Survivin identifies keratinocyte stem cells and is downregulated by anti-β1 integrin during anoikis

Stem Cells

Volumn 25, Issue 1, 2007, Pages 149-155

  Marconi, Alessandra ^a   Dallaglio, Katiuscia ^a   Lotti, Roberta ^a   Vaschieri, Cristina ^a   Truzzi, Francesca ^a   Fantini, Fabrizio ^a   Pincelli, Carlo ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Anoikis; Keratinocytes; Stem cells; Survivin

Indexed keywords

ANTIBODY; BETA1 INTEGRIN; BETA1 INTEGRIN ANTIBODY; ISOPROTEIN; PROTEIN SURVIVIN 2ALPHA; PROTEIN SURVIVIN 2B; PROTEIN SURVIVIN 3B; PROTEIN SURVIVIN DELTAEX3; SURVIVIN; UNCLASSIFIED DRUG;

ANOIKIS; ARTICLE; CELL NUCLEUS; CELL PROLIFERATION; CELL SUBPOPULATION; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; HUMAN; HUMAN CELL; KERATINOCYTE; KERATINOCYTE STEM CELL; MITOSIS; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN VARIANT; REAL TIME POLYMERASE CHAIN REACTION; STEM CELL;

ANOIKIS; ANTIBODIES; ANTIGENS, CD29; BASE SEQUENCE; CELLS, CULTURED; DNA PRIMERS; EXONS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; INTRONS; KERATINOCYTES; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS;

EID: 33845979791     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2006-0165     Document Type: Article

References (40)

1. Li F. Survivin study: What is the next wave? J Cell Physiol 2003;197:8-29.
2. Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 1997;3:917-921.
3. Mahotka C, Wenzel M, Springer E et al. Survivin-deltaEx3 and survivin-2B: Two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. Cancer Res 1999;59:6097-6102.
4. Caldas H, Honsey LE, Altura RA. Survivin 2alpha: A novel Survivin splice variant expressed in human malignancies. Mol Cancer 2005;4:11.
5. Badran A, Yoshida A, Ishikawa K et al. Identification of a novel splice variant of the human anti-apoptopsis gene survivin. Biochem Biophys Res Commun 2004;314:902-907.
6. Xing Z, Conway EM, Kang C et al. Essential role of survivin, an inhibitor of apoptosis protein, in T cell development, maturation, and homeostasis. J Exp Med 2004;199:69-80.
7. Grossman D, Kim PJ, Blanc-Brude OP et al. Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53. J Clin Invest 2001;108:991-999.
8. Dohi T, Okada K, Xia F et al. An IAP-IAP complex inhibits apoptosis. J Biol Chem 2004;279:34087-34090.
9. Dohi T, Beltrami E, Wall NR et al. Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis. J Clin Invest 2004;114:1117-1127.
10. Li F, Ambrosini G, Chu EY et al. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998;396:580-584.
11. Altieri DC. Survivin in apoptosis control and cell cycle regulation in cancer. Prog Cell Cycle Res 2003;5:447-452.
12. Adida C, Crotty PL, McGrath J et al. Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. Am J Pathol 1998;152:43-49.
13. Chiodino C, Cesinaro AM, Ottani D et al. Communication: Expression of the novel inhibitor of apoptosis survivin in normal and neoplastic skin. J Invest Dermatol 1999;113:415-418.
14. Lajtha LG. Haemopoietic stem cells: Concept and definitions. Blood Cells 1979;5:447-455.
15. Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994;124:619-626.
16. Tiberio R, Marconi A, Fila C et al. Keratinocytes enriched for stem cells are protected from anoikis via an integrin signaling pathway in a Bcl-2 dependent manner. FEBS Lett 2002;524:139-144.
17. Marconi A, Atzei P, Panza C et al. FLICE/caspase-8 activation triggers anoikis induced by beta1-integrin blockade in human keratinocytes. J Cell Sci 2004;117:5815-5823.
18. Escaffit F, Perreault N, Jean D et al. Repressed E-cadherin expression in the lower crypt of human small intestine: A cell marker of functional relevance. Exp Cell Res 2005;302:206-220.
19. Janes SM, Watt FM. Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis. J Cell Biol 2004;166:419-431.
20. Zhang Y, Lu H, Dazin P et al. Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: Fibronectin and integrin alphav mediate survival signals through focal adhesion kinase. J Biol Chem 2004;279:48342-48349.
21. Pincelli C, Haake AR, Benassi L et al. Autocrine nerve growth factor protects human keratinocytes from apoptosis through its high affinity receptor (TRK): A role for BCL-2. J Invest Dermatol 1997;109:757-764.
22. Fortugno P, Wall NR, Giodini A et al. Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J Cell Sci 2002;115:575-585.
23. Grossman D, McNiff JM, Li F et al. Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line. Lab Invest 1999;79:1121-1126.
24. Bowen AR, Hanks AN, Murphy KJ et al. Proliferation, apoptosis, and survivin expression in keratinocytic neoplasms and hyperplasias. Am J Dermatopathol 2004;26:177-181.
25. Aziz MH, Ghotra AS, Shukla Y et al. Ultraviolet-B radiation causes an upregulation of survivin in human keratinocytes and mouse skin. Photochem Photobiol 2004;80:602-608.
26. Jones PH, Watt FM. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 1993;73:713-724.
27. Suzuki A, Hayashida M, Ito T et al. Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activation. Oncogene 2000;19:3225-3234.
28. Zhang T, Otevrel T, Gao Z et al. Evidence that APC regulates survivin expression: A possible mechanism contributing to the stem cell origin of colon cancer. Cancer Res 2001;61:8664-8667.
29. Konno R, Yamakawa H, Utsunomiya H et al. Expression of survivin and Bcl-2 in the normal human endometrium. Mol Hum Reprod 2000;6:529-534.
30. Jones PH, Harper S, Watt FM. Stem cell patterning and fate in human epidermis. Cell 1995;80:83-93.
31. Pellegrini G, Dellambra E, Golisano O et al. p63 identifies keratinocyte stem cells. Proc Natl Acad Sci U S A 2001;98:3156-3161.
32. Islam A, Kageyama H, Hashizume K et al. Role of survivin, whose gene is mapped to 17q25, in human neuroblastoma and identification of a novel dominant-negative isoform, survivin-beta/2B. Med Pediatr Oncol 2000;35:550-553.
33. Li F. Role of survivin and its splice variants in tumorigenesis. Br J Cancer 2005;92:212-216.
34. Reed JC. The Survivin saga goes in vivo. J Clin Invest 2001;108:965-969.
35. O'Connor DS, Grossman D, Plescia J et al. Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc Natl Acad Sci U S A 2000;97:13103-13107.
36. Fukuda S, Foster RG, Porter SB et al. The antiapoptosis protein survivin is associated with cell cycle entry of normal cord blood CD34(+) cells and modulates cell cycle and proliferation of mouse hematopoietic progenitor cells. Blood 2002;100:2463-2471.
37. Hassounah M, Lach B, Allam A et al. Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis. J Neurooncol 2005;72:203-208.
38. Morris RJ. A perspective on keratinocyte stem cells as targets for skin carcinogenesis. Differentiation 2004;72:381-386.
39. Wang LH. Molecular signaling regulating anchorage-independent growth of cancer cells. Mt Sinai J Med 2004;71:361-367.
40. Kurata S, Okuyama T, Osada M et al. p51/p63 controls subunit alpha3 of the major epidermis integrin anchoring the stem cells to the niche. J Biol Chem 2004;279:50069-50077.