Remodeling dendritic spines of dentate granule cells in temporal lobe epilepsy patients and the rat pilocarpine model

Epilepsia

Volumn 41, Issue SUPPL. 6, 2000, Pages

  Isokawa, Masako ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Hippocampus; Mossy fiber sprouting; Spine loss; Spine regeneration; Spontaneous seizure

Indexed keywords

PILOCARPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; DENDRITIC SPINE; DENTATE NUCLEUS; HISTOPATHOLOGY; NERVE DEGENERATION; NERVE EXCITABILITY; NERVE FIBER REGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; TEMPORAL LOBE EPILEPSY;

EID: 0033816630     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.2000.tb01550.x     Document Type: Conference Paper

References (14)

1. Structural substrates of seizure foci in the human temporal lobe
2. Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy
3. Single mossy fiber axonal systems of human dentate granule cells studied in hippocampal slices from patients with temporal lobe epilepsy
4. Mossy fiber synaptic reorganization in the epileptic human temporal lobe
5. Dendritic morphology in epileptogenic cortex from TRPE patients, revealed by intracellular Lucifer yellow microinjection and confocal laser scanning microscopy
6. Increased NMDA responses and dendritic degeneration in human epileptic hippocampal neurons in slices
7. Remodeling dendritic spines in the rat pilocarpine model of temporal lobe epilepsy
8. Preservation of dendrites with the presence of reorganized mossy fiber collaterals in hippocampal dentate granule cells in patients with temporal lobe epilepsy
9. Slices have more synapses than perfusion-fixed hippocampus from both young and mature rats
10. Spine loss in experimental epilepsy: Quantitative light and electron microscopic analysis of intracellularly stained CA3 pyramidal cells in hippocampal slice cultures
11. Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity
12. Decreased time constant in hippocampal dentate granule cells in pilocarpine-treated rats with progressive seizure frequencies
13. Glutamate currents in morphologically identified human dentate granule cells in epilepsy
14. Altered pattern of light transmittance and resistance to AMPA-induced swelling in the dentate gyrus of the epileptic hippocampus