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Volumn 13, Issue 2, 2007, Pages 98-106

Particulate matter in the environment: Pulmonary and cardiovascular effects

Author keywords

Cardiovascular effects; PM10; PM2.5; Pulmonary effects; Ultrafine particles

Indexed keywords

ALPHA INTERFERON; CARBON; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 33846585546     PISSN: 10705287     EISSN: 15316971     Source Type: Journal    
DOI: 10.1097/MCP.0b013e328013f47e     Document Type: Review
Times cited : (87)

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    • Glutathione-S-transferase M1, obesity, statins, and autonomic effects of particles: Gene-by-drug-by- environment interaction
    • Original concept that shows in an epidemiological context the role of the susceptibility to inflammation as an effect modifier in the association between heart rate variability and air pollution
    • Schwartz J, Park SK, O'Neill MS, et al. Glutathione-S-transferase M1, obesity, statins, and autonomic effects of particles: gene-by-drug-by- environment interaction. Am J Respir Crit Care Med 2005; 172:1529-1533. Original concept that shows in an epidemiological context the role of the susceptibility to inflammation as an effect modifier in the association between heart rate variability and air pollution.
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    • Translocation of inhaled ultrafine manganese oxide particles to the central nervous system
    • This is a very original study demonstrating that the olfactory neuronal pathway is efficient for translocating inhaled UFPs to the CNS and that this can result in inflammatory changes
    • Elder A, Gelein R, Silva V, et al. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspec 2006; 114:1172-1178. This is a very original study demonstrating that the olfactory neuronal pathway is efficient for translocating inhaled UFPs to the CNS and that this can result in inflammatory changes.
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    • Elder, A.1    Gelein, R.2    Silva, V.3
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    • Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low
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    • Nemmar, A.1    Vanbilloen, H.2    Hoylaerts, M.F.3
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    • Geiser M, Rothen-Rutishauser B, Kapp N, et al. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 2005; 113:1555-1560. This study reports that inhaled ultrafine titanium dioxide particles can be found on the luminal side of airways and alveoli, in all major lung tissue compartments and cells, and within capillaries, and the particle uptake in vitro into cells does not occur by endocytosis, but by diffusion or adhesive interactions.
    • Geiser M, Rothen-Rutishauser B, Kapp N, et al. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 2005; 113:1555-1560. This study reports that inhaled ultrafine titanium dioxide particles can be found on the luminal side of airways and alveoli, in all major lung tissue compartments and cells, and within capillaries, and the particle uptake in vitro into cells does not occur by endocytosis, but by diffusion or adhesive interactions.
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    • Microsphere translocation and immunopotentiation in systemic tissues following intranasal administration
    • Eyles JE, Bramwell VW, Williamsson ED, Alpar HO. Microsphere translocation and immunopotentiation in systemic tissues following intranasal administration. Vaccine 2001; 19:4732-4742.
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    • The influence of hydrogen peroxide and histamine on lung permeability and translocation of iridium nanoparticles in the isolated perfused rat lung
    • This study reports that permeability of the lung barrier to UFPs is controlled both at the epithelial and endothelial level, and is influenced by the inflammation
    • Meiring J, Borm PJA, Bagate K, et al. The influence of hydrogen peroxide and histamine on lung permeability and translocation of iridium nanoparticles in the isolated perfused rat lung. Part Fibre Toxicol 2005; 2. This study reports that permeability of the lung barrier to UFPs is controlled both at the epithelial and endothelial level, and is influenced by the inflammation.
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    • Evaluation of particle translocation across the alveolo-capillary barrier in isolated perfused rabbit lung model
    • This study demonstrates that UFPs diffuse from the vascular compartment into the lungs in an isolated perfused rabbit lung model, when the microvascular permeability is increased by histamine
    • Nemmar A, Hamoir J, Nemery B, Gustin P. Evaluation of particle translocation across the alveolo-capillary barrier in isolated perfused rabbit lung model. Toxicology 2005; 208:105-113. This study demonstrates that UFPs diffuse from the vascular compartment into the lungs in an isolated perfused rabbit lung model, when the microvascular permeability is increased by histamine.
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    • Nemmar, A.1    Hamoir, J.2    Nemery, B.3    Gustin, P.4
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    • Mills NL, Amin N, Robinson SD, et al. Do inhaled carbon nanoparticles translocate directly into the circulation in man? Am J Respir Crit Care Med 2006; 173:426-431. This article did not confirm the earlier findings by Nemmar et al. [66].
    • Mills NL, Amin N, Robinson SD, et al. Do inhaled carbon nanoparticles translocate directly into the circulation in man? Am J Respir Crit Care Med 2006; 173:426-431. This article did not confirm the earlier findings by Nemmar et al. [66].
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    • The rat ear vein model for investigating in vivo thrombogenicity of ultrafine particles (Ufp)
    • This is an excellent study that validated the use of a noninvasive ear vein model in rats to evaluate the thrombogenic effects of UFP deposition in the respiratory tract
    • Silva VM, Corson N, Elder A, Oberdorster G. The rat ear vein model for investigating in vivo thrombogenicity of ultrafine particles (Ufp). Toxicol Sci 2005; 85:983-989. This is an excellent study that validated the use of a noninvasive ear vein model in rats to evaluate the thrombogenic effects of UFP deposition in the respiratory tract.
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    • Silva, V.M.1    Corson, N.2    Elder, A.3    Oberdorster, G.4
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    • Diesel exhaust particles in lung acutely enhance experimental peripheral thrombosis
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    • Pulmonary inflammation and thrombogenicity caused by diesel particles in hamsters - role of histamine
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    • Nemmar, A.1    Nemery, B.2    Hoet, P.H.M.3
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    • Pharmacological stabilization of mast cells abrogates late thrombotic events induced by diesel exhaust particles in hamsters
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    • Silica particles enhance peripheral thrombosis: Key role of lung macrophage-neutrophil cross-talk
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    • Nemmar A, Nemery B, Hoet PH, et al. Silica particles enhance peripheral thrombosis: key role of lung macrophage-neutrophil cross-talk. Am J Respir Crit Care Med 2005; 171:872-879. This is a mechanistic study showing the importance of pulmonary macrophage-neutrophil cross-talk, in releasing neutrophil elastase into the blood, and causing platelet activation and thrombotic events on mildly damaged vasculature.
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    • Nemmar, A.1    Nemery, B.2    Hoet, P.H.3
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    • Particulate air pollution induces progression of atherosclerosis
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    • Suwa, T.1    Hogg, J.C.2    Quinlan, K.B.3
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    • -/- mouse model, that long-term exposure to low concentration of PM2.5 altered vasomotor tone, induced vascular inflammation, and potentiated atherosclerosis.
    • -/- mouse model, that long-term exposure to low concentration of PM2.5 altered vasomotor tone, induced vascular inflammation, and potentiated atherosclerosis.
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    • Geys J, Coenegrachts L, Vercammen V, et al. In vitro study of the pulmonary translocation of nanoparticles: a preliminary study. Toxicol Lett 2006; 160:218-226. An interesting preliminary study on in-vitro translocation of UFPs, reporting that the Calu-3 cell line can be used in an in-vitro translocation study.
    • Geys J, Coenegrachts L, Vercammen V, et al. In vitro study of the pulmonary translocation of nanoparticles: a preliminary study. Toxicol Lett 2006; 160:218-226. An interesting preliminary study on in-vitro translocation of UFPs, reporting that the Calu-3 cell line can be used in an in-vitro translocation study.
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    • E-selectin expression in human endothelial cells exposed to PM10: The role of endotoxin and insoluble fraction
    • in press
    • Alfaro-Moreno E, López-Marure R, Montiel-Dávalos A, et al. E-selectin expression in human endothelial cells exposed to PM10: the role of endotoxin and insoluble fraction. Environ Res (in press).
    • Environ Res
    • Alfaro-Moreno, E.1    López-Marure, R.2    Montiel-Dávalos, A.3
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    • 10 induce the expression of adhesion molecules and the adhesion of monocytic cells to human umbilical vein endothelial cells
    • in press
    • 10 induce the expression of adhesion molecules and the adhesion of monocytic cells to human umbilical vein endothelial cells. Inhalation Toxicol (in press).
    • Inhalation Toxicol
    • Montiel-Dávalos, A.1    Alfaro-Moreno, E.2    López-Marure, R.3
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    • 2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells. Am J Physiol Cell Physiol 2006; 291:C357-C365. An excellent mechanistic study of the effects of urban particles on pulmonary artery endothelial cells.
    • 2 production from NAD(P)H oxidase and mitochondria in human pulmonary artery endothelial cells. Am J Physiol Cell Physiol 2006; 291:C357-C365. An excellent mechanistic study of the effects of urban particles on pulmonary artery endothelial cells.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.