Down-regulation of DNA polymerase β accompanies somatic hypermutation in human BL2 cell lines

DNA Repair

Volumn 6, Issue 2, 2007, Pages 244-253

  Poltoratsky, Vladimir ^a   Prasad, Rajendra ^a   Horton, Julie K ^a   Wilson, Samuel H ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Activation induced cytidine deaminase; B lymphocytes; Base excision repair; DNA polymerase ; Mutagenesis; Somatic hypermutation

Indexed keywords

DNA DIRECTED DNA POLYMERASE BETA;

ARTICLE; BURKITT LYMPHOMA; CELL CLONE; CELL LINE; CONTROLLED STUDY; DNA REPAIR; DOWN REGULATION; EXCISION REPAIR; HUMAN; HUMAN CELL; HYPOTHESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOMATIC HYPERMUTATION;

ADULT; BASE SEQUENCE; CELL LINE; DNA POLYMERASE BETA; DNA REPAIR; DOWN-REGULATION; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOHISTOCHEMISTRY; MALE; MUTAGENESIS; OLIGODEOXYRIBONUCLEOTIDES; RECOMBINANT PROTEINS; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN; SUBSTRATE SPECIFICITY; TONSIL;

MAMMALIA;

EID: 33846090113     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2006.10.003     Document Type: Article

References (42)

1. Weigert M.G., Cesari I.M., Yonkovich S.J., and Cohn M. Variability in the lambda light chain sequences of mouse antibody. Nature 228 (1970) 1045-1047
2. Harris R.S., Kong Q., and Maizels N. Somatic hypermutation and the three R's: repair, replication and recombination. Mutat. Res. 436 (1999) 157-178
3. Poltoratsky V., Goodman M.F., and Scharff M.D. Error-prone candidates vie for somatic mutation. J. Exp. Med. 192 (2000) F27-F30
4. Petersen-Mahrt S.K., Harris R.S., and Neuberger M.S. AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature 418 (2002) 99-103
5. Longerich S., Basu U., Alt F., and Storb U. AID in somatic hypermutation and class switch recombination. Curr. Opin. Immunol. 18 (2006) 164-174
6. Wilson S.H., Sobol R.W., Beard W.A., Horton J.K., Prasad R., and Vande Berg B.J. DNA polymerase β and mammalian base excision repair. Cold Spring Harb. Symp. Quant. Biol. 65 (2000) 143-155
7. Matsuda T., Vande Berg B.J., Bebenek K., Osheroff W.P., Wilson S.H., and Kunkel T.A. The base substitution fidelity of DNA polymerase β-dependent single nucleotide base excision repair. J. Biol. Chem. 278 (2003) 25947-25951
8. Esposito G., Texido G., Betz U.A., Gu H., Muller W., Klein U., and Rajewsky K. Mice reconstituted with DNA polymerase β-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 1166-1171
9. Masuda K., Ouchida R., Takeuchi A., Saito T., Koseki H., Kawamura K., Tagawa M., Tokuhisa T., Azuma T., and OW. J. DNA polymerase θ contributes to the generation of C/G mutations during somatic hypermutation of Ig genes. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 13986-13991
10. Zeng X., Winter D.B., Kasmer C., Kraemer K.H., Lehmann A.R., and Gearhart P.J. DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Nat. Immunol. 2 (2001) 537-541
11. Rada C., Williams G.T., Nilsen H., Barnes D.E., Lindahl T., and Neuberger M.S. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr. Biol. 12 (2002) 1748-1755
12. Sobol R.W., Watson D.E., Nakamura J., Yakes F.M., Hou E., Horton J.K., Ladapo J., Van Houten B., Swenberg J.A., Tindall K.R., Samson L.D., and Wilson S.H. Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 6860-6865
13. Poltoratsky V., Horton J.K., Prasad R., and Wilson S.H. REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast. DNA Repair (Amst) 4 (2005) 1182-1188
14. Denepoux S., Fournier N., Peronne C., Banchereau J., and Lebecque S. T cells can induce somatic mutation in B cell receptor-engaged BL2 Burkitt's lymphoma cells independently of CD40-CD40 ligand interactions. J. Immunol. 164 (2000) 1306-1313
15. Denepoux S., Razanajaona D., Blanchard D., Meffre G., Capra J.D., Banchereau J., and Lebecque S. Induction of somatic mutation in a human B cell line in vitro. Immunity 6 (1997) 35-46
16. Poltoratsky V., Woo C.J., Tippin B., Martin A., Goodman M.F., and Scharff M.D. Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 7976-7981
17. Sobol R.W., Horton J.K., Kuhn R., Gu H., Singhal R.K., Prasad R., Rajewsky K., and Wilson S.H. Requirement of mammalian DNA polymerase-β in base-excision repair. Nature 379 (1996) 183-186
18. Srivastava D.K., Rawson T.Y., Showalter S.D., and Wilson S.H. Phorbol ester abrogates up-regulation of DNA polymerase β by DNA-alkylating agents in Chinese hamster ovary cells. J. Biol. Chem. 270 (1995) 16402-16408
19. Biade S., Sobol R.W., Wilson S.H., and Matsumoto Y. Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA. J. Biol. Chem. 273 (1998) 898-902
20. Wang M., Devereux T.R., Vikis H.G., McCulloch S.D., Holliday W., Anna C., Wang Y., Bebenek K., Kunkel T.A., Guan K., and You M. Pol ι is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. Cancer Res. 64 (2004) 1924-1931
21. Braithwaite E.K., Kedar P.S., Lan L., Polosina Y.Y., Asagoshi K., Poltoratsky V.P., Horton J.K., Miller H., Teebor G.W., Yasui A., and Wilson S.H. DNA polymerase λ protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair. J. Biol. Chem. 280 (2005) 31641-31647
22. Sobol R.W., Foley J.F., Nyska A., Davidson M.G., and Wilson S.H. Regulated over-expression of DNA polymerase β mediates early onset cataract in mice. DNA Repair (Amst) 2 (2003) 609-622
23. Faili A., Aoufouchi S., Gueranger Q., Zober C., Leon A., Bertocci B., Weill J.C., and Reynaud C.A. AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line. Nat. Immunol. 3 (2002) 815-821
24. Bebenek K., Tissier A., Frank E.G., McDonald J.P., Prasad R., Wilson S.H., Woodgate R., and Kunkel T.A. 5′-Deoxyribose phosphate lyase activity of human DNA polymerase ι in vitro. Science 291 (2001) 2156-2159
25. Singhal R.K., Prasad R., and Wilson S.H. DNA polymerase β conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract. J. Biol. Chem. 270 (1995) 949-957
26. Horton J.K., Joyce-Gray D.F., Pachkowski B.F., Swenberg J.A., and Wilson S.H. Hypersensitivity of DNA polymerase β null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions. DNA Repair (Amst) 2 (2003) 27-48
27. Grippo P., Geremia R., Locorotondo G., and Monesi V. DNA-dependent DNA polymerase species in male germ cells of the mouse. Cell Differ. 7 (1978) 237-248
28. Hübscher U., Kuenzle C.C., and Spadari S. Variation of DNA polymerases-α, -β, and γ during perinatal tissue growth and differentiation. Nucleic Acids Res. 4 (1977) 2917-2929
29. Jonason A.S., Baker S.M., and Sweasy J.B. Interaction of DNA polymerase β with GRIP1 during meiosis. Chromosoma 110 (2001) 402-410
30. Imai K., Slupphaug G., Lee W.I., Revy P., Nonoyama S., Catalan N., Yel L., Forveille M., Kavli B., Krokan H.E., Ochs H.D., Fischer A., and Durandy A. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nat. Immunol. 4 (2003) 1023-1028
31. Muramatsu M., Kinoshita K., Fagarasan S., Yamada S., Shinkai Y., and Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell 102 (2000) 553-563
32. Faili A., Aoufouchi S., Flatter E., Gueranger Q., Reynaud C.A., and Weill J.C. Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase ι. Nature 419 (2002) 944-947
33. Machida K., Cheng K.T., Sung V.M., Shimodaira S., Lindsay K.L., Levine A.M., Lai M.Y., and Lai M.M. Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes. Proc. Natl. Acad. Sci. U.S.A. 101 (2004) 4262-4267
34. Zan H., Shima N., Xu Z., Al-Qahtani A., Evinger Iii A.J., Zhong Y., Schimenti J.C., and Casali P. The translesion DNA polymerase θ plays a dominant role in immunoglobulin gene somatic hypermutation. EMBO J. 24 (2005) 3757-3769
35. Garcia-Diaz M., Bebenek K., Sabariegos R., Dominguez O., Rodriguez J., Kirchhoff T., Garcia-Palomero E., Picher A.J., Juarez R., Ruiz J.F., Kunkel T.A., and Blanco L. DNA polymerase λ, a novel DNA repair enzyme in human cells. J. Biol. Chem. 277 (2002) 13184-13191
36. Garcia-Diaz M., Bebenek K., Kunkel T.A., and Blanco L. Identification of an intrinsic 5′-deoxyribose-5-phosphate lyase activity in human DNA polymerase λ: a possible role in base excision repair. J. Biol. Chem. 276 (2001) 34659-34663
37. Matsumoto Y., and Kim K. Excision of deoxyribose phosphate residues by DNA polymerase β during DNA repair. Science 269 (1995) 699-702
38. Piersen C.E., Prasad R., Wilson S.H., and Lloyd R.S. Evidence for an imino intermediate in the DNA polymerase β deoxyribose phosphate excision reaction. J. Biol. Chem. 271 (1996) 17811-17815
39. Krokan H.E., Standal R., Bharati S., Otterlei M., Haug T., Slupphaug G., and Skorpen F. Uracil in DNA and the family of conserved uracil DNA glycosylases. In: Hickson I.D. (Ed). Base Excision Repair of DNA Damage (1997), Landes Bioscience, Austin, TX 7-30
40. Lindahl T. Instability and decay of the primary structure of DNA. Nature 362 (1993) 709-715
41. Johnson R.E., Washington M.T., Haracska L., Prakash S., and Prakash L. Eukaryotic polymerises ι and ζ act sequentially to bypass DNA lesions. Nature 406 (2000) 1015-1019
42. Tissier A., McDonald J.P., Frank E.G., and Woodgate R. polι, a remarkably error-prone human DNA polymerase. Genes Dev. 14 (2000) 1642-1650