Effects of alterations in CAR on bilirubin detoxification in mouse collagen-induced arthritis

Drug Metabolism and Disposition

Volumn 35, Issue 2, 2007, Pages 256-261

  Kawase, Atsushi ^a   Tsunokuni, You ^a   Iwaki, Masahiro ^a  

^a KINKI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BIS(3,5 DICHLORO 2 PYRIDYLOXY)BENZENE; BILIRUBIN; COLLAGEN; CONSTITUTIVE ANDROSTANE RECEPTOR; GLUCURONOSYLTRANSFERASE 1A1; GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE A2; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER 2; PHENOBARBITAL; PREGNANE X RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIRUBIN BLOOD LEVEL; BILIRUBIN METABOLISM; CHRONIC ARTHRITIS; CONTROLLED STUDY; DETOXIFICATION; DRUG EFFECT; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN TRANSPORT; TRANSCRIPTION REGULATION;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BILIRUBIN; GLUTATHIONE TRANSFERASE; ISOENZYMES; MALE; MICE; MICE, INBRED DBA; ORGANIC CATION TRANSPORT PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, MESSENGER; TRANSCRIPTION FACTORS;

MUS;

EID: 33846404878     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.011536     Document Type: Article

References (22)

1. Assenat E, Gerbal-Chaloin S, Larrey D, Saric J, Fabre JM, Maurel P, Vilarem MJ, and Pascussi JM (2004) Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. Hepatology 40:951-960.
2. Fang C, Yoon S, Tindberg N, Jarvelainen HA, Lindros KO, and Ingelman-Sundberg M (2004) Hepatic expression of multiple acute phase proteins and down-regulation of nuclear receptors after acute endotoxin exposure. Biochem Pharmacol 67:1389-1397.
3. Honkakoski P, Zelko I, Sueyoshi T, and Negishi M (1998) The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol 18:5652-5658.
4. Huang W, Zhang J, Chua SS, Qatanani M, Han Y, Granata R, and Moore DD (2003) Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proc Natl Acad Sci USA 100:4156-4161.
5. Huang W, Zhang J, and Moore DD (2004) A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. J Clin Investig 113:137-143.
6. Jansen PL, Bosma PJ, and Chowdhury JR (1995) Molecular biology of bilirubin metabolism. Prog Liver Dis 13:125-150.
7. Kamisako T, Kobayashi Y, Takeuchi K, Ishihara T, Higuchi K, Tanaka Y, Gabazza EC, and Adachi Y (2000) Recent advances in bilirubin metabolism research: the molecular mechanism of hepatocyte bilirubin transport and its clinical relevance. J Gastroenterol 35:659-664.
8. Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterstrom RH, et al. (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92:73-82.
9. Kobayashi K, Sueyoshi T, Inoue K, Moore R, and Negishi M (2003) Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. Mol Pharmacol 64:1069-1075.
10. Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT, and Kliewer SA (2002) Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol Pharmacol 62:638-646.
11. Nishikawa M, Takemura S, Takakura Y, and Hashida M (1998) Targeted delivery of plasmid DNA to hepatocytes in vivo: optimization of the pharmacokinetics of plasmid DNA/galactosylated poly(L-lysine) complexes by controlling their physicochemical properties. J Pharmacol Exp Ther 287:408-415.
12. Pascussi JM, Gerbal-Chaloin S, Pichard-Garcia L, Daujat M, Fabre JM, Maurel P, and Vilarem MJ (2000) Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes. Biochem Biophys Res Commun 274:707-713.
13. Piquette-Miller M and Jamali F (1992) Effect of adjuvant arthritis on the disposition of acebutolol enantiomers in rats. Agents Actions 37:290-296.
14. Piquette-Miller M and Jamali F (1995) Influence of severity of inflammation on the disposition kinetics of propranolol enantiomers in ketoprofen-treated and untreated adjuvant arthritis. Drug Metab Dispos 23:240-245.
15. Pollock SH, Matthews HW, and D'Souza MJ (1989) Pharmacokinetic analysis of cyclosporine in adjuvant arthritic rats. Drug Metab Dispos 17:595-599.
16. Saini SP, Mu Y, Gong H, Toma D, Uppal H, Ren S, Li S, Poloyac SM, and Xie W (2005) Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice. Hepatology 41:497-505.
17. Squires EJ, Sueyoshi T, and Negishi M (2004) Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver. J Biol Chem 279:49307-49314.
18. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, and Sueyoshi T (2001) The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 33:1232-1238.
19. Wagner M, Halilbasic E, Marschall HU, Zollner G, Fickert P, Langner C, Zatloukal K, Denk H, and Trauner M (2005) CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice. Hepatology 42:420-430.
20. Walker KA, Barber HE, and Hawksworth GM (1986) Mechanism responsible for altered propranolol disposition in adjuvant-induced arthritis in the rat. Drug Metab Dispos 14:482-486.
21. Waxman DJ (1999) P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR. Arch Biochem Biophys 369:11-23.
22. Xiong H, Yoshinari K, Brouwer KL, and Negishi M (2002) Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital. Drug Metab Dispos 30:918-923.