Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis

Journal of Neuro-Oncology

Volumn 72, Issue 3, 2005, Pages 203-208

  Hassounah, Maher ^a   Lach, Boleslaw ^b   Allam, Ayman ^a   Al Khalaf, Huda ^a   Siddiqui, Yunus ^a   Pangue Cruz, Nancy ^a   Al Omeir, Abeer ^a   Al Ahdal, Mohammed N ^a   Aboussekhra, Abdelilah ^a,b  

^a Department of Neurosciences ^*  (Saudi Arabia)

^b KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

Author keywords

Apoptosis; Benign tumors; Gamma rays; Nervous system; Survivin; UV light

Indexed keywords

PROTEIN P21; PROTEIN P53; SURVIVIN;

ADOLESCENT; ADULT; APOPTOSIS; ARTICLE; ASTROCYTOMA; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; EPENDYMOMA; FEMALE; FLOW CYTOMETRY; GENE OVEREXPRESSION; HOST CELL; HUMAN; HUMAN CELL; HYPOPHYSIS ADENOMA; IMMUNOBLOTTING; MALE; MENINGIOMA; NERVOUS SYSTEM TUMOR; NEURILEMOMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRESCHOOL CHILD; TUMOR CELL LINE; ULTRAVIOLET RADIATION;

APOPTOSIS; CELL LINE, TUMOR; DNA DAMAGE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLOW CYTOMETRY; GAMMA RAYS; GENES, P53; HUMANS; IMMUNOBLOTTING; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; NERVOUS SYSTEM NEOPLASMS; ONCOGENE PROTEIN P21(RAS); TUMOR CELLS, CULTURED; ULTRAVIOLET RAYS;

EID: 20944450197     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11060-004-2397-4     Document Type: Article

References (20)

1. D Hanahan RA Weinberg 2000 The hallmarks of cancer Cell 100 57-70 1:CAS:528:DC%2BD3cXks1CktA%3D%3D 10647931
2. RW Johnstone AA Ruefli SW Lowe 2002 Apoptosis: A link between cancer genetics and chemotherapy Cell 108 153-164 10.1016/S0092-8674(02)00625-6 1:CAS:528:DC%2BD38XhtV2hsLk%3D 11832206
3. F Li G Ambrosini E Chu J Plescia S Tognin PC Marchisio DC Altieri 1998 Control of apoptosis and mitotic spindle checkpoint by survivin Nature 396 580-584 10.1038/25141 1:CAS:528:DyaK1cXotVWns70%3D 9859993
4. G Ambrosini C Adida DC Altieri 1997 A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma Nat Med 3 917-921 10.1038/ nm0897-917 1:CAS:528:DyaK2sXltVylt7w%3D 9256286
5. WH Hoffman S Biade JT Zilfou J Chen M Murphy 2002 Transcriptional repression of the anti-apoptotic survivin gene by wild type p53 J Biol Chem 277 3247-3257 10.1074/jbc.M106643200 1:CAS:528:DC%2BD38XhtVaksL0%3D 11714700
6. DC Altieri 2003 Validating survivin as a cancer therapeutic target Nat Rev Cancer 3 46-54 10.1038/nrc968 1:CAS:528:DC%2BD38XpvVertb0%3D 12509766
7. I Tamm Y Wang E Sausville DA Scudiero N Vigna T Oltersdorf JC Reed 1998 IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs Cancer Res 58 5315-5320 1:CAS:528:DyaK1cXotVSkt7w%3D 9850056
8. P May E May 1999 Twenty years of p53. research: Structural and functional aspects of the p53. protein Oncogene 18 7621-7636 10.1038/ sj.onc.1203285 1:CAS:528:DC%2BD3cXmt1Skuw%3D%3D 10618702
9. EA Slee DJ O'Connor X Lu 2004 To die or not to die: How does p53. decide? Oncogene 23 2809-2818 10.1038/sj.onc.1207516 1:CAS:528:DC%2BD2cXivFKms7g%3D 15077144
10. WS el-Deiry 1998 Regulation of p53. downstream genes Semin Cancer Biol 8 345-357 10.1006/scbi.1998.0097 1:CAS:528:DyaK1MXitlSks7Y%3D 10101800
11. WS el-Deiry T Tokino VE Velculescu DB Levy R Parsons JM Trent D Lin WE Mercer KW Kinzler B Vogelstein 1993 WAF1, a potential mediator of p53. tumor suppression Cell 75 817-825 10.1016/0092-8674(93)90500-P 1:CAS:528:DyaK2cXpslGguw%3D%3D 8242752
12. JG Gurney N Kadan-Lottick 2001 Brain and other central nervous system tumors: Rates, trends, and epidemiology Curr Opin Oncol 13 160-166 10.1097/00001622-200105000-00005 1:STN:280:DC%2BD3Mzot12lsA%3D%3D 11307058
13. PJ Abrahams AJ Van der 1976 Host-cell reactivation of ultraviolet-irradiated SV40 DNA in five complementation groups of xeroderma pigmentosum Mutat Res 35 13-22 1:CAS:528:DyaE28Xhs1als74%3D 178998
14. M Katoh R Wilmotte MC Belkouch N Tribolet de G Pizzolato P Y Dietrich 2003 Survivin in brain tumors: An attractive target for immunotherapy J Neurooncol 64 71-76 10.1023/A:1024942127462 12952288
15. F Kayaselcuk S Zorludemir N Bal B Erdogan S Erdogan T Erman 2004 The expression of survivin and Ki-67 in meningiomas: Correlation with grade and clinical outcome J Neurooncol 67 209-214 10.1023/ B:NEON.0000021823.05163.2c 15072469
16. DC Altieri 2003 Survivin, versatile modulation of cell division and apoptosis in cancer Oncogene 22 8581-8589 10.1038/sj.onc.1207113 1:CAS:528:DC%2BD3sXptFOmtbY%3D 14634620
17. VE Velculescu SL Madden L Zhang AE Lash J Yu C Rago A Lal CJ Wang GA Beaudry KM Ciriello BP Cook MR Dufault AT Ferguson Y Gao TC He H Hermeking SK Hiraldo PM Hwang MA Lopez HF Luderer B Mathews JM Petroziello K Polyak L Zawel KW Kinzler et al. 1999 Analysis of human transcriptomes Nat Genet 23 387-388 10.1038/70487 1:CAS:528:DyaK1MXnvFOktLs%3D
18. D Grossman PJ Kim JS Schechner DC Altieri 2001 Inhibition of melanoma tumor growth in vivo by survivin targeting Proc Natl Acad Sci USA 98 635-640 10.1073/pnas.230450097 1:CAS:528:DC%2BD3MXnslKnug%3D%3D 11149963
19. A Mirza M McGuirk TN Hockenberry Q Wu H Ashar S Black SF Wen L Wang P Kirschmeier WR Bishop LL Nielsen CB Pickett S Liu 2002 Human survivin is negatively: Regulated by wild-type p53. and participates in p53-dependent apoptotic pathway Oncogene 21 2613-2622 10.1038/ sj.onc.1205353 1:CAS:528:DC%2BD38XjsVSnu7o%3D 11965534
20. D Grossman PJ Kim OP Blanc-Brude DE Brash S Tognin PC Marchisio DC Altieri 2001 Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53 J Clin Invest 108 991-999 10.1172/JCI200113345 1:CAS:528:DC%2BD3MXnt1Crsrw%3D 11581300