Cofactor-independent phosphoglycerate mutase is an essential gene in procyclic form Trypanosoma brucei

Parasitology Research

Volumn 100, Issue 4, 2007, Pages 887-892

  Djikeng, Appolinaire ^a   Raverdy, Sylvine ^b   Foster, Jeremy ^b   Bartholomeu, Daniella ^a   Zhang, Yinhua ^b   El Sayed, Najib M ^a,c   Carlow, Clotilde ^b  

^a J CRAIG VENTER INSTITUTE   (United States)

^b NEW ENGLAND BIOLABS   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PHOSPHOGLYCERATE MUTASE; PROTOZOAL PROTEIN;

ARTICLE; CELL GROWTH; CORRELATION ANALYSIS; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE FUNCTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE DEVELOPMENT; PHENOTYPE; PRIORITY JOURNAL; PROTOZOAL GENETICS; RNA INTERFERENCE; STEADY STATE; TRYPANOSOMA BRUCEI;

ANIMALS; COENZYMES; GENES, ESSENTIAL; PHOSPHOGLYCERATE MUTASE; TIME FACTORS; TRYPANOSOMA BRUCEI BRUCEI;

TRYPANOSOMA BRUCEI;

EID: 33846608670     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-006-0332-7     Document Type: Article

References (30)

1. Albert MA, Haanstra JR, Hannaert V, Van Roy J, Opperdoes FR, Bakker BM, Michels PA (2005) Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei. J Biol Chem 280:28306-28315
2. Barrett MP, Burchmore RJ, Stich A, Lazzari JO, Frasch AC, Cazzulo JJ, Krishna S (2003) The trypanosomiases. Lancet 362:1469-1480
3. Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, Lennard NJ et al. (2005) The genome of the African trypanosome Trypanosoma brucei. Science 309:416-422
4. Besteiro S, Barrett MP, Riviere L, Bringaud F (2005) Energy generation in insect stages of Trypanosoma brucei: metabolism in flux. Trends Parasitol 21:185-191
5. Chevalier N, Rigden DJ, Van Roy J, Opperdoes FR, Michels PA (2000) Trypanosoma brucei contains a 2,3-bisphosphoglycerate independent phosphoglycerate mutase. Eur J Biochem 267:1464-1472
6. Collet JF, Stroobant V, Van Schaftingen E (2001) The 2,3- bisphosphoglycerate-independent phosphoglycerate mutase from Trypanosoma brucei: metal-ion dependency and phosphoenzyme formation. FEMS Microbiol Lett 204:39-44
7. Coustou V, Besteiro S, Biran M, Diolez P, Bouchaud V, Voisin P, Michels PA et al. (2003) ATP generation in the Trypanosoma brucei procyclic form: cytosolic substrate level is essential, but not oxidative phosphorylation. J Biol Chem 278:49625-49635
8. Cross GA, Klein RA, Linstead DJ (1975) Utilization of amino acids by Trypanosoma brucei in culture: L-threonine as a precursor for acetate. Parasitology 71:311-326
9. Cunningham I (1977) New culture medium for maintenance of tsetse tissues and growth of trypanosomatids. J Protozool 24:325-329
10. Djikeng A, Shen S, Tschudi C, Ullu E (2004) Analysis of gene function in Trypanosoma brucei using RNA interference. Methods Mol Biol 270:287-298
11. Drew ME, Morris JC, Wang Z, Wells L, Sanchez M, Landfear SM, Englund PT (2003) The adenosine analog tubercidin inhibits glycolysis in Trypanosoma brucei as revealed by an RNA interference library. J Biol Chem 278:46596-46600
12. El-Sayed NM, Myler PJ, Bartholomeu DC, Nilsson D, Aggarwal G, Tran AN, Ghedin E et al. (2005a) The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science 309:409-415
13. El-Sayed NM, Myler PJ, Blandin G, Berriman M, Crabtree J, Aggarwal G, Caler E et al. (2005b) Comparative genomics of trypanosomatid parasitic protozoa. Science 309: 404-409
14. Guerra DG, Vertommen D, Fothergill-Gilmore LA, Opperdoes FR, Michels PA (2004) Characterization of the cofactor-independent phosphoglycerate mutase from Leishmania mexicana mexicana. Histidines that coordinate the two metal ions in the active site show different susceptibilities to irreversible chemical modification. Eur J Biochem 271:1798-1810
15. Guerra-Giraldez C, Quijada L, Clayton CE (2002) Compartmentation of enzymes in a microbody, the glycosome, is essential in Trypanosoma brucei. J Cell Sci 115:2651-2658
16. Hannaert V, Bringaud F, Opperdoes FR, Michels PA (2003) Evolution of energy metabolism and its compartmentation in Kinetoplastida. Kinetoplastid Biol Dis 2:11
17. Ivens AC, Peacock CS, Worthey EA, Murphy L, Aggarwal G, Berriman M, Sisk E et al. (2005) The genome of the kinetoplastid parasite, Leishmania major. Science 309:436-442
18. Jannin J, Cattand P (2004) Treatment and control of human African trypanosomiasis. Curr Opin Infect Dis 17:565-571
19. Jedrzejas MJ, Chander M, Setlow P, Krishnasamy G (2000a) Mechanism of catalysis of the cofactor-independent phosphoglycerate mutase from Bacillus stearothermophilus. Crystal structure of the complex with 2-phosphoglycerate. J Biol Chem 275:23146-23153
20. Jedrzejas MJ, Chander M, Setlow P, Krishnasamy G (2000b) Structure and mechanism of action of a novel phosphoglycerate mutase from Bacillus stearothermophilus. EMBO J 19:1419-1431
21. Joshi PP, Shegokar VR, Powar RM, Herder S, Katti R, Salkar HR, Dani VS et al. (2005) Human trypanosomiasis caused by Trypanosoma evansi in India: the first case report. Am J Trop Med Hyg 73:491-495
22. Kessler PS, Parsons M (2005) Probing the role of compartmentation of glycolysis in procyclic form Trypanosoma brucei: RNA interference studies of PEX14, hexokinase, and phosphofructokinase. J Biol Chem 280:9030-9036
23. Lamour N, Riviere L, Coustou V, Coombs GH, Barrett MP, Bringaud F (2005) Proline metabolism in procyclic Trypanosoma brucei is down-regulated in the presence of glucose. J Biol Chem 280:11902-11910
24. Leyva-Vazquez MA, Setlow P (1994) Cloning and nucleotide sequences of the genes encoding triose phosphate isomerase, phosphoglycerate mutase, and enolase from Bacillus subtilis. J Bacteriol 176:3903-3910
25. Morris VL, Jackson DP, Grattan M, Hisnworth T, Cuppels DA (1995) Isolation and sequence analysis of the Pseudomonas syringae pv. tomato gene encoding a 2,3-diphosphoglycerate-independent phosphoglyceromutase. J Bacteriol 177:1727-1733
26. Oduro KK, Flynn IW, Bowman IB (1980) Trypanosoma brucei: activities and subcellular distribution of glycolytic enzymes from differently disrupted cells. Exp Parasitol 50:123-135
27. Rigden DJ, Mello LV, Setlow P, Jedrzejas MJ (2002) Structure and mechanism of action of a cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus with broad specificity phosphatase activity. J Mol Biol 315:1129-1143
28. Wang Z, Morris JC, Drew ME, Englund PT (2000) Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters. J Biol Chem 275:40174-40179
29. Wirtz E, Leal S, Ochatt C, Cross GA (1999) A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei. Mol Biochem Parasitol 99:89-101
30. Zhang Y, Foster JM, Kumar S, Fougere M, Carlow CK (2004) Cofactor-independent phosphoglycerate mutase has an essential role in Caenorhabditis elegans and is conserved in parasitic nematodes. J Biol Chem 279:37185-37190