Potassium Channel Dysfunction in Cerebral Arteries of Insulin-Resistant Rats Is Mediated by Reactive Oxygen Species

Stroke

Volumn 35, Issue 4, 2004, Pages 964-969

  Erdös, Benedek ^a,b,c   Simandle, Steve A ^a   Snipes, James A ^a   Miller, Allison W ^a   Busija, David W ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

Author keywords

Diabetes mellitus; Insulin resistance; Middle cerebral artery; Oxidative stress; Potassium channels; Rats

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CATALASE; FRUCTOSE; GLUCOSE; ILOPROST; INSULIN; PINACIDIL; POTASSIUM; POTASSIUM CHANNEL; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; BRAIN ARTERY; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; INSULIN RESISTANCE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; CULTURE TECHNIQUES; ILOPROST; INSULIN RESISTANCE; MALE; MIDDLE CEREBRAL ARTERY; PINACIDIL; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; VASODILATION; VASODILATOR AGENTS;

EID: 1842471240     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000119753.05670.F1     Document Type: Article

References (32)

1. Steinberg HO, Baron AD. Vascular function, insulin resistance and fatly acids. Diabetologia. 2002;45:623-634.
2. Salonen JT, Lakka TA, Lakka HM, Valkonen VP, Everson SA, Kaplan GA. Hyperinsulinemia is associated with the incidence of hypertension and dyslipidemia in middle-aged men. Diabetes. 1998;47:270-275.
3. Jorgensen H, Nakayama H, Raaschou HO, Olsen TS. Stroke in patients with diabetes: the Copenhagen Stroke Study. Stroke. 1994;25:1977-1984.
4. Shinozaki K, Naritomi H, Shimizu T, Suzuki M, Ikebuchi M, Sawada T, Harano Y. Role of insulin resistance associated with compensatory hyperinsulinemia in ischemic stroke. Stroke. 1996;27:37-43.
5. Matsumoto K, Miyake S, Yano M, Ueki Y, Miyazaki A, Hirao K, Tominaga Y. Insulin resistance and classic risk factors in type 2 diabetic patients with different subtypes of ischemic stroke. Diabetes Care. 1999; 22:1191-1195.
6. Megherbi SE, Milan C, Minier D, Couvreur G, Osseby GV, Tilling K, Di Carlo A, Inzitari D, Wolfe CD, Moreau T, Giroud M. Association between diabetes and stroke subtype on survival and functional outcome 3 months after stroke: data from the European BIOMED Stroke Project. Stroke. 2003;34:688-694.
7. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002;287:356-359.
8. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414:782-787.
9. Erdös B, Miller AW, Busija DW. Impaired endothelium-mediated relaxation in isolated cerebral arteries from insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2002;282:H2060-H2065.
10. Ca channel function in cerebral arteries of insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2002;283:H2472-H2477.
11. Kashiwagi A, Shinozaki K, Nishio Y, Okamura T, Toda N, Kikkawa R. Free radical production in endothelial cells as a pathogenetic factor for vascular dysfunction in the insulin resistance state. Diabetes Res Clin Pract. 1999;45:199-203.
12. 2-imbalance in insulin-resistant rat aorta. Diabetes. 1999;48:2437-2445.
13. Guzik TJ, Mussa S, Gastaldi D, Sadowski J, Ratnatunga C, Pillai R, Channon KM. Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation. 2002;105:1656-1662.
14. Perticone F, Ceravolo R, Candigliota M, Ventura G, Iacopino S, Sinopoli F, Mattioli PL. Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C. Diabetes. 2001;50:159-165.
15. Shinozaki K, Hirayama A, Nishio Y, Yoshida Y, Ohtani T, Okamura T, Masada M, Kikkawa R, Kodama K, Kashiwagi A. Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress. J Am Coll Cardiol. 2001;38: 1821-1828.
16. Bagi Z, Koller A, Kaley G. Superoxide-NO interaction decreases flow-and agonist-induced dilations of coronary arterioles in type 2 diabetes mellitus. Am J Physiol Heart Circ Physiol. 2003;285:H1404-H1410.
17. + channel function in cerebral arterioles in piglets. Stroke. 1996;27:1874-1880.
18. Armstead WM. Vasopressin induced cyclooxygenase dependent superoxide generation contributes to K(+) channel function impairment after brain injury. Brain Res. 2001;910:19-28.
19. Liu Y, Gutterman DD. Oxidative stress and potassium channel function. Clin Exp Pharmacol Physiol. 2002;29:305-311.
20. + channels in the cerebral microcirculation of genetically hypertensive rats: evidence for their protection against cerebral vasospasm. Circ Res. 1998;82:729-737.
21. Katakam PV, Ujhelyi MR, Miller AW. EDHF-mediated relaxation is impaired in fructose-fed rats. J Cardiovasc Pharmacol. 1999;34: 461-467.
22. Miller AW, Katakam PV, Ujhelyi MR. Impaired endothelium-mediated relaxation in coronary arteries from insulin-resistant rats. J Vasc Res. 1999;36:385-392.
23. Miller AW, Dimitropoulou C, Han G, White RE, Busija DW, Carrier GO. Epoxyeicosatrienoic acid-induced relaxation is impaired in insulin resistance. Am J Physiol Heart Circ Physiol. 2001;281:H1524-H1531.
24. Nelson MT, Huang Y, Brayden JE, Hescheler J, Standen NB. Arterial dilations in response to calcitonin gene-related peptide involve activation of K+ channels. Nature. 1990;344:770-773.
25. + channels in rabbit myogenic cerebral arteries. Am J Physiol. 1995;269:H348-H355.
26. Johnson TD, Marrelli SP, Steenberg ML, Childres WF, Bryan RM. Inward rectifier potassium channels in the rat middle cerebral artery. Am J Physiol Regul Integr Comp Physiol. 1998;274:R541-R547.
27. Bradley KK, Jaggar JH, Bonev AD, Heppner TJ, Flynn ER, Nelson MT, Horowitz B. Kir2.1 encodes the inward rectifier potassium channel in rat arterial smooth muscle cells. J Physiol. 1999;515:639-651.
28. Faraci FM, Sobey CG. Role of potassium channels in regulation of cerebral vascular tone. J Cereb Blood Flow Metab. 1998;18:1047-1063.
29. Dimitropoulou C, Han G, Miller AW, Molero M, Fuchs LC, White RE, Carrier GO. Potassium (BK(Ca)) currents are reduced in microvascular smooth muscle cells from insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2002;282:H908-H917.
30. Ciorba MA, Heinemann SH, Weissbach H, Brot N, Hoshi T. Modulation of potassium channel function by methionine oxidation and reduction. Proc Natl Acad Sci USA. 1997;94:9932-9937.
31. Marrelli SP, Johnson TD, Khorovets A, Childres WF, Bryan RM Jr. Altered function of inward rectifier potassium channels in cerebrovascular smooth muscle after ischemia/reperfusion. Stroke. 1998;29: 1469-1474.
32. Bastide M, Bordet R, Pu Q, Robin E, Puisieux F, Dupuis B. Relationship between inward rectifier potassium current impairment and brain injury after cerebral ischemia/reperfusion. J Cereb Blood Flow Metab. 1999;19: 1309-1315.