Linkage disequilibrium between the 677C>t and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer

Pharmacogenetics

Volumn 12, Issue 4, 2002, Pages 339-342

  Chen, Jia ^a   Ma, Jing ^a   Stampfer, Meir J ^a   Palomeque, Caroline ^a   Selhub, Jacob ^a   Hunter, David J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Colorectal cancer; Folate; Homocysteine; MTHFR

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); OXIDOREDUCTASE;

ARTICLE; CANCER RISK; CASE CONTROL STUDY; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; FOLIC ACID BLOOD LEVEL; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; BLOOD; CLINICAL TRIAL; COLORECTAL TUMOR; CONTROLLED CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; GENE FREQUENCY; GENETICS; INCIDENCE; MALE; PROSPECTIVE STUDY; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL;

AMINE OXIDOREDUCTASES; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; DOUBLE-BLIND METHOD; FOLIC ACID; GENE FREQUENCY; GENOTYPE; HUMAN; INCIDENCE; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM (GENETICS); PROSPECTIVE STUDIES; QUESTIONNAIRES; SUPPORT, U.S. GOV'T, P.H.S.; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POLYMORPHISM, GENETIC;

EID: 0036016321     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200206000-00011     Document Type: Article

References (10)

1. Methylenetetrahydrofolate reductase
2. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
3. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer
4. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer
5. A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects?
6. A common mutation A1298C in human methylenetetrahydrofolate reductase gene: Association with plasma total homocysteine and folate concentrations
7. The effect of 677C>T and 1298A>C mutations on plasma homocysteine and 5,10-methylenetetrahydrofolate reductase activity in healthy subjects
8. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
9. The 1298A>C polymorphism in methylenetetrahydrofolate reductase (MTHFR): In vitro expression and association with homocysteine