N-Acetylcysteine and ebselen but not nifedipine protected cerebellar granule neurons against 4-hydroxynonenal-induced neuronal death

Neuroscience Research

Volumn 57, Issue 2, 2007, Pages 220-229

  Arakawa, Motoki ^a   Ishimura, Atsushi ^a   Arai, Yoko ^a   Kawabe, Keiko ^a   Suzuki, Shoko ^a   Ishige, Kumiko ^a   Ito, Yoshihisa ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

4 Hydroxynonenal; Calcium; Cerebellar granule neurons; Ebselen; Glutathione; Mitochondria; N Acetylcysteine; Neuronal death; Nifedipine

Indexed keywords

4 HYDROXYNONENAL; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ACETYLCYSTEINE; CALCIUM ION; DIZOCILPINE; EBSELEN; EGTAZIC ACID; NIFEDIPINE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; GRANULE CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; RAT;

ACETYLCYSTEINE; ALDEHYDES; ANIMALS; ANIMALS, NEWBORN; AZOLES; CALCIUM; CELL DEATH; CELLS, CULTURED; CEREBELLUM; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GLUTATHIONE; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEURONS; NEUROPROTECTIVE AGENTS; NIFEDIPINE; ORGANOSELENIUM COMPOUNDS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 33846565859     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2006.10.011     Document Type: Article

References (41)

1. 2+ channel activation in the rat dentate gyrus in vitro. Neurosci. Lett. 370 (2004) 155-159
2. 2+ current by 4-hydroxynonenal in dentate granule cells. Biol. Pharm. Bull. 27 (2004) 174-179
3. Arakawa M., Ushimaru N., Osada N., Oda T., Ishige K., and Ito Y. N-Acetylcysteine selectively protects cerebellar granule cells from 4-hydroxynonenal-induced cell death. Neurosci. Res. 55 (2006) 255-263
4. Awasthi Y.C., Sharma R., Cheng J.Z., Yang Y., Sharma A., Singhal S.S., and Awasthi S. Role of 4-hydroxynonenal in stress-mediated apoptosis signaling. Mol. Aspects Med. 24 (2003) 219-230
5. Bhagwat S.V., Vijayasarathy C., Raza H., Mullick J., and Avadhani N.G. Preferential effects of nicotine and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-1-butanone on mitochondrial glutathione S-transferase A4-4 induction and increased oxidative stress in the rat brain. Biochem. Pharmacol. 56 (1998) 831-839
6. q/11. J. Neurochem. 69 (1997) 570-580
7. 2+ influx in isolated rat hepatocytes. Biochem. Biophys. Res. Commun. 218 (1996) 772-776
8. Cotgreave I.A., Sandy M.S., Berggren M., Moldéus P.W., and Smith M.T. N-Acetylcysteine and glutathione-dependent protective effect of PZ51 (Ebselen) against diquat-induced cytotoxicity in isolated hepatocytes. Biochem. Pharmacol. 36 (1987) 2899-2904
9. Ferrari G., Yan C.Y., and Greene L.A. N-Acetylcysteine (d- and l-stereoisomers) prevents apoptotic death of neuronal cells. J. Neurosci. 15 (1995) 2857-2866
10. Ito Y., Arakawa M., Ishige K., and Fukuda H. Comparative study of survival signal withdrawal- and 4-hydroxynonenal-induced cell death in cerebellar granule cells. Neurosci. Res. 35 (1999) 321-327
11. B receptor in cultured cerebellar granule cells. J. Neurochem. 65 (1995) 75-83
12. Jesberger J.A., and Richardson J.S. Oxygen free radicals and brain dysfunction. Int. J. Neurosci. 57 (1991) 1-17
13. Keller J.N., Mark R.J., Bruce A.J., Blanc E., Rothstein J.D., Uchida K., Waeg G., and Mattson M.P. 4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes. Neuroscience 80 (1997) 685-696
14. Keller J.N., and Mattson M.P. Roles of lipid peroxidation in modulation of cellular signaling pathways, cell dysfunction, and death in the nervous system. Rev. Neurosci. 9 (1998) 105-116
15. Keller J.N., Pang Z., Geddes J.W., Begley J.G., Germeyer A., Waeg G., and Mattson M.P. Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid β-peptide: role of the lipid peroxidation product 4-hydroxynonenal. J. Neurochem. 69 (1997) 273-284
16. Kosuge Y., Koen Y., Ishige K., Minami K., Urasawa H., Saito H., and Ito Y. S-Allyl-l-cysteine selectively protects cultured rat hippocampal neurons from amyloid β-protein- and tunicamycin-induced neuronal death. Neuroscience 122 (2003) 885-895
17. Kruman I., Bruce-Keller A.J., Bredesen D., Waeg G., and Mattson M.P. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis. J. Neurosci. 17 (1997) 5089-5100
18. Long H., Han H., Yang B., and Wang Z. Opposite cell density-dependence between spontaneous and oxidative stress-induced apoptosis in mouse fibroblast L-cells. Cell. Physiol. Biochem. 13 (2003) 401-414
19. Maiorino M., Roveri A., Coassin M., and Ursini F. Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51). Biochem. Pharmacol. 37 (1988) 2267-2271
20. Mark R.J., Lovell M.A., Markesbery W.R., Uchida K., and Mattson M.P. A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid β-peptide. J. Neurochem. 68 (1997) 255-264
21. Meister A. Glutathione metabolism and its selective modification. J. Biol. Chem. 263 (1988) 17205-17208
22. + availability. Chem. Res. Toxicol. 17 (2004) 1272-1279
23. Müller A., Cadenas E., Graf P., and Sies H. A novel biologically active seleno-organic compound-I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen). Biochem. Pharmacol. 33 (1984) 3235-3239
24. Mundy W.R., and Freudenrich T.M. Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium. Neurotoxicology 21 (2000) 1135-1144
25. Murphy T.C., Amarnath V., Gibson K.M., and Picklo M.J. Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A). J. Neurochem. 86 (2003) 298-305
26. Murphy T.C., Amarnath V., and Picklo M.J. Mitochondrial oxidation of 4-hydroxy-2-nonenal in rat cerebral cortex. J. Neurochem. 84 (2003) 1313-1321
27. α-acetyl-l-cysteine but not aminoguanidine act as neuroprotectants from the lipid peroxidation product 4-hydroxy-2-nonenal. Free Radic. Biol. Med. 29 (2000) 1028-1036
28. Orrenius S., and Moldeus P. The multiple roles of glutathione in drug metabolism. Trends Pharmacol. Sci. 5 (1984) 432-435
29. Picklo M.J., Amarnath V., McIntyre J.O., Graham D.G., and Montine T.J. 4-Hydroxy-2(E)-nonenal inhibits CNS mitochondrial respiration at multiple sites. J. Neurochem. 72 (1999) 1617-1624
30. Raha S., and Robinson B.H. Mitochondria, oxygen free radicals, disease and ageing. Trends Biochem. Sci. 25 (2000) 502-508
31. Rappeneau S., Baeza-Squiban A., Jeulin C., and Marano F. Protection from cytotoxic effects induced by the nitrogen mustard mechlorethamine on human bronchial epithelial cells in vitro. Toxicol. Sci. 54 (2000) 212-221
32. Romancino D.P., Montana G., and Di Carlo M. Maternal Paracentrotus lividus RNAs are differentially localized during the first cell division. Arch. Biochem. Biophys. 429 (2004) 164-170
33. Sies H. Ebselen: a glutathione peroxidase mimic. Meth. Enzymol. 234 (1994) 476-482
34. Simonian N.A., and Coyle J.T. Oxidative stress in neurodegenerative diseases. Annu. Rev. Pharmacol. Toxicol. 36 (1996) 83-106
35. Thangnipon W., Kingsbury A., Webb M., and Balazs R. Observations on rat cerebellar cells in vitro: influence of substratum, potassium concentration and relationship between neurones and astrocytes. Brain Res. 313 (1983) 177-189
36. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal. Biochem. 27 (1969) 502-522
37. Wendel A., Fausel M., Safayhi H., Tiegs G., and Otter R. A novel biologically active seleno-organic compound-II. Activity of PZ 51 in relation to glutathione peroxidase. Biochem. Pharmacol. 33 (1984) 3241-3245
38. Xie C., Lovell M.A., and Markesbery W.R. Glutathione transferase protects neuronal cultures against four hydroxynonenal toxicity. Free Radic. Biol. Med. 25 (1998) 979-988
39. Yamashita T., Ando Y., Obayashi K., Terazaki H., Sakashita N., Uchida K., Ohama E., Ando M., and Uchino M. Oxidative injury is present in Purkinje cells in patients with olivopontocerebellar atrophy. J. Neurol. Sci. 175 (2000) 107-110
40. Yan C.Y., Ferrari G., and Greene L.A. N-Acetylcysteine-promoted survival of PC12 cells is glutathione-independent but transcription-dependent. J. Biol. Chem. 270 (1995) 26827-26832
41. Zhao R., and Holmgren A. A novel antioxidant mechanism of ebselen involving ebselen diselenide, a substrate of mammalian thioredoxin and thioredoxin reductase. J. Biol. Chem. 277 (2002) 39456-39462