Alzheimer's disease: An intracellular movement disorder?

Trends in Molecular Medicine

Volumn 11, Issue 9, 2005, Pages 391-393

  Zhu, Xiongwei ^a   Moreira, Paula I ^a,b   Smith, Mark A ^a   Perry, George ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; CYTOSKELETON; DISEASE COURSE; HUMAN; NERVE FIBER TRANSPORT; NONHUMAN; PATHOGENESIS; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW;

EID: 24344483065     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2005.07.002     Document Type: Short Survey

References (18)

1. S. Roy Axonal transport defects: a common theme in neurodegenerative diseases Acta Neuropathol. (Berl.) 109 2005 5 13
2. K. Suzuki, and R.D. Terry Fine structural localization of acid phosphatase in senile plaques in Alzheimer's presenile dementia Acta Neuropathol. (Berl.) 8 1967 276 284
3. G. Perry Neuropil threads of Alzheimer's disease show a marked alteration of the normal cytoskeleton J. Neurosci. 11 1991 1748 1755
4. D. Praprotnik Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease Acta Neuropathol. (Berl.) 91 1996 226 235
5. G.B. Stokin Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease Science 307 2005 1282 1288
6. N. Hirokawa, and R. Takemura Molecular motors and mechanisms of directional transport in neurons Nat. Rev. Neurosci. 6 2005 201 214
7. N. Sergeant Tau protein as a differential biomarker of tauopathies Biochim. Biophys. Acta 1739 2005 179 197
8. C.M. Dhaenens Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease Neurosci. Lett. 368 2004 290 292
9. S.S. Sisodia Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system J. Neurosci. 13 1993 3136 3142
10. A. Kamal Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP Nature 414 2001 643 648
11. J.D. Buxbaum Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path J. Neurosci. 18 1998 9629 9637
12. G. Pigino Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport J. Neurosci. 23 2003 4499 4508
13. A.D. Cash Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation Am. J. Pathol. 162 2003 1623 1627
14. P.J. Yao Defects in expression of genes related to synaptic vesicle trafficking in frontal cortex of Alzheimer's disease Neurobiol. Dis. 12 2003 97 109
15. M.A. Smith Arson. Tracking the culprit in Alzheimer's disease Ann. N. Y. Acad. Sci. 924 2000 35 38
16. V. Cavalli Sunday Driver links axonal transport to damage signaling J. Cell Biol. 168 2005 775 787
17. X. Zhu The role of mitogen-activated protein kinase pathways in Alzheimer's disease Neurosignals 11 2002 270 281
18. O. Lazarov Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited J. Neurosci. 25 2005 2386 2395