2000; 57: 1551-1561