Signaling mechanisms of axon growth inhibition

Drug News and Perspectives

Volumn 19, Issue 9, 2006, Pages 541-547

  Hata, Katsuhiko ^a,b   Kubo, Takekazu ^a   Yamaguchi, Atsushi ^a   Yamashita, Toshihide ^a,b  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOJUVELIN; MYELIN; MYELIN ASSOCIATED GLYCOPROTEIN; PROTEIN NOGO; PROTEOCHONDROITIN SULFATE; RHO FACTOR; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

BRAIN INJURY; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASE; GROWTH INHIBITION; HUMAN; IN VIVO STUDY; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; AXONS; CENTRAL NERVOUS SYSTEM; HUMANS; NERVE REGENERATION; NERVE TISSUE PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 33846531670     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2006.19.9.1050423     Document Type: Review

References (72)

1. McDonald, J.W. and Sadowsky, C. Spinal-cord injury. Lancet 2002, 359: 417-25.
2. David, S. and Aguayo, A.J. Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats. Science 1981, 214: 931-3.
3. Richardson, P.M., McGuinness, U.M. and Aguayo, A.J. Axons from CNS neurons regenerate into PNS grafts. Nature 1980, 284: 264-5.
4. Bixby, J.L. and Harris, W.A. Molecular mechanisms of axon growth and guidance. Annu Rev Cell Biol 1991, 7: 117-59.
5. Schwab, M.E. and Thoenen, H. Dissociated neurons regenerate into sciatic but not optic nerve explants in culture irrespective of neurotrophic factors. J Neurosci 1985, 5: 2415-23.
6. Bandtlow, C., Zachleder, T. and Schwab, M.E. Oligodendrocytes arrest neurite growth by contact inhibition. J Neurosci 1990, 10: 3837-48.
7. Caroni, P. and Schwab, M.E. Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading. J Cell Biol 1988, 106: 1281-8.
8. Chen, M.S., Huber, A.B., van der Haar, M.E. et al. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 2000, 403: 434-9.
9. GrandPre, T., Nakamura, F., Vartanian, T. and Strittmatter, S.M. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 2000, 403: 439-44.
10. Prinjha, R., Moore, S.E., Vinson, M. et al. Inhibitor of neurite outgrowth in humans. Nature 2000, 403: 383-4.
11. Caroni, P. and Schwab, M.E. Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter. Neuron 1988, 1: 85-96.
12. Carenini, S., Montag, D., Cremer, H., Schachner, M. and Martini, R. Absence of the myelin-associated glycoprotein (MAG) and the neural cell adhesion molecule (N-CAM) interferes with the maintenance, but not with the formation of peripheral myelin. Cell Tissue Res 1997, 287: 3-9.
13. Fruttiger, M., Montag, D., Schachner, M. and Martini, R. Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity. Eur J Neurosci 1995, 7: 511-5.
14. Fujita, N., Kemper, A., Dupree, J. et al. The cytoplasmic domain of the large myelin-associated glycoprotein isoform is needed for proper CNS but not peripheral nervous system myelination. J Neurosci 1998, 18: 1970-8.
15. Marcus, J., Dupree, J.L. and Popko, B. Myelin-associated glycoprotein and myelin galactolipids stabilize developing axo-glial interactions. J Cell Biol 2002, 156: 567-77.
16. Mukhopadhyay, G., Doherty, P., Walsh, F.S., Crocker, P.R. and Filbin, M.T. A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 1994, 13: 757-67.
17. McKerracher, L., David, S., Jackson, D.L., Kottis, V., Dunn, R.J. and Braun, P.E. Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth. Neuron 1994, 13: 805-11.
18. Tang, S., Woodhall, R.W., Shen, Y.J. et al. Soluble myelin-associated glycoprotein (MAG) found in vivo inhibits axonal regeneration. Mol Cell Neurosci 1997, 9: 333-46.
19. Tang, S., Qiu, J., Nikulina, E. and Filbin, M.T. Soluble myelin-associated glycoprotein released from damaged white matter inhibits axonal regeneration. Mol Cell Neurosci 2001, 18: 259-69.
20. Mikol, D.D. and Stefansson, K. A phosphatidylinositol-linked peanut agglutinin-binding glycoprotein in central nervous system myelin and on oligodendrocytes. J Cell Biol 1988, 106: 1273-9.
21. Habib, A.A., Marton, L.S., Allwardt, B. et al. Expression of the oligodendrocyte-myelin glycoprotein by neurons in the mouse central nervous system. J Neurochem 1998,70: 1704-11.
22. Wang, K.C., Koprivica, V., Kim, J.A. et al. Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 2002, 417: 941-4.
23. Kottis, V., Thibault, P., Mikol, D. et al. Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth. J Neurochem 2002, 82: 1566-9.
24. Rhodes, K.E. and Fawcett, J.W. Chondroitin sulphate proteoglycans: preventing plasticity or protecting the CNS? J Anat 2004, 204: 33-48.
25. Niederost, B.P., Zimmermann, D.R., Schwab, M.E. and Bandtlow, C.E. Bovine CNS myelin contains neurite growth-inhibitory activity associated with chondroitin sulfate proteoglycans. J Neurosci 1999, 19: 8979-89.
26. Asher, R.A., Morgenstern, D.A., Fidler, P.S. et al. Neurocan is upregulated in injured brain and in cytokine-treated astrocytes. J Neurosci 2000, 20: 2427-38.
27. McKeon, R.J., Jurynec, M.J. and Buck, C.R. The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar. J Neurosci 1999, 19: 10778-88.
28. Snow, D.M., Lemmon, V., Carrino, D.A., Caplan, A.I. and Silver, J. Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro. Exp Neurol 1990, 109: 111-30.
29. Bradbury, E.J., Moon, L.D., Popat, R.J. et al. Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 2002, 416: 636-40.
30. Fournier, A.E., GrandPre, T. and Strittmatter, S.M. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 2001, 409: 341-6.
31. Josephson, A., Trifunovski, A., Widmer, H.R., Widenfalk, J., Olson, L. and Spenger, C. Nogo-receptor gene activity: cellular localization and developmental regulation of mRNA in mice and humans. J Comp Neurol 2002, 453: 292-304.
32. Wang, X., Chun, S.J., Treloar, H., Vartanian, T., Greer, C.A. and Strittmatter, S.M. Localization of Nogo-A and Nogo-66 receptor proteins at sites of axon-myelin and synoptic contact. J Neurosci 2002, 22: 5505-15.
33. Liu, B.P., Fournier, A., GrandPre, T. and Strittmatter, S.M. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 2002, 297: 1190-3.
34. Domeniconi, M., Cao, Z., Spencer, T. et al. Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron 2002, 35: 283-90.
35. Yamashita, T., Higuchi, H. and Tohyama, M. The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. J Cell Biol 2002, 157: 565-70.
36. Wang, K.C., Kim, J.A., Sivasankaran, R., Segal, R. and He, Z. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature 2002, 420: 74-8.
37. Wong, S.T., Henley, J.R., Kanning, K.C., Huang, K.H., Bothwell, M. and Poo, M.M. A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nat Neurosci 2002, 5: 1302-8.
38. Mi, S., Lee, X., Shao, Z. et al. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Nat Neurosci 2004, 7: 221-8.
39. Park, J.B., Yiu, G. Kaneko, S. et al. A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. Neuron 2005, 45: 345-51.
40. Shao, Z., Browning, J.L., Lee, X. et al. TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. Neuron 2005, 45: 353-9.
41. Lehmann, M., Fournier, A., Selles-Navarro, I. et al. Inactivation of Rho signaling pathway promotes CNS axon regeneration. J Neurosci 1999, 19: 7537-47.
42. Yamashita, T. and Tohyama, M. The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat Neurosci 2003, 6: 461-7.
43. Domeniconi, M., Zampieri, N., Spencer, T. et al. MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron 2005, 46: 849-55.
44. Monnier, P.P., Sierra, A., Schwab, J.M., Henke-Fahle, S. and Mueller, B.K. The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar. Mol Cell Neurosci 2003, 22: 319-30.
45. Borisoff, J.F., Chan, C.C., Hiebert, G.W. et al. Suppression of Rho-kinase activity promotes axonal growth on inhibitory CNS substrates. Mol Cell Neurosci 2003, 22: 405-16.
46. Bregman, B.S., Kunkel-Bagden, E., Schnell, L., Dai, H.N., Gao, D. and Schwab, M.E. Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. Nature 1995, 378: 498-501.
47. GrandPre, T., Li, S. and Strittmatter, S.M. Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature 2002, 417: 547-51.
48. Li, S. and Strittmatter, S.M. Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord injury. J Neurosci 2003, 23: 4219-27.
49. Li, S., Liu, B.P., Budel, S. et al. Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury. J Neurosci 2004, 24: 10511-20.
50. Mueller, B.K., Mack, H. and Teusch, N. Rho kinase, a promising drug target for neurological disorders. Nat Rev Drug Discov 2005, 4: 387-98.
51. Grimpe, B. and Silver, J. A novel DNA enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted dorsal root ganglia axons to regenerate beyond lesions in the spinal cord. J Neurosci 2004, 24: 1393-7.
52. Bartsch, U., Bandtlow, C.E., Schnell, L. et al. Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS. Neuron 1995, 15: 1375-81.
53. Li, M., Shibata, A., Li, C. et al. Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse. J Neurosci Res 1996, 46: 404-14.
54. Kim, J.E., Li, S., GrandPre, T., Qiu, D. and Strittmatter, S.M. Axon regeneration in young adult mice lacking Nogo-A/B. Neuron 2003, 38: 187-99.
55. Zheng, B., Ho, C., Li, S., Keirstead, H., Steward, O. and Tessier-Lavigne, M. Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron 2003, 38: 213-24.
56. Simonen, M., Pedersen, V., Weinmann, O. et al. Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron 2003, 38: 201-11.
57. Kim, J.E., Liu, B.P., Park, J.H. and Strittmatter, S.M. Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury. Neuron 2004, 44: 439-51.
58. Zheng, B., Atwal, J., Ho, C. et al. Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A 2005, 102: 1205-10.
59. Song, X.Y., Zhong, J.H., Wang, X. and Zhou, X.F. Suppression of p75NTR does not promote regeneration of injured spinal cord in mice. J Neurosci 2004, 24: 542-6.
60. Monnier, P.P., Sierra, A., Macchi, P. et al. RGM is a repulsive guidance molecule for retinal axons. Nature 2002, 419: 392-5.
61. Muller, B.K., Jay, D.G. and Bonhoeffer, F. Chromophore-assisted laser inactivation of a repulsive axonal guidance molecule. Curr Biol 1996, 6: 1497-502.
62. Stahl, B., Muller, B., von Boxberg, Y., Cox, E.C. and Bonhoeffer, F. Biochemical characterization of a putative axonal guidance molecule of the chick visual system. Neuron 1990, 5: 735-43.
63. Niederkofler, V., Salie, R., Sigrist, M. and Arber, S. Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system. J Neurosci 2004, 24: 808-18.
64. Oldekamp, J., Kramer, N., Alvarez-Bolado, G. and Skutella, T. Expression pattern of the repulsive guidance molecules RGM A, B and C during mouse development. Gene Expr Patterns 2004, 4: 283-8.
65. Schmidtmer, J. and Engelkamp, D. Isolation and expression pattern of three mouse homologues of chick Rgm. Gene Expr Patterns 2004, 4: 105-10.
66. Matsunaga, E., Nakamura, H. and Chedotal, A. Repulsive guidance molecule plays multiple roles in neuronal differentiation and axon guidance. J Neurosci 2006, 26: 6082-8.
67. Rajagopalan, S., Deitinghoff, L., Davis, D. et al. Neogenin mediates the action of repulsive guidance molecule. Nat Cell Biol 2004, 6: 756-62.
68. Matsunaga, E., Tauszig-Delamasure, S., Monnier, P.P. et al. RGM and its receptor neogenin regulate neuronal survival. Nat Cell Biol 2004, 6: 749-55.
69. Schwab, J.M., Conrad, S., Monnier, P.P., Julien, S., Mueller, B.K. and Schluesener, HJ. Spinal cord injury-induced lesional expression of the repulsive guidance male-cute (RGM). Eur J Neurosci 2005, 21: 1569-76.
70. Schwab, J.M., Monnier, P.P., Schluesener, H.J. et al. Central nervous system injury-induced repulsive guidance molecule expression in the adult human brain. Arch Neurol 2005, 62: 1561-8.
71. Manitt, C., Thompson, K.M. and Kennedy, T.E. Developmental shift in expression of netrin receptors in the rat spinal cord: predominance of UNC-5 homologues in adulthood. J Neurosci Res 2004, 77: 690-700.
72. Hata, K., Fujitani, M., Yasuda, Y. et al. RGMa inhibition promotes axonal growth and recovery after spinal cord injury. J Cell Biol 2006, 173: 47-58.