Fatty acids and gene transcription

Scandinavian Journal of Food and Nutrition

Volumn 50, Issue SUPPL. 2, 2006, Pages 5-12

  Jump, Donald B ^a   Botolin, Daniela ^a   Wang, Yun ^a   Xu, Jinghua ^a   Christian, Barbara ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Gene transcription; Hepatic fatty acid metabolism

Indexed keywords

ESSENTIAL FATTY ACID; FATTY ACID; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN KINASE B; TRANSCRIPTION FACTOR;

CONFERENCE PAPER; FATTY ACID METABOLISM; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GLYCOGEN SYNTHESIS; HUMAN; LIPID METABOLISM; LIPOGENESIS; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION;

RODENTIA;

EID: 33845900693     PISSN: 17482976     EISSN: 17482984     Source Type: Journal    
DOI: 10.1080/17482970601069318     Document Type: Conference Paper

References (35)

1. Jump DB. Fatty acid regulation of gene transcription. Crit Rev Clin Lab Sci 2004; 41: 41-78.
2. Jump DB, Botolin D, Wang Y, Xu J, Christian B, Demeure O. Fatty acid regulation of gene transcription. J Nutr 2005; 135: 2503-6.
3. Xu J, Christian B, Jump DB. Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 PUFA and peroxisome proliferator activated receptor-alpha agonist. J Biol Chem 2006; 281: 18351-62.
4. Dentin R, Benhamed F, Pegorier JP, Foufelle F, Viollet B, Vaulont S, et al. Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J Clin Invest 2005; 115: 2843-54.
5. Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, et al. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol Cell 1999; 3: 397-403.
6. Wisely GB, Miller AB, Davis RG, Thornquest AD Jr, Johnson R, Spitzer T, et al. Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. Structure (Camb) 2002; 10: 1225-34.
7. Dhe-Paganon S, Duda K, Iwamoto M, Chi YI, Shoelson SE. Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand. J Biol Chem 2002; 277: 37973-6.
8. Mata de Urquiza A, Liu S, Sjoberg M, Zetterstrom RH, Criffith W, Sjovall J, Perlmann T. Docosahexeanoic acid, a ligand for retinoic X receptor in mouse brain. Science 2000; 290: 2140-4.
9. Ou J, Tu H, Shan B, Luk A, DeBose-Boyd RA, Bashmakov Y, et al. Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. Proc Natl Acad Sci U S A 2001; 98: 6027-32.
10. Ren BA, Thelen P, Peters JM, Gonzalez FJ, Jump DB. Polyunsaturated fatty acid suppression of hepatic fatty acid synthase and S14 gene expression does not require peroxisome proliferator-activated receptor alpha. J Biol Chem 1997; 272: 26827-32.
11. Mater MK, Thelen AP, Pan DA, Jump DB. Sterol regulatory element-binding protein 1c (SREBP1c) is involved in the polyunsaturated fatty acid suppression of hepatic S14 gene transcription. J Biol Chem 1999; 274: 32725-32.
12. Pan DA, Mater MK, Thelen AP, Peters JM, Gonzalez FJ, Jump DB. Evidence against the peroxisome proliferator-activated receptor alpha (PPARalpha) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription. J Lipid Res 2000; 41: 742-51.
13. Wang Y, Botolin D, Christian B, Busik C, Xu J, Jump DB. Tissue-specific, nutritional and developmental regulation of rat fatty acid elongases. J Lipid Res 2005; 46: 706-15.
14. Pawar A, Botolin D, Mangelsdorf DJ, Jump DB. The role of liver X receptor-alpha (LXR-alpha) in the fatty acid regulation of hepatic gene expression. J Biol Chem 2003; 278: 40736-43.
15. Worgall TS, Sturley SL, Seo T, Osborne TF, Deckelbaum RJ. Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein. J Biol Chem 1998; 273: 25537-40.
16. Wang Y, Botolin D, Xu Jinghua, Christian B, Mitchell E, Jayaprakasam B, et al. Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. J Lipid Res 2006; 47: 2028-41.
17. Pawar A, Jump DB. Unsaturated fatty acid regulation of peroxisome proliferator activated receptor-alpha activity in primary rat hepatocytes. J Biol Chem 2003; 278: 35931-9.
18. Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci U S A 2004; 101: 7281-6.
19. Towle HC. Glucose as a regulator of eukaryotic gene transcription. Trends Endocrinol Metab 2005; 16: 489-94.
20. Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS, Goldstein JL. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci U S A 2003; 100: 12027-32.
21. Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002; 109: 1125-31.
22. Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk Jin J, Harper JW, Ericsson J. Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCGFBW7. Cell Metabolism 2005; 1: 379-91.
23. Nagoshi E, Imamoto N, Sato R, Yoneda Y. Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip. Mol Biol Cell 1999; 10: 2221-33.
24. Bennett M, Toth JI, Osborne TF. Selective association of sterol regulatory element binding protein isoforms with target promoters in vivo. J Biol Chem 2004; 279: 37360-7.
25. Hirano Y, Yoshida M, Shimizu M, Sato R. Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway. J Biol Chem 2001; 276: 36431-7.
26. Adams CM, Reitz J, De Brabander JK, Feramisco JD, Li L, Brown MS, Goldstein JL. Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. J Biol Chem 2004; 279: 52772-80.
27. Ribaux PG, Iynedjian PB. Analysis of the role of protein kinase B (cAKT) in insulin-dependent induction of glucokinase and sterol regulatory element-binding protein 1 (SREBP1) mRNAs in hepatocytes. Biochem J 2003; 376: 697-705.
28. Yabe D, Komuro R, Liang G, Goldstein JL, Brown MS. Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. Proc Natl Acad Sci U S A 2003; 100: 3155-60.
29. Botolin D, Wang Y, Christian B, Jump DB. Docosahexaneoic acid [22:6, n-3] stimulates rat hepatic sterol regulatory element binding protein-1c (SREBP-1c) degradation by an Erk- and 26S proteasome-dependent pathway. J Lipid Res 2006; 47: 181-92.
30. Yahagi N, Shimano H, Hasty AH, Amemiya-Kudo M, Okazaki H, Tamura Y, et al. A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids. J Biol Chem 1999; 274: 35840-4.
31. Botolin D, Jump DB. Selective proteolytic processing of rat hepatic sterol regulatory element binding protein-1 (SREBP-1) and SREBP-2 during postnatal development. J Biol Chem 2003; 278: 6959-62.
32. Kabashima T, Kawaguchi T, Wadzinski BE, Uyeda K. Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver. Proc Natl Acad Sci U S A 2003; 100: 5107-12.
33. Jump DB, Clarke SD, Thelen A, Liimatta M. Coordinate regulation of glycolytic and lipogenic gene expression by polyunsaturated fatty acids. J Lipid Res 1994; 35: 1076-84.
34. Liimatta M, Towle HC, Clarke S, Jump DB. Dietary polyunsaturated fatty acids interfere with the insulin/glucose activation of 1-type pyruvate kinase gene transcription. Mol Endocrinol 1994; 8: 1147-53.
35. Jump DB. The biochemistry of n-3 polyunsaturated fatty acids. J Biol Chem 2002; 277: 8755-8.