In vitro study of the pulmonary translocation of nanoparticles: A preliminary study

Toxicology Letters

Volumn 160, Issue 3, 2006, Pages 218-226

  Geys, J ^a   Coenegrachts, L ^a   Vercammen, J ^a   Engelborghs, Y ^a   Nemmar, A ^a   Nemery, B ^a   Hoet, P H M ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Calu 3 cell line; In vitro; Nanoparticles; Rat type II pneumocytes; TEER

Indexed keywords

FLUORESCEIN SODIUM; NANOPARTICLE; POLYSTYRENE;

ANIMAL CELL; ARTICLE; BRONCHUS MUCOSA; CELL LINE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS CELL; LUNG ALVEOLUS CELL TYPE 2; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT;

AIR POLLUTANTS; BRONCHI; CELL LINE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; HUMANS; MODELS, BIOLOGICAL; NANOSTRUCTURES; PARTICLE SIZE; PULMONARY ALVEOLI; RESPIRATORY MUCOSA;

ANIMALIA;

EID: 27744477066     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2005.07.005     Document Type: Article

References (27)

1. R.U. Agu, M. Jorissen, T. Willems, P. Augustijns, R. Kinget, and N. Verbeke In-vitro nasal drug delivery studies: comparison of derivatised, fibrillar and polymerised collagen matrix-based human nasal primary culture systems for nasal drug delivery studies J. Pharm. Pharmacol. 53 2001 1447 1456
2. J.M. Cheek, K.J. Kim, and E.D. Crandall Tight monolayers of rat alveolar epithelial cells: bioelectric properties and active sodium transport Am. J. Physiol. 256 1989 C688 C693
3. V. Colvin The potential environmental impact of engineered nanomaterials Nat. Biotechnol. 21 2003 1166 1170
4. G.R. Cott, K. Sugahara, and R.J. Mason Stimulation of net active ion transport across alveolar type II cell monolayers Am. J. Physiol. 250 1986 C222 C227
5. P.A. Dickinson, J.P. Evans, S.J. Farr, I.W. Kellaway, T.P. Appelqvist, A.C. Hann, and R.J. Richards Putrescine uptake by alveolar epithelial cell monolayers exhibiting differing transepithelial electrical resistances J. Pharm. Sci. 85 1996 1112 1116
6. K. Donaldson, V. Stone, C.L. Tran, W. Kreyling, and P.J. Borm Nanotoxicology Occup. Environ. Med. 61 2004 727 728
7. B.I. Florea, I.C.J. van der Sandt, S.M. Schrier, K. Kooiman, K. Deryckere, A.G. de Boer, H.E. Junginger, and G. Borchard Evidence of P-glycoprotein mediated apical to basolateral transport of flunisolide in human broncho-tracheal epithelial cells (Calu-3) Br. J. Pharmacol. 134 2001 1555 1563
8. K.A. Foster, M.L. Avery, M. Yazdanian, and K.L. Audus Characterization of the Calu-3 cell line as a tool to screen pulmonary drug delivery Int. J. Pharm. 208 2000 1 11
9. K.A. Foster, C.G. Oster, M.M. Mayer, M.L. Avery, and K.L. Audus Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism Exp. Cell Res. 243 1998 359 366
10. K.A. Foster, M. Yazdanian, and K.L. Audus Microparticulate uptake mechanisms of in-vitro cell culture models of the respiratory epithelium J. Pharm. Pharmacol. 53 2001 57 66
11. J. Hamoir, A. Nemmar, D. Halloy, D. Wirth, G. Vincke, A. Vanderplasschen, B. Nemery, and P. Gustin Effect of polystyrene particles on lung microvascular permeability in isolated perfused rabbit lungs: role of size ans surface properties Toxicol. Appl. Pharmacol. 190 2003 278 285
12. P.H. Hoet, C.P. Lewis, D. Dinsdale, M. Demedts, and B. Nemery Putrescine uptake in hamster lung slices and primary cultures of type II pneumocytes Am. J. Physiol. 269 1995 L681 L689
13. P.H. Hoet, A. Nemmar, and B. Nemery Health impact of nanomaterials? Nat. Biotechnol. 22 2004 19
14. - fluxes to net ion transport by alveolar epithelium Respir. Physiol. 85 1991 245 256
15. W. Luther, R. Nass, R. Campbell, U. Dellwo, F. Schuster, F. Tenegal, M. Kallio, P. Lintunen, O. Salata, M. Remškar, M. Zumer, P.H. Hoet, I. Brüske-Hohlfeld, S. Lipscomb, N. Malanowski, and A. Zweck Technological Analysis, Industrial Application Of Nanomaterials - Chances and Risks 2004 Future Technologies Division Düsseldorf
16. N.R. Mathias, J. Timoszyk, P.I. Stetsko, J.R. Megill, R.L. Smith, and D.A. Wall Permeability characteristics of Calu-3 human bronchial epithelial cells: in vitro-in vivo correlation to predict lung absorption in rats J. Drug Target. 10 2002 31 40
17. A. Nemmar, P.H. Hoet, B. Vanquickenborne, D. Dinsdale, M. Thomeer, M.F. Hoylaerts, H. Vanbilloen, L. Mortelmans, and B. Nemery Passage of inhaled particles into the blood circulation in humans Circulation 105 2002 411 414
18. A. Nemmar, M.F. Hoylaerts, P.H. Hoet, D. Dinsdale, T. Smith, H. Xu, J. Vermylen, and B. Nemery Ultrafine particles affect experimental thrombosis in an in vivo hamster model Am. J. Respir. Crit. Care. Med. 166 2002 998 1004
19. A. Nemmar, M.F. Hoylaerts, P.H. Hoet, and B. Nemery Possible mechanisms of the cardiovascular effects of inhaled particles: systemic translocation and prothrombotic effects Toxicol. Lett. 149 2004 243 253
20. A. Nemmar, M.F. Hoylaerts, P.H. Hoet, J. Vermylen, and B. Nemery Size effect of intratracheally instilled particles on pulmonary inflammation and vascular thrombosis Toxicol. Appl. Pharmacol. 186 2003 38 45
21. A. Nemmar, H. Vanbilloen, M.F. Hoylaerts, P.H. Hoet, A. Verbruggen, and B. Nemery Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster Am. J. Respir. Crit. Care Med. 164 2001 1665 1668
22. G. Oberdörster Pulmonary effects of inhaled ultrafine particles Int. Arch. Occup. Environ. Health 74 2001 1 8
23. G. Oberdörster, Z. Sharp, V. Atudorei, A. Elder, R. Gelein, W. Kreyling, and C. Cox Translocation of inhaled ultrafine particles to the brain Inhal. Toxicol. 16 2004 437 445
24. G. Oberdörster, Z. Sharp, V. Atudorei, A. Elder, R. Gelein, A. Lunts, W. Kreyling, and C. Cox Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats J. Toxicol. Environ. Health 65 2002 1531 1543
25. K. Sugahara, G.R. Freidenberg, and R.J. Mason Insulin binding and effects on glucose and transepithelial transport by alveolar type II cells Am. J. Physiol. 247 1984 C472 C477
26. E. Van Craenenbroeck, J. Vercammen, G. Matthys, J. Beirlant, C. Marot, J. Hoebeke, R. Strobbe, and Y. Engelborghs Heuristic statistical analysis of fluorescence fluctuation data with bright spikes: application to ligand binding to the human serotonin receptor expressed in Escherichia coli cells Biol. Chem. 382 2001 355 361
27. H.L. Winton, H. Wan, M.B. Cannell, D.C. Gruenert, P.J. Thompson, D.R. Garrod, G.A. Stewart, and C. Robinson Cell lines of pulmonary and non-pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability Clin. Exp. Allergy 28 1998 1273 1285