-
1
-
-
0037930878
-
The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells
-
Abram CL, Seals DF, Pass I, Salinsky D, Maurer L, Roth TM, Courtneidge SA. 2003. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. J Biol Chem 278:16844-51.
-
(2003)
J Biol Chem
, vol.278
, pp. 16844-16851
-
-
Abram, C.L.1
Seals, D.F.2
Pass, I.3
Salinsky, D.4
Maurer, L.5
Roth, T.M.6
Courtneidge, S.A.7
-
2
-
-
15644362968
-
Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity
-
Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD. 1998. Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity. J Biol Chem 273:33082-90.
-
(1998)
J Biol Chem
, vol.273
, pp. 33082-33090
-
-
Arcaro, A.1
Volinia, S.2
Zvelebil, M.J.3
Stein, R.4
Watton, S.J.5
Layton, M.J.6
Gout, I.7
Ahmadi, K.8
Downward, J.9
Waterfield, M.D.10
-
3
-
-
0034024403
-
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
-
Arcaro A, Zvelebil MJ, Wallasch C, Ullrich A, Waterfield MD, Domin J. 2000. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. Mol Cell Biol 20:3817-30.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 3817-3830
-
-
Arcaro, A.1
Zvelebil, M.J.2
Wallasch, C.3
Ullrich, A.4
Waterfield, M.D.5
Domin, J.6
-
4
-
-
0036791759
-
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation
-
Arcaro A, Khanzada UK, Vanhaesebroeck B, Tetley TD, Waterfield MD, Seckl MJ. 2002. Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation. EMBO J 21:5097-108.
-
(2002)
EMBO J
, vol.21
, pp. 5097-5108
-
-
Arcaro, A.1
Khanzada, U.K.2
Vanhaesebroeck, B.3
Tetley, T.D.4
Waterfield, M.D.5
Seckl, M.J.6
-
5
-
-
0037986310
-
Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting
-
Baumeister MA, Martinu L, Rossman KL, Sondek J, Lemmon MA, Chou MM. 2003. Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting. J Biol Chem 278:11457-64.
-
(2003)
J Biol Chem
, vol.278
, pp. 11457-11464
-
-
Baumeister, M.A.1
Martinu, L.2
Rossman, K.L.3
Sondek, J.4
Lemmon, M.A.5
Chou, M.M.6
-
6
-
-
25444457577
-
hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
-
Byfield MP, Murray JT, Backer JM. 2005. hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem 280:33076-82.
-
(2005)
J Biol Chem
, vol.280
, pp. 33076-33082
-
-
Byfield, M.P.1
Murray, J.T.2
Backer, J.M.3
-
7
-
-
0033591247
-
Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
-
Brown RA, Domin J, Arcaro A, Waterfield MD, Shepherd PR. 1999. Insulin activates the alpha isoform of class II phosphoinositide 3-kinase. J Biol Chem 274:14529-32.
-
(1999)
J Biol Chem
, vol.274
, pp. 14529-14532
-
-
Brown, R.A.1
Domin, J.2
Arcaro, A.3
Waterfield, M.D.4
Shepherd, P.R.5
-
8
-
-
0034866612
-
Growth factor regulation of the novel class II phosphoinositide 3-kinases
-
Brown RA, Shepherd PR. 2001. Growth factor regulation of the novel class II phosphoinositide 3-kinases. Biochem Soc Trans 29:535-7.
-
(2001)
Biochem Soc Trans
, vol.29
, pp. 535-537
-
-
Brown, R.A.1
Shepherd, P.R.2
-
9
-
-
0037248553
-
A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase
-
Brown GE, Stewart MQ, Liu H, Ha VL, Yaffe MB. 2003. A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase. Mol Cell 11:35-47.
-
(2003)
Mol Cell
, vol.11
, pp. 35-47
-
-
Brown, G.E.1
Stewart, M.Q.2
Liu, H.3
Ha, V.L.4
Yaffe, M.B.5
-
10
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC. 2002. The phosphoinositide 3-kinase pathway. Science 296:1655-7.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
13
-
-
0347480266
-
Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: Involvement of PtdIns(3)P in insulin-stimulated glucose transport
-
Chaussade C, Pirola L, Bonnafous S, Blondeau F, Brenz-Verca S, Tronchere H, Portis F, Rusconi S, Payrastre B, Laporte J, Van Obberghen E. 2003. Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport. Mol Endocrinol 17:2448-60.
-
(2003)
Mol Endocrinol
, vol.17
, pp. 2448-2460
-
-
Chaussade, C.1
Pirola, L.2
Bonnafous, S.3
Blondeau, F.4
Brenz-Verca, S.5
Tronchere, H.6
Portis, F.7
Rusconi, S.8
Payrastre, B.9
Laporte, J.10
Van Obberghen, E.11
-
14
-
-
0034947026
-
Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes
-
Cheever ML, Sato TK, de Beer T, Kutateladze TG, Emr SD, Overduin M. 2001. Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes. Nat Cell Biol 3:613-8.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 613-618
-
-
Cheever, M.L.1
Sato, T.K.2
de Beer, T.3
Kutateladze, T.G.4
Emr, S.D.5
Overduin, M.6
-
15
-
-
4344654141
-
Mycobacterium tuberculosis reprograms waves of phosphatidylinositol 3-phosphate on phagosomal organelles
-
Chua J, Deretic V. 2004. Mycobacterium tuberculosis reprograms waves of phosphatidylinositol 3-phosphate on phagosomal organelles. J Biol Chem 279:36982-92.
-
(2004)
J Biol Chem
, vol.279
, pp. 36982-36992
-
-
Chua, J.1
Deretic, V.2
-
16
-
-
17144434525
-
Priming of human neutrophil superoxide generation by tumour necrosis factor-alpha is signalled by enhanced phosphatidylinositol 3,4,5-trisphosphate but not inositol 1,4,5-trisphosphate accumulation
-
Condliffe AM, Hawkins PT, Stephens LR, Haslett C, Chilvers ER. 1998. Priming of human neutrophil superoxide generation by tumour necrosis factor-alpha is signalled by enhanced phosphatidylinositol 3,4,5-trisphosphate but not inositol 1,4,5-trisphosphate accumulation. FEBS Lett 439:147-51.
-
(1998)
FEBS Lett
, vol.439
, pp. 147-151
-
-
Condliffe, A.M.1
Hawkins, P.T.2
Stephens, L.R.3
Haslett, C.4
Chilvers, E.R.5
-
17
-
-
0346099346
-
Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans
-
Dang H, Li Z, Skolnik EY, Fares H. 2004. Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans. Mol Biol Cell 15:189-96.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 189-196
-
-
Dang, H.1
Li, Z.2
Skolnik, E.Y.3
Fares, H.4
-
18
-
-
0035930577
-
Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles
-
Didichenko SA, Thelen M. 2001. Phosphatidylinositol 3-kinase c2alpha contains a nuclear localization sequence and associates with nuclear speckles. J Biol Chem 276:48135-42.
-
(2001)
J Biol Chem
, vol.276
, pp. 48135-48142
-
-
Didichenko, S.A.1
Thelen, M.2
-
19
-
-
16644382070
-
Of yeast and men. The evolution of PtdIns(3,4,5)P(3) synthesis
-
Divecha N, Halstead JR. 2004. Of yeast and men. The evolution of PtdIns(3,4,5)P(3) synthesis. EMBO Rep 5:865-6.
-
(2004)
EMBO Rep
, vol.5
, pp. 865-866
-
-
Divecha, N.1
Halstead, J.R.2
-
20
-
-
0030884527
-
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
-
Domin J, Pages F, Volinia S, Rittenhouse SE, Zvelebil MJ, Stein RC, Waterfield MD. 1997. Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem J 326:139-47.
-
(1997)
Biochem J
, vol.326
, pp. 139-147
-
-
Domin, J.1
Pages, F.2
Volinia, S.3
Rittenhouse, S.E.4
Zvelebil, M.J.5
Stein, R.C.6
Waterfield, M.D.7
-
21
-
-
0034306455
-
Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities
-
Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR. 2000. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J 351:19-31.
-
(2000)
Biochem J
, vol.351
, pp. 19-31
-
-
Dowler, S.1
Currie, R.A.2
Campbell, D.G.3
Deak, M.4
Kular, G.5
Downes, C.P.6
Alessi, D.R.7
-
22
-
-
0035899869
-
Phosphatidylinositol 3-phosphate is generated in phagosomal membranes
-
Ellson CD, Anderson KE, Morgan G, Chilvers ER, Lipp P, Stephens LR, Hawkins PT. 2001a. Phosphatidylinositol 3-phosphate is generated in phagosomal membranes. Curr Biol 11:1631-5.
-
(2001)
Curr Biol
, vol.11
, pp. 1631-1635
-
-
Ellson, C.D.1
Anderson, K.E.2
Morgan, G.3
Chilvers, E.R.4
Lipp, P.5
Stephens, L.R.6
Hawkins, P.T.7
-
23
-
-
0034743311
-
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox)
-
Ellson CD, Gobert-Gosse S, Anderson KE, Davidson K, Erdjument-Bromage H, Tempst P, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Gaffney PR, Coadwell J, Chilvers ER, Hawkins PT, Stephens LR. 2001b. PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol 3:679-82.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 679-682
-
-
Ellson, C.D.1
Gobert-Gosse, S.2
Anderson, K.E.3
Davidson, K.4
Erdjument-Bromage, H.5
Tempst, P.6
Thuring, J.W.7
Cooper, M.A.8
Lim, Z.Y.9
Holmes, A.B.10
Gaffney, P.R.11
Coadwell, J.12
Chilvers, E.R.13
Hawkins, P.T.14
Stephens, L.R.15
-
24
-
-
33746885455
-
Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing
-
Ellson CD, Davidson K, Ferguson GJ, O'Connor R, Stephens LR, Hawkins PT. 2006. Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing. J Exp Med 203:1927-37.
-
(2006)
J Exp Med
, vol.203
, pp. 1927-1937
-
-
Ellson, C.D.1
Davidson, K.2
Ferguson, G.J.3
O'Connor, R.4
Stephens, L.R.5
Hawkins, P.T.6
-
26
-
-
0035103107
-
The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking
-
Gaidarov I, Smith ME, Domin J, Keen JH. 2001. The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking. Mol Cell 7:443-9.
-
(2001)
Mol Cell
, vol.7
, pp. 443-449
-
-
Gaidarov, I.1
Smith, M.E.2
Domin, J.3
Keen, J.H.4
-
27
-
-
28844472833
-
Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function
-
Gaidarov I, Zhao Y, Keen JH. 2005. Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function. J Biol Chem 280:40766-72.
-
(2005)
J Biol Chem
, vol.280
, pp. 40766-40772
-
-
Gaidarov, I.1
Zhao, Y.2
Keen, J.H.3
-
28
-
-
0034282751
-
Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
-
Gillooly DJ, Morrow IC, Lindsay M, Gould R, Bryant NJ, Gaullier JM, Parton RG, Stenmark H. 2000. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J 19:4577-88.
-
(2000)
EMBO J
, vol.19
, pp. 4577-4588
-
-
Gillooly, D.J.1
Morrow, I.C.2
Lindsay, M.3
Gould, R.4
Bryant, N.J.5
Gaullier, J.M.6
Parton, R.G.7
Stenmark, H.8
-
29
-
-
0031724592
-
Identification of a family of sorting nexin molecules and characterization of their association with receptors
-
Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI. 1998. Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol Cell Biol 18:7278-87.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 7278-7287
-
-
Haft, C.R.1
de la Luz Sierra, M.2
Barr, V.A.3
Haft, D.H.4
Taylor, S.I.5
-
30
-
-
0035916811
-
A novel pathway of cellular phosphatidylinositol(3,4,5)-trisphosphate synthesis is regulated by oxidative stress
-
Halstead JR, Roefs M, Ellson CD, D'Andrea S, Chen C, D'Santos CS, Divecha N. 2001. A novel pathway of cellular phosphatidylinositol(3,4,5)-trisphosphate synthesis is regulated by oxidative stress. Curr Biol 11:386-95.
-
(2001)
Curr Biol
, vol.11
, pp. 386-395
-
-
Halstead, J.R.1
Roefs, M.2
Ellson, C.D.3
D'Andrea, S.4
Chen, C.5
D'Santos, C.S.6
Divecha, N.7
-
32
-
-
23344431984
-
Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides
-
Ishiki M, Randhawa VK, Poon V, Jebailey L, Klip A. 2005. Insulin regulates the membrane arrival, fusion, and C-terminal unmasking of glucose transporter-4 via distinct phosphoinositides. J Biol Chem 280:28792-802.
-
(2005)
J Biol Chem
, vol.280
, pp. 28792-28802
-
-
Ishiki, M.1
Randhawa, V.K.2
Poon, V.3
Jebailey, L.4
Klip, A.5
-
33
-
-
85047691831
-
Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization
-
Kanda H, Tamori Y, Shinoda H, Yoshikawa M, Sakaue M, Udagawa J, Otani H, Tashiro F, Miyazaki J, Kasuga M. 2005. Adipocytes from Munc18c-null mice show increased sensitivity to insulin-stimulated GLUT4 externalization. J Clin Inves 115:291-301.
-
(2005)
J Clin Inves
, vol.115
, pp. 291-301
-
-
Kanda, H.1
Tamori, Y.2
Shinoda, H.3
Yoshikawa, M.4
Sakaue, M.5
Udagawa, J.6
Otani, H.7
Tashiro, F.8
Miyazaki, J.9
Kasuga, M.10
-
34
-
-
0032515042
-
Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains
-
Kavran JM, Klein DE, Lee A, Falasca M, Isakoff SJ, Skolnik EY, Lemmon MA. 1998. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J Biol Chem 273:30497-508.
-
(1998)
J Biol Chem
, vol.273
, pp. 30497-30508
-
-
Kavran, J.M.1
Klein, D.E.2
Lee, A.3
Falasca, M.4
Isakoff, S.J.5
Skolnik, E.Y.6
Lemmon, M.A.7
-
35
-
-
33748329395
-
Phosphoinositide 3-Kinase C2beta Regulates Cytoskeletal Organization and Cell Migration via Rac-dependent Mechanisms
-
Katso RM, Pardo OE, Palamidessi A, Franz CM, Marinov M, De Laurentiis A, Downward J, Scita G, Ridley AJ, Waterfield MD, Arcaro A. 2006. Phosphoinositide 3-Kinase C2beta Regulates Cytoskeletal Organization and Cell Migration via Rac-dependent Mechanisms. Mol Biol Cell 17:3729-44.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 3729-3744
-
-
Katso, R.M.1
Pardo, O.E.2
Palamidessi, A.3
Franz, C.M.4
Marinov, M.5
De Laurentiis, A.6
Downward, J.7
Scita, G.8
Ridley, A.J.9
Waterfield, M.D.10
Arcaro, A.11
-
36
-
-
0037040182
-
Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease
-
Kim SA, Taylor GS, Torgersen KM, Dixon JE. 2002. Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease. J Biol Chem 277:4526-31.
-
(2002)
J Biol Chem
, vol.277
, pp. 4526-4531
-
-
Kim, S.A.1
Taylor, G.S.2
Torgersen, K.M.3
Dixon, J.E.4
-
37
-
-
33746975370
-
Phosphatidylinositol 3-phosphate [PtdIns (3)P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: Endogenous PtdIns(3)P can promote GLUT4 translocation to the plasma membrane
-
Kong AM, Horan KA, Sriratana A, Bailey CG, Collyer LJ, Nandurkar HH, Shisheva A, Layton MJ, Rasko JE, Rowe T, Mitchell CA. 2006. Phosphatidylinositol 3-phosphate [PtdIns (3)P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns(3)P can promote GLUT4 translocation to the plasma membrane. Mol Cell Biol 26:6065-81.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 6065-6081
-
-
Kong, A.M.1
Horan, K.A.2
Sriratana, A.3
Bailey, C.G.4
Collyer, L.J.5
Nandurkar, H.H.6
Shisheva, A.7
Layton, M.J.8
Rasko, J.E.9
Rowe, T.10
Mitchell, C.A.11
-
38
-
-
0038392645
-
TNF-alpha and leptin activate the alpha-isoform of class II phosphoinositide 3-kinase
-
Ktori C, Shepherd PR, O'Rourke L. 2003. TNF-alpha and leptin activate the alpha-isoform of class II phosphoinositide 3-kinase. Biochem Biophys Res Commun 306:139-43.
-
(2003)
Biochem Biophys Res Commun
, vol.306
, pp. 139-143
-
-
Ktori, C.1
Shepherd, P.R.2
O'Rourke, L.3
-
39
-
-
0036677159
-
The PtdIns3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane ruffles
-
Laporte J, Blondeau F, Gansmuller A, Lutz Y, Vonesch JL, Mandel JL. 2002. The PtdIns3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane ruffles. J Cell Sci 115:3105-17.
-
(2002)
J Cell Sci
, vol.115
, pp. 3105-3117
-
-
Laporte, J.1
Blondeau, F.2
Gansmuller, A.3
Lutz, Y.4
Vonesch, J.L.5
Mandel, J.L.6
-
40
-
-
33645078650
-
Regulation of membrane traffic by phosphoinositide 3-kinases
-
Lindmo K, Stenmark H. 2006. Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci 119:605-14.
-
(2006)
J Cell Sci
, vol.119
, pp. 605-614
-
-
Lindmo, K.1
Stenmark, H.2
-
41
-
-
0345256531
-
Insulin stimulates movement of sorting nexin 9 between cellular compartments: A putative role mediating cell surface receptor expression and insulin action
-
MaCaulay SL, Stoichevska V, Grusovin J, Gough KH, Castelli LA, Ward CW. 2003. Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. Biochem J 376:123-34.
-
(2003)
Biochem J
, vol.376
, pp. 123-134
-
-
MaCaulay, S.L.1
Stoichevska, V.2
Grusovin, J.3
Gough, K.H.4
Castelli, L.A.5
Ward, C.W.6
-
42
-
-
0032904432
-
PTEN: A tumour suppressor that functions as a phospholipid phosphatase
-
Maehama T, Dixon JE. 1999. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol 9:125-8.
-
(1999)
Trends Cell Biol
, vol.9
, pp. 125-128
-
-
Maehama, T.1
Dixon, J.E.2
-
43
-
-
0035850897
-
Specificity in pleckstrin homology (PH) domain membrane targeting: A role for a phosphoinositide-protein co-operative mechanism
-
Maffucci T, Falasca M. 2001. Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism. FEBS Lett 506:173-9.
-
(2001)
FEBS Lett
, vol.506
, pp. 173-179
-
-
Maffucci, T.1
Falasca, M.2
-
44
-
-
0042466604
-
Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation
-
Maffucci T, Brancaccio A, Piccolo E, Stein RC, Falasca M. 2003a. Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation. EMBO J 22:4178-89.
-
(2003)
EMBO J
, vol.22
, pp. 4178-4189
-
-
Maffucci, T.1
Brancaccio, A.2
Piccolo, E.3
Stein, R.C.4
Falasca, M.5
-
45
-
-
0041765784
-
Role of pleckstrin homology domain in regulating membrane targeting and metabolic function of insulin receptor substrate 3
-
Maffucci T, Razzini G, Ingrosso A, Chen H, Iacobelli S, Sciacchitano S, Quon MJ, Falasca M. 2003b. Role of pleckstrin homology domain in regulating membrane targeting and metabolic function of insulin receptor substrate 3. Mol Endocrinol 17:1568-79.
-
(2003)
Mol Endocrinol
, vol.17
, pp. 1568-1579
-
-
Maffucci, T.1
Razzini, G.2
Ingrosso, A.3
Chen, H.4
Iacobelli, S.5
Sciacchitano, S.6
Quon, M.J.7
Falasca, M.8
-
46
-
-
22344452002
-
Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration
-
Maffucci T, Cooke FT, Foster FM, Traer CJ, Fry MJ, Falasca M. 2005. Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration. J Cell Biol 169:789-99.
-
(2005)
J Cell Biol
, vol.169
, pp. 789-799
-
-
Maffucci, T.1
Cooke, F.T.2
Foster, F.M.3
Traer, C.J.4
Fry, M.J.5
Falasca, M.6
-
47
-
-
0027288910
-
A putative modular domain present in diverse signaling proteins
-
Mayer BJ, Ren R, Clark KL, Baltimore D. 1993. A putative modular domain present in diverse signaling proteins. Cell 73:629-30.
-
(1993)
Cell
, vol.73
, pp. 629-630
-
-
Mayer, B.J.1
Ren, R.2
Clark, K.L.3
Baltimore, D.4
-
48
-
-
26244461921
-
Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis
-
Meunier FA, Osborne SL, Hammond GR, Cooke FT, Parker PJ, Domin J, Schiavo G. 2005. Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis. Mol Biol Cell 16:4841-51.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 4841-4851
-
-
Meunier, F.A.1
Osborne, S.L.2
Hammond, G.R.3
Cooke, F.T.4
Parker, P.J.5
Domin, J.6
Schiavo, G.7
-
49
-
-
3342908518
-
A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast
-
Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC, Ross AH. 2004. A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J Cell Biol 166:205-11.
-
(2004)
J Cell Biol
, vol.166
, pp. 205-211
-
-
Mitra, P.1
Zhang, Y.2
Rameh, L.E.3
Ivshina, M.P.4
McCollum, D.5
Nunnari, J.J.6
Hendricks, G.M.7
Kerr, M.L.8
Field, S.J.9
Cantley, L.C.10
Ross, A.H.11
-
50
-
-
0032546654
-
Activation of G1 progression, JNK mitogen-activated protein kinase, and actin filament assembly by the exchange factor FGD1
-
Nagata K, Driessens M, Lamarche N, Gorski JL, Hall A. 1998. Activation of G1 progression, JNK mitogen-activated protein kinase, and actin filament assembly by the exchange factor FGD1. J Biol Chem 273:15453-7.
-
(1998)
J Biol Chem
, vol.273
, pp. 15453-15457
-
-
Nagata, K.1
Driessens, M.2
Lamarche, N.3
Gorski, J.L.4
Hall, A.5
-
51
-
-
0042025774
-
Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP
-
Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA. 2003. Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. Proc Natl Acad Sci U S A 100:8660-5.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8660-8665
-
-
Nandurkar, H.H.1
Layton, M.2
Laporte, J.3
Selan, C.4
Corcoran, L.5
Caldwell, K.K.6
Mochizuki, Y.7
Majerus, P.W.8
Mitchell, C.A.9
-
52
-
-
0034735512
-
Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain
-
Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M. 2000. Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. J Cell Biol 151:601-12.
-
(2000)
J Cell Biol
, vol.151
, pp. 601-612
-
-
Nielsen, E.1
Christoforidis, S.2
Uttenweiler-Joseph, S.3
Miaczynska, M.4
Dewitte, F.5
Wilm, M.6
Hoflack, B.7
Zerial, M.8
-
53
-
-
26444575415
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
-
Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, Gulati P, Byfield MP, Backer JM, Natt F, Bos JL, Zwartkruis FJ, Thomas G. 2005. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A 102:14238-43.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 14238-14243
-
-
Nobukuni, T.1
Joaquin, M.2
Roccio, M.3
Dann, S.G.4
Kim, S.Y.5
Gulati, P.6
Byfield, M.P.7
Backer, J.M.8
Natt, F.9
Bos, J.L.10
Zwartkruis, F.J.11
Thomas, G.12
-
54
-
-
0035374391
-
Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases
-
Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ. 2001. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J Biol Chem 276:19332-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 19332-19339
-
-
Parks, W.T.1
Frank, D.B.2
Huff, C.3
Renfrew Haft, C.4
Martin, J.5
Meng, X.6
de Caestecker, M.P.7
McNally, J.G.8
Reddi, A.9
Taylor, S.I.10
Roberts, A.B.11
Wang, T.12
Lechleider, R.J.13
-
55
-
-
0033605718
-
The role of phosphoinositide 3-kinase lipid products in cell function
-
Rameh LE, Cantley LC. 1999. The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 274:8347-50.
-
(1999)
J Biol Chem
, vol.274
, pp. 8347-8350
-
-
Rameh, L.E.1
Cantley, L.C.2
-
56
-
-
0034685801
-
The role of the pleckstrin homology domain in membrane targeting and activation of phospholipase Cbeta(1)
-
Razzini G, Brancaccio A, Lemmon MA, Guarnieri S, Falasca M. 2000a. The role of the pleckstrin homology domain in membrane targeting and activation of phospholipase Cbeta(1). J Biol Chem 275:14873-81.
-
(2000)
J Biol Chem
, vol.275
, pp. 14873-14881
-
-
Razzini, G.1
Brancaccio, A.2
Lemmon, M.A.3
Guarnieri, S.4
Falasca, M.5
-
57
-
-
0034463086
-
Different subcellular localization and phosphoinositides binding of insulin receptor substrate protein pleckstrin homology domains
-
Razzini G, Ingrosso A, Brancaccio A, Sciacchitano S, Esposito DL, Falasca M. 2000b. Different subcellular localization and phosphoinositides binding of insulin receptor substrate protein pleckstrin homology domains. Mol Endocrinol 2000 14:823-6.
-
(2000)
Mol Endocrinol 2000
, vol.14
, pp. 823-826
-
-
Razzini, G.1
Ingrosso, A.2
Brancaccio, A.3
Sciacchitano, S.4
Esposito, D.L.5
Falasca, M.6
-
58
-
-
33746729798
-
Myotubularin phosphatases:policing 3-phosphoinositides
-
Robinson FL, Dixon JE. 2006. Myotubularin phosphatases:policing 3-phosphoinositides. Trends in Cell Biol 16:403-12.
-
(2006)
Trends in Cell Biol
, vol.16
, pp. 403-412
-
-
Robinson, F.L.1
Dixon, J.E.2
-
59
-
-
1642580751
-
Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation
-
Safi A, Vandromme M, Caussanel S, Valdacci L, Baas D, Vidal M, Brun G, Schaeffer L, Goillot E. 2004. Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation. Mol Cell Biol 24:1245-55.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 1245-1255
-
-
Safi, A.1
Vandromme, M.2
Caussanel, S.3
Valdacci, L.4
Baas, D.5
Vidal, M.6
Brun, G.7
Schaeffer, L.8
Goillot, E.9
-
60
-
-
19344365468
-
The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms
-
Schnatwinkel C, Christoforidis S, Lindsay MR, Uttenweiler-Joseph S, Wilm M, Parton RG, Zerial M. 2004. The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms. PLoS Biol 2:E261.
-
(2004)
PLoS Biol
, vol.2
-
-
Schnatwinkel, C.1
Christoforidis, S.2
Lindsay, M.R.3
Uttenweiler-Joseph, S.4
Wilm, M.5
Parton, R.G.6
Zerial, M.7
-
61
-
-
0027905021
-
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
-
Schu PV, Takegawa K, Fry MJ, Stack JH, Waterfield MD, Emr SD. 1993. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 260:88-91.
-
(1993)
Science
, vol.260
, pp. 88-91
-
-
Schu, P.V.1
Takegawa, K.2
Fry, M.J.3
Stack, J.H.4
Waterfield, M.D.5
Emr, S.D.6
-
62
-
-
13844264301
-
The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells
-
Seals DF, Azucena EF Jr, Pass I, Tesfay L, Gordon R, Woodrow M, Resau JH, Courtneidge SA. 2005. The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. Cancer Cell 7:155-65.
-
(2005)
Cancer Cell
, vol.7
, pp. 155-165
-
-
Seals, D.F.1
Azucena Jr, E.F.2
Pass, I.3
Tesfay, L.4
Gordon, R.5
Woodrow, M.6
Resau, J.H.7
Courtneidge, S.A.8
-
63
-
-
0032581654
-
EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
-
Simonsen A, Lippe R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H. 1998. EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 394:494-8.
-
(1998)
Nature
, vol.394
, pp. 494-498
-
-
Simonsen, A.1
Lippe, R.2
Christoforidis, S.3
Gaullier, J.M.4
Brech, A.5
Callaghan, J.6
Toh, B.H.7
Murphy, C.8
Zerial, M.9
Stenmark, H.10
-
64
-
-
33746547806
-
Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells
-
Srivastava S, Ko K, Choudhury P, Li Z, Johnson AK, Nadkarni V, Unutmaz D, Coetzee WA, Skolnik EY. 2006a. Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells. Mol Cell Biol 26:5595-602.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 5595-5602
-
-
Srivastava, S.1
Ko, K.2
Choudhury, P.3
Li, Z.4
Johnson, A.K.5
Nadkarni, V.6
Unutmaz, D.7
Coetzee, W.A.8
Skolnik, E.Y.9
-
65
-
-
30044440424
-
Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1
-
Srivastava S, Choudhury P, Li Z, Liu G, Nadkarni V, Ko K, Coetzee WA, Skolnik EY. 2006b. Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1. Mol Biol Cell 17:146-54.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 146-154
-
-
Srivastava, S.1
Choudhury, P.2
Li, Z.3
Liu, G.4
Nadkarni, V.5
Ko, K.6
Coetzee, W.A.7
Skolnik, E.Y.8
-
66
-
-
0037138361
-
The phosphatidylinositol 3-phosphate-binding FYVE finger
-
Stenmark H, Aasland R, Driscoll PC. 2002. The phosphatidylinositol 3-phosphate-binding FYVE finger. FEBS Lett 513:77-84.
-
(2002)
FEBS Lett
, vol.513
, pp. 77-84
-
-
Stenmark, H.1
Aasland, R.2
Driscoll, P.C.3
-
67
-
-
33746896166
-
The phosphoinositide-binding protein p40phox activates the NADPH oxidase during Fc{gamma}IIA receptor-induced phagocytosis
-
Suh CI, Stull ND, Li XJ, Tian W, Price MO, Grinstein S, Yaffe MB, Atkinson S, Dinauer MC. 2006. The phosphoinositide-binding protein p40phox activates the NADPH oxidase during Fc{gamma}IIA receptor-induced phagocytosis. J Exp Med 203:1915-25.
-
(2006)
J Exp Med
, vol.203
, pp. 1915-1925
-
-
Suh, C.I.1
Stull, N.D.2
Li, X.J.3
Tian, W.4
Price, M.O.5
Grinstein, S.6
Yaffe, M.B.7
Atkinson, S.8
Dinauer, M.C.9
-
68
-
-
0032428684
-
SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
-
Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL. 1998. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 95:779-91.
-
(1998)
Cell
, vol.95
, pp. 779-791
-
-
Tsukazaki, T.1
Chiang, T.A.2
Davison, A.F.3
Attisano, L.4
Wrana, J.L.5
-
69
-
-
0032476036
-
The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha
-
Turner SJ, Domin J, Waterfield MD, Ward SG, Westwick J. 1998. The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha. J Biol Chem 273:25987-95.
-
(1998)
J Biol Chem
, vol.273
, pp. 25987-25995
-
-
Turner, S.J.1
Domin, J.2
Waterfield, M.D.3
Ward, S.G.4
Westwick, J.5
-
70
-
-
0034911881
-
Synthesis and function of 3-phosphorylated inositol lipids
-
Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ, Waterfield MD. 2001. Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 70:535-602.
-
(2001)
Annu Rev Biochem
, vol.70
, pp. 535-602
-
-
Vanhaesebroeck, B.1
Leevers, S.J.2
Ahmadi, K.3
Timms, J.4
Katso, R.5
Driscoll, P.C.6
Woscholski, R.7
Parker, P.J.8
Waterfield, M.D.9
-
71
-
-
0041920891
-
Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade
-
Vergne I, Chua J, Deretic V. 2003. Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade. J Exp Med 198:653-9.
-
(2003)
J Exp Med
, vol.198
, pp. 653-659
-
-
Vergne, I.1
Chua, J.2
Deretic, V.3
-
72
-
-
0035494493
-
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation
-
Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC, Grinstein S. 2001. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J Cell Biol 155:19-25.
-
(2001)
J Cell Biol
, vol.155
, pp. 19-25
-
-
Vieira, O.V.1
Botelho, R.J.2
Rameh, L.3
Brachmann, S.M.4
Matsuo, T.5
Davidson, H.W.6
Schreiber, A.7
Backer, J.M.8
Cantley, L.C.9
Grinstein, S.10
-
73
-
-
0035818611
-
Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate
-
Virbasius JV, Song X, Pomerleau DP, Zhan Y, Zhou GW, Czech MP. 2001. Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A 98:12908-13.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 12908-12913
-
-
Virbasius, J.V.1
Song, X.2
Pomerleau, D.P.3
Zhan, Y.4
Zhou, G.W.5
Czech, M.P.6
-
74
-
-
33644991658
-
Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle
-
Wang Y, Yoshioka K, Azam MA, Takuwa N, Sakurada S, Kayaba Y, Sugimoto N, Inoki I, Kimura T, Kuwaki T, Takuwa Y. 2006. Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle. Biochem J 394:581-92.
-
(2006)
Biochem J
, vol.394
, pp. 581-592
-
-
Wang, Y.1
Yoshioka, K.2
Azam, M.A.3
Takuwa, N.4
Sakurada, S.5
Kayaba, Y.6
Sugimoto, N.7
Inoki, I.8
Kimura, T.9
Kuwaki, T.10
Takuwa, Y.11
-
75
-
-
0034944422
-
SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P
-
Xu Y, Hortsman H, Seet L, Wong SH, Hong W. 2001a. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Nat Cell Biol 3:658-66.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 658-666
-
-
Xu, Y.1
Hortsman, H.2
Seet, L.3
Wong, S.H.4
Hong, W.5
-
76
-
-
0035921426
-
Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides
-
Xu J, Liu D, Gill G, Songyang Z. 2001b. Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides. J Cell Biol 154:699-705.
-
(2001)
J Cell Biol
, vol.154
, pp. 699-705
-
-
Xu, J.1
Liu, D.2
Gill, G.3
Songyang, Z.4
-
78
-
-
0032486378
-
A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate
-
Zhang J, Banfic H, Straforini F, Tosi L, Volinia S, Rittenhouse SE. 1998. A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate. J Biol Chem 273:14081-4.
-
(1998)
J Biol Chem
, vol.273
, pp. 14081-14084
-
-
Zhang, J.1
Banfic, H.2
Straforini, F.3
Tosi, L.4
Volinia, S.5
Rittenhouse, S.E.6
-
79
-
-
0035976614
-
RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking
-
Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG. 2001. RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. Science 294:1939-42.
-
(2001)
Science
, vol.294
, pp. 1939-1942
-
-
Zheng, B.1
Ma, Y.C.2
Ostrom, R.S.3
Lavoie, C.4
Gill, G.N.5
Insel, P.A.6
Huang, X.Y.7
Farquhar, M.G.8
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