Characterization of the substrate specificity of PhlD, a type III polyketide synthase from Pseudomonas fluorescens

Journal of Biological Chemistry

Volumn 281, Issue 42, 2006, Pages 32036-32047

  Zha, Wenjuan ^a   Rubin Pitel, Sheryl B ^a   Zhao, Huimin ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMBINATORIAL BIOSYNTHESIS; PHLOROGLUCINOL; POLYKETIDE SYNTHASE; PSEUDOMONAS FLUORESCENS;

BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; CONDENSATION; MUTAGENESIS; SUBSTRATES;

ENZYME KINETICS;

LONG CHAIN FATTY ACID COENZYME A LIGASE; PHLD ENZYME; PHLOROGLUCINOL; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME KINETICS; ENZYME REACTIVATION; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SYNTHESIS; MASS SPECTROMETRY; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS FLUORESCENS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

BACTERIAL PROTEINS; CATALYSIS; CLONING, MOLECULAR; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; POLYKETIDE SYNTHASES; PROTEIN BINDING; PROTEIN CONFORMATION; PSEUDOMONAS FLUORESCENS; SUBSTRATE SPECIFICITY;

PSEUDOMONAS FLUORESCENS;

EID: 33845968510     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M606500200     Document Type: Article

References (37)

1. Edwards, M. L., Stemreick, D. M., and Sunkara, P. S. (1990) J. Med. Chem. 33, 1948-1954
2. Hopwood, D. A. (1997) Chem. Rev. 97, 2465-2497
3. Jang, M. (1997) Science 275, 218-220
4. Katz, L., and Donadia, S. (1993) Annu. Rev. Microbiol. 47, 875-912
5. Keating, T. A., and Walsh, C. T. (1999) Curr. Opin. Chem. Biol. 3, 598-606
6. Khosla, C., Gokhale, R. S., Jacobsen, J. R., and Cane, D. E. (1999) Annu. Rev. Biochem. 68, 219-253
7. Donadia, S., Staver, M. J., McAlpine, J. B., Swanson, S. J., and Katz, L. (1991) Science 252, 675-679
8. Shen, B. (2000) Biosynthesis: Aromatic Polyketides, Isoprenoids, Alkaloids 209, 1-51
9. Shen, B., and Hutchinson, C. R. (1993) Science 262, 1535-1540
10. Rawlings, B. J. (2001) Nat. Prod. Rep. 18, 190-227
11. Rawlings, B. J. (2001) Nat. Prod. Rep. 18, 231-281
12. Staunton, J., and Weissman, K. J. (2001) Nat. Prod. Rep. 18, 380-416
13. Rawlings, B. J. (1999) Nat. Prod. Rep. 16, 425-484
14. Tropf, S., Kaercher, B., Schroeder, J., and Schroeder, G. (1995) J. Biol. Chem. 270, 7922-7928
15. Moore, B. S., and Hopke, J. N. (2001) Chembiochem. 2, 35-38
16. Austin, M. B., and Noel, J. P. (2003) Nat. Prod. Rep. 20, 79-110
17. Ueda, K., Kim, K. M., Beppu, T., and Horinouchi, S. (1995) J. Antibiot. (Tokyo) 48, 638-646
18. Funa, N., Ohnishi, Y., Fujii, I., Shibuya, M., Ebizuka, Y., and Horinouchi, S. (1999) Nature 400, 897-899
19. Chen, H., Tseng, C. C., Hubbard, B. K., and Walsh, C. T. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 14901-14906
20. Tseng, C. C., McLoughlin, S. M., Kelleher, N. L., and Walsh, C. T. (2004) Biochemistry 43, 970-980
21. Saxena, P., Yadav, G., Mohanty, D., and Gokhale, R. S. (2003) J. Biol. Chem. 278, 44780-44790
22. Achkar, J., Xian, M., Zhao, H. M., and Frost, J. W. (2005) J. Am. Chem. Soc. 127, 5332-5333
23. Bangera, M. G., and Thomashow, L. S. (1996) Mol. Plant Microbe. Interact. 9, 83-90
24. Bangera, M. G., and Thomashow, L. S. (1999) J. Bacteriol. 181, 3155-3163
25. Austin, M. B., Izumikawa, M., Bowman, M. E., Udwary, D. W., Ferrer, J. L., Moore, B. S., and Noel, J. P. (2004) J. Biol. Chem. 279, 45162-45174
26. Schuz, R., Heller, W., and Hahlbrock, K. (1983) J. Biol. Chem. 258, 6730-6734
27. Funa, N., Ohnishi, Y., Ebizuka, Y., and Horinouchi, S. (2002) J. Biol. Chem. 277, 4628-4635
28. Ferrer, J. L., Jez, J. M., Bowman, M. E., Dixon, R. A., and Noel, J. P. (1999) Nat. Struct. Biol. 6, 775-784
29. Jez, J. M., Austin, M. B., Ferrer, J. L., Bowman, M. E., Schroder, J., and Noel, J. P. (2000) Chem. Biol. 7, 919-930
30. Abe, I., Oguro, S., Utsumi, Y., Sano, Y., and Noguchi, H. (2005) J. Am. Chem. Soc. 127, 12709-12716
31. Austin, M. B., Bowman, M. E., Ferrer, J. L., Schroder, J., and Noel, J. P. (2004) Chem. Biol. 11, 1179-1194
32. Sankaranarayanan, R., Saxena, P., Marathe, U. B., Gokhale, R. S., Shanmugam, V. M., and Rukmini, R. (2004) Nat. Struct. Mol. Biol. 11, 894-900
33. Halgren, T. A. (1999) J. Comput. Chem. 20, 720-729
34. Sarkar, G., and Sommer, S. S. (1990) BioTechniques 8, 404-407
35. Georgescu, R., Bandara, G., and Sun, L. (2003) Methods Mol. Biol. 231, 75-83
36. Chockalingam, K., Chen, Z. L., Katzenellenbogen, J. A., and Zhao, H. M. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 5691-5696
37. Lee, J., Ang, E. L., and Zhao, H. M. (2006) J. Bacteriol. 188, 6179-6183