A novel pathway of cellular phosphatidylinositol(3,4,5)-trisphosphate synthesis is regulated by oxidative stress

Current Biology

Volumn 11, Issue 6, 2001, Pages 386-395

  Halstead, J R ^a   Roefs, M ^a   Ellson, C D ^d   D'Andrea, S ^b   Chen, C S ^c   D'Santos, C S ^a   Divecha, N ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b CEMAGREF   (France)

^c University of Kentucky   (United States)

^d BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CERCOPITHECUS; EUKARYOTA; MURINAE;

EID: 0035916811     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00121-X     Document Type: Article

References (33)

1. The role of phosphoinositide 3-kinase lipid products in cell function
2. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains
3. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
4. Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B
5. Mechanism of activation and function of protein kinase B
6. Role of translocation in the activation and function of protein kinase B
7. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
8. Platelet-derived growth factor stimulates synthesis of Ptdlns(3,4,5)P3 by activating a Ptdlns(4,5)P2 3-OH kinase
9. Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils
10. Pathway for the formation of D-3 phosphate containing inositol phospholipids in intact human platelets
11. Pathway for the formation of D-3 phosphate containing inositol phospholipids in PDGF stimulated NIH 3T3 fibroblasts
12. Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets
13. A novel integrin-activated pathway forms PKB/Akt-stimulatory phosphatidylinositol 3,4-bisphosphate via phosphatidylinositol 3-phosphate in platelets
14. The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases
15. Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase
16. Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules
17. Type I phosphatidylinositol-4phosphate 5-kinases are distinct members of this novel lipid kinase family
18. Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family
19. Interaction of the type I alpha PlPkinase with phospholipase D: A role for the local generation of phosphatidylinositol 4,5-bisphosphate in the regulation of PLD2 activity
20. The diversity and possible functions of the inositol polyphosphate 5-phosphatases
21. The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase
22. p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity
23. Redox-dependent signal transduction
24. Signal transduction by reactive oxygen species in non-phagocytic cells
25. Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation
26. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction
27. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells
28. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells
29. Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses
30. Type I alpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly
31. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3
32. Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases
33. Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation