Antigen presenting cells and stromal cells trigger human natural killer lymphocytes to autoreactivity: Evidence for the involvement of natural cytotoxicity receptors (NCR) and NKG2D

Clinical and Developmental Immunology

Volumn 13, Issue 2-4, 2006, Pages 325-336

  Poggi, Alessandro ^a,c   Zocchi, Maria Raffaella ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

HLA I; Inhibitory receptor superfamily; Natural killer lymphocyte; TNF

Indexed keywords

CELL RECEPTOR; GAMMA INTERFERON; HLA ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; NATURAL KILLER CELL RECEPTOR NKG2D; PROTEIN MIC A; PROTEIN NKP30; PROTEIN NKP46; PROTEIN UL16; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; BONE MARROW; CELL ADHESION; CELL INTERACTION; CELL KILLING; CYTOKINE PRODUCTION; HLA SYSTEM; HUMAN; MIXED LYMPHOCYTE REACTION; NATURAL KILLER CELL; PRIORITY JOURNAL; SKIN FIBROBLAST; STROMA CELL; T LYMPHOCYTE;

ANTIGEN-PRESENTING CELLS; HUMANS; KILLER CELLS, NATURAL; RECEPTORS, IMMUNOLOGIC; STROMAL CELLS;

EID: 33845640823     PISSN: 17402522     EISSN: 10292357     Source Type: Journal    
DOI: 10.1080/17402520600578194     Document Type: Article

References (48)

1. Aggarwal S, Pittenger MF. 2005. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105:1815-1822.
2. Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T. 1999. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 282:727-729.
3. Beyth S, Borovsky Z, Mevorach D, Liebergall M, Gazit Z, Aslan H, Galun E, Rachmilewitz J. 2005. Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T cell unresponsiveness. Blood 105:2214-2219.
4. Carbone E, Terrazzano G, Ruggiero G, Zanzi D, Ottaiano A, Manzo C, Karre K, Zappacosta S. 1999. Recognition of autologous dendritic cells by human NK cells. Eur J Immunol 29:4022-4029.
5. Cosman D, Mullberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ. 2001. ULBPs, novel MHC class-I-related molecules, bind to CMV glicoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 14:123-133.
6. Diefenbach A, Jamieson AM, Liu SD, Shastri N, Raulet DH. 2000. Ligands for the murine NKG2D receptor: Expression by tumor cells and activation of NK cells and macrophages. Nat Immunol 1:119.
7. Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P, Grisanti S, Gianni AM. 2002. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99:3838-3843.
8. Djouad F, Plence P, Bony C, Tropel P, Apparailly F, Sany J, Noel D, Jorgensen C. 2003. Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood 102:3837-3844.
9. Farag SS, Fehniger TA, Ruggeri L, Velardi A, Caligiuri MA. 2002. Natural killer cell receptors: New biology and insights into the graft-versus-leukemia effect. Blood 100:1935-1947.
10. Ferlazzo G, Thomas D, Lin SL, Goodman K, Morandi B, Muller WA, Moretta A, Munz C. 2004. The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic. J Immunol 172:1455-1462.
11. Ferlazzo G, Tsang ML, Moretta L, Melioli G, Steinman RM, Munz C. 2002. Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J Exp Med 195:343-351.
12. Goodnow CC. 1996. Balancing immunity and tolerance: Deleting and tuning lymphocyte repertoires. Proc Natl Acad Sci 93:2264-2271.
13. Groh V, Wu J, Yee C, Spies T. 2002. Tumor-derived soluble MIC ligands impair expression of NKG2D and T cell activation. Nature 419:734-738.
14. von Herrath MG, Harrison LC. 2003. Antigen-induced regulatory T cells in autoimmunity. Nat Rev Immunol 3:223-232.
15. Hunter CA. 2005. New IL-12-family members: IL23 and Il-27, cytokines with divergent functions. Nat Rev Immunol 5:521-531.
16. Janaway Jr., CA. 1992. The immune system evolved to discriminate infectious nonself from non-infectious self. Immunol Today 13:11-16.
17. Lanier LL. 1998. NK cell receptors. Annu Rev Immunol 16:359-393.
18. Lanzavecchia A, Sallusto F. 2001. Antigen decoding by T lymphocytes: From synapses to fate determination. Nat Immunol 2:487-492.
19. Le Blanc K. 2003. Immunomodulatory effects of fetal and adult mesenchymal stem cells. Cytotherapy 5:485-489.
20. Le Blanc K, Rasmusson I, Sundberg B, Gotherstrom C, Hassan M, Uzunel M, Ringden O. 2004. Treatment of severe acute graft-versus host disease with third party haploidentical mesenchymal stem cells. Lancet 363:1439-1441.
21. Leibson PJ. 1997. Signal transduction during natural killer cell activation: Inside the mind of a killer. Immunity 6:655-661.
22. Ljunggren HG, Karre K. 1990. In search of the "missing self": MHC molecules and NK cell recognition. Immunol Today 11:237-244.
23. Long EO. 1999. Regulation of immune responses through inhibitory receptors. Annu Rev Immunol 17:875-904.
24. Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D. 2004. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 103:4619-4621.
25. Mingari MC, Poggi A, Biassoni R, Bellomo R, Ciccone E, Pella N, Morelli L, Verdiani S, Moretta A, Moretta L. 1991. In vitro proliferation and cloning of CD3 - CD16+ cells from human thymocyte precursors. J Exp Med 174:21-26.
26. Moretta A, Bottino C, Vitale M, Pende D, Biassoni R, Zingari MC, Moretta L. 1996. Receptors for HLA-class I molecules in human natural killer cells. Annu Rev Immunol 14:619-648.
27. Moretta A, Bottino C, Vitale M, Pende D, Cantoni C, Zingari MC, Biassoni R, Moretta L. 2001. Activating receptors and co-receptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol 19:197-223.
28. Parajuli P, Nishioka Y, Nishimura N, Singh SM, Hanibuchi M, Nokihara H, Yanagawa H, Sone S. 1999. Cytolysis of human dendritic cells by autologous lymphokine-activated killer cells: Participation of both T cells and NK cells in the killing. J Leukoc Biol 65:764-770.
29. Pende D, Castriconi R, Romagnani P, Spaggiari GM, Marcenaro S, Dondero A, Lazzeri E, Lasagni L, Martini S, Rivera P, Capobianco A, Moretta L, Moretta A, Bottino C. 2005. Expression of the DNAM-1 ligands nectin-2 (CD112) and poliovirus receptor (CD155) on dendritic cells: Relevance for natural killer/dendritic cells interaction. Blood, in press.
30. Pende D, Rivera P, Marcenaro S, Chang CC, Biassoni R, Conte R, Kubin M, Cosman D, Ferrone S, Moretta L, Moretta A. 2002. Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: Analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytoxicity. Cancer Res 62:6178-6186.
31. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. 1999. Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147.
32. + stroma stimulates proliferation of human hematopoietic progenitors. J Biol Chem 280:5343-5349.
33. Poggi A, Biassoni R, Pella N, Paolieri F, Bellomo R, Bertolini A, Moretta L, Mingari MC. 1990. In vitro expansion of CD3/TCR-human thymocyte populations that selectively lack CD3 delta gene expression: A phenotypic and functional analysis. J Exp Med 172:1409-1418.
34. Poggi A, Carosio R, Spaggairi GM, Fortis C, Tambussi G, Dell'Antonio G, Dal Cin E, Rubartelli A, Zocchi MR. 2002. NK cell activation by dendritic cells is dependent on LFA1-mediated induction of calcium-calmodulin kinase II: Inhibition by HIV-1 tat C-terminal domain. J Immunol 168:95-101.
35. Poggi A, Massaro AM, Negrini S, Pierri I, Balocco M, Michelis G, Aquino S, Albarello A, Gobbi M, Zocchi MR. 2004. Evidence for killing of mesenchymal stem cells (MSC) by autologous natural killer lymphocytes. Blood ASH Annual Meeting Abstracts, November 104:1290.
36. Poggi A, Prevosto C, massaro AM, Negrini S, Urbani S, Pierri I, Saccardi R, Gobbi M, Zocchi MR. 2005. Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: Role of NKp30 and NKG2D receptors. J Immunol 175:6352-6360.
37. Poggi A, Venturino C, Castellani S, Clavio M, Miglino M, Gobbi M, Steinle A, Ghia P, Stella S, Caligaris-Cappio F, Zocchi MR. 2004. Vd1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and upregulated by transretinoic acid. Cancer Res 64:9172-9179.
38. Potian JA, Aviv H, Ponzio NM, Harrison JS, Rameshwar P. 2003. Veto-like activity of mesenchymal stem cells: Functional discrimination between cellular responses to alloantigens and recall antigens. J Immunol 171:3426-3434.
39. Rodriguez Mdel C, Bernad A, Aracil M. 2004. Interleukin-6 deficiency affects bone marrow stromal precursors, resulting in defective hematopoietic support. Blood 103:3349-3354.
40. Sekiya I, Larson BL, Smith JR, Pochampally R, Cui JG, Prockop DJ. 2002. Expansion of human adult stem cells from bone marrow stroma: Conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells 20:530-541.
41. Spaggiari GM, Carosio R, Pende D, Marcenaro S, Rivera P, Zocchi MR, Moretta L, Poggi A. 2001. NK cell-mediated lysis of autologous antigen-presenting cells is triggered by the engagement of the phosphatidylinositol 3-kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46. Eur J Immunol 31:1656-1665.
42. Trinchieri G. 1989. Biology of natural killer cells. Adv Immunol 47:187-376.
43. Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC. 2003. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: Implications in transplantation. Transplantation 75:389-397.
44. + cells: Efficient production in the co-culture with OP9 stromal cells and analysis of lymphohematopoietic potential. Blood 105:617-626.
45. Wilson JL, Heffler LC, Charo J, Scheynius A, Bejarano M-T, Ljunggren HG. 1999. Targeting of human dendritic cells by autologous NK cells. J Immunol 163:6365-6370.
46. Woo JT, Shinohara C, Sakai K, Hasumi K, Endo A. 1998. Isolation, characterization and biological activities of concanamycins as inhibitors of lysosomal acidification. J Antibiot 45:1108-1116.
47. Woodbury D, Schwarz EJ, Prockop DJ, Black IB. 2000. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 61:364-370.
48. Zocchi MR, Rubartelli A, Morgavi P, Poggi A. 1998. HIV-1 tat inhibits human natural killer cell function by blocking L-type calcium channels. J Immunol 161:2938-2943.