-
1
-
-
27644478722
-
One hundred years of research in the pathogenesis of pulmonary hypertension
-
Zaiman, A., Fijalkowska, I., Hassoun, P.M. and Tuder, R.M. One hundred years of research in the pathogenesis of pulmonary hypertension. Am J Respir Cell Mol Biol 2005, 33: 425-31.
-
(2005)
Am J Respir Cell Mol Biol
, vol.33
, pp. 425-431
-
-
Zaiman, A.1
Fijalkowska, I.2
Hassoun, P.M.3
Tuder, R.M.4
-
2
-
-
28444461454
-
Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension
-
Guilluy, C., Sauzeau, V., Derkinderen, M.R. et al. Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension. Br J Pharmacol 2005, 146: 1010-8.
-
(2005)
Br J Pharmacol
, vol.146
, pp. 1010-1018
-
-
Guilluy, C.1
Sauzeau, V.2
Derkinderen, M.R.3
-
3
-
-
22744455284
-
Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation
-
Hyvelin, J.M., Howell, K., Nichol, A., Costello, C.M., Preston, R.J. and McLoughlin. P. Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation. Circ Res 2005, 97: 185-91.
-
(2005)
Circ Res
, vol.97
, pp. 185-191
-
-
Hyvelin, J.M.1
Howell, K.2
Nichol, A.3
Costello, C.M.4
Preston, R.J.5
McLoughlin, P.6
-
4
-
-
15944403568
-
Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hvpertension
-
Nagaoka, T., Fagan, K.A., Gebb, S.A. et al. Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hvpertension. Am J Respir Crit Care Med 2005, 171: 494-9.
-
(2005)
Am J Respir Crit Care Med
, vol.171
, pp. 494-499
-
-
Nagaoka, T.1
Fagan, K.A.2
Gebb, S.A.3
-
5
-
-
33645816773
-
Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat
-
Nagaoka, T., Gebb, S.A., Karoor, V. et al. Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat. J Appl Physiol 2006, 100: 996-1002.
-
(2006)
J Appl Physiol
, vol.100
, pp. 996-1002
-
-
Nagaoka, T.1
Gebb, S.A.2
Karoor, V.3
-
6
-
-
4544388803
-
Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rhokinase
-
Fagan, K.A., Oka, M., Bauer, N.R. et al. Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rhokinase. Am J Physiol Lung Cell Mol Physiol 2004, 287: L656-64.
-
(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.287
-
-
Fagan, K.A.1
Oka, M.2
Bauer, N.R.3
-
7
-
-
10744222390
-
Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats
-
Abe, K., Shimokawa, H., Morikawa, K. et al. Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res 2004, 94: 385-93.
-
(2004)
Circ Res
, vol.94
, pp. 385-393
-
-
Abe, K.1
Shimokawa, H.2
Morikawa, K.3
-
8
-
-
0025117674
-
Molecular switch for signal transduction: Structural differences between active and inactive forms of protooncogenic ras proteins
-
Milburn, M.V., Tong, L., deVos, A.M. et al. Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science 1990, 247: 939-45.
-
(1990)
Science
, vol.247
, pp. 939-945
-
-
Milburn, M.V.1
Tong, L.2
deVos, A.M.3
-
9
-
-
0028967665
-
Direct involvement of the small GTP-binding protein Rho in lbc oncogene function
-
Zheng, Y., Olson, M.F., Hall, A., Cerione, R.A. and Toksoz, D. Direct involvement of the small GTP-binding protein Rho in lbc oncogene function. J Biol Chem 1995, 270: 9031-4.
-
(1995)
J Biol Chem
, vol.270
, pp. 9031-9034
-
-
Zheng, Y.1
Olson, M.F.2
Hall, A.3
Cerione, R.A.4
Toksoz, D.5
-
10
-
-
0035021049
-
Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)
-
Fauré, J. and Dagher M.C. Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI). Biochimie 2001, 83: 409-14.
-
(2001)
Biochimie
, vol.83
, pp. 409-414
-
-
Fauré, J.1
Dagher, M.C.2
-
11
-
-
0027972582
-
Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases
-
Lancaster, C.A., Taylor-Harris, P.M., Self, A.J., Brill, S., van Erp, H.E. and Hall, A. Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases. J Biol Chem 1994, 269: 1137-42.
-
(1994)
J Biol Chem
, vol.269
, pp. 1137-1142
-
-
Lancaster, C.A.1
Taylor-Harris, P.M.2
Self, A.J.3
Brill, S.4
van Erp, H.E.5
Hall, A.6
-
12
-
-
0027732538
-
Proteins regulating Ras and its relatives
-
Boguski, M.S. and McCormick, F. Proteins regulating Ras and its relatives. Nature 1993, 366: 643-54.
-
(1993)
Nature
, vol.366
, pp. 643-654
-
-
Boguski, M.S.1
McCormick, F.2
-
13
-
-
0037069690
-
Rho GTPases in cell biology
-
Etienne-Manneville, S. and Hall, A. Rho GTPases in cell biology. Nature 2002, 420: 629-35.
-
(2002)
Nature
, vol.420
, pp. 629-635
-
-
Etienne-Manneville, S.1
Hall, A.2
-
14
-
-
0030968580
-
Rho GTPases and signaling networks
-
Van Aelst, L. and D'Souza-Schorey, C. Rho GTPases and signaling networks. Genes Dev 1997, 11: 2295-322.
-
(1997)
Genes Dev
, vol.11
, pp. 2295-2322
-
-
Van Aelst, L.1
D'Souza-Schorey, C.2
-
15
-
-
9244257348
-
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho
-
Matsui, T., Amano, M., Yamamoto, T. et al. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J 1996, 15: 2208-16.
-
(1996)
EMBO J
, vol.15
, pp. 2208-2216
-
-
Matsui, T.1
Amano, M.2
Yamamoto, T.3
-
16
-
-
0029789678
-
The p160 RhoA-binding kinase RoKalpha is a member of a kinase family and is involved in the reorganization of a kinase family and is involved in the reorganization of the cytoskeleton
-
Leung, T., Chen, X.Q., Manser, E. and Lim, L. The p160 RhoA-binding kinase RoKalpha is a member of a kinase family and is involved in the reorganization of a kinase family and is involved in the reorganization of the cytoskeleton. Mol Cell Biol 1996, 16: 5313-27.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 5313-5327
-
-
Leung, T.1
Chen, X.Q.2
Manser, E.3
Lim, L.4
-
17
-
-
0028863142
-
A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes
-
Leung, T., Manser, E., Tan, L. and Lim, L. A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes. J Bio Chem 1995, 270: 29051-4.
-
(1995)
J Bio Chem
, vol.270
, pp. 29051-29054
-
-
Leung, T.1
Manser, E.2
Tan, L.3
Lim, L.4
-
18
-
-
0030603119
-
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice
-
Nakagawa, O., Fujisawa, K., Ishizaki, T., Saito, Y., Nakao, K. and Narumiya, S. ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett 1996, 392: 189-93.
-
(1996)
FEBS Lett
, vol.392
, pp. 189-193
-
-
Nakagawa, O.1
Fujisawa, K.2
Ishizaki, T.3
Saito, Y.4
Nakao, K.5
Narumiya, S.6
-
19
-
-
9444242736
-
Regulation of myosin phosphatase by Rho and Rho-associated kinase(Rho-kinase)
-
Kimura, K., Ito, M., Amano, M. et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase(Rho-kinase). Science 1996, 273: 245-8.
-
(1996)
Science
, vol.273
, pp. 245-248
-
-
Kimura, K.1
Ito, M.2
Amano, M.3
-
20
-
-
0032416863
-
Rho A regulates sustained smooth muscle contraction through cytoskeletal reorganization of HSP27
-
Wang, P. and Bitar, K.N. Rho A regulates sustained smooth muscle contraction through cytoskeletal reorganization of HSP27. Am J Physiol 1998, 275: G1454-62.
-
(1998)
Am J Physiol
, vol.275
-
-
Wang, P.1
Bitar, K.N.2
-
21
-
-
27644497981
-
Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway
-
Kozai, T., Eto, M., Yang, Z., Shimokawa, H. and Luscher, T.F. Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway. Cardiovasc Res 2005, 68: 475-82.
-
(2005)
Cardiovasc Res
, vol.68
, pp. 475-482
-
-
Kozai, T.1
Eto, M.2
Yang, Z.3
Shimokawa, H.4
Luscher, T.F.5
-
22
-
-
1542374720
-
Rho kinase inhibition initiates apoptosis in human airway epithelial cells
-
Moore, M., Marroquin, B.A., Gugliotta, W., Tse, R. and White, S.R. Rho kinase inhibition initiates apoptosis in human airway epithelial cells. Am J Respir Cell Mol Biol 2004, 30: 379-87.
-
(2004)
Am J Respir Cell Mol Biol
, vol.30
, pp. 379-387
-
-
Moore, M.1
Marroquin, B.A.2
Gugliotta, W.3
Tse, R.4
White, S.R.5
-
23
-
-
25444442816
-
Attenuated noradrenaline-induced contraction of pulmonary arteries from rats treated with monocrotaline: Role of Rho Kinase
-
Khan, I., Oriowo, M.A., Chandrasekhar, B. and Kadavil, E.A. Attenuated noradrenaline-induced contraction of pulmonary arteries from rats treated with monocrotaline: role of Rho Kinase. J Vasc Res 2005, 42: 433-40.
-
(2005)
J Vasc Res
, vol.42
, pp. 433-440
-
-
Khan, I.1
Oriowo, M.A.2
Chandrasekhar, B.3
Kadavil, E.A.4
-
25
-
-
2642579001
-
RhoA activation by hypoxia in pulmonary arterial smooth muscle cells is age and site specific
-
Bailly, K., Ridley, A.J., Hall, S.M. and Haworth, S.G. RhoA activation by hypoxia in pulmonary arterial smooth muscle cells is age and site specific. Circ Res 2004, 94: 1383-91.
-
(2004)
Circ Res
, vol.94
, pp. 1383-1391
-
-
Bailly, K.1
Ridley, A.J.2
Hall, S.M.3
Haworth, S.G.4
-
26
-
-
0030656619
-
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
-
Uehata, M., Ishizaki, T., Satoh, H. et al. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 1997, 389: 990-4.
-
(1997)
Nature
, vol.389
, pp. 990-994
-
-
Uehata, M.1
Ishizaki, T.2
Satoh, H.3
-
27
-
-
19444379631
-
Opposing roles of endothelial and smooth muscle phosphatidylinositol 3-kinase in vasoconstriction: Effects of rho-kinase and hypertension
-
Budzyn, K., Marley, P.D. and Sobey, C.G. Opposing roles of endothelial and smooth muscle phosphatidylinositol 3-kinase in vasoconstriction: effects of rho-kinase and hypertension. J Pharmacol Exp Ther 2005, 313: 1248-53.
-
(2005)
J Pharmacol Exp Ther
, vol.313
, pp. 1248-1253
-
-
Budzyn, K.1
Marley, P.D.2
Sobey, C.G.3
-
28
-
-
0033822011
-
Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat
-
Robertson, T.P., Dipp, M., Ward, J.P., Aaronson, P.I. and Evans, A.M. Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat. Br J Pharmacol 2000, 131: 5-9.
-
(2000)
Br J Pharmacol
, vol.131
, pp. 5-9
-
-
Robertson, T.P.1
Dipp, M.2
Ward, J.P.3
Aaronson, P.I.4
Evans, A.M.5
-
29
-
-
0034017744
-
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases
-
Ishizaki, T., Uehata, M., Tamechika, I. et al. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol 2000, 57: 976-83.
-
(2000)
Mol Pharmacol
, vol.57
, pp. 976-983
-
-
Ishizaki, T.1
Uehata, M.2
Tamechika, I.3
-
30
-
-
0023359056
-
Mechanism of action of a novel antivasospasm drug, HA1077
-
Asano, T., Ikegaki, I., Satoh, S. et al. Mechanism of action of a novel antivasospasm drug, HA1077. J Pharmacol Exp Ther 1987, 241: 1033-40.
-
(1987)
J Pharmacol Exp Ther
, vol.241
, pp. 1033-1040
-
-
Asano, T.1
Ikegaki, I.2
Satoh, S.3
-
31
-
-
0032877847
-
Rho-kinase pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm
-
Shimokawa, H., Seto, M., Katsumata, N. et al. Rho-kinase pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc Res 1999, 43: 1029-39.
-
(1999)
Cardiovasc Res
, vol.43
, pp. 1029-1039
-
-
Shimokawa, H.1
Seto, M.2
Katsumata, N.3
-
32
-
-
0032894607
-
Intra-arterial infusion of fasudil hydrochloride for treating vasospasm following subarachnoid haemorrhage
-
Tachibana, E., Harada, T., Shibuya, M. et al. Intra-arterial infusion of fasudil hydrochloride for treating vasospasm following subarachnoid haemorrhage. Acta Neurochir (Wien) 1999, 141: 13-9.
-
(1999)
Acta Neurochir (Wien)
, vol.141
, pp. 13-19
-
-
Tachibana, E.1
Harada, T.2
Shibuya, M.3
-
33
-
-
14244260105
-
Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension
-
Fukumoto, Y., Matoba, T., Ito, A. et al. Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart 2005, 91: 391-2.
-
(2005)
Heart
, vol.91
, pp. 391-392
-
-
Fukumoto, Y.1
Matoba, T.2
Ito, A.3
-
34
-
-
31644431508
-
-
Ishikura, K., Yamada, N., Ito, M. et al. Beneficial acute effects of Rho-Kinase inhibitor in patients with pulmonary arterial hypertension. Circ J 2006, 70: 174-8.0
-
Ishikura, K., Yamada, N., Ito, M. et al. Beneficial acute effects of Rho-Kinase inhibitor in patients with pulmonary arterial hypertension. Circ J 2006, 70: 174-8.0
-
-
-
-
35
-
-
33846548925
-
Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
-
European Patent, EP1256574A1
-
Takami, A., Iijima, H., Iwakubo, M. and Okada, Y. Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same. European Patent 2001, EP1256574A1.
-
(2001)
-
-
Takami, A.1
Iijima, H.2
Iwakubo, M.3
Okada, Y.4
-
36
-
-
23044457380
-
Endothelial dysfunction in pulmonary hypertension
-
Fonseca, J.C., Balzano, C.D. and de Leon, R.S. Endothelial dysfunction in pulmonary hypertension. Arch Bronconeumol 2005, 41: 389-92.
-
(2005)
Arch Bronconeumol
, vol.41
, pp. 389-392
-
-
Fonseca, J.C.1
Balzano, C.D.2
de Leon, R.S.3
-
37
-
-
0034799502
-
Plasma markers of endothelial dysfunction in pulmonary hypertension
-
Cella, G, Bellotto, F., Tona, F. et al. Plasma markers of endothelial dysfunction in pulmonary hypertension. Chest 2001, 120: 1226-30.
-
(2001)
Chest
, vol.120
, pp. 1226-1230
-
-
Cella, G.1
Bellotto, F.2
Tona, F.3
-
38
-
-
0033032949
-
Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension
-
Tuder, R.M., Cool, C.D., Geraci, M.W. et al. Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am J Respir Crit Care Med 1999, 159: 1925-32.
-
(1999)
Am J Respir Crit Care Med
, vol.159
, pp. 1925-1932
-
-
Tuder, R.M.1
Cool, C.D.2
Geraci, M.W.3
-
39
-
-
0033036838
-
Endothelin-1 is elevated in monocrotaline pulmonary hypertension
-
Frasch, H.F., Marshall, C. and Marshall, B.E. Endothelin-1 is elevated in monocrotaline pulmonary hypertension. Am J Physiol 1999, 276: L304-10.
-
(1999)
Am J Physiol
, vol.276
-
-
Frasch, H.F.1
Marshall, C.2
Marshall, B.E.3
-
40
-
-
0027324745
-
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
-
Giaid, A., Yanagisawa, M., Langleben, D. et al. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med 1993, 328: 1732-9.
-
(1993)
N Engl J Med
, vol.328
, pp. 1732-1739
-
-
Giaid, A.1
Yanagisawa, M.2
Langleben, D.3
-
41
-
-
0037249512
-
Endogenous endothelins and nitric oxide in hypoxic pulmonary vasoconstriction
-
Hubloue, I., Biarent, D., Abdel Kafi, S. et al. Endogenous endothelins and nitric oxide in hypoxic pulmonary vasoconstriction. Eur Respir J 2003, 21: 19-24.
-
(2003)
Eur Respir J
, vol.21
, pp. 19-24
-
-
Hubloue, I.1
Biarent, D.2
Abdel Kafi, S.3
-
42
-
-
0035092464
-
Reduced hypoxic pulmonary vascular remodeling by nitric oxide from the endothelium
-
Ozaki, M., Kawashima, S., Yamashita, T. et al. Reduced hypoxic pulmonary vascular remodeling by nitric oxide from the endothelium. Hypertension 2001, 37: 322-7.
-
(2001)
Hypertension
, vol.37
, pp. 322-327
-
-
Ozaki, M.1
Kawashima, S.2
Yamashita, T.3
-
43
-
-
0036334770
-
Nitric oxide gas de endothelin-1 mRNA in cultured pulmonary artery endothelial cells
-
Smith, A.P., Demoncheaux, E.A. and Higenbottam, T.W. Nitric oxide gas de endothelin-1 mRNA in cultured pulmonary artery endothelial cells. Nitric Oxide 2002, 6: 153-9.
-
(2002)
Nitric Oxide
, vol.6
, pp. 153-159
-
-
Smith, A.P.1
Demoncheaux, E.A.2
Higenbottam, T.W.3
-
44
-
-
0027325255
-
-
Marletta, M,A. Nitric oxide synthase structure and mechanism. J Biol Chem 1993, 268: 12231-4.
-
Marletta, M,A. Nitric oxide synthase structure and mechanism. J Biol Chem 1993, 268: 12231-4.
-
-
-
-
45
-
-
0029055964
-
Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
-
Giaid, A. and Saleh, D. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 1995, 333: 214-21.
-
(1995)
N Engl J Med
, vol.333
, pp. 214-221
-
-
Giaid, A.1
Saleh, D.2
-
46
-
-
0030955626
-
Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene
-
Steudel, W., Ichinose, F., Huang, P.L. et al. Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene. Circ Res 1997, 81: 34-41.
-
(1997)
Circ Res
, vol.81
, pp. 34-41
-
-
Steudel, W.1
Ichinose, F.2
Huang, P.L.3
-
47
-
-
0032508533
-
Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
-
Laufs, U. and Liao, J.K. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem 1998, 273: 24266-71.
-
(1998)
J Biol Chem
, vol.273
, pp. 24266-24271
-
-
Laufs, U.1
Liao, J.K.2
-
48
-
-
19044372537
-
Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery
-
Shiga, N., Hirano, K., Hirano, M., Nishimura, J., Nawata, H. and Kanaide, H. Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery. Circ Res 2005, 96: 1014-21.
-
(2005)
Circ Res
, vol.96
, pp. 1014-1021
-
-
Shiga, N.1
Hirano, K.2
Hirano, M.3
Nishimura, J.4
Nawata, H.5
Kanaide, H.6
-
49
-
-
26944494575
-
Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibition
-
Yamanouchi, D., Banno, H., Nakayama, M. et al. Hydrophilic statin suppresses vein graft intimal hyperplasia via endothelial cell-tropic Rho-kinase inhibition. J Vasc Surg 2005, 42: 757-64.
-
(2005)
J Vasc Surg
, vol.42
, pp. 757-764
-
-
Yamanouchi, D.1
Banno, H.2
Nakayama, M.3
-
50
-
-
0036645303
-
Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase
-
Takemoto, M., Sun, J., Hiroki, J., Shimokawa, H. and Liao, J.K. Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation 2002, 106: 57-62.
-
(2002)
Circulation
, vol.106
, pp. 57-62
-
-
Takemoto, M.1
Sun, J.2
Hiroki, J.3
Shimokawa, H.4
Liao, J.K.5
-
51
-
-
0033774752
-
5- hydroxytryptamine and the pulmonary circulation: Receptors, transporters and relevance to pulmonary arterial hypertension
-
MacLean, M.R., Herve, P., Eddahibi, S. and Adnot, S. 5- hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension. Br J Pharmacol 2000, 131: 161-8.
-
(2000)
Br J Pharmacol
, vol.131
, pp. 161-168
-
-
MacLean, M.R.1
Herve, P.2
Eddahibi, S.3
Adnot, S.4
-
52
-
-
33644837177
-
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats
-
Weigand, L., Sylvester, J.T. and Shimoda, L.A. Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 2006, 290: L284-90.
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.290
-
-
Weigand, L.1
Sylvester, J.T.2
Shimoda, L.A.3
-
53
-
-
29144477627
-
Pharmacological reversal of endothelin-1 mediated constriction of the spiral modiolar artery: A potential new treatment for sudden sensorineural hearing loss
-
Scherer, E.Q., Arnold, W. and Wangemann, P. Pharmacological reversal of endothelin-1 mediated constriction of the spiral modiolar artery: a potential new treatment for sudden sensorineural hearing loss. BMC Ear Nose Throat Disord 2005, 5: 10.
-
(2005)
BMC Ear Nose Throat Disord
, vol.5
, pp. 10
-
-
Scherer, E.Q.1
Arnold, W.2
Wangemann, P.3
-
54
-
-
29544450461
-
5,6-EET-induced contraction of intralobar pulmonary arteries depends on the activation of Rho-kinase
-
Losapio, J.L., Sprague, R.S., Lonigro, A.J. and Stephenson, A.H. 5,6-EET-induced contraction of intralobar pulmonary arteries depends on the activation of Rho-kinase. J Appl Physiol 2005, 99: 1391-6.
-
(2005)
J Appl Physiol
, vol.99
, pp. 1391-1396
-
-
Losapio, J.L.1
Sprague, R.S.2
Lonigro, A.J.3
Stephenson, A.H.4
-
55
-
-
0034705765
-
Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase
-
Koyama, M., Ito, M., Feng, J. et al. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase. FEBS Lett 2000, 475: 197-200.
-
(2000)
FEBS Lett
, vol.475
, pp. 197-200
-
-
Koyama, M.1
Ito, M.2
Feng, J.3
-
56
-
-
21044460169
-
RhoA-Rho kinase pathway mediates thrombin- and U-46619-induced phosphorylation of a myosin phosphatase inhibitor, CPI-17, in vascular smooth muscle ceils
-
Pang, H., Guo, Z., Su, W., Xie, Z., Eto, M. and Gong, M.C. RhoA-Rho kinase pathway mediates thrombin- and U-46619-induced phosphorylation of a myosin phosphatase inhibitor, CPI-17, in vascular smooth muscle ceils. Am J Physiol Cell Physiol 2005, 289: C352-60.
-
(2005)
Am J Physiol Cell Physiol
, vol.289
-
-
Pang, H.1
Guo, Z.2
Su, W.3
Xie, Z.4
Eto, M.5
Gong, M.C.6
-
57
-
-
0030977123
-
Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation
-
Kureishi, Y., Kobayashi, S., Amano, M. et al. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem 1997, 272: 12257-60.
-
(1997)
J Biol Chem
, vol.272
, pp. 12257-12260
-
-
Kureishi, Y.1
Kobayashi, S.2
Amano, M.3
-
58
-
-
0141637161
-
Hypoxia inhibits myosin phosphatase in pulmonary arterial smooth muscle cells
-
Wang, Z., Lanner, M.C., Jin, N.J., Swartz, D., Li, L. and Rhoades, R.A. Hypoxia inhibits myosin phosphatase in pulmonary arterial smooth muscle cells. Am J Respir Cell Mol Biol 2003, 29: 465-71.
-
(2003)
Am J Respir Cell Mol Biol
, vol.29
, pp. 465-471
-
-
Wang, Z.1
Lanner, M.C.2
Jin, N.J.3
Swartz, D.4
Li, L.5
Rhoades, R.A.6
-
60
-
-
4544244944
-
Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats
-
Nagaoka, T., Morio, Y., Casanova, N., Bauer, N., Gebb, S., McMurtry, I. and Oka, M. Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 2004, 287: L665-72.
-
(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.287
-
-
Nagaoka, T.1
Morio, Y.2
Casanova, N.3
Bauer, N.4
Gebb, S.5
McMurtry, I.6
Oka, M.7
-
61
-
-
0041508986
-
Contribution of RhoA and Rho kinase to platelet-derived growth factor-BB-induced proliferation of vascular smooth muscle cells
-
Kamiyama, M., Utsunomiya, K., Taniguchi, K. et al. Contribution of RhoA and Rho kinase to platelet-derived growth factor-BB-induced proliferation of vascular smooth muscle cells. J Atheroscler Thromb 2003, 10: 117-23.
-
(2003)
J Atheroscler Thromb
, vol.10
, pp. 117-123
-
-
Kamiyama, M.1
Utsunomiya, K.2
Taniguchi, K.3
-
62
-
-
0033612371
-
Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration
-
Seasholtz, T.M., Majumdar, M., Kaplan, D.D. and Brown, J.H. Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration. Circ Res 1999, 84: 1186-93.
-
(1999)
Circ Res
, vol.84
, pp. 1186-1193
-
-
Seasholtz, T.M.1
Majumdar, M.2
Kaplan, D.D.3
Brown, J.H.4
-
63
-
-
0035827716
-
-
Sauzeau, V., LeMellionnec, E., Bertoglio, J., Scalbert, E., Pacaud, P. and Loirand, G. Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase. Circ Res 2001, 88: 1102-A
-
Sauzeau, V., LeMellionnec, E., Bertoglio, J., Scalbert, E., Pacaud, P. and Loirand, G. Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase. Circ Res 2001, 88: 1102-A
-
-
-
-
64
-
-
9144227431
-
Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: Involvement of multiple mechanisms
-
Matsumoto, Y., Uwatoku, T., Oi, K. et al. Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms. Arterioscler Thromb Vasc Biol 2004, 24: 181-6.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 181-186
-
-
Matsumoto, Y.1
Uwatoku, T.2
Oi, K.3
-
65
-
-
0033527623
-
Cell migration-movin' on
-
Horwitz, A.R. and Parsons, J.T. Cell migration-movin' on. Science 1999, 286: 1102-3.
-
(1999)
Science
, vol.286
, pp. 1102-1103
-
-
Horwitz, A.R.1
Parsons, J.T.2
-
66
-
-
0033765588
-
Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo
-
Miyata, K., Shimokawa, H., Kandabashi, H. et al. Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo. Arterioscler Thromb Vase Biol 2000, 20: 2351-8.
-
(2000)
Arterioscler Thromb Vase Biol
, vol.20
, pp. 2351-2358
-
-
Miyata, K.1
Shimokawa, H.2
Kandabashi, H.3
-
67
-
-
0031805916
-
Alleviation of monocrotaline-induced pulmonary hypertension by antibodies to monocyte chemotactic and activating factor/monocyte chemoattractant protein-1
-
Kimura, H., Kasahara, Y., Kurosu, K. et al. Alleviation of monocrotaline-induced pulmonary hypertension by antibodies to monocyte chemotactic and activating factor/monocyte chemoattractant protein-1. Lab Invest 1998, 78: 571-81.
-
(1998)
Lab Invest
, vol.78
, pp. 571-581
-
-
Kimura, H.1
Kasahara, Y.2
Kurosu, K.3
-
68
-
-
0028358125
-
Immediate-early gene expression in response to hypertrophic and proliferative stimuli in pulmonary arterial smooth muscle cells
-
Rothman, A., Wolner, B., Button, D. and Taylor, P. Immediate-early gene expression in response to hypertrophic and proliferative stimuli in pulmonary arterial smooth muscle cells. J Biol Chem 1994, 269: 6399-404.
-
(1994)
J Biol Chem
, vol.269
, pp. 6399-6404
-
-
Rothman, A.1
Wolner, B.2
Button, D.3
Taylor, P.4
-
69
-
-
26444540768
-
Reversal of experimental pulmonary hypertension by PDGF inhibition
-
Schermuly, R.T., Dony, E., Ghofrani, H.A. et al. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 2005, 115: 2811-21.
-
(2005)
J Clin Invest
, vol.115
, pp. 2811-2821
-
-
Schermuly, R.T.1
Dony, E.2
Ghofrani, H.A.3
-
70
-
-
33645370510
-
Vasodilatory effect of subsequent administration of fasudil, a rho-kinase inhibitor, surpasses that of nitroglycerin at the concentric coronary stenosis in patients with stable angina pectoris
-
Otsuka, T., Ibuki, C., Suzuki, T. et al. Vasodilatory effect of subsequent administration of fasudil, a rho-kinase inhibitor, surpasses that of nitroglycerin at the concentric coronary stenosis in patients with stable angina pectoris. Circ J 2006, 70: 402-8.
-
(2006)
Circ J
, vol.70
, pp. 402-408
-
-
Otsuka, T.1
Ibuki, C.2
Suzuki, T.3
-
71
-
-
0035679020
-
Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans
-
Masuraoto, A., Hirooka, Y., Shimokawa, H., Hironaga, K., Setoguchi, S. and Takeshita, A. Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans. Hypertension 2001, 38: 1307-10.
-
(2001)
Hypertension
, vol.38
, pp. 1307-1310
-
-
Masuraoto, A.1
Hirooka, Y.2
Shimokawa, H.3
Hironaga, K.4
Setoguchi, S.5
Takeshita, A.6
-
72
-
-
20344383268
-
Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure
-
Kishi, T., Hirooka, Y., Masumoto, A. et al. Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure. Circulation 2005, 111: 2741-7.
-
(2005)
Circulation
, vol.111
, pp. 2741-2747
-
-
Kishi, T.1
Hirooka, Y.2
Masumoto, A.3
|