Chromosome Transfer Activates and Delineates a Locus Control Region for Perforin

Immunity

Volumn 26, Issue 1, 2007, Pages 29-41

  Pipkin, Matthew E ^a   Ljutic, Belma ^c,d   Cruz Guilloty, Fernando ^e   Nouzova, Marcela ^a   Rao, Anjana ^e   Zúñiga Pflücker, Juan Carlos ^c,d   Lichtenheld, Mathias G ^a,b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d Sunnybrook Health Sciences Centre   (Canada)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

DNA; MOLIMMUNO

Indexed keywords

DEOXYRIBONUCLEASE; PERFORIN;

ARTICLE; CELL LINE; CHROMOSOME NOR; GENE; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE SEQUENCE; GENE SILENCING; HUMAN; NATURAL KILLER CELL; NONHUMAN; PRF1 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATOR GENE; TRANSGENE;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; CHROMOSOMES, ARTIFICIAL, BACTERIAL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IN SITU HYBRIDIZATION; LOCUS CONTROL REGION; MICE; POLYMERASE CHAIN REACTION; PORE FORMING CYTOTOXIC PROTEINS; PROMOTER REGIONS (GENETICS); TRANSCRIPTION, GENETIC;

EID: 33846200835     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2006.11.009     Document Type: Article

References (50)

1. Alami R., Greally J.M., Tanimoto K., Hwang S., Feng Y.Q., Engel J.D., Fiering S., and Bouhassira E.E. Beta-globin YAC transgenes exhibit uniform expression levels but position effect variegation in mice. Hum. Mol. Genet. 9 (2000) 631-636
2. Bachmann M.F., Barner M., Viola A., and Kopf M. Distinct kinetics of cytokine production and cytolysis in effector and memory T cells after viral infection. Eur. J. Immunol. 29 (1999) 291-299
3. Bulger M., Schubeler D., Bender M.A., Hamilton J., Farrell C.M., Hardison R.C., and Groudine M. A complex chromatin landscape revealed by patterns of nuclease sensitivity and histone modification within the mouse beta-globin locus. Mol. Cell. Biol. 23 (2003) 5234-5244
4. Cho S.K., Webber T.D., Carlyle J.R., Nakano T., Lewis S.M., and Zuniga-Pflucker J.C. Functional characterization of B lymphocytes generated in vitro from embryonic stem cells. Proc. Natl. Acad. Sci. USA 96 (1999) 9797-9802
5. Datsenko K.A., and Wanner B.L. One-step activation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. USA 97 (2000) 6640-6645
6. De Rosa S.C., Andrus J.P., Perfetto S.P., Mantovani J.J., Herzenberg L.A., and Roederer M. Ontogeny of gamma delta T cells in humans. J. Immunol. 172 (2004) 1637-1645
7. Desbaillets I., Ziegler U., Groscurth P., and Gassmann M. Embryoid bodies: an in vitro model of mouse embryogenesis. Exp. Physiol. 85 (2000) 645-651
8. Epner E., Reik A., Cimbora D., Telling A., Bender M.A., Fiering S., Enver T., Martin D.I., Kennedy M., Keller G., and Groudine M. The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus. Mol. Cell 2 (1998) 447-455
9. Festenstein R., Tolaini M., Corbella P., Mamalaki C., Parrington J., Fox M., Miliou A., Jones M., and Kioussis D. Locus control region function and heterochromatin-induced position effect variegation. Science 271 (1996) 1123-1125
10. Forrester W.C., Epner E., Driscoll M.C., Enver T., Brice M., Papayannopoulou T., and Groudine M. A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus. Genes Dev. 4 (1990) 1637-1649
11. Fournier R.E. A general high-efficiency procedure for production of microcell hybrids. Proc. Natl. Acad. Sci. USA 78 (1981) 6349-6353
12. Garcia-Sanz J.A., and Podack E.R. Regulation of perforin gene expression in a T cell hybrid with inducible cytolytic activity. Eur. J. Immunol. 23 (1993) 1877-1883
13. Glimcher L.H., Townsend M.J., Sullivan B.M., and Lord G.M. Recent developments in the transcriptional regulation of cytolytic effector cells. Nat. Rev. Immunol. 4 (2004) 900-911
14. Grossman W.J., Verbsky J.W., Barchet W., Colonna M., Atkinson J.P., and Ley T.J. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 21 (2004) 589-601
15. Grosveld F., van Assendelft G.B., Greaves D.R., and Kollias G. Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell 51 (1987) 975-985
16. Gumperz J.E., Miyake S., Yamamura T., and Brenner M.B. Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J. Exp. Med. 195 (2002) 625-636
17. Hebbes T.R., Clayton A.L., Thorne A.W., and Crane-Robinson C. Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain. EMBO J. 13 (1994) 1823-1830
18. Henkart P.A. Mechanism of lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 3 (1985) 31-58
19. Kagi D., Ledermann B., Burki K., Zinkernagel R.M., and Hengartner H. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu. Rev. Immunol. 14 (1996) 207-232
20. Keefe D., Shi L., Feske S., Massol R., Navarro F., Kirchhausen T., and Lieberman J. Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis. Immunity 23 (2005) 249-262
21. Labrador M., and Corces V.G. Setting the boundaries of chromatin domains and nuclear organization. Cell 111 (2002) 151-154
22. Lee G.R., Fields P.E., Griffin T.J., and Flavell R.A. Regulation of the Th2 cytokine locus by a locus control region. Immunity 19 (2003) 145-153
23. Lee D.U., Avni O., Chen L., and Rao A. A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison. J. Biol. Chem. 279 (2004) 4802-4810
24. Lichtenheld M.G., and Podack E.R. Structure and function of the murine perforin promoter and upstream region. Reciprocal gene activation or silencing in perforin positive and negative cells. J. Immunol. 149 (1992) 2619-2626
25. Lichtenheld M.G., Podack E.R., and Levy R.B. Transgenic control of perforin gene expression. Functional evidence for two separate control regions. J. Immunol. 154 (1995) 2153-2163
26. + T cells. J. Immunol. 148 (1992) 3354-3360
27. Martin P., Wallich R., Pardo J., Mullbacher A., Munder M., Modolell M., and Simon M.M. Quiescent and activated mouse granulocytes do not express granzyme A and B or perforin: similarities or differences with human polymorphonuclear leukocytes?. Blood 106 (2005) 2871-2878
28. Mayor C., Brudno M., Schwartz J.R., Poliakov A., Rubin E.M., Frazer K.A., Pachter L.S., and Dubchak I. VISTA: visualizing global DNA sequence alignments of arbitrary length. Bioinformatics 16 (2000) 1046-1047
29. Nagy A., Rossant J., Nagy R., Abramow-Newerly W., and Roder J.C. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90 (1993) 8424-8428
30. Nakata M., Kawasaki A., Azuma M., Tsuji K., Matsuda H., Shinkai Y., Yagita H., and Okumura K. Expression of perforin and cytolytic potential of human peripheral blood lymphocyte subpopulations. Int. Immunol. 4 (1992) 1049-1054
31. + T cells. Immunology 103 (2001) 281-290
32. Patrinos G.P., de Krom M., de Boer E., Langeveld A., Imam A.M., Strouboulis J., de Laat W., and Grosveld F.G. Multiple interactions between regulatory regions are required to stabilize an active chromatin hub. Genes Dev. 18 (2004) 1495-1509
33. Pershouse M.A., Stubblefield E., Hadi A., Killary A.M., Yung W.K., and Steck P.A. Analysis of the functional role of chromosome 10 loss in human glioblastomas. Cancer Res. 53 (1993) 5043-5050
34. Pipkin M.E., and Lichtenheld M.G. A reliable method to display authentic DNase I hypersensitive sites at long-ranges in single-copy genes from large genomes. Nucleic Acids Res. 34 (2006) e34
35. Roh T.Y., Cuddapah S., and Zhao K. Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping. Genes Dev. 19 (2005) 542-552
36. Rollini P., and Fournier R.E. Long-range chromatin reorganization of the human serpin gene cluster at 14q32.1 accompanies gene activation and extinction in microcell hybrids. Genomics 56 (1999) 22-30
37. Rollini P., Xu L., and Fournier R.E. Stable expression and cell-specific chromatin structure of human alpha1-antitrypsin cosmid transgenes in rat hepatoma cells. Nucleic Acids Res. 28 (2000) 3605-3614
38. Saitoh N., Bell A.C., Recillas-Targa F., West A.G., Simpson M., Pikaart M., and Felsenfeld G. Structural and functional conservation at the boundaries of the chicken beta-globin domain. EMBO J. 19 (2000) 2315-2322
39. Salcedo T.W., Azzoni L., Wolf S.F., and Perussia B. Modulation of perforin and granzyme messenger RNA expression in human natural killer cells. J. Immunol. 151 (1993) 2511-2520
40. Schlesinger B.C., and Cheng L. Characterization of a novel monoclonal antibody against human perforin using transfected cell lines. Immunology 81 (1994) 291-295
41. Schmitt T.M., and Zuniga-Pflucker J.C. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17 (2002) 749-756
42. Schmitt T.M., de Pooter R.F., Gronski M.A., Cho S.K., Ohashi P.S., and Zuniga-Pflucker J.C. Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro. Nat. Immunol. 5 (2004) 410-417
43. Schubeler D., Francastel C., Cimbora D.M., Reik A., Martin D.I., and Groudine M. Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human beta-globin locus. Genes Dev. 14 (2000) 940-950
44. Stepp S.E., Dufourcq-Lagelouse R., Le Deist F., Bhawan S., Certain S., Mathew P.A., Henter J.I., Bennett M., Fischer A., de Saint Basile G., and Kumar V. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science 286 (1999) 1957-1959
45. Uellner R., Zvelebil M.J., Hopkins J., Jones J., MacDougall L.K., Morgan B.P., Podack E., Waterfield M.D., and Griffiths G.M. Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain. EMBO J. 16 (1997) 7287-7296
46. Voskoboinik I., Smyth M.J., and Trapani J.A. Perforin-mediated target-cell death and immune homeostasis. Nat. Rev. Immunol. 6 (2006) 940-952
47. Wang Z., Engler P., Longacre A., and Storb U. An efficient method for high-fidelity BAC/PAC retrofitting with a selectable marker for mammalian cell transfection. Genome Res. 11 (2001) 137-142
48. Youn B.S., Kim K.K., and Kwon B.S. A critical role of Sp1- and Ets-related transcription factors in maintaining CTL-specific expression of the mouse perforin gene. J. Immunol. 157 (1996) 3499-3509
49. Zhang Y., and Lichtenheld M.G. Non-killer cell-specific transcription factors silence the perforin promoter. J. Immunol. 158 (1997) 1734-1741
50. Zhang J., Scordi I., Smyth M.J., and Lichtenheld M.G. Interleukin 2 receptor signaling regulates the perforin gene through signal transducer and activator of transcription (Stat)5 activation of two enhancers. J. Exp. Med. 190 (1999) 1297-1308