Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: A human study in vivo

British Journal of Dermatology

Volumn 139, Issue 2, 1998, Pages 332-339

  Dreher, F ^a   Gabard, B ^b   Schwindt, D A ^a   Maibach, H I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Spirig Pharma Ltd   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; MELATONIN; SUNSCREEN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ERYTHEMA; FEMALE; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RADIATION INJURY; RANDOMIZED CONTROLLED TRIAL; SKIN BLOOD FLOW; SKIN COLOR; SKIN INJURY; SKIN MANIFESTATION; SUN EXPOSURE; TOPICAL DRUG ADMINISTRATION; ULTRAVIOLET RADIATION;

ADMINISTRATION, CUTANEOUS; ADULT; ANTIOXIDANTS; ASCORBIC ACID; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ERYTHEMA; FEMALE; HUMANS; MALE; MELATONIN; MIDDLE AGED; RADIATION INJURIES; RADIATION-PROTECTIVE AGENTS; ULTRAVIOLET RAYS; VITAMIN E;

EID: 0031816167     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.1998.02447.x     Document Type: Article

References (51)

1. Witt EH, Motchnik P, Packer L. Evidence for UV light as an oxidative stressor in skin. In: Oxidative Stress in Dermatology (Fuchs J, Packer L, eds). New York: Marcel Dekker, 1993: 29-47.
2. Darr D, Fridovich I. Free radicals in cutaneous biology. J Invest Dermatol 1994; 102: 671-5.
3. Puchs J, Hullejt ME, Rothfuss LM et al. Impairment of enzymic and nonenzymic antioxidants in skin by UVB irradiation. J Invest Dermatol 1989; 93: 769-73.
4. Shindo Y, Witt E, Packer L. Antioxidant defense mechanisms in murine epidermis and dermis and their responses to ultraviolet light. J Invest Dermatol 1993; 100: 260-5.
5. Shindo Y, Witt E, Han D, Packer L. Dose-response effects of acute ultraviolet irradiation on antioxidants and molecular markers of oxidation in murine epidermis and dermis. J Invest Dermatol 1994; 102: 470-5.
6. Fryer MJ. Evidence for the photoprotective effects of vitamin E. Photochem Photobiol 1993; 58: 304-12.
7. Trevithick JR. Vitamin E prevention of ultraviolet-induced skin damage. In: Oxidative Stress in Dermatology (Fuchs J, Packer L, eds). New York: Marcel Dekker, 1993: 67-80.
8. Darr D, Pinnell SR. Reactive oxygen species and antioxidant protection in photodermatology. In: Sunscreens - Development, Evaluation, and Regulatory Aspects (Lowe NJ, Shaath NA, Pathak MA, eds), 2nd edn. New York: Marcel Dekker, 1997: 155-73.
9. Roshchupkin DI, Pistsov MY, Potapenko AY. Inhibition of ultraviolet light-induced erythema by antioxidants. Arch Dermatol Res 1979; 266: 91-4.
10. Bissett DL, Hillebrand GG, Hannon DP. The hairless mouse as a model of skin photoaging: its use to evaluate photoprotective materials. Photodermatol 1989; 6: 228-33.
11. Bissett DL, Chatterjee R, Hannon DP. Photoprotective effect of superoxide-scavenging antioxidants against ultraviolet radiation-induced chronic skin damage in the hairless mouse. Photodermatol Photoimmunol Photomed 1990; 7: 56-62.
12. Gensler HL, Magdaleno M. Topical vitamin E inhibition of immunosuppression and tumorigenesis induced by ultraviolet irradiation. Nutr Cancer 1991; 15: 97-106.
13. Darr D, Combs S, Dunston S et al. Topical vitamin C protects porcine skin from ultraviolet radiation-induced damage. Br J Dermatol 1992; 127: 247-53.
14. Jurkiewicz BA, Bissett DL, Buettner GR. Effect of topically applied tocopherol on ultraviolet radiation-mediated free radical damage in skin. J Invest Dermatol 1995; 104: 484-8.
15. Bissett DL, Oelrich DM, Hannon DP. Evaluation of a topical iron chelator in animals and in human beings: short-term photoprotection by 2-furildioxime. J Am Acad Dermatol 1994; 31: 572-8.
16. Darr D, Dunston S, Faust H, Pinnell S. Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants. Acta Derm Venereol (Stockh) 1996; 76: 264-8.
17. Bissett DL, Chatterjee R, Hannon DP. Protective effect of a topically applied anti-oxidant plus an anti-inflammatory agent against ultraviolet radiation-induced chronic skin damage in the hairless mouse. J Soc Cosmet Chem 1992; 43: 85-92.
18. Bangha E, Elsner P, Kistler GS. Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). Influence of the application time point. Dermatology 1997; 195: 248-52.
19. Reiter RJ, Melchiorri D, Sewerynek E et al. A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 1995; 18: 1-11.
20. Diffey BL, Robson J. A new substrate to measure sunscreen protection factors throughout the ultraviolet spectrum. J Soc Cosmet Chem 1989; 40: 127-33.
21. Gabard B, Treffel P, Bieli E, Schwab S. Emollients and photo (chemo) therapy: a call for caution. Dermatology 1996; 192: 242-5.
22. Learn DB, Beard J, Moloney SJ. The ultraviolet C energy emitted from FS lamps contributes significantly to the induction of human erythema and murine ear edema. Photodermatol Photoimmunol Photomed 1993; 9: 147-53.
23. Frosch PJ, Kligman AM. The soap chamber test - a new method for assessing the irritancy of soaps. J Am Acad Dermatol 1979; 1: 35-41.
24. Westerhof W, van Hasselt BAAM, Kammeijer A. Quantification of UV-induced erythema with a portable computer-controlled chromameter. Photodermatol 1986; 3: 310-14.
25. Elsner P. Chromametry: hardware, measuring principles, and standardization of measurements. In: Bioengineering of the Skin: Cutaneous Blood Flow and Erythema (Berardesca E, Elsner P, Maibach HI, eds). Boca Raton: CRC Press, 1995: 247-52.
26. Drouard V, Wilson DR, Maibach HI, Guy RH. Quantitative assessment of UV-induced changes in microcirculatory flow by laser Doppler velocimetry. J Invest Dermatol 1984; 83: 188-92.
27. Bernardi L, Leuzzi S, Laser Doppler flowmetry and photoplethysmography: basic principles and hardware. In: Bioengineering of the Skin: Cutaneous Blood Flow and Erythema (Berardesca E, Elsner P, Maibach HI, eds). Boca Raton: CRC Press, 1995: 31-55.
28. Nilsson GE. Measurement of water exchange through skin. Med Biol Eng Comput 1977; 15: 209-18.
29. Pinnagoda J, Tupker RA, Agner T, Serup J. Guidelines for transepidermal water loss (TEWL) measurement. Contact Dermatitis 1990; 22: 164-78.
30. Courage W. Hardware and measuring principle: corneometer. In: Bioengineering of the Skin: Water and the Stratum Corneum (Elsner P, Berardesca E, Maibach HI, eds). Boca Raton: CRC Press, 1994: 171-5.
31. Siegel S, Castellan NJ. Nonparametric Statistics for the Behavioral Sciences. 2nd edn. New York: McGraw-Hill, 1988.
32. Yuen KS, Halliday GM. α-Tocopherol, an inhibitor of epidermal lipid peroxidation, prevents ultraviolet radiation from suppressing the skin immune system. Photochem Photobiol 1997; 65: 587-92.
33. McVean M, Liebler DC. Inhibition of UVB-induced DNA photodamage in mouse epidermis by topically applied α-tocopherol. Carcinogenesis 1997; 18: 1617-22.
34. Ritter EF, Axelrod M, Minn KW et al. Modulation of ultraviolet light-induced epidermal damage: beneficial effects of tocopherol. Plast Reconstr Surg 1997; 100: 973-80.
35. Darr D, Dunston S, Kamino H et al. Effectiveness of a combination of vitamins C and E in inhibiting UV damage to porcine skin. J Invest Dermatol 1993; 100: 597.
36. Weber C, Podda M, Rallis M et al. Efficacy of topically applied tocopherols and tocotrienols in protection of murine skin from oxidative damage induced by UV-irradiation. Free Radic Biol Med 1997; 22: 761-9.
37. Thiele JJ, Traber MG, Packer L. Depletion of human stratum corneum vitamin E: an early and sensitive in vivo marker of UV-induced photooxidation. J Invest Dermatol (in press).
38. Kagan V, Witt E, Goldman R et al. Ultraviolet light-induced generation of vitamin E radicals and their recycling. A possible photosensitizing effect of vitamin E in skin. Free Radic Res Commun 1992; 16: 51-64.
39. Thomas CE, McLean LR, Parker RA, Ohlweiler DF. Ascorbate and phenolic antioxidant interactions in prevention of liposomal oxidation. Lipids 1992; 27: 543-50.
40. Carlotti ME, Gallarate M, Gasco MR et al. Synergistic action of vitamin C and amino acids on vitamin E in inhibition of the lipoperoxidation of linoleic acid in disperse systems. Int J Pharm 1997; 155: 251-61.
41. Kramer KA, Liebler DC. UVB induced photooxidation of vitamin E. Chem Res Toxicol 1997; 10: 219-24.
42. Cole CA, Davies RE, Forbes PD, D'Aloisio LC. Comparison of action spectra for acute cutaneous responses to ultraviolet radiation: man and albino hairless mouse. Photochem Photobiol 1983; 37: 623-31.
43. Livrea MA, Tesoriere L, D'Arpa D, Morreale M. Reaction of melatonin with lipoperoxyl radicals in phospholipid bilayers. Free Radic Biol Med 1997; 23: 706-11.
44. Poeggeler B, Reiter RJ, Hardeland R et al. Melatonin, a mediator of electron transfer and repair reactions, acts synergistically with the chain-breaking antioxidants ascorbate. Trolox and glutathione. Neuroendocrinol Lett 1995; 17: 87-92.
45. Morreale M, Livrea MA. Synergism between glycolic acid and melatonin in inhibiting lipid peroxidation in vitro. Med Sci Res 1997; 25: 163-4.
46. Susa N, Ueno S, Furukawa Y et al. Potent protective effect of melatonin on chromium (VI)-induced DNA single-strand breaks, cytotoxicity, and lipid peroxidation in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol 1997; 144: 377-84.
47. Franchi AM, Gimeno MF, Cardinali DP, Vacas MI. Melatonin, 5-methoxytryptamine and some of their analogs as cyclooxygenase inhibitors in rat medial basal hypothalamus. Brain Res 1987; 405: 384-8.
48. Martinuzzo M, Del Zar MM, Cardinali DP et al. Melatonin effect on arachidonic acid metabolism to cyclooxygenase derivatives in human platelets. J Pineal Res 1991; 11: 111-15.
49. Bojanowska E, Forsling ML. The effects of melatonin on vasopressin secretion in vivo: interactions with acetylcholine and prostaglandins. Brain Res Bull 1997; 42: 457-61.
50. Bissett DL, Chatterjee R, Hannon DP. Photoprotective effect of topical anti-inflammatory agents against ultraviolet radiation-induced chronic skin damage in the hairless mouse. Photodermatol Photoimmunol Photomed 1990; 7: 153-8.
51. Andersen PH, Abrams K, Maibach H. Ultraviolet B dose-dependent inflammation in humans: a reflectance spectroscopic and laser Doppler flowmetric study using topical pharmacologic antagonists on irradiated skin. Photodermatol Photoimmunol Photomed 1992; 9: 17-23.