Vitamin C;Vitamina C

Actas Dermo-Sifiliograficas

Volumn 97, Issue 9, 2006, Pages 557-568

  Valdés, Fernando ^a  

^a HOSPITAL DA COSTA   (Spain)

Author keywords

Antioxidants; Ascorbic acid; Ascorbic acid deficiency; Scurvy

Indexed keywords

ASCORBIC ACID; COLLAGEN FIBER; FREE RADICAL; GULONOLACTONE OXIDASE; LYSINE; PROLINE;

ASCORBIC ACID DEFICIENCY; CLINICAL FEATURE; DIETARY INTAKE; ENZYME BLOOD LEVEL; FOOD COMPOSITION; HUMAN; HYDROXYLATION; REVIEW; SCURVY; SYMPTOMATOLOGY;

EID: 33845642096     PISSN: 00017310     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0001-7310(06)73466-4     Document Type: Review

References (119)

1. Lehninger AL. Vitaminas y coenzimas. En: Lehninger AL, editor. Bioquímica. Las bases moleculares de la estructura y función celular. 2nd ed. Barcelona: Ediciones Omega, S.A.; 1995. p. 341-70.
2. Flórez J. Vitaminas liposolubles e hidrosolubles. En: Flórez J, Armijo JA, Mediavilla A, editores. Farmacología humana. 3rd ed. Barcelona: Editorial Massen, S.A.; 1999. p. 991-1005.
3. Nelson DL, Cox MM, Cuchillo CM. Estructura tridimensional de las proteínas. En: Nelson DL, Cox MM, Cuchillo CM, editores. Lehninger. Principios de Bioquímica. 4th ed. Sabadell: Ediciones Omega S.A.; 2006. p. 116-56.
4. Naidu KA. Vitamin C in human health and disease is still a mystery? An overview. Nutr J. 2003;2:7.
5. Cohen SA, Paeglow RJ. Scurvy: an unusual cause of anemia. J Am Board Fam Pract. 2001;14:314-6.
6. Covarrubias-Espinoza R, Sotelo-Cruz N. Escorbuto en la infancia. Presentación de un caso. Bol Clin Hosp Infant Edo Son. 2003;20:114-8.
7. Rusell R. Deficiencias y excesos de vitaminas y oligoelementos. En: Kasper DL, Braunwald E, Fauci AS, et al, editores. Harrison principios de Medicina Interna. México: McGraw-Hill Interamericana; 2005. p. 452-9.
8. Agte V, Tarwadi K, Mengale S, Hinge A, Chiplonkar S. Vitamin profile of cooked foods: how healthy is the practice of ready-to-eat foods? Int J Food Sci Nutr. 2002;53:197-208.
9. Frei B, Trabe MG. The new US Dietary Reference Intakes for vitamins C and E. Redox Rep. 2001;6:5-9.
10. Padayatty SJ, Levine M. New insights into the physiology and pharmacology of vitamin C. CMAJ. 2001;164:353-5.
11. Torres H. Tratamiento medico del fotoenvejecimiento cutaneo. Piel. 2002;17:449-53.
12. Hampl JS, Taylor CA, Johnston CS. Vitamin C deficiency and depletion in the United States: the Third National Health and Nutrition Examination Survey, 1988 to 1994. Am J Public Health. 2004;94:870-5.
13. Gascón-Vila P, Ribas L, García-Closas R, Farrán A, Serra-Majem L. Fuentes alimentarias de vitaminas A, C, E y beta-caroteno en una población adulta mediterránea. Gac Sanit. 1999;13:22-9.
14. Fletcher RH, Fairfield KM. Vitamins for chronic disease prevention in adults: clinical applications. JAMA. 2002;287:3127-9.
15. Shohaimi S, Bingham S, Welch A, Luben R, Day N, Wareham N, et al. Occupational social class, educational level and area deprivation independently predict plasma ascorbic acid concentration: a cross-sectional population based study in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk). Eur J Clin Nutr. 2004;58:1432-5.
16. Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, Dhariwal KR, et al. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci USA. 1996;93:3704-9.
17. Oeffinger KC. Scurvy: more than historical relevance. Am Fam Physician. 1993;48:609-13.
18. Lykkesfeldt J, Prieme H, Loft S, Poulsen HE. Effect of smoking cessation on plasma ascorbic acid concentration. BMJ. 1996;313:91.
19. Riviere S, Birlouez-Aragón I, Nourhashemi F, Vellas B. Low plasma vitamin C in Alzheimer patients despite an adequate diet. Int J Geriatr Psychiatry. 1998;13:749-54.
20. Sagin FG, Sozmen EY. Anti-inflammatory effects of dietary antioxidants. Curr Med Chem. 2004;3:19-30.
21. Rokhsar CK, Lee S, Fitzpatrick RE. Review of photorejuvenation: devices, cosmeceuticals, or both? Dermatol Surg. 2005;31:1166-78; discussion 78.
22. Podda M. The role of reactive oxygen species and antioxidants in dermatology. Vet Dermatol. 2004;15:11.
23. Venereo JR. Daño oxidativo, radicales libres y antioxidantes. Rev Cubana Med Milit. 2002;31:126-33.
24. Black HS. Mechanisms of pro- and antioxidation. J Nutr. 2004;134:3169S-70S.
25. Head KA. Ascorbic acid in the prevention and treatment of cancer. Altern Med Rev. 1998;3:174-86.
26. Ueta E, Suzuki E, Nanba E, Tadokoro Y, Otsuka Y, Kurata T. Regulation of cigarette smoke-induced cytochrome P4501A1 gene expression in osteogenic disorder Shionogi rat liver and in lung by large ascorbic acid dose. Biosci Biotechnol Biochem. 2001;65:2548-51.
27. George J. Ascorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats. Clin Chim Acta. 2003;335:39-47.
28. Catani MV, Savini I, Rossi A, Melino G, Avigliano L. Biological role of vitamin C in keratinocytes. Nutr Rev. 2005;63:81-90.
29. Anderson JW, Gowri MS, Turner J, Nichols L, Diwadkar VA, Chow CK, et al. Antioxidant supplementation effects on low-density lipoprotein oxidation for individuals with type 2 diabetes mellitus. J Am Coll Nutr. 1999;18:451-61.
30. Peake JM. Vitamin C: effects of exercise and requirements with training. Int J Sport Nutr Exerc Metab. 2003;13:125-51.
31. Stankova L, Gerhardt NB, Nagel L, Bigley RH. Ascorbate and phagocyte function. Infect Immun. 1975;12:252-6.
32. Maxwell SR. Antioxidant vitamin supplements: update of their potential benefits and possible risks. Drug Saf. 1999;21:253-66.
33. Khaw KT, Bingham S, Welch A, Luben R, Wareham N, Oakes S, et al. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition. Lancet. 2001;357:657-63.
34. Mendivil CO, Sierra ID, Pérez CE, Hernández B. Antioxidantes y enfermedad vascular. Clin Invest Arterioscl. 2002;14:26-40.
35. Carr AC, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr. 1999;69:1086-107.
36. Libby P, Aikawa M. Vitamin C, collagen, and cracks in the plaque. Circulation. 2002;105:1396-8.
37. Salonen JT. Clinical trials testing cardiovascular benefits of antioxidant supplementation. Free Radic Res. 2002;36:1299-306.
38. Shekelle P, Morton S, Hardy ML. Effect of supplemental antioxidants vitamin C, vitamin E, and coenzyme Q10 for the prevention and treatment of cardiovascular disease. Evid Rep Technol Assess (Summ). 2003;1-3.
39. Asplund K. Antioxidant vitamins in the prevention of cardiovascular disease: a systematic review. J Intern Med. 2002;251:372-92.
40. Greenberg ER, Sporn MB. Antioxidant vitamins, cancer, and cardiovascular disease. N Engl J Med. 1996;334:1189-90.
41. North G, Booth A. Why appraise the evidence? A case study of vitamin C and the healing of pressure sores. J Hum Nutr. 1999;12:237-44.
42. Shekelle P, Hardy ML, Coulter I, Udani J, Spar M, Oda K, et al. Effect of the supplemental use of antioxidants vitamin C, vitamin E, and coenzyme Q10 for the prevention and treatment of cancer. Evid Rep Technol Assess (Summ). 2003;1-3.
43. Hunter DJ, Manson JE, Colditz GA, Stampfer MJ, Rosner B, Hennekens CH, et al. A prospective study of the intake of vitamins C, E, and A and the risk of breast cancer. N Engl J Med. 1993;329:23440.
44. Meyer CH, Sekunde W. Nutritional supplementation to prevent cataract formation. Dev Ophthalmol. 2005;38:103-19.
45. Heckelen A, Hermel M, Kondring B, Schrage NF. Ascorbic acid reversibly inhibits proliferation of retinal pigment epithelial cells. Acta Ophthalmol Scand. 2004;82:564-8.
46. Rodríguez-Porcel M, Herrman J, Chade AR, Krier JD, Breen JF, Lerman A, et al. Long-term antioxidant intervention improves myocardial microvascular function in experimental hypertension. Hypertension. 2004;43:493-8.
47. Duffy SJ, Gokce N, Holbrook M, Huang A, Frei B, Keaney JF Jr., et al. Treatment of hypertension with ascorbic acid. Lancet. 1999;354:2048-9.
48. Rodríguez-Iturbe B, Zhan CD, Quiroz Y, Sindhu RK, Vaziri ND. Antioxidant-rich diet relieves hypertension and reduces renal immune infiltration in spontaneously hypertensive rats. Hypertension. 2003;41:341-6.
49. Virlos IT, Mason J, Schofield D, McCloy RF, Eddleston JM, Siriwardena AK. Intravenous n-acetylcysteine, ascorbic acid and selenium-based anti-oxidant therapy in severe acute pancreatitis. Scand J Gastroenterol. 2003;38:1262-7.
50. Turow V. Alternative therapy for colds. Pediatrics. 1997;100:274-5.
51. Editorial. Vitamin C and the common cold. Br Med J. 1976;1:606-7.
52. Farris PK. Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions. Dermatol Surg. 2005;31:814-7; discussion 18.
53. Pinnell SR, Yang H, Omar M, Monteiro-Riviere N, DeBuys HV, Walker LC, et al. Topical L-ascorbic acid: percutaneous absorption studies. Dermatol Surg. 2001;27:137-42.
54. Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ. Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med. 1997;337:1419-28.
55. Nusgens BV, Humbert P, Rougier A, Colige AC, Haftek M, Lambert CA, et al. Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis. J Invest Dermatol. 2001;116:853-9.
56. Leveque N, Robin S, Makki S, Muret P, Rougier A, Humbert P. Iron and ascorbic acid concentrations in human dermis with regard to age and body sites. Gerontology. 2003;49:117-22.
57. Humbert PG, Haftek M, Creidi P, Lapiere C, Nusgens B, Richard A, et al. Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo. Exp Dermatol. 2003;12:237-44.
58. Fitzpatrick RE, Rostan EF. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage. Dermatol Surg. 2002;28:231-6.
59. Dreher F, Gabard B, Schwindt DA, Maibach HI. Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: a human study in vivo. Br J Dermatol. 1998;139:332-9.
60. Lin JY, Selim MA, Shea CR, Grichnik JM, Omar MM, Monteiro-Riviere NA, et al. UV photoprotection by combination topical antioxidants vitamin C and vitamin E. J Am Acad Dermatol. 2003;48:866-74.
61. Darr D, Combs S, Dunston S, Manning T, Pinnell S. Topical vitamin C protects porcine skin from ultraviolet radiation-induced damage. Br J Dermatol. 1992;127:247-53.
62. Moison RM, Beijersbergen van Henegouwen GM. Topical antioxidant vitamins C and E prevent UVB-radiation-induced peroxidation of eicosapentaenoic acid in pig skin. Radiat Res. 2002;157:402-9.
63. Bradberry SM, Vale JA. Therapeutic review: is ascorbic acid of value in chromium poisoning and chromium dermatitis? J Toxicol Clin Toxicol. 1999;37:195-200.
64. Gafvert E, Nilsson JL, Hagelthorn G, Karlberg AT. Free radicals in antigen formation: reduction of contact allergic response to hydroperoxides by epidermal treatment with antioxidants. Br J Dermatol. 2002;146:649-56.
65. Van Den Broeke LT, Graslund A, Larsson PH, Nilsson JL, Wahlberg JE, Scheynius A, et al. Free radicals as potential mediators of metal allergy: effect of ascorbic acid on lymphocyte proliferation and IFN-gamma production in contact allergy to Ni2+ and Co2+. Acta Derm Venereol. 1998;78:95-8.
66. Boyce ST, Supp AP, Swope VB, Warden GD. Vitamin C regulates keratinocyte viability, epidermal barrier, and basement membrane in vitro, and reduces wound contraction after grafting of cultured skin substitutes. J Invest Dermatol. 2002;118:565-72.
67. Fujiwara Y, Sahashi Y, Aritro M, Hasegawa S, Akimoto K, Ninomiya S, et al. Effect of simultaneous administration of vitamin C, L-cysteine and vitamin E on the melanogenesis. Biofactors. 2004;21:415-8.
68. Espinal-Pérez LE, Moncada B, Castanedo-Cazares JP. A double-blind randomized trial of 5 % ascorbic acid vs. 4 % hydroquinone in melasma. Int J Dermatol. 2004;43:604-7.
69. Matsuda T, Tanaka H, Shimazaki S, Matsuda H, Abcarian H, Reyes H, et al. High-dose vitamin C therapy for extensive deep dermal burns. Burns. 1992;18:127-31.
70. Yoshida WB, Campos EB. Ischemia and reperfusion in skin flaps: effects of mannitol and vitamin C in reducing necrosis area in a rat experimental model. Acta Cir Bras. 2005;20:358-63.
71. Arslan E, Basterzi Y, Aksoy A, Majka C, Unal S, Sari A, et al. The additive effects of carnitine and ascorbic acid on distally burned dorsal skin flap in rats. Med Sci Monit. 2005;11:BR176-80.
72. Leveque N, Robin S, Muret P, Mac-Mary S, Makki S, Berthelot A, et al. In vivo assessment of iron and ascorbic acid in psoriatic dermis. Acta Derm Venereol. 2004;84:2-5.
73. Tsujikawa T, Kanauchi O, Andoh A, Saotome T, Sasaki M, Fujiyama Y, et al. Supplement of a chitosan and ascorbic acid mixture for Crohn's disease: a pilot study. Nutrition. 2003;19:137-9.
74. Castello T, Girona L, Gómez MR, Mena Mur A, García L. The possible value of ascorbic acid as a prophylactic agent for urinary tract infection. Spinal Cord. 1996;34:592-3.
75. Zhang SM, Hernan MA, Olek MJ, Spiegelman D, Willett WC, Ascherio A. Intakes of carotenoids, vitamin C, and vitamin E and MS risk among two large cohorts of women. Neurology. 2001;57:75-80.
76. Etminan M, Gill SS, Samii A. Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis. Lancet Neurol. 2005;4:362-5.
77. Kamiji MM, Oliveira RB. Efeito da administracao de vitamina C sobre a colonizacao do estomago por Helicobacter pylori. Arq Gastroenterol. 2005;42:167-72.
78. Bramwell B, Ferguson S, Scarlett N, Macintosh A. The use of ascorbigen in the treatment of fibromyalgia patients: a preliminary trial. Altern Med Rev. 2000;5:455-62.
79. Zollinger PE, Tuinebreijer WE, Kreis RW, Breederveld RS. Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomised trial. Lancet. 1999;354:2025-8.
80. Tamura Y, Welch DC, Zic JA, Cooper WO, Stein SM, Hummell DS. Scurvy presenting as painful gait with bruising in a young boy. Arch Pediatr Adolesc Med. 2000;154:732-5.
81. Weinstein M, Babyn P, Zlotkin S. An orange a day keeps the doctor away: scurvy in the year 2000. Pediatrics. 2001;108:E55.
82. Hernández L, Flores G, Solares M, Lavalle A. Escorbuto en la infancia. Presentación de un caso. Rev Mex Pediatr. 2002;69:239-42.
83. Rajakumar K. Infantile scurvy: a historical perspective. Pediatrics. 2001;108:E76.
84. Giménez R, Cabrera C, Olalla M, Ruiz MD, López MC. Ascorbic acid in diet supplements: loss in the manufacturing process and storage. Int J Food Sci Nutr. 2002;53:509-18.
85. Vasseur E, Delaunay J, Meyniel D, Cocheton JJ. Scorbut compliquant un regime sans residus au cours d'une maladie de Crohn. Presse Med. 1997;26:214.
86. Berger ML, Siegel DM, Lee EL. Scurvy as an initial manifestation of Whipple's disease. Ann Intern Med. 1984;101:58-9.
87. Leggett J, Convery R. Images in clinical medicine. Scurvy. N Engl J Med. 2001;345:1818.
88. Fain O, Mathieu E, Thomas M. Scurvy in patients with cancer. BMJ. 1998;316:1661-2.
89. Echeverría L, García B, Campelo O, González A, Konning M, Bracamonte Bermejo T, et al. Escorbuto asociado a enfermedad celiaca. An Esp Pediatr. 2002;57:587.
90. Christopher K, Tammaro D, Wing EJ. Early scurvy complicating anorexia nervosa. South Med J. 2002;95:1065-6.
91. Nguyen RT, Cowley DM, Muir JB. Scurvy: a cutaneous clinical diagnosis. Australas J Dermatol. 2003;44:48-51.
92. Hughes M, Clark N, Forbes L, Colin-Jones DG. A case of scurvy. Br Med J (Clin Res Ed). 1986;293:366.
93. McKenna KE, Dawson JF. Scurvy occurring in a teenager. Clin Exp Dermatol. 1993;18:75-7.
94. Vasudevan AR, Kumar S, Lim A, Kimani R, Brensilver JM, Tamarin FM. Purple skin and a swollen thigh in an alcoholic. Postgrad Med J. 2002;78:430-4.
95. Monks G, Juracek L, Weigand D, Magro C, Cornelison R, Crowson AN. A case of scurvy in an autistic boy. J Drugs Dermatol. 2002;1:67-9.
96. Akikusa JD, Garrick D, Nash MC. Scurvy: forgotten but not gone. J Paediatr Child Health. 2003;39:75-7.
97. Walter JF. Scurvy resulting from a self-imposed diet. West J Med. 1979;130:177-9.
98. Majewski A, Burdelski M, Hampel V. Sauglingsskorbut bei Glukose-Galaktose-Malabsorption. Rontgenblatter. 1982;35:447-9.
99. Assefa F, Jabarkhil MZ, Salama P, Spiegel P. Malnutrition and mortality in Kohistan District, Afghanistan, April 2001. JAMA. 2001;286:2723-8.
100. Graham GG. Starvation in the modern world. N Engl J Med. 1993;328:1058-61.
101. Hodges RE, Baker EM, Hood J, Sauberlich HE, March SC. Experimental scurvy in man. Am J Clin Nutr. 1969;22:535-48.
102. Roé E, Dalmau J, Peramiquel L, Alomar A. Escorbuto: púrpura folicular como signo guía. Actas Dermosifiliogr. 2005;96:400-2.
103. Ratanachu-Ek S, Sukswai P, Jeerathanyasakun Y, Wongtapradit L. Scurvy in pediatric patients: a review of 28 cases. J Med Assoc Thai. 2003;86 Suppl 3:8734-40.
104. Rye K, Weeke J, Moller N. Skorbug og binyrebarkinsufficiens. Ugeskr Laeger. 2002;164:4548-9.
105. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 39-1995. A 72-year-old man with exertional dyspnea, fatigue, and extensive ecchymoses and purpuric lesions. N Engl J Med. 1995;333:1695-702.
106. Francescone MA, Levitt J. Scurvy masquerading as leukocytoclastic vasculitis: a case report and review of the literature. Cutis. 2005;76:261-6.
107. Helms AE, Brodell RT. Scurvy in a patient with presumptive oral lichen planus. Nutr Clin Pract. 2002;17:237-9.
108. Clemetson CA. Child abuse or Barlow's disease? Pediatr Int. 2003;45:758.
109. Jaffe RM, Kasten B, Young DS, MacLowry JD. False-negative stool occult blood tests caused by ingestion of ascorbic acid (vitamin C). Ann Intern Med. 1975;83:824-6.
110. Cook GC. Scurvy in the British Mercantile Marine in the 19th century, and the contribution of the Seamen's Hospital Society. Postgrad Med J. 2004;80:224-9.
111. Barker JA. Lind and Limeys, part 1: a brief early history of scurvy and the search for its cure in the 18th century. J Biol Educ. 1992;26:576-662.
112. Boschung U. Principios físicos y morales de la medicina 1700-1800. En: Vilella A, Borra V, editores. Crónica de la medicina. 1st ed. Barcelona: Plaza & Janés Editores, S.A.; 1995. p. 201-19.
113. Bartholomew M. James Lind's Treatise of the Scurvy (1753). Postgrad Med J. 2002;78:695-6.
114. Dunn PM. James Lind (1716-94) of Edinburgh and the treatment of scurvy. Arch Dis Child Fetal Neonatal Ed. 1997;76:F64-5.
115. Raizman N. Scurvy. J Clin Invest 2004;114:1690.
116. Rosenfeld L. Vitamine-vitamin. The early years of discovery. Clin Chem. 1997;43:680-5.
117. Hughes RE. The rise and fall of the «antiscorbutics»: some notes on the traditional cures for «land scurvy». Med Hist. 1990;34:52-64.
118. Lomax E. Difficulties in diagnosing infantile scurvy before 1878. Med Hist. 1986;30:70-80.
119. Raju TN. The Nobel chronicles. 1937: Albert von Szent-Gyorgyi (1893-1986). Lancet. 1999;353-8.