Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation

Molecular Biology of the Cell

Volumn 14, Issue 2, 2003, Pages 432-444

  Gupta, Neetu ^a   DeFranco, Anthony L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; B LYMPHOCYTE RECEPTOR; CD45 ANTIGEN; CHIMERIC PROTEIN; CHOLERA TOXIN B SUBUNIT; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN M ANTIBODY; LIPID; LYMPHOCYTE ANTIGEN RECEPTOR; LYSOZYME; PROTEIN TYROSINE KINASE;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL MEMBRANE; CELL STRUCTURE; CHEMICAL ANALYSIS; CYTONEME; FILOPODIUM; GENE TRANSLOCATION; IMAGING; MICROSCOPY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; B-LYMPHOCYTES; CELL LINE; CELL MEMBRANE; CROSS-LINKING REAGENTS; GREEN FLUORESCENT PROTEINS; LIPID METABOLISM; LUMINESCENT PROTEINS; LYMPHOCYTE ACTIVATION; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MURAMIDASE; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, TRANSFERRIN; SIGNAL TRANSDUCTION; SPLEEN; TEMPERATURE; TIME FACTORS; TUMOR CELLS, CULTURED;

ANIMALIA; MUS MUSCULUS;

EID: 0037329199     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.02-05-0078     Document Type: Article

References (45)

1. Aman, M.J., and Ravichandran, K.S. (2000). A requirement for lipid rafts in B cell receptor induced Ca(2+) flux. Curr. Biol. 10, 393-396.
2. Bavari, S., Bosio, C.M., Wiegand, E., Ruthel, G., Will, A.B., Geisbert, T.W., Hevey, M., Schmaljohn, C., Schmaljohn, A., and Aman, M.J. (2002). Lipid raft microdomains: a gateway for compartmentalized trafficking of Ebola and Marburg viruses. J. Exp. Med. 195, 593-602.
3. Brown, D.A., and London, E. (1998). Functions of lipid rafts in biological membranes. Annu. Rev. Cell Dev. Biol. 14, 111-136.
4. Chan, A.C., Desai, D.M., and Weiss, A. (1994). The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction. Annu. Rev. Immunol. 12, 555-592.
5. Chan, V.W., Meng, F., Soriano, P., DeFranco, A.L., and Lowell, C.A. (1997). Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and downregulation. Immunity 7, 69-81.
6. Cheng, P.C., Brown, B.K., Song, W., and Pierce, S.K. (2001b). Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling. J. Immunol. 166, 3693-3701.
7. Cheng, P.C., Cherukuri, A., Dykstra, M., Malapati, S., Sproul, T., Chen, M.R., and Pierce, S.K. (2001a). Floating the raft hypothesis: the roles of lipid rafts in B cell antigen receptor function. Semin. Immunol. 13, 107-114.
8. Cheng, P.C., Dykstra, M.L., Mitchell, R.N., and Pierce, S.K. (1999). A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. J. Exp. Med. 190, 1549-1560.
9. Chung, J.B., Baumeister, M.A., and Monroe, J.G. (2001). Differential sequestration of plasma membrane-associated B cell antigen receptor in mature and immature B cells into glycosphingolipid-enriched domains. J. Immunol. 166, 736-740.
10. DeFranco, A.L. (1997). The complexity of signaling pathways activated by the BCR. Curr. Opin. Immunol. 9, 296-308.
11. Dustin, M.L., and Cooper, J.A. (2000). The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. Nat. Immunol. 1, 23-29.
12. Field, K.A., Holowka, D., and Baird, B. (1995). FcεRI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling. Proc. Natl. Acad. Sci. USA 92, 9201-9205.
13. Finkelman, F.D., Lees, A., and Morris, S.C. (1992). Antigen presentation by B lymphocytes to CD4+ T lymphocytes in vivo: importance for B lymphocyte and T lymphocyte activation. Semin. Immunol. 4, 247-255.
14. Galkina, S.I., Sud'ina, G.F., Ullrich, V. (2001). Inhibition of neutrophil spreading during adhesion to fibronectin reveals formation of long tubulovesicular cell extensions (cytonemes). Exp. Cell Res. 266, 222-228.
15. Guo, B., Kato, R.M., Garcia-Lloret, M., Wahl, M.I., and Rawlings, D.J. (2000). Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex. Immunity.13, 243-253.
16. Harder, T., Scheiffele, P., Verkade, P., and Simons, K. (1998). Lipid domain structure of the plasma membrane revealed by patching of membrane components. J. Cell Biol. 14, 929-942.
17. Holowka, D., and Baird, B. (2001). FcεRI as a paradigm for a lipid raft-dependent receptor in hematopoietic cells. Semin. Immunol. 13, 99-105.
18. Hutchcroft, J.E., Harrison, M.L., and Geahlen, R.L. (1992). Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor. J. Biol. Chem. 267, 8613-8619.
19. Johnson, K.G., Bromley, S.K., Dustin, M.L., and Thomas, M.L. (2000). A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation. Proc. Natl. Acad. Sci. USA 97, 10138-10143.
20. Khan, A.A., Bose, C., Yam, L.S., Soloski, M.J., and Rupp, F. (2001). Physiological regulation of the immunological synapse by agrin. Science 292, 1681-1686.
21. Krummel, M., Wulfing, C., Sumen, C., and Davis, M.M. (2000). Thirty-six views of T-cell recognition. Phil. Trans. R. Soc. Lond. B. Biol. Sci. 355, 1071-1076.
22. Kurosaki, T. (1999). Genetic analysis of B cell antigen receptor signaling. Annu. Rev. Immunol. 17, 555-592.
23. Kurzchalia, T.V., and Parton, R.G. (1999). Membrane microdomains and caveolae. Curr. Opin. Cell Biol. 11, 424-431.
24. Law, D.A., Chan, V.W.-F., Datta, S.K., and DeFranco, A.L. (1993). B cell antigen receptor motifs have redundant signaling capabilities and bind the tyrosine kinases PTK72, Lyn, and Fyn. Curr. Biol. 3, 645-657.
25. Lee, S.J., Liyanage, U., Bickel, P.E., Xia, W., Lansbury, P.T., Jr., and Kosik, K.S. (1998). A detergent-insoluble membrane compartment contains Aβ in vivo. Nat. Med. 4, 730-734.
26. Ma, H., Yankee, T.M., Hu, J., Asai, D.J., Harrison, M.L., and Geahlen, R.L. (2001). Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization. J. Immunol. 166, 1507-1516.
27. Mason, D.Y., Jones, M., and Goodnow, C.C. (1992). Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD transgenic mice. Int. Immunol. 4, 163-175.
28. Melkonian, K.A., Ostermeyer, A.G., Chen, J.Z., Roth, M.G., and Brown, D.A. (1999). Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated. J. Biol. Chem. 274, 3910-3917.
29. Miceli, M.C., Moran, M., Chung, C.D., Patel, V.P., Low, T., and Zinnanti, W. (2001). Co-stimulation and counter-stimulation: lipid raft clustering controls TCR signaling and functional outcomes. Semin. Immunol. 13, 115-128.
30. Miller, L.A., Hong, J.J., Kinch, M.S., Harrison, M.L., and Geahlen, R.L. (1999). The engagement of β1 integrins on promonocytic cells promotes phosphorylation of Syk and formation of a protein complex containing Lyn and β1 integrin. Eur. J. Immunol. 29, 1426-1434.
31. Mocsai, A., Zhou, M., Meng, F., Tybulewicz, V.L., and Lowell, C.A. (2002). Syk is required for integrin signaling in neutrophils. Immunity 16, 547-558.
32. Naslavsky, N., Stein, R., Yanai, A., Friedlander, G., and Taraboulos, A. (1997). Characterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoform. J. Biol. Chem. 272, 6324-6331.
33. Ono, A., and Freed, E.O. (2001). Plasma membrane rafts play a critical role in HIV-1 assembly and release. Proc. Natl. Acad. Sci. USA 98, 13925-13930.
34. Petrie, R.J., Schnetkamp, P.P., Patel, K.D., Awasthi-Kalia, M., and Deans, J.P. (2000). Transient translocation of the B cell receptor and Src homology 2 domain-containing inositol phosphatase to lipid rafts: evidence toward a role in calcium regulation. J. Immunol. 165, 1220-1227.
35. Pierce, S.K. (2002). Lipid rafts and B-cell activation. Nat. Rev. Immunol. 2, 96-105.
36. Raghunathan, A., Sivakamasundari, R., Wolenski, J., Poddar, R., and Weissman, S.M. (2001). Functional analysis of B144/LST1: a gene in the tumor necrosis factor cluster that induces formation of long filopodia in eukaryotic cells. Exp. Cell Res. 268, 230-244.
37. Ramirez-Weber, F.A., and Kornberg, T.B. (1999). Cytonemes: cellular processes that project to the principal signaling center in Drosophila imaginal discs. Cell 97, 599-607.
38. Simons, K., and Toomre, D. (2000). Lipid rafts and signal transduction. Nat. Rev. Mol. Cell. Biol. 1, 31-39.
39. Sproul, T.W., Malapati, S., Kim, J., and Pierce, S.K. (2000). B cell antigen receptor signaling occurs outside lipid rafts in immature B cells. J. Immunol. 165, 6020-6023.
40. Stupack, D.G., Li, E., Silletti, S.A., Kehler, J.A., Geahlen, R.L., Hahn, K., Nemerow, G.R., and Cheresh, D.A. (1999). Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase. J. Cell Biol. 144, 777-788.
41. Thomas, M.L., and Brown, E.J. (1999). Positive and negative regulation of Src-family membrane kinases by CD45. Immunol. Today 20, 406-411.
42. van der Goot, F.G., and Harder, T. (2001). Raft membrane domains: from a liquid-ordered membrane phase to a site of pathogen attack. Semin. Immunol. 13, 89-97.
43. Wolf, A.A., Fujinaga, Y., and Lencer, W.I. (2002). Uncoupling of the cholera toxin-GM1 ganglioside receptor complex from endocytosis, retrograde Golgi trafficking, and downstream signal transduction by depletion of membrane cholesterol. J. Biol. Chem. 277, 16249-16256.
44. Xavier, R., Brennan, T., Li, Q., McCormack, C., and Seed, B. (1998). Membrane compartmentation is required for efficient T cell activation. Immunity 8, 723-732.
45. Yanagi, S., Sugawara, H., Kurosaki, M., Sabe, H., Yamamura, H., and Kurosaki, T. (1996). CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells. J. Biol. Chem. 271, 30487-30492.