Apoptosis induced by intracellular ceramide accumulation in MDA-MB-435 breast carcinoma cells is dependent on the generation of reactive oxygen species

Experimental and Molecular Pathology

Volumn 82, Issue 1, 2007, Pages 1-11

  Chan, S Y Velda ^a   Hilchie, Ashley L ^a   Brown, Michael G ^a   Anderson, Robert ^a   Hoskin, David W ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Apoptosis; Breast cancer; Ceramidase; Ceramide; Glucosylceramide synthase; Reactive oxygen species

Indexed keywords

1 PHENYL 2 PALMITOYLAMINO 3 MORPHOLINO 1 PROPANOL; ACETYLCYSTEINE; ACYLSPHINGOSINE DEACYLASE; ALCOHOL DERIVATIVE; ANTIOXIDANT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; C6 CERAMIDE; CASPASE; CERAMIDE; CERAMIDE DERIVATIVE; CERAMIDE GLUCOSYLTRANSFERASE; DEXTRO ERYTHRO 2 (N MYRISTOYLAMINO) 1 PHENYL 1 PROPANOL; ENZYME INHIBITOR; GLUCOSYLCERAMIDE; GLUTATHIONE; MORPHOLINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SPHINGOMYELIN SYNTHASE; SYNTHETASE; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CATABOLISM; CELL PROTECTION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EXPOSURE; DRUG POTENTIATION; ENZYMATIC DEGRADATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIPID STORAGE; MITOCHONDRIAL MEMBRANE;

APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CERAMIDES; DNA FRAGMENTATION; ENZYME INHIBITORS; FEMALE; HUMANS; REACTIVE OXYGEN SPECIES;

EID: 33845957644     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2006.03.001     Document Type: Article

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