Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates

Journal of Biological Chemistry

Volumn 279, Issue 43, 2004, Pages 45162-45174

  Austin, Michael B ^a,b   Izumikawa, Miho ^c   Bowman, Marianne E ^a   Udwary, Daniel W ^c   Ferrer, Jean Luc ^d   Moore, Bradley S ^c,e   Noel, Joseph P ^a,b  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

^d INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^e University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; ENZYMES;

ITERATIVE CONSIDERATION; MALONYL UNITS; POLYKETIDE SYNTHASE;

BACTERIA;

POLYKETIDE SYNTHASE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE IDENTIFICATION; MOLECULAR MODEL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES COELICOLOR;

ACYLTRANSFERASES; ASPARAGINE; ASPARTIC ACID; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; CODON; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NAPHTHOLS; NAPHTHOQUINONES; OXALIC ACID; POLYKETIDE SYNTHASES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SERINE; STREPTOMYCES; STREPTOMYCES COELICOLOR;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); STREPTOMYCES; STREPTOMYCES COELICOLOR; UNCULTURED ACTINOMYCETE;

EID: 7244239181     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M406567200     Document Type: Article

References (47)

1. Feng, B., Wang, X., Hauser, M., Kaufmann, S., Jentsch, S., Haase, G., Becker, J. M., and Szaniszlo, P. J. (2001) Infect. Immun. 69, 1781-1794
2. Ueda, K, Kim, K. M., Beppu, T., and Horinouchi, S. (1995) J. Antibiot. (Tokyo) 48, 638-646
3. Kalaitzis, J. A., Hamano, Y., Nilsen, G., and Moore, B. S. (2003) Org. Lett. 5, 4449-4452
4. Fujii, I., Mori, Y., Watanabe, A., Kubo, Y., Tsuji, G., and Ebizuka, Y. (2000) Biochemistry 39, 8853-8858
5. Funa, N., Ohnishi, Y., Fujii, I., Shibuya, M., Ebizuka, Y., and Horinouchi, S. (1999) Nature 400, 897-899
6. Cortes, J., Velasco, J., Foster, G., Blackaby, A. P., Rudd, B. A. M., and Wilkinson, B. (2002) Mol. Microbiol. 44, 1213-1224
7. Funa, N., Ohnishi, Y., Ebizuka, Y., and Horinouchi, S. (2002) Biochem. J. 367, 781-789
8. Izumikawa, M., Shipley, P. R., Hopke, J. N., O'Hare, T., Xiang, L., Noel, J. P., and Moore, B. S. (2003) J. Ind. Microbiol. Biotechnol. 30, 510-515
9. Schröder, J. (1997) Trends Plant Sci. 2, 373-378
10. Schröder, J. (2000) Recent Adv. Phytochem. 34, 55-89
11. Austin, M. B., and Noel, J. P. (2003) Nat. Prod. Rep. 20, 79-110
12. Kreuzaler, F., and Hahlbrock, K. (1972) FEBS Lett. 28, 69-72
13. Kreuzaler, F., and Hahlbrock, K. (1975) Arch. Biochem. Biophys. 169, 84-90
14. Heller, W., and Hahlbrock, K. (1980) Arch. Biochem. Biophys. 200, 617-619
15. Reimold, U., Kroeger, M., Dreuzaler, F., and Hahlbrock, K. (1983) EMBO J. 2, 1801-1805
16. Moore, B. S., and Hopke, J. N. (2001) ChemBioChem. 2, 35-38
17. Ferrer, J. L., Jez, J. M., Bowman, M. E., Dixon, R. A., and Noel, J. P. (1999) Nat. Struct. Biol. 6, 775-784
18. Lanz, T., Tropf, S., Marner, F. J., Schröder, J., and Schröder, G. (1991) J. Biol. Chem. 266, 9971-9976
19. Jez, J. M., Ferrer, J. L., Bowman, M. E., Dixon, R. A., and Noel, J. P. (2000) Biochemistry 39, 890-902
20. Jez, J. M., and Noel, J. P. (2000) J. Biol. Chem. 275, 39640-39646
21. Suh, D. Y., Kagami, J., Fukuma, K., and Sankawa, U. (2000) Biochem. Biophys. Res. Commun. 275, 725-730
22. Jez, J. M., Austin, M. B., Ferrer, J., Bowman, M. E., Schröder, J., and Noel, J. P. (2000) Chem. Biol. 7, 919-930
23. Austin, M. B., Bowman, M. E., Ferrer, J., Schröder, J., and Noel, J. P. (2004) Chem. Biol., in press
24. Harris, T. M., and Harris, C. M. (1986) Pure Appl. Chem. 58, 283-294
25. Moore, B. S., Hertweck, C., Hopke, J. N., Izumikawa, M., Kalaitzis, J. A., Nilsen, G., O'Hare, T., Piel, J., Shipley, P. R., Xiang, L., Austin, M. B., and Noel, J. P. (2002) J. Nat. Prod. 65, 1956-1962
26. Bentley, S. D., Chater, K. F., Cerdeno-Tarraga, A. M., Challis, G. L., Thomson, N. R., James, K. D., Harris, D. E., Quail, M. A., Kieser, H., Harper, D., Bateman, A., Brown, S., Chandra, G., Chen, C. W., Collins, M., Cronin, A., Fraser, A., Goble, A., Hidalgo, J., Hornsby, T., Howarth, S., Huang, C. H., Kieser, T., Larke, L., Murphy, L., Oliver, K., O'Neil, S., Rabbinowitsch, E., Rajandream, M. A., Rutherford, K., Rutter, S., Seeger, K., Saunders, D., Sharp, S., Squares, R., Squares, S., Taylor, K., Warren, T., Wietzorrek, A., Woodward, J., Barrell, B. G., Parkhill, J., and Hopwood, D. A. (2002) Nature 417, 141-147
27. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
28. Dodson, E. J., Winn, M., Ralph, A. (1997) Methods Enzymol. 277, 620-633
29. Terwilliger, T. C., and Berendzen, J. (1999) Acta Crystallogr. Sect. D Biol. Crystallogr. 55, 849-861
30. Jones, T. A., Zou, J. Y., Cowan, S. W., and Kjeldgaard, M. (1993) Acta Crystallogr. Sect. D Biol. Crystallogr. 49, 148-157
31. Sali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
32. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, R. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 54, 905-921
33. Ferrin, T. E., Huang, C. C., Jarvis, L. E., and Langridge, R. (1988) J. Mol. Graph. 6, 13-27
34. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
35. Funa, N., Ohnishi, Y., Ebizuka, Y., and Horinouchi, S. (2002) J. Biol. Chem. 277, 4628-4635
36. Jez, J. M., Bowman, M. E., and Noel, J. P. (2001) Biochemistry 40, 14829-14838
37. Abe, I., Utsumi, Y., Oguro, S., and Noguchi, H. (2004) FEBS Lett. 562, 171-176
38. Kyte, J. (1995) Structure in Protein Chemistry, p. 59, Garland, New York
39. Qiu, X., Janson, C. A., Konstantinidis, A. K., Nwagwu, S., Silverman, C., Smith, W. W., Khandekar, S., Lonsdale, J., and Abdel-Meguid, S. S. (1999) J. Biol. Chem. 274, 36465-36471
40. Davies, C., Heath, R. J., White, S. W., and Rock, C. O. (2000) Struct. Fold. Des. 8, 185-195
41. Qiu, X., Janson, C. A., Smith, W. W., Head, M., Lonsdale, J., and Konstantinidis, A. K. (2001) J. Mol. Biol. 307, 341-356
42. Scarsdale, J. N., Kazanina, G., He, X., Reynolds, K. A., and Wright, H. T. (2001) J. Biol. Chem. 276, 20516-20522
43. Saxena, P., Yadav, G., Mohanty, D., and Gokhale, R. S. (2003) J. Biol. Chem. 278, 44780-44790
44. Fujii, I., Mori, Y., Watanabe, A., Kubo, Y., Tsuji, G., and Ebizuka, Y. (1999) Biosci. Biotechnol. Biochem. 63, 1445-1452
45. Thomas, R. (2001) Chembiochem. 2, 612-627
46. Brown, H. C., McDaniel, D. H., and Haaflinger, O. (1955) in Determination of Organic Structures by Physical Methods (Braude, E. A., and Nachod, F. C., eds) Academic Press, Inc., New York
47. Smith, M. B., and March, J. (2001) March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 5th Ed., John Wiley & Sons, Inc., New York