Prediction of species differences (rats, dogs, humans) in the in vivo metabolic clearance of YM796 by the liver from in vitro data

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 2, 1997, Pages 462-469

  Iwatsubo, Takafumi ^a   Suzuki, Hiroshi ^b   Sugiyama, Yuichi ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2,8 DIMETHYL 3 METHYLENE 1 OXA 8 AZASPIRO[4.5]DECANE; NOOTROPIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; DEMENTIA; DOG; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG METABOLISM; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

ANIMALS; DEMENTIA; DOGS; HUMANS; INTESTINE, SMALL; LIVER; MALE; METABOLIC CLEARANCE RATE; PARASYMPATHOMIMETICS; RATS; RATS, INBRED F344; SPECIES SPECIFICITY; SPIRO COMPOUNDS;

EID: 0030781510     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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