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Volumn 45, Issue 1, 2004, Pages 164-173

The role of de novo ceramide synthesis in the mechanism of action of the tricyclic xanthate D609

Author keywords

Apoptosis; Brefeldin A; Endoplasmic reticulum export; Eukaryotic initiation factor 2 ; Fumonisin B1; Protein translation; Serine palmitoyltransferase

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; BREFELDIN A; CERAMIDE; CHELERYTHRINE; CYCLOSERINE; FUMONISIN B1; INITIATION FACTOR 2; THAPSIGARGIN; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE; XANTHIC ACID DERIVATIVE;

EID: 0842326180     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M300300-JLR200     Document Type: Article
Times cited : (21)

References (51)
  • 1
    • 0030448021 scopus 로고    scopus 로고
    • Functions of ceramide in coordinating cellular responses to stress
    • Hannun, Y. A. 1996. Functions of ceramide in coordinating cellular responses to stress. Science. 274: 1855-1859.
    • (1996) Science , vol.274 , pp. 1855-1859
    • Hannun, Y.A.1
  • 2
    • 0033974782 scopus 로고    scopus 로고
    • Ceramide in the eukaryotic stress response
    • Hannun, Y. A., and C. Luberto. 2000. Ceramide in the eukaryotic stress response. Trends Cell Biol. 10: 73-80.
    • (2000) Trends Cell Biol. , vol.10 , pp. 73-80
    • Hannun, Y.A.1    Luberto, C.2
  • 3
    • 0033575310 scopus 로고    scopus 로고
    • Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid
    • Chalfant, C. E., K. Kishikawa, M. C. Mumby, C. Kamibayashi, A. Bielawska, and Y. A. Hannun. 1999. Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. J. Biol. Chem. 274: 20313-20317.
    • (1999) J. Biol. Chem. , vol.274 , pp. 20313-20317
    • Chalfant, C.E.1    Kishikawa, K.2    Mumby, M.C.3    Kamibayashi, C.4    Bielawska, A.5    Hannun, Y.A.6
  • 4
    • 0035853831 scopus 로고    scopus 로고
    • Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX
    • Ruvolo, P. P., F. Gao, W. L. Blalock, X. Deng, and W. S. May. 2001. Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX. J. Biol. Chem. 276: 11754-11758.
    • (2001) J. Biol. Chem. , vol.276 , pp. 11754-11758
    • Ruvolo, P.P.1    Gao, F.2    Blalock, W.L.3    Deng, X.4    May, W.S.5
  • 6
    • 15844387528 scopus 로고    scopus 로고
    • Ceramide inactivates cellular protein kinase Calpha
    • Lee, J. Y., Y. A. Hannun, and L. M. Obeid. 1996. Ceramide inactivates cellular protein kinase Calpha. J. Biol. Chem. 271: 13169-13174.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13169-13174
    • Lee, J.Y.1    Hannun, Y.A.2    Obeid, L.M.3
  • 8
    • 0029090337 scopus 로고
    • Neurotrophins induce sphingomyelin hydrolysis. Modulation by coexpression of p75NTR with Trk receptors
    • Dobrowsky, R. T., G. M. Jenkins, and Y. A. Hannun. 1995. Neurotrophins induce sphingomyelin hydrolysis. Modulation by coexpression of p75NTR with Trk receptors. J. Biol. Chem. 270: 22135-22142.
    • (1995) J. Biol. Chem. , vol.270 , pp. 22135-22142
    • Dobrowsky, R.T.1    Jenkins, G.M.2    Hannun, Y.A.3
  • 9
    • 0026007737 scopus 로고
    • Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation
    • Kim, M. Y., C. Linardic, L. Obeid, and Y. Hannun. 1991. Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. J. Biol. Chem. 266: 484-489.
    • (1991) J. Biol. Chem. , vol.266 , pp. 484-489
    • Kim, M.Y.1    Linardic, C.2    Obeid, L.3    Hannun, Y.4
  • 10
    • 0028537064 scopus 로고
    • The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation
    • Kolesnick, R. N., A. Haimovitz-Friedman, and Z. Fuks. 1994. The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation. Biochem. Cell Biol. 72: 471-474.
    • (1994) Biochem. Cell Biol. , vol.72 , pp. 471-474
    • Kolesnick, R.N.1    Haimovitz-Friedman, A.2    Fuks, Z.3
  • 11
    • 0034708594 scopus 로고    scopus 로고
    • Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis
    • Perry, D. K., J. Carton, A. K. Shah, F. Meredith, D.J. Uhlinger, and Y. A. Hannun. 2000. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J. Biol. Chem. 275: 9078-9084.
    • (2000) J. Biol. Chem. , vol.275 , pp. 9078-9084
    • Perry, D.K.1    Carton, J.2    Shah, A.K.3    Meredith, F.4    Uhlinger, D.J.5    Hannun, Y.A.6
  • 12
    • 0032541179 scopus 로고    scopus 로고
    • The multidrug resistance modulator SDZ PSC 833 is a potent activator of cellular ceramide formation
    • Cabot, M. C., T. Y. Han, and A. E. Giuliano. 1998. The multidrug resistance modulator SDZ PSC 833 is a potent activator of cellular ceramide formation. FEBS Lett. 431: 185-188.
    • (1998) FEBS Lett. , vol.431 , pp. 185-188
    • Cabot, M.C.1    Han, T.Y.2    Giuliano, A.E.3
  • 13
    • 0029148660 scopus 로고
    • Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
    • Bose, R., M. Verheij, A. Haimovitz-Friedman, K. Scotto, Z. Fuks, and R. Kolesnick. 1995. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell. 82: 405-414.
    • (1995) Cell , vol.82 , pp. 405-414
    • Bose, R.1    Verheij, M.2    Haimovitz-Friedman, A.3    Scotto, K.4    Fuks, Z.5    Kolesnick, R.6
  • 15
    • 17544402409 scopus 로고    scopus 로고
    • Sequential operation of ceramide synthesis and ICE cascade in CPT-11-initiated apoptotic death signaling
    • Suzuki, A., M. Iwasaki, M. Kato, and N. Wagai. 1997. Sequential operation of ceramide synthesis and ICE cascade in CPT-11-initiated apoptotic death signaling. Exp. Cell Res. 233: 41-47.
    • (1997) Exp. Cell Res. , vol.233 , pp. 41-47
    • Suzuki, A.1    Iwasaki, M.2    Kato, M.3    Wagai, N.4
  • 16
    • 0030612721 scopus 로고    scopus 로고
    • Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells
    • Boland, M. P., S. J. Foster, and L. A. O'Neill. 1997. Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells. J. Biol. Chem. 272: 12952-12960.
    • (1997) J. Biol. Chem. , vol.272 , pp. 12952-12960
    • Boland, M.P.1    Foster, S.J.2    O'Neill, L.A.3
  • 17
    • 0027413499 scopus 로고
    • The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver
    • Hirschberg, K., J. Rodger, and A. H. Futerman. 1993. The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver. Biochem. J. 290: 751-757.
    • (1993) Biochem. J. , vol.290 , pp. 751-757
    • Hirschberg, K.1    Rodger, J.2    Futerman, A.H.3
  • 18
    • 0033593788 scopus 로고    scopus 로고
    • Genetic evidence for ATP-dependent endoplasmic reticulum-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in Chinese hamster ovary cells
    • Fukasawa, M., M. Nishijima, and K. Hanada. 1999. Genetic evidence for ATP-dependent endoplasmic reticulum-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in Chinese hamster ovary cells. J. Cell Biol. 144: 673-685.
    • (1999) J. Cell Biol. , vol.144 , pp. 673-685
    • Fukasawa, M.1    Nishijima, M.2    Hanada, K.3
  • 19
    • 0032568836 scopus 로고    scopus 로고
    • Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death
    • Xu, J., C. H. Yeh, S. Chen, L. He, S. L. Sensi, L. M. Canzoniero, D. W. Choi, and C. Y. Hsu. 1998. Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death. J. Biol. Chem. 273: 16521-16526.
    • (1998) J. Biol. Chem. , vol.273 , pp. 16521-16526
    • Xu, J.1    Yeh, C.H.2    Chen, S.3    He, L.4    Sensi, S.L.5    Canzoniero, L.M.6    Choi, D.W.7    Hsu, C.Y.8
  • 20
    • 0035199418 scopus 로고    scopus 로고
    • Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis
    • Birbes, H., S. El Bawab, Y. A. Hannun, and L. M. Obeid. 2001. Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J. 15: 2669-2679.
    • (2001) FASEB J. , vol.15 , pp. 2669-2679
    • Birbes, H.1    El Bawab, S.2    Hannun, Y.A.3    Obeid, L.M.4
  • 21
    • 0034640391 scopus 로고    scopus 로고
    • Differential effects of sphingomyelin hydrolysis and resynthesis on the activation of NF-kappa B in normal and SV40-transformed human fibroblasts
    • Luberto, C., D. S. Yoo, H. S. Suidan, G. M. Bartoli, and Y. A. Hannun. 2000. Differential effects of sphingomyelin hydrolysis and resynthesis on the activation of NF-kappa B in normal and SV40-transformed human fibroblasts. J. Biol. Chem. 275: 14760-14766.
    • (2000) J. Biol. Chem. , vol.275 , pp. 14760-14766
    • Luberto, C.1    Yoo, D.S.2    Suidan, H.S.3    Bartoli, G.M.4    Hannun, Y.A.5
  • 22
    • 0030480576 scopus 로고    scopus 로고
    • The antiviral, antitumural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C
    • Amtmann, E. 1996. The antiviral, antitumural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp. Clin. Res. 22: 287-294.
    • (1996) Drugs Exp. Clin. Res. , vol.22 , pp. 287-294
    • Amtmann, E.1
  • 23
    • 0023749089 scopus 로고
    • Interruption of growth signal transduction by an antiviral and antitumoral xanthate compound
    • Muller-Decker, K., C. Doppler, E. Amtmann, and G. Sauer. 1988. Interruption of growth signal transduction by an antiviral and antitumoral xanthate compound. Exp. Cell Res. 177: 295-302.
    • (1988) Exp. Cell Res. , vol.177 , pp. 295-302
    • Muller-Decker, K.1    Doppler, C.2    Amtmann, E.3    Sauer, G.4
  • 24
    • 0035976851 scopus 로고    scopus 로고
    • Effect of D609 on phosphatidylcholine metabolism in the nuclei of LA-N-1 neuroblastoma cells: A key role for diacylglycerol
    • Antony, P., A. A. Farooqui, L. A. Horrocks, and L. Freysz. 2001. Effect of D609 on phosphatidylcholine metabolism in the nuclei of LA-N-1 neuroblastoma cells: a key role for diacylglycerol. FEBS Lett. 509: 115-118.
    • (2001) FEBS Lett. , vol.509 , pp. 115-118
    • Antony, P.1    Farooqui, A.A.2    Horrocks, L.A.3    Freysz, L.4
  • 25
    • 0034940205 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha activates the phosphorylation of ERK, SAPK/JNK, and P38 kinase in primary cultures of neurons
    • Barbin, G., M. P. Roisin, and B. Zalc. 2001. Tumor necrosis factor alpha activates the phosphorylation of ERK, SAPK/JNK, and P38 kinase in primary cultures of neurons. Neurochem. Res. 26: 107-112.
    • (2001) Neurochem. Res. , vol.26 , pp. 107-112
    • Barbin, G.1    Roisin, M.P.2    Zalc, B.3
  • 27
    • 0036131211 scopus 로고    scopus 로고
    • Priming of alveolar macrophage respiratory burst by H(2)O(2) is prevented by phosphatidylcholine-specific phospholipase C inhibitor tricyclodecan-9-yl-xanthate (D609)
    • Giron-Calle, J., K. Srivatsa, and H. J. Forman. 2002. Priming of alveolar macrophage respiratory burst by H(2)O(2) is prevented by phosphatidylcholine-specific phospholipase C inhibitor tricyclodecan-9-yl-xanthate (D609). J. Pharmacol. Exp. Ther. 301: 87-94.
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , pp. 87-94
    • Giron-Calle, J.1    Srivatsa, K.2    Forman, H.J.3
  • 28
    • 0036236938 scopus 로고    scopus 로고
    • Synthesis and phospholipase C inhibitory activity of D609 diastereomers
    • Gonzalez-Roura, A., J. Casas, and A. Llebaria. 2002. Synthesis and phospholipase C inhibitory activity of D609 diastereomers. Lipids. 37: 401-406.
    • (2002) Lipids , vol.37 , pp. 401-406
    • Gonzalez-Roura, A.1    Casas, J.2    Llebaria, A.3
  • 30
    • 0034721516 scopus 로고    scopus 로고
    • Phosphatidylcholine-specific phospholipase C inhibitor, tricyclodecan-9-yl xanthogenate (D609), increases phospholipase D-mediated phosphatidylcholine hydrolysis in UMR-106 osteoblastic osteosarcoma cells
    • Singh, A. T., J. M. Radeff, J. G. Kunnel, and P. H. Stern. 2000. Phosphatidylcholine-specific phospholipase C inhibitor, tricyclodecan-9-yl xanthogenate (D609), increases phospholipase D-mediated phosphatidylcholine hydrolysis in UMR-106 osteoblastic osteosarcoma cells. Biochim. Biophys. Acta. 1487: 201-208.
    • (2000) Biochim. Biophys. Acta , vol.1487 , pp. 201-208
    • Singh, A.T.1    Radeff, J.M.2    Kunnel, J.G.3    Stern, P.H.4
  • 31
    • 0037053378 scopus 로고    scopus 로고
    • The lysosomal transport of prosaposin requires the conditional interaction of its highly conserved d domain with sphingomyelin
    • Lefrancois, S., T. May, C. Knight, D. Bourbeau, and C. R. Morales. 2002. The lysosomal transport of prosaposin requires the conditional interaction of its highly conserved d domain with sphingomyelin. J. Biol. Chem. 277: 17188-17199.
    • (2002) J. Biol. Chem. , vol.277 , pp. 17188-17199
    • Lefrancois, S.1    May, T.2    Knight, C.3    Bourbeau, D.4    Morales, C.R.5
  • 32
    • 0028979940 scopus 로고
    • 25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells
    • Ridgway, N. D. 1995. 25-Hydroxycholesterol stimulates sphingomyelin synthesis in Chinese hamster ovary cells. J. Lipid Res. 36: 1345-1358.
    • (1995) J. Lipid Res. , vol.36 , pp. 1345-1358
    • Ridgway, N.D.1
  • 33
    • 0028937092 scopus 로고
    • Metabolism of short-chain ceramide and dihydroceramide analogues in Chinese hamster ovary (CHO) cells
    • Ridgway, N. D., and D. L. Merriam. 1995. Metabolism of short-chain ceramide and dihydroceramide analogues in Chinese hamster ovary (CHO) cells. Biochim. Biophys. Acta. 1256: 57-70.
    • (1995) Biochim. Biophys. Acta , vol.1256 , pp. 57-70
    • Ridgway, N.D.1    Merriam, D.L.2
  • 34
    • 0022970190 scopus 로고
    • Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells
    • Preiss, J., C. R. Loomis, W. R. Bishop, R. Stein, J. E. Niedel, and R. M. Bell. 1986. Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells. J. Biol. Chem. 261: 8597-8600.
    • (1986) J. Biol. Chem. , vol.261 , pp. 8597-8600
    • Preiss, J.1    Loomis, C.R.2    Bishop, W.R.3    Stein, R.4    Niedel, J.E.5    Bell, R.M.6
  • 36
    • 0021109019 scopus 로고
    • Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells
    • Merrill, A. H., Jr. 1983. Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells. Biochim. Biophys. Acta. 754: 284-291.
    • (1983) Biochim. Biophys. Acta , vol.754 , pp. 284-291
    • Merrill Jr., A.H.1
  • 37
    • 0026612730 scopus 로고
    • Use of N-[1-14C]hexanoyl)-D-erythro-sphingolipids to assay sphingolipid metabolism
    • Futerman, A. H., and R. E. Pagano. 1992. Use of N-[1-14C]hexanoyl)-D-erythro-sphingolipids to assay sphingolipid metabolism. Methods Enzymol. 209: 437-446.
    • (1992) Methods Enzymol. , vol.209 , pp. 437-446
    • Futerman, A.H.1    Pagano, R.E.2
  • 38
    • 0035941303 scopus 로고    scopus 로고
    • A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis
    • Yasuda, S., H. Kitagawa, M. Ueno, H. Ishitani, M. Fukasawa, M. Nishijima, S. Kobayashi, and K. Hanada. 2001. A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis. J. Biol. Chem. 276: 43994-44002.
    • (2001) J. Biol. Chem. , vol.276 , pp. 43994-44002
    • Yasuda, S.1    Kitagawa, H.2    Ueno, M.3    Ishitani, H.4    Fukasawa, M.5    Nishijima, M.6    Kobayashi, S.7    Hanada, K.8
  • 39
    • 0034947717 scopus 로고    scopus 로고
    • Golgi localization and phosphorylation of oxysterol binding protein in Niemann-Pick C and U18666A-treated cells
    • Mohammadi, A., R. J. Perry, M. K. Storey, H. W. Cook, D. M. Byers, and N. D. Ridgway. 2001. Golgi localization and phosphorylation of oxysterol binding protein in Niemann-Pick C and U18666A-treated cells. J. Lipid Res. 42: 1062-1071.
    • (2001) J. Lipid Res. , vol.42 , pp. 1062-1071
    • Mohammadi, A.1    Perry, R.J.2    Storey, M.K.3    Cook, H.W.4    Byers, D.M.5    Ridgway, N.D.6
  • 40
    • 0026465921 scopus 로고
    • Protein phosphorylation in translational control
    • Proud, C. G. 1992. Protein phosphorylation in translational control. Curr. Top. Cell. Regul. 32: 243-369.
    • (1992) Curr. Top. Cell. Regul. , vol.32 , pp. 243-369
    • Proud, C.G.1
  • 41
    • 0033213918 scopus 로고    scopus 로고
    • Translation initiation: Adept at adapting
    • Dever, T. E. 1999. Translation initiation: adept at adapting. Trends Biochem. Sci. 24: 398-403.
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 398-403
    • Dever, T.E.1
  • 42
    • 0033056848 scopus 로고    scopus 로고
    • RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling
    • Ito, T., M. Yang, and W. S. May. 1999. RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. J. Biol. Chem. 274: 15427-15432.
    • (1999) J. Biol. Chem. , vol.274 , pp. 15427-15432
    • Ito, T.1    Yang, M.2    May, W.S.3
  • 43
    • 0032553324 scopus 로고    scopus 로고
    • Differential effects of sphingomyelin hydrolysis and cholesterol transport on oxysterol-binding protein phosphorylation and Golgi localization
    • Ridgway, N. D., T. A. Lagace, H. W. Cook, and D. M. Byers. 1998. Differential effects of sphingomyelin hydrolysis and cholesterol transport on oxysterol-binding protein phosphorylation and Golgi localization. J. Biol. Chem. 273: 31621-31628.
    • (1998) J. Biol. Chem. , vol.273 , pp. 31621-31628
    • Ridgway, N.D.1    Lagace, T.A.2    Cook, H.W.3    Byers, D.M.4
  • 44
    • 0032484965 scopus 로고    scopus 로고
    • Inhibition of phosphorylation of the oxysterol binding protein by brefeldin A
    • Ridgway, N. D., K. Badiani, D. M. Byers, and H. W. Cook. 1998. Inhibition of phosphorylation of the oxysterol binding protein by brefeldin A. Biochim. Biophys. Acta. 1390: 37-51.
    • (1998) Biochim. Biophys. Acta , vol.1390 , pp. 37-51
    • Ridgway, N.D.1    Badiani, K.2    Byers, D.M.3    Cook, H.W.4
  • 45
    • 0026660272 scopus 로고
    • Brefeldin A-induced increase of sphingomyelin synthesis. Assay for the action of the antibiotic in mammalian cells
    • Bruning, A., A. Karrenbauer, E. Schnabel, and F. T. Wieland. 1992. Brefeldin A-induced increase of sphingomyelin synthesis. Assay for the action of the antibiotic in mammalian cells. J. Biol. Chem. 267: 5052-5055.
    • (1992) J. Biol. Chem. , vol.267 , pp. 5052-5055
    • Bruning, A.1    Karrenbauer, A.2    Schnabel, E.3    Wieland, F.T.4
  • 46
    • 0028902989 scopus 로고
    • Brefeldin A renders Chinese hamster ovary cells insensitive to transcriptional suppression by 25-hydroxycholesterol
    • Ridgway, N. D., and T. A. Lagace. 1995. Brefeldin A renders Chinese hamster ovary cells insensitive to transcriptional suppression by 25-hydroxycholesterol. J. Biol. Chem. 270: 8023-8031.
    • (1995) J. Biol. Chem. , vol.270 , pp. 8023-8031
    • Ridgway, N.D.1    Lagace, T.A.2
  • 47
    • 0032895139 scopus 로고    scopus 로고
    • Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol
    • Lagace, T. A., D. M. Byers, H. W. Cook, and N. D. Ridgway. 1999. Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol. J. Lipid Res. 40: 109-116.
    • (1999) J. Lipid Res. , vol.40 , pp. 109-116
    • Lagace, T.A.1    Byers, D.M.2    Cook, H.W.3    Ridgway, N.D.4
  • 48
    • 0034567169 scopus 로고    scopus 로고
    • Applications of BODIPY-sphingolipid analogs to study lipid traffic and metabolism in cells
    • Pagano, R. E., R. Watanabe, C. Wheatley, and M. Dominguez. 2000. Applications of BODIPY-sphingolipid analogs to study lipid traffic and metabolism in cells. Methods Enzymol. 312: 523-534.
    • (2000) Methods Enzymol. , vol.312 , pp. 523-534
    • Pagano, R.E.1    Watanabe, R.2    Wheatley, C.3    Dominguez, M.4
  • 49
    • 0032486257 scopus 로고    scopus 로고
    • Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?
    • Luberto, C., and Y. A. Hannun. 1998. Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? J. Biol. Chem. 273: 14550-14559.
    • (1998) J. Biol. Chem. , vol.273 , pp. 14550-14559
    • Luberto, C.1    Hannun, Y.A.2
  • 51
    • 0034531395 scopus 로고    scopus 로고
    • PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR
    • Patel, C. V., I. Handy, T. Goldsmith, and R. C. Patel. 2000. PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR. J. Biol. Chem. 275: 37993-37998.
    • (2000) J. Biol. Chem. , vol.275 , pp. 37993-37998
    • Patel, C.V.1    Handy, I.2    Goldsmith, T.3    Patel, R.C.4


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