Enhanced de novo ceramide generation through activation of serine palmitoyltransferase by the P-glycoprotein antagonist SDZ PSC 833 in breast cancer cells

Molecular Cancer Therapeutics

Volumn 1, Issue 9, 2002, Pages 719-726

  Wang, Hongtao ^a   Giuliano, Armando E ^a   Cabot, Myles C ^a  

^a JOHN WAYNE CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; ANTINEOPLASTIC AGENT; CERAMIDE; DIHYDROCERAMIDE DESATURASE; FAA2 PROTEIN, S CEREVISIAE; GLYCOPROTEIN P; LONG CHAIN FATTY ACID COENZYME A LIGASE; LONG-CHAIN-FATTY-ACID-COA LIGASE; OXIDOREDUCTASE; REPRESSOR PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; SERINE PALMITOYLTRANSFERASE; SPTLC2 PROTEIN, HUMAN;

ARTICLE; BIOLOGICAL MODEL; CELL CULTURE; CHEMICAL MODEL; DOSE RESPONSE; ENZYME ACTIVATION; HUMAN; LIPID METABOLISM; METABOLISM; TIME;

ACYLTRANSFERASES; ANTINEOPLASTIC AGENTS; CELLS, CULTURED; CERAMIDES; COENZYME A LIGASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; LIPID METABOLISM; MODELS, BIOLOGICAL; MODELS, CHEMICAL; OXIDOREDUCTASES; P-GLYCOPROTEIN; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SERINE C-PALMITOYLTRANSFERASE; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0036633148     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Bernal, S. D. (ed.). Drug Resistance in Oncology. New York: Marcel Dekker, 1997.
2. Volm, M., Kastel, M., Mattern, J., and Efferth, T. Expression of resistance factors (P-glycoprotein, glutathione S-transferase-pi, and topoisomerase II) and their interrelationship to proto-oncogene products in renal cell carcinomas. Cancer (Phila.), 71: 3981-3987, 1993. (Pubitemid 23172981)
3. Sparreboom, A., and Nooter, K. Does P-glycoprotein play a role in anticancer drug pharmacokinetics? Drug Resistance Updates, 3: 357-363, 2000. (Pubitemid 32118401)
4. Callaghan, R., and Higgins, C. F. Interaction of tamoxifen with the multidrug resistance P-glycoprotein. Br. J. Cancer, 71: 294-299, 1995.
5. Covelli, A. SDZ PSC 833: a novel modulator of MDR. Tumori, 83: s21-s24, 1997.
6. Fisher, G. A., Lum, B. L., Hausdorff, J., and Sikic, B. I. Pharmacological considerations in modulation of multidrug resistance. Eur. J. Cancer, 32A: 1082-1088, 1996.
7. Slater, L. M., Sweet, P., Stupecky, M., and Gupta, S. Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro. J. Clin. Investig., 77: 1405-1408, 1986. (Pubitemid 16047169)
8. Twentyman, P. R. Cyclosporins as drug resistance modifiers. Biochem. Pharmacol., 43: 109-117, 1992.
9. Yanagisawa, T., Newman, A., Coley, H., Renshaw, J., Pinkerton C. R., and Pritchard-Junes, K. BIRICODAR (VX-710; Incel): an effective chemosensitizer in neuroblastoma. Br. J. Cancer, 80: 1190-1196, 1999. (Pubitemid 29264079)
10. Lutzker, S. G., and Levine, A. J. Apoptosis and cancer chemotherapy. Cancer Treat. Res., 87: 345-356, 1996.
11. Senchenkov, A., Litvak, D. A., and Cabot, M. C. Targeting ceramide metabolism - a strategy for overcoming drug resistance. J. Natl. Cancer Inst., 93: 347-357, 2001. (Pubitemid 32229379)
12. Jaffrezou, J. P., Levade, T., Bettaieb, A., Andrieu, N., Bezombes, C., Maestre, N., Vermeersch, S., Rouse, A., and Laurent, G. Daunorubicininduced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. EMBO J., 15: 2417-2422, 1996.
13. Lucci, A., Han, T-Y., Liu, Y-Y., Giuliano, A. E., and Cabot, M. C. Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells. Cancer (Phila.), 86: 300-311, 1999. (Pubitemid 29327587)
14. Charles, A. G., Han, T-Y., Liu, Y-Y., Hansen, N., Giuliano, A. E., and Cabot, M. C. Taxol-induced ceramide generation and apoptosis in human breast cancer cells. Cancer Chemother. Pharmacol., 47: 444-450, 2001. (Pubitemid 32397622)
15. Wang, H., Maurer, B. J., Reynolds, C. P., and Cabot, M. C. N-(4- Hydroxylphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase. Cancer Res., 61: 5102-5105, 2001. (Pubitemid 32681541)
16. Cabot, M. C., Han, T-Y., and Giuliano, A. E. The multidrug resistance modulator SDZ PSC 833 is a potent activator of cellular ceramide formation. FEBS Lett., 431: 185-188, 1998. (Pubitemid 28334213)
17. Cabot, M. C., Giuliano, A. E., Han, T-Y., and Liu, Y-Y. SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increase vinblastine sensitivity in drugsensitive and drug-resistant cancer cells. Cancer Res., 59: 880-885, 1999. (Pubitemid 29086743)
18. Goulding, C. W., Giuliano, A. E., and Cabot, M. C. SDZ PSC 833 the drug resistance modulator activates cellular ceramide formation by a pathway independent of P-glycoprotein. Cancer Lett., 149: 143-151, 2000. (Pubitemid 30100570)
19. Kolesnick, R. N. 1,2-Diacylglycerols but not phorbol esters stimulate sphingomyelin hydrolysis in GH3 pituitary cells. J. Biol. Chem., 262: 16759-16762, 1987. (Pubitemid 18019025)
20. Kolesnick, R. N., and Clegg, S. 1,2-Diacylglycerols, but not phorbol esters, activate a potential inhibitory pathway for protein-kinase C in GH3 pituitary cells. Evidence for involvement of a sphingomyelinase. J. Biol. Chem., 263: 6534-6537, 1988.
21. Bose, R., Verheij, M., Haimovitz-Friedman, A, Scotto, K., Fuks, Z., and Kolesnick, R. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell, 82: 405-414, 1995.
22. Mandon, E. C., Ehses, I., Rother, J., van Echter, G., and Sandhoff, K. Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. J. Biol. Chem., 267: 11144-11148, 1992.
23. Perry, D. K., Carton, J., Shah, A. K., Meredith, F., Uhlinger, J., and Hannun, Y. A. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J. Biol. Chem., 275: 9078-9084, 2000. (Pubitemid 30180269)
24. Santana, P., Pena, L. A., Haimovitz-Friedman, A., Martin, S., Green, D., McLaughlin, M., Cordon-Cardo, C., Schuchman, E. H., Fuks, Z., and Kolesnick, R. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell, 86: 189-199, 1996. (Pubitemid 26286102)
25. Malisa, F., and Testi, R. Lipid signaling in CD 95-mediated apoptosis. FEBS Lett., 452: 100-103, 1999.
26. Kolesnick, R. N., and Kronke, M. Regulation of ceramide production and apoptosis. Annu. Rev. Physiol., 60: 643-665, 1998.
27. Holleran, W. M., Williams, M. L., Gao, W. N., and Elias, P. M. Serinepalmitoyltransferase activity in cultured human keratinocytes. J. Lipid Res., 31: 1655-1661, 1990. (Pubitemid 20321726)
28. Bourteele, S., Hausser, A., Doppler, H., Horn-Muller, J., Ropke, C., Schwarzmann, G., Pfizenmaier, K., and Muller, G. Tumor necrosis factor induces ceramide oscillations and negatively controls sphingolipid synthesis by caspases in apoptotic KYM-1 cells. J. Biol. Chem., 273: 31245- 31251, 1998.
29. Morand, O., and Aigrot, M. S. A model for studying membrane fatty acid transport: acyl-coenzyme A synthesis in human erythrocyte ghosts. In: L. Freysz, H. Dreyfus, R. Massarelli, and S. Gatt (eds.), Enzymes of Lipid Metabolism II, pp. 437-449. New York: Plenum Publishing Corp., 1986.
30. Chico, I., Kang, M. H., Bergan, R., Abraham, J., Bakke, S., Meadows, B., Rutt, A., Robey, R., Choyke, P., Merino, M., Goldspiel, B., Smith, T., Steinberg, S., Figg, W. D., Fojo, T., and Bates, S. Phase I study of infusional paclitaxel in combination with the P-glycoprotein antagonist PSC 833. J. Clin. Oncol., 19: 832-842, 2001. (Pubitemid 32119099)
31. Dorr, R., Karanes, C., Spier, C., Grogan, T., Greer, J., Moore, J., Weinberger, B., Schiller, G., Pearce, T., Litchman, M., Dalton, W., Roe, D., and List, A. F. Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia. J. Clin. Oncol., 19: 1589-1599, 2001. (Pubitemid 32230858)
32. Fracasso, P. M., Brady, M. F., Moore, D. H., Walker, J. L., Rose, P. G., Letvak, L., Grogan, T. M., and McGuire, W. P. Phase II study of paclitaxel and valspodar (PSC 833) in refractory ovarian carcinoma: a gynecologic oncology group study. J. Clin. Oncol., 19: 2975-2982, 2001. (Pubitemid 32565435)
33. Archinal-Mattheis, A., Rzepka, R. W., Watanabe, T., Kokubu, N., Itoh, Y., Combates, N. J., Bair, K. W., and Cohen, D. Analysis of the interactions of SDZ PSC 833 ([3′-keto-Bmtl-Val2]-cyclosporine), a multidrug resistance modulator, with P-glycoprotein. Oncol. Res., 7: 603-610, 1995. (Pubitemid 26107677)
34. Pallis, M., and Russell, N. P-Glycoprotein plays a drug-efflux- independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway. Blood, 95: 2897-2904, 2000. (Pubitemid 30235901)
35. Kreis, W., Budman, D. R., and Calabro, A. A reexamination of PSC 833 (Valspodar) as a cytotoxic agent and in combination with anticancer agents. Cancer Chemother. Pharmacol., 47: 78-82, 2001. (Pubitemid 32664517)
36. Azare, J., Pankova-Kholmyansky, I., Salnikow, K., Cohen, D., and Flescher, E. Selective susceptibility of transformed T lymphocytes to induction of apoptosis by PSC 833, an inhibitor of P-glycoprotein. Oncol. Res., 12: 315-323, 2000.
37. Smith, A. J., van Helvoort, A., van Meer, G., Szabo, K., Welker, E., Szakacs, G., Varadi, A., Sarkadi, B., and Borst, P. MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. J. Biol. Chem., 275: 23530-23539, 2000. (Pubitemid 30624635)
38. van Helvoort, A., Giuidici, M. L., Thielemans, M., and van Meer, G. Transport of sphingomyelin to the cell surface is inhibited by brefeldin A and in mitosis, where C6-NBD-sphingomyelin is translocated across the plasma membrane by a multidrug transporter activity. J. Cell Sci., 110: 75-83, 1997. (Pubitemid 27057946)
39. Liu, Y-Y., Han, T-Y., Giuliano, A. E., Hansen, N., and Cabot, M. C. Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses Adriamycin resistance. J. Biol. Chem., 275: 7138-7143, 2000. (Pubitemid 30146262)