Evaluation of omeprazole genotoxicity in a battery of in vitro and in vivo assays

Toxicology

Volumn 130, Issue 1, 1998, Pages 29-41

  Martelli, Antonietta ^a   Mattioli, Francesca ^a   Mereto, Eugenio ^a   Brambilla Campart, Giulia ^a   Sini, Daniela ^a   Bergamaschi, Giovanna ^a   Brambilla, Giovanni ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Genotoxicity tests; In vitro and in vivo assays; Omeprazole

Indexed keywords

AZOXYMETHANE; OMEPRAZOLE; PROTON PUMP INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; COLON MUCOSA; CONTROLLED STUDY; DNA REPAIR; ERYTHROCYTE; FEMALE; GENOTOXICITY; HUMAN; HUMAN CELL; LIVER CELL; LYMPHOCYTE; MICRONUCLEUS; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT;

ADULT; AGED; ANIMALS; ANTI-ULCER AGENTS; CELLS, CULTURED; COLON; DNA REPAIR; FEMALE; HUMANS; LIVER; LYMPHOCYTES; MALE; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; OMEPRAZOLE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0031737429     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(98)00101-2     Document Type: Article

References (29)

1. Bailey N.T.J. Statistical Methods in Biology. 1959;The English Universities Press, London.
2. Brambilla G., Robbiano L., Martelli A., Cajelli E., Allavena A., Mazzei M. Genotoxicity of N-nitrosochlordiazepoxide in cultured mammalian cells. Toxicol. Appl. Pharmacol. 97:1989;480-488.
3. Diaz D., Fabre I., Daujat M., Saint Aubert B., Bories P., Michel H. et al. Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450. Gastroenterology. 99:1990;737-747.
4. Ekman L., Hausson E., Havu N., Carlsson E., Lundberg C. Toxicological studies on omeprazole. Scand. J. Gastroenterol. 20(Suppl. 108):1985;53-59.
5. Furihata C., Ikui E., Matsushima T. DNA single-strand scission in the pyloric mucosa of rat stomach induced by four glandular stomach carcinogens and three other chemicals. Mutat. Res. 368:1996;1-6.
6. Havu N. Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric acid secretion. Digestion. 35(Suppl. 1):1986;42-55.
7. Hurwitz A., Sztern M.I., Looney G.A., Pinson D.M., Bauer K.D., Kimler B.F. Effects of omeprazole on cell kinetics of carcinogen-induced colon tumours in rats. Cell. Prolif. 28:1995;525-531.
8. Hwang J.-J., Hsia M.T.S., Jirtle R.L. Induction of sister chromatid exchange and micronuclei in primary cultures of rat and human hepatocytes by the peroxisome proliferator, Wy-14.643. Mutat. Res. 286:1993;123-133.
9. m2 in exon 4, in Japanese subjects. Clin. Pharmacol. Ther. 59:1996;647-653.
10. Kashfi K., Mcdougall C.J., Dannenberg A.J. Comparative effects of omeprazole on xenobiotic metabolizing enzymes in the rat and human. Clin. Pharmacol. Ther. 58:1995;625-630.
11. Larsson H., Håkanson R., Mattsson H., Ryberg B., Sundler F., Carlsson E. Omeprazole: its influence on gastric acid secretion, gastrin and ECL cells. Toxicol. Pathol. 16:1988;267-271.
12. Lewinski A., Rybicka I., Wajs E., Szkudlinski M., Pawlikowski M. Influence of pineal indoleamines on the mitotic activity of gastric and colonic mucosa epithelial cells in the rat: interaction with omeprazole. J. Pineal Res. 10:1991;104-108.
13. Madle S., Dean S.W., Andrae U., Brambilla G., Burlinson B., Doolittle D.J. et al. Recommendations for the performance of UDS tests in vitro and in vivo. Mutat. Res. 312:1994;263-285.
14. Martelli A. Primary human and rat hepatocytes in genotoxicity assessment. In vivo. 11:1997;189-194.
15. Martelli A., Mattioli F., Pastorino G., Robbiano L., Allavena A., Brambilla G. Genotoxicity testing of chloramphenicol in rodent and human cells. Mutat. Res. 260:1991;65-72.
16. McDonnell W.M., Scheiman J.M., Traber P.G. Induction of cytochrome P4501A genes (CYP1A) by omeprazole in the human alimentary tract. Gastroenterology. 103:1992;1509-1516.
17. McLellan E.A., Medline A., Bird R.P. Sequential analyses of the growth and morphological characteristics of aberrant crypt foci: putative preneoplastic lesions. Cancer Res. 51:1991;5270-5274.
18. Mereto E., Ghia M., Martelli A., Brambilla G. Lack of evidence of omeprazole genotoxicity in Sprague-Dawley rats. Mutagenesis. 8:1993;379-386.
19. Mereto E., Frencia L., Ghia M. Effect of aspirin on incidence and growth of aberrant crypt foci induced in the rat colon by 1,2-dimethylhydrazine. Cancer Lett. 76:1994;5-9.
20. Penman I.D., El-Omar E., McGregor J.R., Hillan K.J., O'Dwyer P.J., McColl K.E. Omeprazole inhibits colorectal carcinogenesis induced by azoxymethane in rats. Gut. 34:1993;1559-1565.
21. Quattrochi L.C., Tukey R.H. Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: transcriptional activation of the human CYP1A1 gene. Mol. Pharmacol. 43:1993;504-508.
22. Rümke C.L., De Jonge H. Design, statistical analysis and interpretation. Laurence D.R., Bacharach A.L. Evaluation of Drug Activities. Pharmacometrics. 1964;80-82 Academic Press, New York.
23. Ryberg B., Tielemans Y., Axelson J., Carlsson E., Håkanson R., Mattsson H. et al. Gastrin stimulates the self-replication rate of enterochromaffinelike cells in the rat stomach. Gastroenterology. 99:1990;935-942.
24. Schmid W. The micronucleus test. Mutat. Res. 31:1975;9-15.
25. Sewell R.B., Brook C.W., Mihaly G.W., Morgan D.J., Smallwood R.A. Intracellular binding is an important determinant of the avid hepatic uptake of the high clearance drug omeprazole. Biochem. Pharmacol. 48:1994;846-849.
26. Strom S.C., Jirtle R.L., Jones R.S., Novicki D.L., Rosenberg M.R., Novotny A. et al. Isolation, culture, and transplantation of human hepatocytes. J. Natl. Cancer Inst. 68:1982;771-778.
27. Tates A.D., Neuteboom I., Hofker M., Den Engelse L. A micronucleus technique for detecting clastogenic effects of mutagens/carcinogens (DEN, DMN) in hepatocytes of rat liver in vivo. Mutat. Res. 74:1980;11-20.
28. Tudek B., Bird R.P., Bruce W.R. Foci of aberrant crypts in the colons of mice and rats exposed to carcinogens associated with foods. Cancer Res. 49:1989;1236-1240.
29. Williams G.M. Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures. Cancer Res. 37:1977;1845-1851.