Cilostazol, a cAMP phosphodiesterase inhibitor, attenuates the production of monocyte chemoattractant protein-1 in response to tumor necrosis factor-α in vascular endothelial cells

Hormone and Metabolic Research

Volumn 29, Issue 10, 1997, Pages 491-495

  Nishio, I ^a   Kashiwagi, Atsunori ^a   Takahara, N ^a   Hidaka, H ^a   Kikkawa, R ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Cyclic AMP; Endothelial Cells; Monocyte Chemoattractant Protein 1; NF B; Phosphodiesterase Inhibitor

Indexed keywords

CILOSTAZOL; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHODIESTERASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN INDUCTION; PROTEIN SECRETION; VASCULAR ENDOTHELIUM;

EID: 9844267305     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-979086     Document Type: Article

References (32)

1. Gerrity, R. G.: The role of the monocyte in atherogenesis. I. Transition of blood-born monocyte into foam cells in fatty lesions. Am. J. Pathol. 103: 181-190 (1981)
2. Ross, R.: The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 362: 801-809 (1992)
3. Rollins, B. J., T. Yoshimura, E. J. Leonard, J. S. Pober: Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am. J. Pathol. 136: 1229-1233 (1990)
4. Nelken, N. A., S. R. Coughlin, D. Gordon, J. N. Wilcox: Monocyte chemoattractant protein-1 in human atheromatous plaques. J. Clin. Invest. 88: 1121-1127 (1991)
5. Rovin, B. H., T. Yoshimura, L. Tan: Cytokine-induced production of monocyte chemoattractant protein-1 by cultured human mesangial cells. J. Immunol. 148: 2148-2153 (1992)
6. Sica, A. J., M. Wang, F. Colotta, E. Djana, A. Mantovani, J. J. Oppenheim, C. G. Larsen, C. O. C. Zachariae, K. Matsushima: Monocyte chemotactic and activating factor gene expression induced in endothelial cells by 1L-1 and tumor necrosis factor. J. Immunol. 144: 3034-3038 (1990)
7. Satriano, J. A., K. Hora, Z, Shan, E. R. Stanley, T. Mori, D. Scholndorff: Regulation of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor-1 by IFN-γ, tumor necrosis factor-α, IgG aggregates, and cAMP in mouse mesangial cells. J. Immunol. 150: 1971-1978 (1993)
8. Takahara, N., A. Kashiwagi, H. Maegnwa, Y. Shigeta: Lysophosphatidylcholine stimulates the expression and production of MCP-1 by human vascular endothelial cells. Metabolism 45: 559-564 (1996)
9. Sen, R., D. Baltimore: Multiple nuclear factors interact with immunoglobulin enhancer sequences. Cell 46: 705-716 (1986)
10. Shyy, Y.-J., Y.-S. Li, P. E. Kolattukudy: Structure of human monocyte chemotactic protein gene and its regulation by TPA. Biochem. Biophys. Res. Commun. 169: 346-351 (1990)
11. Ueda, A., K. Okuda, S. Ohno, A. Shirai, T. Igarashi, K. Matsunaga, J. Fukushima, S. Kawamoto, Y. Ishigatsubo, T. Okubo: NF-κB and SP- 1 regulate transcription of the human monocyte chemoattractant protein-1 gene. J. Immunol. 153: 2052-2063 (1994)
12. Satriano, J., D. Schlondorff: Activation and attenuation of transcription factor NF-κB in mouse glomerular mesangial cells in response to tumor necrosis factor-α, immunoglobulin G, and adenosine 3′:5′-cyclic monophosphate. J. Clin. Invest. 94: 1629-1636 (1994)
13. Lugnier, C., V. B. Schini: Characterization of cyclic nucleotide phosphodiesterase from cultured bovine aortic endothelial cells. Biochim. Pharmacol. 39: 75-84 (1990)
14. Souness, J. E., B. K. Diocee, W. Maartin, S. A. Moodie: Pig aortic endothelial-cell cyclic nucleotide phosphodiesterase. Biochem. J. 266: 127-132 (1990)
15. Jaffe, E. A., R. L. Nachman, C. G. Becker, C. R. Minick: Culture of human endothelial cells derived from umbilical veins; identification by morphologic and immunologic criteria. J. Clin. Invest. 52: 2745-2756 (1973)
16. 2 in human umbilical vein endothelial cells cultured in high glucose medium. Diabetologia 37: 300-307 (1994)
17. Chomczynski, P., N. Sacchi: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159 (1987)
18. Osborn, L., S. Kunkel, G. J. Nabel: Tumor necrosis factor α and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor κB. Proc. Natl. Acad. Sci. USA 86: 2336-2340 (1989)
19. Beavo, J. A.: Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms. Physiol Rev 75: 725-748 (1995)
20. Ysunaga, K., K. Mase: Clinical effects of oral cilostazol on suppression of platelet function in patients with cerebrovascular disease. Arzneimittelforschung 35: 1186-1188 (1985)
21. Suttorp, N., U. Weber, T. Welsch, C. Schudt: Role of phosphodiesterases in the regulation of endothelial permeability in vitro. J. Clin. Invest. 91: 1421-1428 (1993)
22. Barnard J. W., A. F. Seibert, R. Prasad, D. A. Smart, S. J. Strada. A. E. Taylor, W. J. Thompson: Reversal of pulmonary capillary ischemia-reperfusion injury by rolipram, a cAMP phosphodiesterase inhibitor. J. Appl. Physiol. 77: 774-781 (1994)
23. Leonard, E. J., T. Yoshimura: Human monocyte chemoattractant protein-1 (MCP-1). Immunol. Today 12: 97 (1990)
24. Sachs, A. B.: Messenger RNA degradation in eukaryotes. Cell 74: 413-421 (1993)
25. Schreck, R., P. River, P. A. Baeuerle: Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF- κB transcription factor and HIV-1. MBO (Eur. Mol. Biol. Organ) J. 10: 2247-2258 (1991)
26. Toledano, M. B., W. J. Leonard: Modulation of transcription factor NF-κB binding activity by oxidation-reduction in vitro. Proc. Natl. Acad. Sci. USA 88: 4328-4332 (1991)
27. Henkel, T., T. Machleidt, I. Alkalay, Y. Ben-Neirah, M. Kronke, P. A. Baeuerle: Rapid proteolysis of IκB is necessary for activation of transcription factor NF-κB. Nature 365: 82-85 (1993)
28. DeLuca, L. G., D. R. Johnson, M. Z. Whitely, T. Collins, J. S. Pober: cAMP and tumor necrosis factor competitively regulate transcriptional activation through and nuclear factor binding to the cAMP-responsive element/activating transcription factor element of the endothelial leukocyte adhesion molecule-1 (E-selectin) promoter. J. Biol. Chem. 269: 1913-1919 (1994)
29. Koga, S., S. Morris, S. Ogawa, H. Liao, J. P. Bilezikkian, G. Chen, W. J. Thompson, T. Ashikaga, J. Brett, D. M. Stern, D. J. Pinsky: TNF modulates endothelial properties by decreasing cAMP. Am. J. Physiol. 268: C1104-1113 (1995)
30. Brand, K., S. Page, G. Rogler, A. Bartsch, R. Knuechel, M. Page, C. Kaltschmidt, P. A. Baeuerle, D. Neumeier: Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion. J. Clin. Invest. 97: 1715-1722 (1996)
31. Bells, R. E., J. S. Lee, G. E. Sonenshein: Expression of a constitutive NF-κB like activity is essential for proliferation of cultured bovine vascular smooth muscle cells. J. Clin. Invest. 96: 2521-2527 (1995)
32. Takahashi, S., K. Oida, R. Fujiwara, H. Maeda, S. Hayashi, H. Takai, T. Tamai, T. Nakai, S. Miyabo: Effect of cilostazol, a cyclic AMP phosphodiesterase inhibitor, on the proliferation of rat aortic smooth muscle cells in culture. J. Cardiovasc. Pharmacol. 20: 900-906 (1992)