메뉴 건너뛰기




Volumn 54, Issue 1, 2000, Pages 212-221

Protection from cytotoxic effects induced by the nitrogen mustard mechlorethamine on human bronchial epithelial cells in vitro

Author keywords

Interaction; Mechlorethamine; Oxidative stress; PARP; Protection; Respiratory epithelium

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; 3 AMINOBENZAMIDE; ACETYLCYSTEINE; CHLORMETHINE DERIVATIVE; MUSTARD GAS DERIVATIVE; NICOTINAMIDE; PROPIDIUM IODIDE; THIOL DERIVATIVE;

EID: 0034064339     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/54.1.212     Document Type: Article
Times cited : (33)

References (32)
  • 1
    • 0024422398 scopus 로고
    • Nucleophilic selectivity as a determinant of carcinogenic potency (TD 50) in rodents: A comparison of mono- and bi-functional alkylating agents and vinyl chloride metabolites
    • Barbin, A., and Bartsch, H. (1989). Nucleophilic selectivity as a determinant of carcinogenic potency (TD 50) in rodents: A comparison of mono-and bi-functional alkylating agents and vinyl chloride metabolites. Mutat. Res. 215, 95-106.
    • (1989) Mutat. Res. , vol.215 , pp. 95-106
    • Barbin, A.1    Bartsch, H.2
  • 2
    • 0032802391 scopus 로고    scopus 로고
    • Comparative toxicity of sulfur mustard and nitrogen mustard on tracheal epithelial cells in primary culture
    • in press
    • Calvet, J. H., Feuermann, M., Llorente, B., Loison, F., Harf, A., and Marano, F. (1999). Comparative toxicity of sulfur mustard and nitrogen mustard on tracheal epithelial cells in primary culture. Tox. in Vitro (in press).
    • (1999) Tox. in Vitro
    • Calvet, J.H.1    Feuermann, M.2    Llorente, B.3    Loison, F.4    Harf, A.5    Marano, F.6
  • 3
    • 0026098776 scopus 로고
    • Inhibition of iodoacetamide and t-butylhydroperoxide toxicity in LLC-PK1 cells by antioxidants: A role for lipid peroxidation in alkylation-induced cytotoxicity
    • Chen. Q., and Stevens, J. L. (1991). Inhibition of iodoacetamide and t-butylhydroperoxide toxicity in LLC-PK1 cells by antioxidants: A role for lipid peroxidation in alkylation-induced cytotoxicity. Arch. Biochem. Biophys. 284, 422-430.
    • (1991) Arch. Biochem. Biophys. , vol.284 , pp. 422-430
    • Chen, Q.1    Stevens, J.L.2
  • 4
    • 0002385099 scopus 로고
    • The alkylating agents
    • B. Chabner, Ed. W.B. Saunders, Philadelphia
    • Colvin, M. (1982). The alkylating agents. In Pharmacological Principles of Cancer Treatment (B. Chabner, Ed.), pp. 276-308. W.B. Saunders, Philadelphia.
    • (1982) Pharmacological Principles of Cancer Treatment , pp. 276-308
    • Colvin, M.1
  • 6
    • 0029931420 scopus 로고    scopus 로고
    • Toxicology and pharmacology of the chemical warfare agent sulfur mustard
    • Dacre, J. C., and Goldman, M. (1996). Toxicology and pharmacology of the chemical warfare agent sulfur mustard. Pharmacol. Rev. 48, 289-326.
    • (1996) Pharmacol. Rev. , vol.48 , pp. 289-326
    • Dacre, J.C.1    Goldman, M.2
  • 7
    • 0025786068 scopus 로고
    • Clinical and morphological findings on mustard gas [Bis(2-chloroethyl)sulfide] poisoning
    • Eisenmenger, W., Drasch, G., von Clarmann, M., Kretschmer, E., and Roider, G. (1991). Clinical and morphological findings on mustard gas [Bis(2-chloroethyl)sulfide] poisoning. J. Forensic Sci. 36, 1688-1698.
    • (1991) J. Forensic Sci. , vol.36 , pp. 1688-1698
    • Eisenmenger, W.1    Drasch, G.2    Von Clarmann, M.3    Kretschmer, E.4    Roider, G.5
  • 8
    • 0030944337 scopus 로고    scopus 로고
    • Amifostine for protection from antineoplastic drug cytotoxicity
    • Foster-Nora, J. A., and Siden, R. (1997). Amifostine for protection from antineoplastic drug cytotoxicity. Am. J. Health. Sys. Pharm. 54, 787-800.
    • (1997) Am. J. Health. Sys. Pharm. , vol.54 , pp. 787-800
    • Foster-Nora, J.A.1    Siden, R.2
  • 9
    • 0025249903 scopus 로고
    • NMR studies of the conjugation of mechlorethamine with glutathione
    • Gamcsik, M. P., Hamill, T. G., and Colvin, M. (1990). NMR studies of the conjugation of mechlorethamine with glutathione. J. Med. Chem. 33, 1009-1014.
    • (1990) J. Med. Chem. , vol.33 , pp. 1009-1014
    • Gamcsik, M.P.1    Hamill, T.G.2    Colvin, M.3
  • 10
    • 0026555839 scopus 로고
    • Action of bis(betachloroethyl)sulphide (BCES) on human epidermis reconstituted in culture: Morphological alterations and biochemical depletion of glutathione
    • Gentilhomme, E., Neveux, Y., Hua, A., Thiriot, C., Faure, M., and Thivolet, J. (1992). Action of bis(betachloroethyl)sulphide (BCES) on human epidermis reconstituted in culture: morphological alterations and biochemical depletion of glutathione. Toxicol. In Vitro 6, 139-147.
    • (1992) Toxicol. In Vitro , vol.6 , pp. 139-147
    • Gentilhomme, E.1    Neveux, Y.2    Hua, A.3    Thiriot, C.4    Faure, M.5    Thivolet, J.6
  • 11
    • 0030807786 scopus 로고    scopus 로고
    • Early cytotoxic effects of mechlorethamine, a nitrogen mustard, on mammalian airway epithelium
    • Giuliani, I., Baeza-Squiban, A., and Marano, F. (1997). Early cytotoxic effects of mechlorethamine, a nitrogen mustard, on mammalian airway epithelium. Toxicology in Vitro 11, 695-702.
    • (1997) Toxicology in Vitro , vol.11 , pp. 695-702
    • Giuliani, I.1    Baeza-Squiban, A.2    Marano, F.3
  • 12
    • 0029080684 scopus 로고
    • The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy
    • Griffin, R. J., Curtin, N. J., Newell, D. R., Golding, B. T., Durkarcz, B. W., and Calvert, A. H. (1995). The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy. Biochimie 77, 408-422.
    • (1995) Biochimie , vol.77 , pp. 408-422
    • Griffin, R.J.1    Curtin, N.J.2    Newell, D.R.3    Golding, B.T.4    Durkarcz, B.W.5    Calvert, A.H.6
  • 13
    • 0031846810 scopus 로고    scopus 로고
    • Reducing the toxicity of anticancer therapy: New strategies
    • Griggs, J. J. (1998). Reducing the toxicity of anticancer therapy: new strategies. Leuk. Res. 1001, S27-S33.
    • (1998) Leuk. Res. , vol.1001
    • Griggs, J.J.1
  • 14
    • 0030904340 scopus 로고    scopus 로고
    • L-oxothiazolidine 4-carboxylate pretreatment of isolated human peripheral blood lymphocytes reduces sulfur mustard cytotoxicity
    • Gross, C. L., Giles, K. C., and Smith, W. J. (1997). L-oxothiazolidine 4-carboxylate pretreatment of isolated human peripheral blood lymphocytes reduces sulfur mustard cytotoxicity. Cell Biol. Toxicol. 13, 167-173.
    • (1997) Cell Biol. Toxicol. , vol.13 , pp. 167-173
    • Gross, C.L.1    Giles, K.C.2    Smith, W.J.3
  • 15
    • 0027420576 scopus 로고
    • Biochemical manipulation of intracellular glutathione levels influences cytotoxicity to isolated human lymphocytes by sulfur mustard
    • Gross, C. L., Innace, J. K., Hovatter, R. C., Meier H. L., and Smith, W. J. (1993). Biochemical manipulation of intracellular glutathione levels influences cytotoxicity to isolated human lymphocytes by sulfur mustard. Cell Biol. Toxicol. 9, 259-268.
    • (1993) Cell Biol. Toxicol. , vol.9 , pp. 259-268
    • Gross, C.L.1    Innace, J.K.2    Hovatter, R.C.3    Meier, H.L.4    Smith, W.J.5
  • 16
    • 0026532439 scopus 로고
    • Hepatocyte toxicity of mechlorethamine and other alkylating anticancer drugs
    • Khan, S., Ramwani, J. J., and O' Brien, P. J. (1992). Hepatocyte toxicity of mechlorethamine and other alkylating anticancer drugs. Biochem. Pharmacol. 43, 1963-1967.
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 1963-1967
    • Khan, S.1    Ramwani, J.J.2    O' Brien, P.J.3
  • 17
    • 0031046452 scopus 로고    scopus 로고
    • Protection of A549 cells against the toxic effects of sulfur mustard by hexamethylenetetramine
    • Lindsay, C. D., and Hambrook, J. L. (1997). Protection of A549 cells against the toxic effects of sulfur mustard by hexamethylenetetramine. Hum. Exp. Toxicol. 16, 106-114.
    • (1997) Hum. Exp. Toxicol. , vol.16 , pp. 106-114
    • Lindsay, C.D.1    Hambrook, J.L.2
  • 18
    • 0030730317 scopus 로고    scopus 로고
    • Monoisopropylglutathione ester protects A549 cells from the cytotoxic effects of sulfur mustard
    • Lindsay, C. D., Hambrook, J. L., and Lailey, A. F. (1997). Monoisopropylglutathione ester protects A549 cells from the cytotoxic effects of sulfur mustard. Hum. Exp. Toxicol. 16, 636-644.
    • (1997) Hum. Exp. Toxicol. , vol.16 , pp. 636-644
    • Lindsay, C.D.1    Hambrook, J.L.2    Lailey, A.F.3
  • 19
    • 0029866602 scopus 로고    scopus 로고
    • Activation of heat-shock factor by alkylating agents is triggered by glutathione depletion and oxidation of protein thiols
    • Liu, H., Lightfoot, R., and Stevens, J. L. (1996). Activation of heat-shock factor by alkylating agents is triggered by glutathione depletion and oxidation of protein thiols. J. Biol. Chem. 271, 4805-4812.
    • (1996) J. Biol. Chem. , vol.271 , pp. 4805-4812
    • Liu, H.1    Lightfoot, R.2    Stevens, J.L.3
  • 20
    • 0029904254 scopus 로고    scopus 로고
    • The time-dependent effect of 2,2′-dichlorodiethyl sulfide (sulfur mustard, HD, 1.1′-thiobis [2-chloroethane]) on the lymphocyte viability and the kinetics of protection by poly(ADP-ribose)polymerase inhibitors
    • Meier, H. L. (1996). The time-dependent effect of 2,2′-dichlorodiethyl sulfide (sulfur mustard, HD, 1.1′-thiobis [2-chloroethane]) on the lymphocyte viability and the kinetics of protection by poly(ADP-ribose)polymerase inhibitors. Cell. Biol. Toxicol. 12, 147-153.
    • (1996) Cell. Biol. Toxicol. , vol.12 , pp. 147-153
    • Meier, H.L.1
  • 22
    • 0026766122 scopus 로고
    • The determination and prevention of cytotoxic effects induced in human lymphocytes by the alkylating agent 2,2′-dichlorodiethyl sulfide (sulfur mustard, HD)
    • Meier, H. L, and Johnson, J. B. (1992). The determination and prevention of cytotoxic effects induced in human lymphocytes by the alkylating agent 2,2′-dichlorodiethyl sulfide (sulfur mustard, HD). Toxicol. Appl. Pharm. 113, 234-239.
    • (1992) Toxicol. Appl. Pharm. , vol.113 , pp. 234-239
    • Meier, H.L.1    Johnson, J.B.2
  • 23
    • 0028273316 scopus 로고
    • Glutathione, ascorbate, and cellular protection
    • Meister, A. (1994). Glutathione, ascorbate, and cellular protection. Cancer Res. 54, 1969-1975s.
    • (1994) Cancer Res. , vol.54
    • Meister, A.1
  • 24
    • 0024524043 scopus 로고
    • NAD+ levels and glucose uptake of cultured human epidermal cells exposed to sulfur mustard
    • Mol, M. A. E., Van de Ruit, A.-M. B. C., and Kluivers, A. W. (1989). NAD+ levels and glucose uptake of cultured human epidermal cells exposed to sulfur mustard. Toxicol. Appl. Pharmacol. 98, 159-165.
    • (1989) Toxicol. Appl. Pharmacol. , vol.98 , pp. 159-165
    • Mol, M.A.E.1    Van De Ruit, A.-M.B.C.2    Kluivers, A.W.3
  • 25
    • 0028956461 scopus 로고
    • Silybum marianum (Carduus marianus)
    • Morazzoni, P., and Bombardelli, E. (1995). Silybum marianum (Carduus marianus). Fitoterapia 66, 3-39.
    • (1995) Fitoterapia , vol.66 , pp. 3-39
    • Morazzoni, P.1    Bombardelli, E.2
  • 26
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 27
    • 0024503002 scopus 로고
    • Cytotoxicity of an organic hydroperoxide and cellular antioxidant defense system against hydroperoxides in cultured mammalian cells
    • Ochi, T., and Miyaura, S. (1989). Cytotoxicity of an organic hydroperoxide and cellular antioxidant defense system against hydroperoxides in cultured mammalian cells. Toxicology 55, 69-82.
    • (1989) Toxicology , vol.55 , pp. 69-82
    • Ochi, T.1    Miyaura, S.2
  • 29
    • 0032875976 scopus 로고    scopus 로고
    • Use of fluorescent probes to assess the early sulfhydryl depletion and oxidative stress induced by mechlorethamine on airway epithelium
    • Rappeneau, S., Baeza-Squiban, A., Braut-Boucher, F., Aubery, M., Gendron, M. C., and Marano, F. (1999). Use of fluorescent probes to assess the early sulfhydryl depletion and oxidative stress induced by mechlorethamine on airway epithelium. Toxicology In vitro 13, 765-771.
    • (1999) Toxicology in Vitro , vol.13 , pp. 765-771
    • Rappeneau, S.1    Baeza-Squiban, A.2    Braut-Boucher, F.3    Aubery, M.4    Gendron, M.C.5    Marano, F.6
  • 31
    • 0026076851 scopus 로고
    • Protective effect of O-phenanthroline against mechlorethamine toxicity in the rat liver-slice system and in the guinea pig skin
    • Wormser, U., and Nyska, A. (1991). Protective effect of O-phenanthroline against mechlorethamine toxicity in the rat liver-slice system and in the guinea pig skin. Arch. Toxicol. 65, 666-670.
    • (1991) Arch. Toxicol. , vol.65 , pp. 666-670
    • Wormser, U.1    Nyska, A.2
  • 32
    • 0018694564 scopus 로고
    • Differential protection of normal and malignant tissues against the cytotoxic effects of mechlorethamine
    • Yudas, J. M. (1979). Differential protection of normal and malignant tissues against the cytotoxic effects of mechlorethamine. Cancer Treat. Rep. 63, 971-976.
    • (1979) Cancer Treat. Rep. , vol.63 , pp. 971-976
    • Yudas, J.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.