Atrial natriuretic peptide in hypoxia

Peptides

Volumn 26, Issue 6 SPEC. ISS., 2005, Pages 1068-1077

  Chen, Yiu Fai ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

Atrial natriuretic peptide; Gene expression; Growth factors; Hypoxia; Pulmonary hypertension; Receptors; Signaling transduction

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; FIBROBLAST GROWTH FACTOR; NATRIURETIC PEPTIDE TYPE C; PLATELET DERIVED GROWTH FACTOR;

ADAPTATION; DOWN REGULATION; GENE EXPRESSION; HEART MUSCLE CELL; HUMAN; HYPOXIA; IN VITRO STUDY; LUNG ARTERY PRESSURE; LUNG CIRCULATION; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REGULATORY MECHANISM; REVIEW;

MAMMALIA;

EID: 19444363672     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2004.08.030     Document Type: Article

References (108)

1. S. Adnot, P. Andrivet, P.E. Chabrier, J. Piquet, P. Plas, and P. Braquet Atrial natriuretic factor in chronic obstructive lung disease with pulmonary hypertension: physiological correlates and response to peptide infusion J Clin Invest 83 1989 986 993
2. R. Almirez, and A.A. Protter Clearance of human brain natriuretic peptide in rabbit; effect of the kidney, the natriuretic peptide clearance receptor, and peptidase activity J Pharmacol Exp Ther 289 1997 976 980
3. M.B. Anand-Srivastava, M.R. Sairam, and M. Cantin Ring-deleted analogs of atrial natriuretic factor inhibit adenylate cyclase/cAMP system J Biol Chem 265 1990 8566 8572
4. M.B. Anand-Srivastava, P.D. Sehl, and D.G. Lowe Cytoplasmic domain of natriuretic peptide receptor-C inhibits adenylyl cyclase J Biol Chem 271 1996 19324 19329
5. M.B. Anand-Srivastava Atrial natriuretic peptide-C receptor and membrane signalling in hypertension J Hyperten 15 1997 815 826
6. A.J. Baertschi, C. Hausmaninger, R.S. Walsh, R.M. Mentzer, D.A. Wyatt, and R.A. Pence Hypoxia-induced release of atrial natriuretic factor (ANF) from the isolated rat and rabbit heart Biochem Biophys Res Commun 140 1986 427 433
7. A.J. Baertschi, J.M. Adams, and M.P. Sullivan Acute hypoxemia stimulates atrial natriuretic factor secretion in vivo Am J Physiol 255 1988 H295 H300
8. A.J. Baertschi, and W.G. Teague Alveolar hypoxia is powerful stimulus for ANF release in conscious lambs Am J Physiol 256 1989 H990 H998
9. J.T. Berg, E.C. Breen, Z. Fu, O. Mathieu-Costello, and J.B. West Alveolar hypoxia increases gene expression of extracellular matrix proteins and platelet-derived growth factor-B in lung parenchyma Am J Resp Critical Care Med 158 1998 1920 1928
10. K.D. Block, J.G. Seidman, J.D. Naftilan, J.T. Fallon, and C.E. Seidman Neonatal atria and ventricles secrete atrial natriuretic factor via tissue-specific pathways Cell 47 1986 695 702
11. B.M.B. Brenner, B.J. Ballermann, M.E. Gunning, and M.L. Zeidel Diverse biological actions of atrial natriuretic peptide Physiol Rev 70 1990 665 699
12. L.A. Brown, D.J.R. Nunez, and M.R. Wilkins Differential regulation of natriuretic peptide receptor messenger RNAs during the development of cardiac hypertrophy in the rat J Clin Invest 92 1993 2702 2712
13. P.A. Cahill, and A. Hassic ANF-C-receptor-mediated inhibition of aortic smooth muscle cell proliferation and thymidine kinase activity Am J Physiol 266 1994 R194 R203
14. Y.-F. Chen, H. Jin, R. Paul, and S. Nagahama Blunted pressor responsiveness to quinpirole, a specific dopamine D2 receptor agonist, in conscious DOCA/NaCl hypertensive rats is related to ANP release J Pharmacol Exp Ther 246 1988 485 492
15. Y.-F. Chen, J. Durand, and W.C. Claycomb Hypoxia stimulates atrial natriuretic peptide gene expression in cultured AT-1 cardiac myocytes Hypertension 29 1997 75 82
16. Y.S. Chun, J.Y. Hyun, Y.G. Kwak, I.S. Kim, C.H. Kim, and E. Choi Hypoxic activation of the atrial natriuretic peptide gene promoter through direct and indirect actions of hypoxia-inducible factor-1 Biochem J 370 2003 149 157
17. E. Cogan, M.F. Debieve, I. Philipart, T. Pepersack, and M. Abramow High plasma levels of atrial natriuretic factor in SIADH N Eng J Med 314 1986 1258 1259
18. A.J. de Bold Atrial natriuretic factor: a hormone produced by the heart Science 230 1985 767 770
19. M.B. De Young, K.C. Keller, R.M. Graham, and G.M. Wildey Brefeldin A defines distinct pathways for atrial natriuretic factor secretion in neonatal rat atrial and ventricular myocytes Circ Res 74 1994 33 40
20. + current during hypoxia: correlation with tissue ATP levels Am J Physiol 261 1991 H671 H676
21. J.G. Drewett, R.J. Ziegler, and G.L. Trachte Neuromodulatory effects of atrial natriuretic peptides correlate with an inhibition of adenylate cyclase but not an activation of guanylate cyclase J Pharmacol Exp Ther 260 1992 689 696
22. E.A. Espiner Physiology of natriuretic peptide W.K. Samson E.R. Levin Natriuretic peptides in health and disease 1997 Humana Press New Jersey 123 146
23. T.G. Flynn The biochemistry of atrial natriuretic peptides W.K. Samson E.R. Levin Natriuretic peptides in health and disease 1997 Humana Press New Jersey 1 20
24. D.C. Foster, D.L. Garber, and B.J. Wedel The guanylyl cyclase-A receptor W.K. Samson E.R. Levin Natriuretic peptides in health and disease 1997 Humana Press New Jersey 21 34
25. F. Fuller, J.G. Porter, A.E. Arfsten, J. Miller, J.W. Schilling, and R.M. Scarborough Atrial natriuretic peptide clearance receptor J Biol Chem 263 1988 9395 9401
26. F. Fyhrquist, M.L. Sirvio, K. Helin, O. Saijonmaa, K. Metsarinne, and I. Paakkari Endothelin antiserum decreases volume-stimulated and basal plasma concentration of atrial natriuretic peptide Circulation 88 1993 1172 1176
27. D.G. Gardner, J. Wu, and B. Kovacic-Milivojevic Cellular and molecular aspects of the A-type natriuretic peptide W.K. Samson E.R. Levin Natriuretic peptides in health and disease 1997 Humana Press New Jersey 71 94
28. R.L. Ge, H.R. Shai, M. Takeoka, M. Hanaoka, T. Koizumi, and Y. Matsuzawa Atrial natriuretic peptide and red cell 2,3-diphosphoglycerate in patients with chronic mountain sickness Wilderness Environ Med 12 2001 2 7
29. C.C. Glembotski Cellular and molecular biology of B-type natriuretic peptide W.K. Samson E.R. Levin Natriuretic peptides in health and disease 1997 Humana Press New Jersey 95 106
30. M. Goldberg, H.L. Zhang, and S.F. Steinberg Hypoxia alters the subcellular distribution of protein kinase C isoforms in neonatal rat ventricular myocytes J Clin Invest 99 1997 55 61
31. J.A. Grantham, and J.C. Burnett Jr. Natriuretic peptides in cardiovascular disease: a focus on congestive heart failure W.K. Samson E.R. Levin Natriuretic peptides in health and disease 1997 Humana Press New Jersey 309 328
32. A.R. Hohimer, M. Mysliwiec, K. Lee, L.E. Davis, and G.A. Pantely Perinatal hypoxia causes ventricular enlargement associated with increased atrial natriuretic peptide (ANP) mRNA levels in newborn mice High Alt Med Biol 4 2003 241 254
33. C. Hohne, M. Drzimalla, M.O. Krebs, W. Boemke, and G. Kaczmarczyk Atrial natriuretic peptide ameliorates hypoxic pulmonary vasoconstriction without influencing systemic circulation J Physiol Pharmacol 54 2003 497 510
34. H. Itoh, S. Suga, Y. Ogawa, Y. Komatsu, N. Tamura, and T. Igaki Cellular and molecular aspects of B-type natriuretic peptide W.K. Samson E.R. Levin Natriuretic peptides in health and disease 1997 Humana Press New Jersey 107 122
35. H. Jin, R.H. Yang, Y.-F. Chen, R.M. Jackson, and S. Oparil Chronic infusion of ANP prevents pulmonary hypertension in hypoxia-adapted rats Trans Assoc Am Physicians 101 1988 185 192
36. H. Jin, R.H. Yang, R.M. Thornton, Y.-F. Chen, R.M. Jackson, and S. Oparil Atrial natriuretic peptide (ANP) lowers pulmonary arterial pressure in hypoxia-adapted rats J Appl Physiol 65 1988 1729 1735
37. H. Jin, Y.-F. Chen, R.H. Yang, R.M. Jackson, and S. Oparil Atrial natriuretic peptide clearance receptor agonist lowers pulmonary pressure in hypoxic rats J Appl Physiol 68 1990 2413 2418
38. H. Jin, R.H. Yang, Y.-F. Chen, R.M. Jackson, and S. Oparil ANP attenuates the development of pulmonary hypertension in rats adapted to chronic hypoxia J Clin Invest 85 1990 115 120
39. H. Jin, R.H. Yang, Y.-F. Chen, R.M. Jackson, H. Itoh, and M. Mukoyama ANP in acute hypoxia-induced pulmonary hypertension in rats J Appl Physiol 71 1991 807 814
40. J. Kato, K.L. Lanier-Smith, and M.G. Currie Cyclic GMP down-regulates atrail natriuretic peptide receptors on cultured vascular endothelial cells J Biol Chem 266 1991 14681 14685
41. I.M. Keith The role of endogenous lung neuropeptides in regulation of the pulmonary circulation Physiol Res 49 2000 519 537
42. B.W. Kimes, and B.L. Brandt Properties of a clonal muscle cell line from rat heart Exp Cell Res 98 1976 367 381
43. I. Kishimoto, K. Nakao, S.I. Suga, K. Hosoda, T. Yoshimasa, and H. Itoh Downregulation of C-receptor by natriuretic peptides via ANP-B receptor in vascular smooth muscle cells Am J Physiol 265 1993 H1373 H1379
44. J.R. Klinger, R. Moalli, R.R. Warburton, D.A. Wrenn, and N.S. Hill C-receptor ligand blocks pulmonary clearance of atrial natriuretic peptide in isolated rat lungs Proc Soc Exp Biol Med 201 1992 154 158
45. J.R. Klinger, R.D. Petit, L.A. Curtin, R.R. Warburton, D.S. Wrenn, and M.E. Steinhelper Cardiopulmonary responses to chronic hypoxia in transgenic mice that overexpress ANP J Appl Physiol 75 1993 198 205
46. J.R. Klinger, F. Arnal, R.R. Warburton, L.C. Ou, and N.S. Hill Downregulation of pulmonary atrial natriuretic peptide receptors in rats exposed to chronic hypoxia J Appl Physiol 77 1994 1309 1316
47. J.R. Klinger, and M. Cutaia The natriuretic peptides. Clinical applications in patients with COPD Chest 110 1996 1136 1138
48. J.R. Klinger, R.R. Warburton, L.A. Pietras, O. Smithies, R. Swift, and N.S. Hill Genetic disruption of atrial natriuretic peptide causes pulmonary hypertension in normoxic and hypoxic mice Am J Physiol 276 1999 L868 L874
49. J.R. Klinger, L. Pietras, R. Warburton, and N.S. Hill Reduced oxygen tension increases atrial natriuretic peptide release from atrial cardiocytes Exp Biol Med 226 2001 847 853
50. J.R. Klinger, R.R. Warburton, L. Pietras, P. Oliver, J. Fox, and O. Smithies Targeted disruption of the gene for natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy Am J Physiol Heart Circ Physiol 282 2002 H58 H65
51. R.E. Lang, H. Tholken, D. Ganten, F.C. Fuft, H. Rushoaho, and T. Uter Atrial natriuretic factor; a circulating hormone stimulated by volume loading Nature 314 1985 828 834
52. E.R. Levin Natriuretic peptides as antigrowth factors W.K. Samson E.R. Levin Natriuretic peptides in health and disease 1997 Humana Press New Jersey 223 238
53. E.T. Levin Natriuretic peptide C-receptor: more than a clearance receptor Am J Physiol 264 1993 E483 E489
54. R.A. Lew, and A.J. Baertschi Mechanisms of hypoxia-induced atrial natriuretic factor release from rat hearts Am J Physiol 255 1988 H295 H300
55. J.A. Lewicki, and A.A. Protter Molecular determinants of natriuretic peptide clearance receptor function W.K. Samson E.R. Levin Natriuretic peptides in health and disease 1997 New Jersey Humana Press 51 70
56. H.B. Li, S. Oparil, Q.C. Meng, and Y.-F. Chen Selective down-regulation of ANP clearance receptor gene expression in lung of rats adapted to hypoxia Am J Physiol 268 1995 L328 L335
57. P. Li, S. Oparil, J.Z. Sun, J.A. Thompson, and Y.-F. Chen Fibroblast growth factor mediates hypoxia-induced endothelin-A receptor expression in lung artery smooth muscle cells J Appl Physiol 95 2003 643 651
58. L. Liu, H. Cheng, W. Chin, H. Jin, and S. Oparil Atrial natriuretic peptide lowers pulmonary arterial pressure in patients with high altitude disease Am J Med Sci 298 1989 397 401
59. C. Llorens-Cortes, H. Hunag, P. Vicart, J.M. Gase, D. Paulin, and P. Corvol Identification and characterization on neutral endopeptidase in endothelial cells from venous or arterial origins J Biol Chem 267 1992 14012 14018
60. V. Louzier, S. Eddahibi, B. Raffestin, I. Deprez, M. Adam, and M. Levame Adenovirus-mediated atrial natriuretic protein expression in the lung protects rats from hypoxia-induced pulmonary hypertension Hum Gene Ther 12 2001 503 513
61. D.G. Lowe The guanylyl cyclase-B receptor W.K. Samson E.R. Levin Natriuretic peptides in health and disease 1997 Humana Press New Jersey 35 50
62. J.K.H. Luk, E.F.C. Wong, and N.L.M. Wong Downregulation of atrial natriuretic peptide factor clearance receptors in experimental chronic renal failure rats Am J Physiol 269 1995 902 908
63. T. Maack, M. Suzuki, F.A. Almeida, D. Nussenzveig, R.M. Scarborough, and G.A. McEnroe Physiological role of silent receptors of atrial natriuretic factor Science 238 1987 675 678
64. N. Matsukawa, W.J. Grzesik, N. Takahashi, K.N. Pandey, S. Pang, and M. Yamauchi The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system Proc Natl Acad Sci USA 96 1999 7403 7408
65. H. Matsuo, K. Kangawa, and A. Miyata Atrial natriuretic polypeptide (ANP) molecular forms and distribution in mammalian tissues and plasma C.M. Deber V.J. Hruby K.D. Kopple Peptides: structure and function 1985 Pierce Chemical Co. Illinois 932 952
66. J.C. McKenzie, I. Tanaka, T. Inagami, K.S. Misono, and R.M. Klein Alterations in atrial and plasma atrial natriuretic factor (ANF) content during development of hypoxia-induced pulmonary hypertension in the rat Proc Soc Exp Biol Med 181 1986 459 463
67. M. Meyer, and W.G. Forssmann Renal actions of atrial natriuretic peptide W.K. Samson E.R. Levin Natriuretic peptides in health and disease 1997 Humana Press New Jersey 147 170
68. M. Nagase, K. Ando, T. Katafuchi, A. Kato, S. Hirose, and T. Fujita Role of natriuretic peptide receptor type C in Dahl salt-sensitive hypertensive rat Hypertension 30 1997 177 183
69. N. Nagaya, T. Nishikimi, Y. Okano, M. Uematsu, T. Satoh, and S. Kyotani Plasma brain natriuretic peptide levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension J Am Coll Cardiol 31 1998 202 208
70. K. Nakanishi, F. Tajima, H. Itoh, Y. Nakata, H. Osada, and N. Hama Changes in atrial natriuretic peptide and brain natriuretic peptide associated with hypobaric hypoxia-induced pulmonary hypertension in rats Virchows Arch 439 2001 808 817
71. M. Naruse, Y. Takeyama, A. Tanabe, J. Hiroshige, K. Naruse, and T. Yoshimoto Atrial and brain natriuretic peptides in cardiovascular diseases Hypertension 23 1994 1231 1234
72. W.F. Oehlenschlager, D.T. Kurtz, D.A. Baron, and M.G. Currie Enhanced activity of the cardiac endocrine system during right ventricular hypertrophy Mol Cell Endocrin 62 1989 243 251
73. G.M. Olins, D.R. Patrron, F.S. Tjoeng, and D.J. Blehm Specific receptors for atriopeptin III in rabbit lung Biochem Biophys Res Commun 140 1986 302 307
74. L.C. Ou, G.L. Sardella, N.S. Hill, and C.D. Thron Does atrial natriuretic factor protect against right ventricular overload? II. Hemodynamic study J Appl Physiol 67 1989 1606 1611
75. L.C. Ou, S. Yen, and N.S. Hill Does atrial natriuretic factor protect against right ventricular overload? II. Tissue binding J Appl Physiol 67 1989 1612 1617
76. J.M. Pei, G.M. Kravtsov, S. Wu, R. Das, M.L. Fung, and T.M. Wong Calcium homeostasis in rat cardiomyocytes during chronic hypoxia: a time course study Am J Physiol 285 2003 C1420 C1428
77. B.A. Prins, M.J. Weber, R.M. Hu, A. Pedram, M. Daniels, and E.R. Levin Atrial natriuretic peptide inhibits mitogen-activated protein kinase through the clearance receptor J Biol Chem 271 1996 14156 14162
78. M. Racker Therapeutic application of calcium-channel antagonists for pulmonary hypertension Am J Cardiol 55 1985 196B 201B
79. B. Raffestin, M. Levame, S. Eddahibi, I. Viossat, P. Braquet, and P.E. Chabrier Pulmonary vasodilatory action of endogenous atrial natriuretic factor in rats with hypoxic pulmonary hypertension: effects of monoclonal atrial natriuretic factor antibody Circ Res 70 1992 184 192
80. L.M. Reid Structure and function in pulmonary hypertension Chest 89 1986 279 286
81. T.K. Rogers, J.S. Thompson, and A.H. Morice Inhibition of hypoxic pulmonary vasoconstriction in isolated rat resistance arteries by atrial natriuretic peptide Eur Respir J 10 1997 2061 2065
82. M. Ruiz-Meana, D. Garcia-Dorado, P. Pina, J. Inserte, L. Agullo, and J. Soler-Soler Cariporide preserves mitochondrial proton gradient and delays ATP depletion in cardiomyocytes during ischemic conditions Am J Physiol 285 2003 H999 H1006
83. M. Sakamoto, K. Nakao, N. Morii, A. Sugawara, T. Yamada, and H. Itoh The lung as a possible target organ for atrial natriuretic polypeptide secreted from the heart Biochem Biophys Res Commun 135 1986 515 520
84. F. Sato, K. Kamoi, Y. Wakiya, T. Ozawa, O. Arai, and M. Ishibashi Relationship between plasma atrial natriuretic peptide levels and atrial pressure in man J Clin Endocrinol Metab 63 1986 823 827
85. R.J. Schiebinger, C.M. Joseph, Y. Li, and E.J. Cragoe Jr. Mechanism of hyperosmolality stimulation of ANP secretion: its dependency on calcium and sodium Am J Physiol 268 1995 E476 E483
86. E.L. Schiffrin, J. Gutkowska, O. Kuchel, M. Gantin, and J. Genest Plasma concentration of atrial natriuretic factor in a patient with paroxysmal atrial tachycardia N Eng J Med 312 1985 1196 1197
87. L.A. Sechi, J.P. Valentin, C.A. Griffin, E. Lee, E. Bartoli, and M.H. Humphreys Receptors for atrial natriuretic peptide are decreased in the kidney of rats with streptozotocin-induced diabetes mellitus J Clin Invest 95 1995 2451 2457
88. G.L. Semenza Oxygen-regulated transcription factors and their role in pulmonary disease Respir Res 1 2000 159 162
89. G.L. Semenza HIF-1 and mechanisms of hypoxia sensing Curr Opin Cell Biol 13 2001 167 171
90. P.P. Shields, and C.C. Glembotski Regulation of atrial natriuretic factor-(99-126) secretion from neonatal rat primary atrial cultures by activators of protein kinases A and C J Biol Chem 264 1989 9322 9328
91. P.T. Stockman, D.H. Will, S.D. Sides, S.R. Brunnert, G.D. Wilner, and K.M. Leahy Reversible induction of right ventricular atriopeptin synthesis in hypertrophy due to hypoxia Circ Res 63 1988 207 213
92. T. Sudoh, K. Kangawa, N. Minamino, and H. Matsuo A new natriuretic peptide in porcine brain Nature 332 1988 78 81
93. T. Sudoh, N. Minamino, K. Kangawa, and H. Matsuo C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain Biochem Biophys Res Commun 168 1990 863 870
94. S. Suga, K. Nakao, K. Hosoda, M. Mukoyama, Y. Ogawa, and G. Shirakami Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide and C-type natriuretic peptide Endocrinology 130 1992 229 239
95. S. Suga, K. Nakao, I. Kishimoto, K. Hosoda, M. Mukoyama, and H. Arai Phenotype-related alteration in expression of natriuretic peptide receptors in aortic smooth muscle cells Circ Res 71 1992 34 39
96. J.Z. Sun, S.J. Chen, G. Li, and Y.-F. Chen Hypoxia reduces atrial natriuretic peptide clearance receptor gene expression in ANP knockout mice Am J Physiol 279 2000 L511 L519
97. J.Z. Sun, S. Oparil, P. Lucchesi, J.A. Thompson, and Y.-F. Chen Tyrosine kinase receptor activation inhibits NPR-C in lung arterial smooth muscle cells Am J Physiol 281 2001 L155 L163
98. J.Z. Sun, S.J. Chen, E. Majid-Hasan, S. Oparil, and Y.-F. Chen Dietary salt supplementation selectively downregulates NPR-C receptor expression in kidney independently of ANP Am J Physiol 282 2002 F220 F227
99. S.D. Sun, J. Durand, Y.-F. Chen, and S. Oparil Hypoxia decreases atrial natriuretic peptide clearance receptor gene expression in pulmonary vascular smooth muscle cells in situ J Invest Med 44 1996 78A
100. + exchange inhibitor, inhibits the mitochondrial death pathway Circulation 108 2003 2275 2281
101. G.J. Trachte Physiology of the clearance receptor W.K. Samson E.R. Levin Natriuretic peptides in health and disease 1997 Humana Press New Jersey 259 274
102. D. Villarreal, and R.H. Freeman Natriuretic peptides and salt sensitivity W.K. Samson E.R. Levin Natriuretic peptides in health and disease 1997 Humana Press New Jersey 239 258
103. D. Wang, S. Oparil, J.A. Feng, P. Li, G.J. Perry, and L.B. Chen Effects of pressure overload on extracellular matrix expression in heart of the atrial natriuretic peptide null mice Hypertension 42 2003 88 95
104. E.K. Weir, and J.T. Reeves Pulmonary hypertension 1st ed. 1984 Futura Publishing Company New York
105. E.O. Weselcouch, W.R. Humphrey, and J.W. Aiken Effect of pulmonary and renal circulations on activity of atrial natriuretic peptide Am J Physiol 249 1985 R595 R602
106. R.J.D. Winter, L. Zhao, T. Krausz, and J.M.B. Hughes Neutral endopeptidase 24.11 inhibition reduces pulmonary vascular remodeling in rats exposed to chronic hypoxia Am Rev Respir Dis 144 1991 1342 1346
107. T. Yoshimoto, M. Naruse, K. Naruse, K. Arai, T. Imaki, and A. Tanabe Vascular action of circulating and local natriuretic peptide systems in potentiated in obese/hyperglycemic and hypertensive rats Endocrinology 137 1996 5552 5557
108. L. Zhao, L. Long, N.W. Morrell, and M.R. Wilkins NPR-A-deficient mice show increased susceptibility to hypoxia-induced pulmonary hypertension Circulation 99 1999 605 607