Mechanisms of trafficking in axons and dendrites: Implications for development and neurodegeneration

Progress in Neurobiology

Volumn 55, Issue 6, 1998, Pages 577-594

  Sheetz, Michael P ^a   Pfister, K Kevin ^b   Bulinski, J Chloe ^c   Cotman, Carl W ^d  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^c The New York Presbyterian Hospital   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; CELL INTERACTION; CELL MOTILITY; CYTOSKELETON; DENDRITE; NERVE CELL DEGENERATION; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVIEW;

EID: 0032144774     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(98)00021-5     Document Type: Article

References (138)

1. Ahmad F. J., Baas P. W. Microtubules released from the neuronal centrosome are transported into the axon. J. Cell Sci. 108:1995;2761-2769.
2. Ainger K., Avossa D., Morgan F., Hill S. J., Barry C., Barbarese E., Carson J. H. Transport and localization of exogenous myelin basic protein mRNA microinjected into oligodendrocytes. J. Cell Biol. 123:1993;431-441.
3. Aizawa H., Emori Y., Mirofushi H., Kawasaki H., Sakai H., Suzuki K. Molecular cloning of a ubiquitously distributed microtubule-associated protein with Mr 190 000. J. biol. Chem. 265:1990;13849-13855.
4. Aizawa H., Sekine Y., Takemura R., Zhang Z., Nangaku M., Hirowawa N. Kinesin family in murine central nervous system. J. Cell Biol. 119:1992;11287-11296.
5. Baas P. W. Microtubules and axonal growth. Curr. Opin. Cell Biol. 9:1997;29-36.
6. Baas P. W. The neuronal centrosome as a generator of microtubules for the axon. Curr. Top. Dev. Biol. 33:1997;281-298.
7. Baas P. W., Yu W. A composite model for establishing the microtubule arrays of the neuron. Molec. Neurol. 12:1996;145-161.
8. Baas P. W., Deitch J. S., Black M. M., Banker G. A. Polarity orientation of microtubules in hippocampal neurons: uniformity in the axon and nonuniformity in the dendrite. Proc. natl. Acad. Sci. U.S.A. 85:1988;8335-8339.
9. Barton N. R., Goldstein L. S. B. Going mobile: microtubule motors and chromosome segregation. Proc. natl. Acad. Sci. U.S.A. 93:1996;1735-1742.
10. Black M. M. Microtubule transport and assembly cooperate to generate the microtubule array of growing axons. Prog. Brain. Res. 102:1994;61-77.
11. Blocker A., Severin F. F., Burkhardt J. K., Bingham J. B., Yu H., Olivo J. C., Schroer T. A., Hyman A. A., Griffiths G. Molecular requirements for bi-directional movement of phagosomes along microtubules. J. Cell Biol. 137:1997;113-129.
12. Bloom G. S., Endow S. A. Motor proteins 1: kinesins. Protein Profiles. 2:1995;1109-1111.
13. Bloom G. S., Wagner M. C., Pfister K. K., Brady S. T. Native structure and physical properties of bovine brain kinesin and identification of the ATP-binding subunit polypeptide. Biochemistry. 27:1988;3409-3416.
14. Brady S. T. Molecular motors in the nervous system. Neuron. 7:1991;521-533.
15. Brady S. T., Sperry A. O. Biochemical and functional diversity of microtubule motors in the nervous system. Curr. Opin. Neurobiol. 5:1995;551-558.
16. Brady S. T., Lasek R. J., Allen R. D. Fast axonal transport in extruded axoplasm from squid giant axon. Science. 218:1982;1129-1131.
17. Bramblett G. T., Goedert M., Jakes R., Merrick S. E., Trojanowski J. Q., Lee V. M.-Y. Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron. 10:1993;1089-1099.
18. Bray J. J., Mills R. G. Transport complexes associated with slow axonal flow. Neurochem. Res. 16:1991;645-649.
19. Bulinski J. C., Borisy G. G. Self-assembly of HeLa tubulin and the identification of HeLa microtubule-associated proteins. Proc. natl. Acad. Sci. U.S.A. 76:1979;293-297.
20. Bulinski J. C., Borisy G. G. Widespread distribution of a 210 000 mol wt microtubule-associated protein in cells and tissues of primates. J. Cell Biol. 87:1980;802-808.
21. Bulinski, J. C., McGraw, T. E., Gruber, D., Nguyen, H. L. and Sheetz, M. P. (in press) Overexpression of MAP4 inhibits organelle motility and trafficking in vivo. J. Cell Sci.
22. Caceres A., Kosik K. S. Inhibition of neurite polarity by antisense oligonucleotides in primary cerebellar neurons. Nature. 343:1990;461-463.
23. Campenot B., Lund K., Senger D. L. Delivery of newly synthesized tubulin to rapidly growing distal axons of sympathetic neurons in compartmental cultures. J. Cell Biol. 135:1996;701-709.
24. Caporaso G. L., Takei K., Ggandy S. E., Matteoli M., Mundigl O., Greengard P., De Camilli P. Morphological and bioxhemical analysis of the intracellular trafficking of the Alzheimer's β/A4 amyloid precursor protein. J. Neurosci. 14:1994;3122-3138.
25. Chapin S., Bulinski J. C. Non-neuronal 210 kD microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of MAP2 and tau. J. Cell Sci. 98:1991;27-36.
26. Chapin S., Bulinski J. C. Microtubule stabilization by assembly promoting microtubule-associated proteins: a repeat performance. Cell Motil. Cytoskeleton. 4:1992;236-243.
27. Cleveland D. W., Hwo S.-Y., Kirschner M. W. Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. J. Molec. Biol. 116:1977;227-247.
28. Cotman C. W., Su J. H. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol. 6:1996;493-506.
29. Cotman, C. W., Cribbs, D. H. and Anderson, A. J. (1996) The β-amyloid Model of Alzheimer's disease. In: Molecular Mechanisms of Dementia, pp. 73-90. Eds. W. Wasco and R. E. Tanzi. Humana Press, Totowa, NJ.
30. Craig A. M., Banker G. Neuronal polarity. A. Rev. Neurosci. 17:1994;267-310.
31. Cribbs D. H., Davis-Salinas J., Cotman C. W., Van Nostrand W. E. Aβ induces increased expression and processing of amyloid precursor protein in cortical neurons. Alzheimer's Research. 1(4):1995;197-200.
32. Cribbs D. H., Kreng V. M., Anderson A. J., Cotman C. W. Crosslinking of concanavalin A receptors on cortical neurons induces programmed cell death. Neuroscience. 75:1996;173-185.
33. Cummings B. J., Cotman C. W. Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity. Lancet. 346:1995;1524-1528.
34. Cummings B. J., Su J. H., Geddes J. W., van Nostrand W. E., Wagner S. L., Cunningham D. D., Cotman C. W. Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience. 48(4):1992;763-777.
35. Dai J., Sheetz M. P. Axon membrane flows from the growth cone to the cell body. Cell. 83:1995;693-701.
36. Dillman J. F., Dabney L. P., Pfister K. K. Cytoplasmic dynein is associated with slow axonal transport. Proc. natl. Acad. Sci. U.S.A. 93:1996;141-144.
37. Dillman J. F., Dabney L. P., Karki S., Paschal B. M., Holzbaur E. L. F., Pfister K. K. Functional analysis of dynactin and cytoplasmic dynein in slow axonal transport. J. Neurosci. 16:1996;6742-6752.
38. Dinsmore J. H., Solomon F. Inhibition of MAP2 expression affects both morphological and cell division phenotypes of neuronal differentation. Cell. 64:1991;817-826.
39. Doll, T., Papandrikopoulou, A. and Matus, A. (1990) Nucleotide and amino acid sequences of embryonic rat MAP2c. Nucleic Acids Res. 18-361.
40. Doll T., Meichsner M., Riederer B. M., Honegger P., Matus A. An isoform of microtubule-associated protein 2 (MAP2) containing four repeats of the tubulin-binding motif. J. Cell Sci. 106:1993;633-640.
41. Drewes G., Ebneth A., Preuss U., Mandelkow E.-M., Mandelkow E. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell. 89:1997;297-308.
42. Fath K. R., Trimbur G. M., Burgess D. R. Molecular motors are differentially distributed on Golgi membranes from polarized epithelial cells. J. Cell Biol. 126:1994;661-675.
43. Ferralli J., Doll T., Matus A. Sequence analysis of MAP2 function in living cells. J. Cell Sci. 107:1994;3115-3125.
44. Ferreira A., Niclas J., Vale R. D., Banker G., Kosik K. Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides. J. Cell Biol. 117:1992;5959-5966.
45. Funakoshi T., Takeda S., Hirokawa N. Active transport of photoactivated tubulin molecules in growing axons revealed by a new electron microscopic analysis. J. Cell Biol. 133:1996;1347-1353.
46. Gho M., McDonald K., Ganetzky B., Saxton W. M. Effects of kinesin mutations on neuronal functions. Science. 258:1992;313-316.
47. Gibbons I. R. Cilia and flagella of eukaryotes. J. Cell Biol. 91:1981;107s-124s.
48. Goedert M., Jakes R. Expression of separate isoforms of tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J. 9:1990;4225-4230.
49. Goldstein L. S. B. With apologies to Scheherazade: tails of 1001 kinesin motors. A. Rev. Genet. 27:1993;3199-3351.
50. Grafstein B., Forman D. S. Intracellular transport in neurons. Physiol. Rev. 60:1980;1167-1283.
51. Gundersen G. G., Bulinski J. C. Stabilization and post-translational modification of microtubules during cellular morphogenesis. Bioessays. 13:1991;285-293.
52. Gundersen G. G., Khawaja S., Bulinski J. C. Generation of a stable, posttranslationally modified microtubule array is an early event in myogenic differentiation. J. Cell Biol. 109:1989;2275-2288.
53. Hammerschlag, R. and Brady, S. T. (1989) Axonal Transport and the Neuronal Cytoskeleton. In Basic Neurochemistry, pp. 457-478. Eds. G. J. Siegel, B. W. Agranoff, R. W. Albers and P. B. Molinoff. Raven Press, New York.
54. Harada A., Oguchi K., Okabe S., Kuno J., Terada S., Ohshima T., Sato-Yoshitake R., Takei Y., Noda T., Hirokawa N. Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature. 369:1994;488-491.
55. Heidemann S. R., Kanders J. M., Hamborg M. A. Polarity orientation of axonal microtubules. J. Cell Biol. 91:1981;661-665.
56. Hirokawa N. Axonal transport and the cytoskeleton. Curr. Opin. Neurobiol. 3:1993;724-731.
57. Hirokawa N., Pfister K. K., Yorifuji H., Wagner M. C., Brady S. T., Bloom G. S. Submolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration. Cell. 56:1989;867-878.
58. Hirokawa N., Sato-Yoshitake R., Kobayashi N., Pfister K. K., Bloom G. S., Brady S. T. Kinesin associates with anterogradely transported membranous organelles in vivo. J. Cell Biol. 114:1991;295-302.
59. Holleran E. A., Tokito M. K., Karki S., Holzbaur E. L. F. Centractin (ARP1) associates with spectrin revealing a potential mechanism to link dynactin to intracellular organelles. J. Cell Biol. 135:1996;1815-1829.
60. Holzbaur E. L., Vallee R. B. Dyneins: molecular structure and cellular function. A. Rev. Cell Biol. 10:1994;339-372.
61. Huber G., Matus A. Microtubule-associated protein 3 (MAP3) expression in non-neuronal tissues. J. Cell Sci. 95:1990;237-246.
62. Hurd D. D., Stern M., Saxton W. M. Mutation of the axonal transport motor kinesin enhances paralytic and suppresses Shaker in Drosophila. Genetics. 142:1996;195-204.
63. Kanai Y., Takemura R., Oshima T., Mori H., Ihara Y., Yanangisawa M., Masaki T., Hirokawa N. Expression of multiple isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA. J. Cell Biol. 109:1989;1173-1184.
64. Karki S., Holzbaur E. L. Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex. J. biol. Chem. 270:1995;28806-28811.
65. Keating T. J., Peloquin J. G., Rodionov V. I., Momcilovic D., Borisy G. G. Microtubule release from the centrosome. Proc. natl. Acad. Sci. U.S.A. 94:1997;5078-5083.
66. Khawaja S., Gundersen G. G., Bulinski J. C. Enhanced stability of microtubules enriched in detyrosinated tubulin is not a direct function of detyrosination level. J. Cell Biol. 106:1988;141-149.
67. King S. M., Barbarese E., Dillman J. F., Patel-King R. S., Carson J. H., Pfister K. K. Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved Mr 8,000 light chain. J. biol. Chem. 271:1996;19358-19366.
68. King S. M., Dillman J. F., Benashski S. E., Lye R. J., Patel-King R. S., Pfister K. K. The mouse t-complex-encoded protein tctex-1 is a light chain of cytoplasmic dynein. J. biol. Chem. 271:1996;32281-32287.
69. Knowles R. B., Sabry J. H., Martone M. E., Deerinck T. J., Ellisman M. H., Bassell G. J., Kosik K. S. Translocation of RNA granules in living neurons. J. Neurosci. 16:1996;7812-7820.
70. Kondo S., Sato-Yoshitake R., Noda Y., Aizawa H., Nakata T., Matsuura Y., Hirokawa N. KIF3A is a new microtubule-based anterograde motor in the nerve axon. J. Cell Biol. 125:1994;1095-1107.
71. Koo E. H., Sisodia S. S., Archer D. A., Martin L. J., Wiedemann A., Beyreuther K., Masters C. L., Price D. L. Precursor of amyloid precursoe protein in Alzheiemr's disease undergoes fast anterograde axonal transport. Proc. natl. Acad. Sci. U.S.A. 87:1990;1561-1565.
72. Kumar J., Yu H., Sheetz M. P. Kinectin, an essential anchor for kinesin-driven vesicle motility. Science. 267:1995;1834-1837.
73. Kuriyama R., Kofron M., Essner R., Kato T., Dragas-Granoic S., Omoto C. K., Khodjakov A. Characterization of a minus end-directed kinesin-like motor protein from cultured mammalian cells. J. Cell Biol. 129:1995;1049-1059.
74. Langkopf A., Hammarback J. A., Muller R., Vallee R. B., Garner C. C. Microtubule-associated proteins 1A and LC2. Two proteins encoded in one messenger RNA. J. biol. Chem. 267:1992;16561-16566.
75. Lasek R. J. Polymer sliding in axons. J. Cell Sci. 5s:1986;161-179.
76. Lasek R. J., Garner J. A., Brady S. T. Axonal transport of the cytoplasmic matrix. J. Cell Biol. 99:1984;212s-221s.
77. Lee G., Rook S. L. Expression of tau protein in non-neuronal cells: microtubule binding and stabilization. J. Cell Sci. 102:1992;227-237.
78. Levine J., Willard M. Fodrin: axonally transported polypeptides associated with the internal periphery of many cells. J. Cell Biol. 90:1981;631-643.
79. Lewis, S. A., Ivanov, I. F., Lee, G. H. and Cowan, N. J. (1989) Organization of microtubules in dendrites and axons is determined by a short hydrophobic zipper in microtubule-associated proteins MAP2 and tau. Nature 342, 498-505 [Lewis, S. A. and Cowan, N. J. (correction) (1990) Nature 345, 674].
80. Lewis, S. A., Ivanov, I. F., Lee, G. H. and Cowan, N. J. (1989) Organization of microtubules in dendrites and axons is determined by a short hydrophobic zipper in microtubule-associated proteins MAP2 and tau. Nature 342, 498-505 [Lewis, S. A. and Cowan, N. J. (correction) (1990) Nature 345, 674].
81. Lin S. X., Pfister K. K., Collins C. A. Comparison of the intracellular distribution of cytoplasmic dynein and kinesin in cultured cells: motor protein location does not reliably predict function. Cell Motil. Cytoskel. 34:1996;299-312.
82. Loo D. T., Copani A. G., Pike C. J., Whittemore E. R., Walencewicz A. J., Cotman C. W. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc. natl. Acad. Sci. U.S.A. 90:1993;7951-7955.
83. Lopez L., Sheetz M. P. Steric inhibition of cytoplasmic dynein and kinesin motility by MAP2. Cell Motil. Cytoskel. 24:1993;1-16.
84. Lopez L., Sheetz M. P. A microtubule-associated protein (MAP2) kinase restores microtubule motility in embryonic brain. J. biol. Chem. 270:1995;12511-12517.
85. Lye R. J., Porter M. E., Scholey J. M., McIntosh J. R. Identification of a microtubule-based cytoplasmic motor in the nematode C. elegans. Cell. 51:1987;309-318.
86. Mattson M., Barger S., Cheng B., Lieberburg I., Smith-Swintosky V., Rydel R. β-amyloid precursor protein metabolites and loss of neuronal Ca++ homeostasis is Alzheimer's disease. TINS. 16:1993;409-414.
87. McGrail M., Gepner J., Silvanovich A., Ludman S., Serr M., Hays T. S. Regulation of cytoplasmic dynein function in vivo by the Drosophila Glued complex. J. Cell Biol. 131:1995;411-425.
88. McQuarrie I. G., Brady S. T., Lasek R. J. Diversity in the axonal transport of structural proteins: major differences between optic and spinal axons in the rat. J. Neurosci. 6:1986;1593-1605.
89. Miller K. E., Joshi H. C. Tubulin transport in neurons. J. Cell Biol. 133:1996;1355-1366.
90. Murphy D. B., Borisy G. G. Association of high molecular weight proteins with microtubules and their role in microtubule assembly in vitro. Proc. natl. Acad. Sci. U.S.A. 72:1975;2696-2700.
91. Nangaku M., Sato-Yoshitake R., Okada Y., Noda Y., Takemura R., Yamazaki H., Hirokawa N. KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell. 79:1994;1209-1220.
92. Nguyen L., Chari S., Lue C.-M., Gruber D., Chapin S., Bulinski J. C. Overexpression of full- or partial-length MAP4 stabilizes microtubules and alters cell growth. J. Cell Sci. 110:1997;281-294.
93. Nislow C., Lombillo V. A., Kuriyama R., McIntosh J. R. A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles. Nature. 359:1992;543-547.
94. Okada Y., Sato-Yoshitake R., Hirokawa N. The activation of protein kinase A pathway selectively inhibits anterograde axonal transport of vesicles but not mitochondria transport or retrograde transport in vivo. J. Neurosci. 15:1995;3053-3064.
95. Ookata K., Hisanaga S., Bulinski J. C., Murofushi H., Aizawa H., Itoh T., Hotani H., Okumura E., Tachibana K., Kishimoto T. Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics. J. Cell Biol. 128:1995;849-862.
96. Parysek L. M., Asnes C. F., Olmsted J. B. MAP4: occurrence in mouse tissues. J. Cell Biol. 99:1984;1309-1315.
97. Paschal B. M., Shpetner H. S., Vallee R. B. MAP 1C is a microtubule-activated ATPase which translocates microtubules in vitro and has dynein-like properties. J. Cell Biol. 105:1987;1273-1282.
98. Pearson R. C. A., Esiri M. M., Hioms R. W., Witlock G. K. P. Anatomical Correlates of the distribution of the pathological changes in the Neocortex in Alzheimer's disease. Proc. natl. Acad. Sci. U.S.A. 82:1985;4531-4534.
99. Pike C. J., Walencewicz A. J., Glabe C. G., Cotman C. W. In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 563:1992;311-314.
100. Pike C. J., Cummings B. J., Cotman C. W. β-amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology. Neuroreport. 3:1992;769-772.
101. Redenbach D. A., Vogl A. W. Microtubule polarity in Sertoli cells: a model for microtubule-based spermatid transport. Eur. J. Cell Biol. 54:1991;277-290.
102. Riederer B., Matus A. Differential expression of distinct microtubule-associated proteins during brain development. Proc. natl. Acad. Sci. U.S.A. 82:1985;6006-6009.
103. Saito N., Okada Y., Noda Y., Kinoshita Y., Kondo S., Hirokawa N. KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles. Neuron. 18:1997;425-438.
104. Saper C. B., Wainer B. H., German D. C. Axonal and transbeuronal transport in the transmission of neurological disease: potential role in systems degeneration including Alzheimer's disease. Neuroscience. 23:1987;389-398.
105. Saxton W. M., Stemple D. L., Leslie R. J., Salmon E. D., Zavortink M., McIntosh J. R. Tubulin dynamics in cultured mammalian cells. J. Cell Biol. 99:1984;2175-2186.
106. Schafer D. A., Gill S. R., Cooper J. A., Heuser J. E., Schroer T. A. Ultrastructural analysis of the dynactin complex: an actin-related protein is a component of a filament that resembles F-actin. J. Cell Biol. 126:1994;403-412.
107. Schroer T. A. New insights into the interaction of cytoplasmic dynein with the actin-related protein, Arp1. J. Cell Biol. 127:1994;1-4.
108. Schroer T. A., Steuer E. R., Sheetz M. P. Cytoplasmic dynein is a minus end-directed motor for membranous organelles. Cell. 56:1989;937-946.
109. Schulze E., Kirschner M. Dynamic and stable populations of microtubules in cells. J. Cell Biol. 104:1987;277-288.
110. Sharp D. J., Yu W., Baas P. W. Transport of dendritic microtubules establishes their nonuniform polarity orientation. J. Cell Biol. 130:1995;93-103.
111. Sharp D. J., Kuriyama R., Baas P. W. Expression of kinesin-related motor protein induces Sf9 cells to form dendrite-like processes with nonuniform microtubule polarity orientation. J. Neurosci. 16:1996;4375.
112. Sheetz M. P., Yu H. Regulation of kinesin and cytoplasmic dynein-driven organelle motility. Semin. Cell Dev. Biol. 7:1996;329-334.
113. Simons M., Ikonen E., Tienari P. J., Cid-Arregui A., Mönning U., Beyreuther K., Dotti C. G. Intracellular routing of human amyloid precursor axonal delivery followed by transport to the dendrites. J. Neurosci. Res. 41:1995;121-128.
114. Steffen W., Hodgkinson J. L., Wiche G. Immunogold localization of the intermediate chain within the protein complex of cytoplasmic dynein. J. Struct. Biol. 117:1996;227-235.
115. Storey E., Beyreuther K., Masters C. L. Alzheimer's disease amyloid precursor protein on the surface of corticaö neurons in primary culture co-localizes with adhesion patch components. Brain Res. 735:1996;217-231.
116. Strasser A. Apoptosis. Death of a T cell [news; comment]. Nature. 373:1995;385-386.
117. Terasaki M., Schmidek A., Galbraith J. A., Gallant P. E., Reese T. S. Transport of cytoskeletal elements in the squid giant axon. Proc. natl. Acad. Sci. U.S.A. 92:1995;11500-11503.
118. Tienari P. J., De strooper B., Ikonen E., Simons M., Weidemann A., Czech C., Hartmann T., Ida N., Multhaup G., Masters C. L., Van Leuven F., Beyreuther K., Dotti C. G. The β-amyloid domain is essential for axonal sorting of amyloid precursor protein. EMBO J. 15(19):1996;5218-5229.
119. Tokito M. K., Howland D. S., Lee V. M., Holzbaur E. L. Functionally distinct isoforms of dynactin are expressed in human neurons. Molec. biol. Cell. 7:1996;1167-1180.
120. Toyoshima I., Sheetz M. P. Kinectin distribution in chicken nervous system. Neurosci. Lett. 211:1996;1-4.
121. Toyoshima I., Yu H., Steuer E. R., Sheetz M. P. Kinectin, a major kinesin-binding protein on ER. J. Cell Biol. 118:1992;1121-1131.
122. Vale R. D., Reese T. S., Sheetz M. P. Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Cell. 42:1985;39-50.
123. Vale R. D., Schnapp B. J., Mitchison T., Steuer E., Reese T. S., Sheetz M. P. Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro. Cell. 43:1985;623-632.
124. Vallee R. B., Sheetz M. P. Targeting of motor proteins. Science. 271:1996;1539-1544.
125. Vandré D. D., Centonze V. E., Peloquin J., Tombes R. M., Borisy G. G. Proteins of the mammalian mitotic spindle: phosphorylation/dephosphorylation of MAP4 during mitosis. J. Cell Sci. 98:1991;577-588.
126. Vaughan K. T., Vallee R. B. Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150glued. J. Cell Biol. 131:1995;1507-1516.
127. Wang X. M., Peloquin J. J., Zhai Y., Bulinski J. C., Borisy G. G. Removal of MAP4 from microtubules in vivo produces no discernible phenotype at the cellular level. J. Cell Biol. 132:1996;349-358.
128. Wang Z., Khan S., Sheetz M. P. Single cytoplasmic dynein molecule movements: characterization and comparison with kinesin. Biophys. J. 69:1995;2011-2023.
129. Waterman-Storer C. M., Karki S., Holzbaur E. L. The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). Proc. natl. Acad. Sci. U.S.A. 92:1995;1634-1638.
130. Wehland J., Weber K. Turnover of the carboxy-terminal tyrosine of alpha-tubulin and means of reaching elevated levels of detyrosination in living cells. J. Cell Sci. 88:1987;185-193.
131. West R. R., Tenbarge K. M., Olmsted J. B. A model for microtubule-associated protein 4 structure. J. biol. Chem. 266:1991;21886-21896.
132. Whitson J. S., Glabe C. G., Shitani E., Abcar A., Cotman C. W. β-amyloid protein promotes neuritic branching in hippocampal cultures. Neurosci. Lett. 110:1990;319-324.
133. Witman G. B. Axonemal dyneins. Curr. Opin. Cell Biol. 4:1992;74-79.
134. Yamazaki T., Selkoe D. J., Koo E. H. Trafficking of cell surface β-amyloid precursor protein: retrograge and transcyotic transport in cultured neurons. J. Cell Biol. 129:1995;431-442.
135. Yu H., Toyoshima I., Steuer E. R., Sheetz M. P. Kinesin and cytoplasmic dynein binding to brain microsomes. J. biol. Chem. 267:1992;20457-20464.
136. Yu W., Schwei M. J., Baas P. W. Microtubule transport and assembly during growth. J. Cell Biol. 133:1996;151-157.
137. Yu W., Sharp D. J., Kuriyama R., Mallik P., Baas P. W. Inhibition of a mitotic motor compromises the formation of dendrite-like processes from neuroblastoma cells. J. Cell Biol. 136:1997;659-668.
138. Zhai Y., Borisy G. G. Quantitative determination of the proportion of microtubule polymer present during the mitosis-interphase transition. J. Cell Sci. 107:1994;881-890.