Differences in steady-state inactivation between Na channel isoforms affect local anesthetic binding affinity

Biophysical Journal

Volumn 73, Issue 2, 1997, Pages 779-788

  Wright, Sterling N ^a   Wang, Sho Ya ^b   Kallen, Roland G ^c   Wang, Ging Kuo ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIDOCAINE; SODIUM CHANNEL;

ARTICLE; BINDING AFFINITY; CELL MEMBRANE STEADY POTENTIAL; DRUG EFFECT; DRUG PROTEIN BINDING; HEART ARRHYTHMIA; HEART INFARCTION; HUMAN; HUMAN CELL; LOCAL ANESTHESIA;

HELICOBACTER HEILMANNII TYPE 1;

EID: 0030852083     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(97)78110-4     Document Type: Article

References (31)

1. Bean, B. P., C. J. Cohen, and R. W. Tsien. 1983. Lidocaine block of cardiac sodium channels. J. Gen. Physiol. 81:613-642.
2. Bigger, J. T., Jr., and B. F. Hoffman. 1985. Antiarrhythmic drugs. In Local Anesthetics in the Pharmacological Basis of Therapeutics. A. G. Gilman, L. S. Goodman, T. W. Rall, and F. Murod, editors. Macmillan, New York. 748-783.
3. + channels: modification of block by alterations in the α-subunit III-IV interdomain. Circ. Res. 77:584-592.
4. Cannon, S. C., and S. M. Strittmatter. 1993. Functional expression of sodium channel mutations identified in families with periodic paralysis. Neuron. 10:317-326.
5. Chahine, M., L.-Q. Chen, R. L. Barchi, R. G. Kallen, and R. Horn. 1992. Lidocaine block of human heart sodium channels expressed in Xenopus oocytes. J. Mol. Cell Cardiol. 24:1231-1236.
6. Clarkson, C. W., and L. M. Hondeghem. 1985. Mechanism for bupivacaine depression of cardiac conduction: fast block of sodium channels during the action potential with slow recovery from block during diastole. Anesthesiology. 62:396-405.
7. Courtney, R. K. 1975. Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA 968. J. Pharmacol. Exp. Ther. 195:225-236.
8. Crumb, W. J., Jr., and C. W. Clarkson. 1990. Characterization of cocaine-induced block of cardiac sodium channels. Biophys. J. 57:589-599.
9. Crumb, W. J., Jr., and C. W. Clarkson. 1992. Characterization of the sodium channel blocking properties of the major metabolites of cocaine in single cardiac myocytes. J. Pharmacol. Exp. Ther. 261:910-917.
10. Crumb, W. J., Jr., P. J. Kadowitz, Y.-Q. Xu, and C. W. Clarkson. 1990. Electrocardiographic evidence for cocaine cardiotoxicity in cat. Can. J. Physiol. Pharmacol. 68:622-625.
11. Gellens, M. E., A. L. George, Jr., L. Chen, M. Chahine, R. Horn, R. L. Barchi, and R. G. Kallen. 1992. Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proc. Nat. Acad. Sci. USA. 89:554-558.
12. George, A. L., J. Komisarof, R. G. Kallen, and R. L. Barchi. 1992. Primary structure of the adult human skeletal muscle voltage-dependent sodium channel. Ann. Neurol. 31:131-137.
13. Grant, A. O., C. F. Starmer, and H. C. Strauss. 1984. Antiarrhythmic drug action: blockade of the inward sodium current. Circ. Res. 55:427-439.
14. Guyton, A. C. 1986. Textbook of Medical Physiology. 7th Ed. W. B. Saunders, Philadelphia.
15. Hamill, O. P., A. Marty, E. Neher, B. Sakmann, and F. J. Sigworth. 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391:85-100.
16. Hille, B. 1977. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J. Gen. Physiol. 69:497-515.
17. Hille, B. 1978. Local anesthetic action on inactivation of the Na channel in nerve and skeletal muscle. In Biophysical Aspects of Cardiac Muscle. M. Morad, editor. Academic Press, New York. 55-74.
18. Hille, B. 1992. Ionic Channels in Excitable Membranes. 2nd Ed. Sinauer Associates, Sunderland, MA.
19. Hondeghem, L. M., and B. G. Katzung. 1977. Time-and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochem. Biophys. Acta. 472:373-398.
20. Jia, H., T. Furukawa, D. H. Singer, Y. Sakakibara, S. Eager, C. Backer, C. Arentzen, and J. A. Wasserstrom. 1993. Characteristics of lidocaine block of sodium channels in single human atrial cells. J. Pharmacol. Exp. Ther. 264:1275-1284.
21. Nuss, H. B., G. F. Tomaselli, and E. Marbán. 1995. Cardiac sodium channels (hH1) are intrinsically more sensitive to block by lidocaine than are skeletal muscle (μ1) channels. J. Gen. Physiol. 106:1193-1209.
22. O'Leary, M. E., and R. Horn. 1994. Internal block of human heart sodium channels by symmetrical tetra-alkylammoniums. J. Gen. Physiol. 104: 507-522.
23. + channels by local anesthetics. Science. 265:1724-1728.
24. Schwarz, W., P. T. Palade, and B. Hille. 1977. Local anesthetics: effect of pH on use-dependent block of sodium channels in frog muscle. Biophys. J. 20:343-368.
25. Simkhovich, B. Z., R. A. Kloner, K. J. Alker, and J. Giaconi. 1994. Time course of direct cardiotoxic effects of high cocaine concentration in isolated rabbit heart. J. Cardiovasc. Pharmacol. 23:509-516.
26. Starmer, C. F. 1987. Theoretical characterization of ion channel blockade: competitive binding to periodically accessible receptors. Biophys. J. 52:405-412.
27. Strichartz, G. R. 1973. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J. Gen. Physiol. 62:37-57.
28. Trimmer, J. S., S. S. Cooperman, S. A. Tomiko, J. Zhou, S. M. Crean, M. B. Boyle, R. G. Kallen, Z. Sheng. R. L. Barchi. F. J. Sigworth. R. H. Goodman, W. S. Agnew, and G. Mandel. 1989. Primary structure and functional expression of a mammalian skeletal muscle sodium channel. Neuron. 3:33-49.
29. Virmani, R., M. Robinowitz, J. E. Smialek, and D. F. Smyth. 1988. Cardiovascular effects of cocaine: an autopsy study of 40 patients. Am. Heart J. 115:1068-1076.
30. Wang, D. W., A. L. George, Jr., and P. B. Bennett. 1996a. Comparison of heterologously expressed human cardiac and skeletal muscle sodium channels. Biophys. J. 70:238-245.
31. + channel subtypes. Biophys. J. 70: 1700-1708.