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Volumn 255, Issue 1, 2000, Pages 18-29

Ceramide-induced apoptosis in Fas-resistant Hodgkin's disease cell lines is caspase independent

Author keywords

Apoptosis; Caspases; Ceramide; Fas; Hodgkin's disease

Indexed keywords

CASPASE; CASPASE INHIBITOR; CERAMIDE; FAS ANTIGEN;

EID: 0034712251     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4773     Document Type: Article
Times cited : (14)

References (49)
  • 3
    • 0028790239 scopus 로고
    • Multiple pathways originate at the Fas/APO-1 (CD95) receptor: Sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal
    • Cifone, G., Roncaioli, P., Maria, D., Camarda, G., Santoni, A., Ruberti, G., and Testi, R. (1995). Multiple pathways originate at the Fas/APO-1 (CD95) receptor: Sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. EMBO J. 14, 5859-5868.
    • (1995) EMBO J. , vol.14 , pp. 5859-5868
    • Cifone, G.1    Roncaioli, P.2    Maria, D.3    Camarda, G.4    Santoni, A.5    Ruberti, G.6    Testi, R.7
  • 4
    • 0030774818 scopus 로고    scopus 로고
    • CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP-32 inhibition
    • Tepper, A. D., Jeanine, G. R., de Vries, E., Borst, J., and Blitterswijk, W. J. (1997). CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3/CPP-32 inhibition. J. Biol. Chem. 272, 24308-24312.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24308-24312
    • Tepper, A.D.1    Jeanine, G.R.2    De Vries, E.3    Borst, J.4    Blitterswijk, W.J.5
  • 5
    • 0030473287 scopus 로고    scopus 로고
    • Sphingomyelin breakdown and cell fate
    • Testi, R. (1996). Sphingomyelin breakdown and cell fate. Trends Biochem. Sci. 21, 468-471.
    • (1996) Trends Biochem. Sci. , vol.21 , pp. 468-471
    • Testi, R.1
  • 6
    • 0030448021 scopus 로고    scopus 로고
    • Functions of ceramide in coordinating cellular responses to stress
    • Hannun, Y. A. (1996). Functions of ceramide in coordinating cellular responses to stress. Science 274, 1855-1859.
    • (1996) Science , vol.274 , pp. 1855-1859
    • Hannun, Y.A.1
  • 7
    • 0031919157 scopus 로고    scopus 로고
    • Regulation of ceramide production and apoptosis
    • Kolesnick, R. N., and Kronke, M. (1998). Regulation of ceramide production and apoptosis. Annu. Rev. Physiol. 60, 643-665.
    • (1998) Annu. Rev. Physiol. , vol.60 , pp. 643-665
    • Kolesnick, R.N.1    Kronke, M.2
  • 9
    • 0029008234 scopus 로고
    • Flow cytometric analysis of apoptosis and BCL2 in human solid neoplasms
    • Steck, K. D., McDonell, T. J., and El-Naggar, A. K. (1995). Flow cytometric analysis of apoptosis and BCL2 in human solid neoplasms. Cytometry 20, 154-161.
    • (1995) Cytometry , vol.20 , pp. 154-161
    • Steck, K.D.1    McDonell, T.J.2    El-Naggar, A.K.3
  • 10
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F., and Riccardi, C. (1991). A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139, 271-279.
    • (1991) J. Immunol. Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 11
    • 0029043888 scopus 로고
    • A novel assay for apoptosis: Flow cytometric detection of phosphotidylserine expression on early apoptotic cells using fluorescein-labelled annexin V
    • Vermes, I., Haanen, I., Steffens-Nakken, H., and Reutlin-sperger, C. (1995). A novel assay for apoptosis: Flow cytometric detection of phosphotidylserine expression on early apoptotic cells using fluorescein-labelled annexin V. J. Immunol. Methods 184, 39-51.
    • (1995) J. Immunol. Methods , vol.184 , pp. 39-51
    • Vermes, I.1    Haanen, I.2    Steffens-Nakken, H.3    Reutlin-sperger, C.4
  • 12
    • 0028903933 scopus 로고
    • Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
    • Zamzami, N., Marchetti, P., Castedo, M., Zanin, C., Vayssiere, J. L., Petit, P. X., and Kroemer, G. (1995). Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med. 181, 1661-1672.
    • (1995) J. Exp. Med. , vol.181 , pp. 1661-1672
    • Zamzami, N.1    Marchetti, P.2    Castedo, M.3    Zanin, C.4    Vayssiere, J.L.5    Petit, P.X.6    Kroemer, G.7
  • 13
    • 0030039453 scopus 로고    scopus 로고
    • CD40 Ligand is expressed and functional on activated neonatal T cells
    • Splawski, J. B., Nishioka, J., Nishioka, Y., and Lipsky, P. E. (1996). CD40 Ligand is expressed and functional on activated neonatal T cells. J. Immunol. 156, 119-127.
    • (1996) J. Immunol. , vol.156 , pp. 119-127
    • Splawski, J.B.1    Nishioka, J.2    Nishioka, Y.3    Lipsky, P.E.4
  • 15
    • 0030063193 scopus 로고    scopus 로고
    • Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis
    • Cascino, I., Papoff, G., De Maria, R., Testi, R., and Ruberti, G. (1996). Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis. J. Immunol. 156, 7-13.
    • (1996) J. Immunol. , vol.156 , pp. 7-13
    • Cascino, I.1    Papoff, G.2    De Maria, R.3    Testi, R.4    Ruberti, G.5
  • 17
    • 0029930681 scopus 로고    scopus 로고
    • An N-terminal domain shared by Fas/Apo-1 (CD95) soluble variants prevents cell death in vitro
    • Papoff, G., Cascino, I., Eramo, A., Starace, G., Lynch, D. H., and Ruberti, G. (1996). An N-terminal domain shared by Fas/Apo-1 (CD95) soluble variants prevents cell death in vitro. J. Immunol. 156, 4622-4630.
    • (1996) J. Immunol. , vol.156 , pp. 4622-4630
    • Papoff, G.1    Cascino, I.2    Eramo, A.3    Starace, G.4    Lynch, D.H.5    Ruberti, G.6
  • 18
    • 0030670626 scopus 로고    scopus 로고
    • Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis
    • Herr, I., Wilhelm, D., Bohler, T., Angel, P., and Debatin, K. M. (1997). Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J. 16, 6200-6208.
    • (1997) EMBO J. , vol.16 , pp. 6200-6208
    • Herr, I.1    Wilhelm, D.2    Bohler, T.3    Angel, P.4    Debatin, K.M.5
  • 19
    • 0031712721 scopus 로고    scopus 로고
    • CD40-ligation mediated protection of a Fas-sensitive Hodgkin's disease derived cell line from apoptosis
    • Metkar, S. S., Naresh, K. N., Redkar, A. A., and Nadkarni, J. J. (1998). CD40-ligation mediated protection of a Fas-sensitive Hodgkin's disease derived cell line from apoptosis. Can. Immunol. Immunother. 47, 104-112.
    • (1998) Can. Immunol. Immunother. , vol.47 , pp. 104-112
    • Metkar, S.S.1    Naresh, K.N.2    Redkar, A.A.3    Nadkarni, J.J.4
  • 20
    • 0019171140 scopus 로고
    • Two neoplastic cell lines with unique features derived from Hodgkin's disease
    • Schaadt, M., Diehl, V., Stein, H., Fonatsch, C., and Kirschner, H. H. (1980) Two neoplastic cell lines with unique features derived from Hodgkin's disease. Int. J. Can. 26, 723-731.
    • (1980) Int. J. Can. , vol.26 , pp. 723-731
    • Schaadt, M.1    Diehl, V.2    Stein, H.3    Fonatsch, C.4    Kirschner, H.H.5
  • 21
    • 0022504817 scopus 로고
    • Cytochemical, immunologic, chromosomal, and molecular genetic analysis of a novel cell line derived from Hodgkin's disease
    • Kamesaki, O. H., Fukuhara, S., Tatsumi, E., Uchino, H., Yamabe, H., Miwa, H., Shirakawa, S., Hatanaka, M., and Honjo, T. (1986). Cytochemical, immunologic, chromosomal, and molecular genetic analysis of a novel cell line derived from Hodgkin's disease. Blood 68, 285-292.
    • (1986) Blood , vol.68 , pp. 285-292
    • Kamesaki, O.H.1    Fukuhara, S.2    Tatsumi, E.3    Uchino, H.4    Yamabe, H.5    Miwa, H.6    Shirakawa, S.7    Hatanaka, M.8    Honjo, T.9
  • 24
    • 0027161158 scopus 로고
    • Effect of bcl-2 on Fas antigen-mediated cell death
    • Itoh, N., Tsujimoto, Y., and Nagata, S. (1993). Effect of bcl-2 on Fas antigen-mediated cell death. J. Immunol. 151, 621-627.
    • (1993) J. Immunol. , vol.151 , pp. 621-627
    • Itoh, N.1    Tsujimoto, Y.2    Nagata, S.3
  • 25
    • 0029849215 scopus 로고    scopus 로고
    • Bcl-2 prevents CD95 (Fas/APO-1)-induced degradation of lamin B and poly(ADP-ribose) polymerase and restores the NF-kappaB signaling pathway
    • Mandal, M., Maggirwar, S. B., Sharma, N., Kaufmann, S. H., Sun, S., and Kumar, R. (1996). Bcl-2 prevents CD95 (Fas/APO-1)-induced degradation of lamin B and poly(ADP-ribose) polymerase and restores the NF-kappaB signaling pathway. J. Biol. Chem. 271, 30354-30359.
    • (1996) J. Biol. Chem. , vol.271 , pp. 30354-30359
    • Mandal, M.1    Maggirwar, S.B.2    Sharma, N.3    Kaufmann, S.H.4    Sun, S.5    Kumar, R.6
  • 26
    • 0028790829 scopus 로고
    • Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma
    • Memon, S. A., Morens, M. B., Petra, K. D., and Zacharchuck, C. M. (1995). Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma. J. Immunol. 155, 4644-4652.
    • (1995) J. Immunol. , vol.155 , pp. 4644-4652
    • Memon, S.A.1    Morens, M.B.2    Petra, K.D.3    Zacharchuck, C.M.4
  • 27
    • 0028979118 scopus 로고
    • The role of bclx(L) in CD40 mediated rescue from anti-mu induced apoptosis in Wehi-231 B lymphoma cells
    • Choi, M. S. K., Boise, L. N., Gottschalk, A. R., Quintans, J., Thomson, C. B., and Klaus, G. G. B. (1995). The role of bclx(L) in CD40 mediated rescue from anti-mu induced apoptosis in Wehi-231 B lymphoma cells. Eur. J. Immunol. 25, 1352-1357.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1352-1357
    • Choi, M.S.K.1    Boise, L.N.2    Gottschalk, A.R.3    Quintans, J.4    Thomson, C.B.5    Klaus, G.G.B.6
  • 28
    • 0029084999 scopus 로고
    • Modulation of anti-IgM-induced B cell apoptosis by Bcl-xL and CD40 in WEHI-231 cells. Dissociation from cell cycle arrest and dependence on the avidity of the antibody-IgM receptor interaction
    • Merino, R., Grillot, D. A., Simonian, P. L., Muthukumar, S., Fanslow, W. C., Bondada, S., and Nunez, G. (1995). Modulation of anti-IgM-induced B cell apoptosis by Bcl-xL and CD40 in WEHI-231 cells. Dissociation from cell cycle arrest and dependence on the avidity of the antibody-IgM receptor interaction. J. Immunol. 155, 3830-3838.
    • (1995) J. Immunol. , vol.155 , pp. 3830-3838
    • Merino, R.1    Grillot, D.A.2    Simonian, P.L.3    Muthukumar, S.4    Fanslow, W.C.5    Bondada, S.6    Nunez, G.7
  • 30
    • 0029091387 scopus 로고
    • Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells
    • Wang, Z., Karras, J. G., Howard, R. G., and Rothstein, T. L. (1995). Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells. J. Immunol. 155, 3722-3725.
    • (1995) J. Immunol. , vol.155 , pp. 3722-3725
    • Wang, Z.1    Karras, J.G.2    Howard, R.G.3    Rothstein, T.L.4
  • 31
    • 0032571251 scopus 로고    scopus 로고
    • CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase
    • Cock, J. G. R., Tepper, A. D., de Vries, E., Blitterswijk, W. J., and Borst, J. (1998). CD95 (Fas/APO-1) induces ceramide formation and apoptosis in the absence of a functional acid sphingomyelinase. J. Biol. Chem. 273, 7560-7565.
    • (1998) J. Biol. Chem. , vol.273 , pp. 7560-7565
    • Cock, J.G.R.1    Tepper, A.D.2    De Vries, E.3    Blitterswijk, W.J.4    Borst, J.5
  • 33
    • 0031035381 scopus 로고    scopus 로고
    • Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis
    • Sawai, H., Okazaki, T., Takeda, M., Tashima, M., Sawada, H., Okuma, M., Kishi, S., Umehara, H., and Domae, N. (1997). Ceramide-induced translocation of protein kinase C-delta and -epsilon to the cytosol. Implications in apoptosis. J. Biol. Chem. 272, 2452-2458.
    • (1997) J. Biol. Chem. , vol.272 , pp. 2452-2458
    • Sawai, H.1    Okazaki, T.2    Takeda, M.3    Tashima, M.4    Sawada, H.5    Okuma, M.6    Kishi, S.7    Umehara, H.8    Domae, N.9
  • 34
    • 0029965928 scopus 로고    scopus 로고
    • Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24)
    • Wright, S. C., Zheng, H., and Zhong, J. (1996). Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24). FASEB J. 10, 325-332.
    • (1996) FASEB J. , vol.10 , pp. 325-332
    • Wright, S.C.1    Zheng, H.2    Zhong, J.3
  • 35
    • 0025003424 scopus 로고
    • Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation
    • Okazaki, T., Bielawska, A., Bell, R. M., and Hannun, Y. A. (1990). Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J. Biol. Chem. 265, 15823-15831.
    • (1990) J. Biol. Chem. , vol.265 , pp. 15823-15831
    • Okazaki, T.1    Bielawska, A.2    Bell, R.M.3    Hannun, Y.A.4
  • 36
    • 0030950234 scopus 로고    scopus 로고
    • Anti-immunoglobulin-induced apoptosis in WEHI 231 cells involves the slow formation of ceramide from sphingomyelin and is blocked by bcl-xL
    • Weisner, D. A., Kilkus, J. P., Gottschalk, J. R., Quintans, J., and Dawson, G. (1997). Anti-immunoglobulin-induced apoptosis in WEHI 231 cells involves the slow formation of ceramide from sphingomyelin and is blocked by bcl-xL. J. Biol. Chem. 272, 9868-9876.
    • (1997) J. Biol. Chem. , vol.272 , pp. 9868-9876
    • Weisner, D.A.1    Kilkus, J.P.2    Gottschalk, J.R.3    Quintans, J.4    Dawson, G.5
  • 38
    • 0008206988 scopus 로고    scopus 로고
    • TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival
    • Lee, S. Y., Reichlin, A., Santana, A., Sokol, K. A., Nussenweig, M. C., and Choi, Y. (1997). TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival. Immunity 7, 703-713.
    • (1997) Immunity , vol.7 , pp. 703-713
    • Lee, S.Y.1    Reichlin, A.2    Santana, A.3    Sokol, K.A.4    Nussenweig, M.C.5    Choi, Y.6
  • 39
    • 0029949938 scopus 로고    scopus 로고
    • prICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2
    • Smyth, M. J., Perry, D. K., Zhang, J., Poirier, G. G., Hannun, Y. A., and Obeid, L. M. (1996). prICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem. J. 316, 25-28.
    • (1996) Biochem. J. , vol.316 , pp. 25-28
    • Smyth, M.J.1    Perry, D.K.2    Zhang, J.3    Poirier, G.G.4    Hannun, Y.A.5    Obeid, L.M.6
  • 40
    • 0031813012 scopus 로고    scopus 로고
    • Neurotrophic factors prevent ceramide-induced apoptosis down-stream of c-Jun N-terminal kinase activation in PC12 cells
    • Hartfield, P. J., Bilney, A. J., and Murray, A. W. (1997). Neurotrophic factors prevent ceramide-induced apoptosis down-stream of c-Jun N-terminal kinase activation in PC12 cells. J. Neurochem. 71, 161-169.
    • (1997) J. Neurochem. , vol.71 , pp. 161-169
    • Hartfield, P.J.1    Bilney, A.J.2    Murray, A.W.3
  • 41
    • 0032562089 scopus 로고    scopus 로고
    • Ceramide-induced apoptosis is mediated by caspase activation independently from retinoblastoma protein post-translational modification
    • Spinedi, A., Amendola, A., Di Bartolomeo, S., and Piacentini, M. (1998). Ceramide-induced apoptosis is mediated by caspase activation independently from retinoblastoma protein post-translational modification. Biochem. Biophy. Res. Commun. 243, 852-857.
    • (1998) Biochem. Biophy. Res. Commun. , vol.243 , pp. 852-857
    • Spinedi, A.1    Amendola, A.2    Di Bartolomeo, S.3    Piacentini, M.4
  • 42
    • 0032523042 scopus 로고    scopus 로고
    • Apoptotic signal of Fas is not mediated by ceramide
    • Hsu, S. C., Wu, C. C., Luh, T. Y., Chou, C. K., Han, S. H., and Lai, M. Z. (1998). Apoptotic signal of Fas is not mediated by ceramide. Blood 91, 2658-2663.
    • (1998) Blood , vol.91 , pp. 2658-2663
    • Hsu, S.C.1    Wu, C.C.2    Luh, T.Y.3    Chou, C.K.4    Han, S.H.5    Lai, M.Z.6
  • 44
    • 0028102478 scopus 로고
    • Cleavage of poly (ADP-ribose) polymerase by a proteinase with properties like ICE
    • Lazebnik, Y. A., Kauffmann, S. H., Desnoyers, S., Poirier, G. G., and Earnshaw, W. C. (1994). Cleavage of poly (ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346-347.
    • (1994) Nature , vol.371 , pp. 346-347
    • Lazebnik, Y.A.1    Kauffmann, S.H.2    Desnoyers, S.3    Poirier, G.G.4    Earnshaw, W.C.5
  • 46
    • 0028990125 scopus 로고
    • Yama/CPP32 beta, mammalian homolog of CED-3, is a crmA inhibitable protease that cleaves the substrate poly (ADP-ribose) polymerase
    • Tewari, M., Quan, L. T., O'Rourke, K., Desnoyer, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvessen, G. S., and Dixit, V. M. (1995). Yama/CPP32 beta, mammalian homolog of CED-3, is a crmA inhibitable protease that cleaves the substrate poly (ADP-ribose) polymerase. Cell 81, 801-809.
    • (1995) Cell , vol.81 , pp. 801-809
    • Tewari, M.1    Quan, L.T.2    O'Rourke, K.3    Desnoyer, S.4    Zeng, Z.5    Beidler, D.R.6    Poirier, G.G.7    Salvessen, G.S.8    Dixit, V.M.9


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