Evaluating scoring functions for docking and designing β-secretase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 3, 2007, Pages 823-827

  Katharine Holloway, M ^a   McGaughey, Georgia B ^a   Coburn, Craig A ^a   Stachel, Shawn J ^a   Jones, Kristen G ^a   Stanton, Elizabeth L ^a   Gregro, Alison R ^a   Lai, Ming Tain ^a   Crouthamel, Ming Chih ^a   Pietrak, Beth L ^a   Munshi, Sanjeev K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Secretase; Alzheimer's disease; BACE 1; LIGSCORE; LUDI; MMFF; PLP; PMF; X score

Indexed keywords

BETA SECRETASE INHIBITOR;

ARTICLE; CORRELATION ANALYSIS; DRUG DESIGN; DRUG MANUFACTURE; HIGH THROUGHPUT SCREENING; SCORING SYSTEM;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION;

EID: 33846193320     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.10.051     Document Type: Article

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