Isolation, characterization and biological activities of concanamycins as inhibitors of lysosomal acidification

The Journal of Antibiotics

Volumn 45, Issue 7, 1992, Pages 1108-1116

  Woo, Je Tae ^a   Shinohara, Chikara ^a   Sakai, Kaoru ^a   Hasumi, Keiji ^a   Endo, Akira ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAMYCIN; CONCANAMYCIN D; CONCANAMYCIN E; CONCANAMYCIN F; CONCANAMYCIN G; MACROLIDE; UNCLASSIFIED DRUG;

ACIDIFICATION; ARTICLE; DRUG ACTIVITY; DRUG ISOLATION; DRUG PURIFICATION; LIVER LYSOSOME; MYCELIUM; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES; YEAST;

ANIMAL; ANTIBIOTICS, MACROLIDE; CELLS, CULTURED; CHOLESTEROL ESTERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LYSOSOMES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; OLEIC ACID; OLEIC ACIDS; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET; STREPTOMYCES; SUPPORT, NON-U.S. GOV'T;

EID: 0026720109     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.7164/antibiotics.45.1108     Document Type: Article

References (15)

1. Kinashi, H.; K. Someno & K. Sakaguchi: Isolation and characterization of concanamycins A, B and C. J. Antibiotics 37: 1333-1343, 1984
2. Westley, J. W.; C.-M. Liu, L. H. Sello, R. H. Evans, N. Troupe, J. F. Blount, A. M. Cmu, L. J. Todaro & P. A. Miller: The structure and absolute configuration of the 18-membered macrolide lactone antibiotic X-4357B (concanamycin A). J. Antibiotics 37: 1738-1740, 1984
3. Woo, J.-T.; C. Shinohara, K. Sakai, K. Hasumi & A. Endo: Inhibition of the acidification of endosomes and lysosomes by the antibiotic concanamycin B in macrophage J774. Eur. J. Biochem., in press
4. Naganuma, S.; N. Kuzuya, K. Sakai, K. Hasumi & A. Endo: Inhibition of the accumulation of lipid droplets in macrophage J774 by bafilomycin B, and destruxin E. Biochim. Biophys. Acta, in press
5. Goldstein, J. L.; S. K. Basu & M. S. Brown: Receptor-mediated endocytosis of low density lipoprotein in cultured cells. Methods in Enzymol. 98: 241-260, 1983
6. Yokode, M.; T. Kita, Y. Kikawa, T. Ogorochi, S. Narumiya & C. Kawai: Stimulated arachidonate metabolism during foam cell transformation of mouse peritoneal macrophages with oxidized low density lipoprotein. J. Clin. Invest. 81: 720-729, 1988
7. Shirling, E. B. & D. Gottlieb: Methods for characterization of Streptomyces species. Int. J. Syst. Bacteriol. 16: 313-340, 1966
8. Becker, B.; M. P. Lechevalier, R. E. Gordon & H. A. Lechevalier: Rapid differentiation between Nocardia and Streptomyces by paper chromatography of whole-cell hydrolysates. Appl. Microbiol. 12: 421-423, 1964
9. Yamaguchi, T.: Comparison of the cell-wall composition of morphologically distinct actinomycetes. J. Bacteriol. 89: 444-453, 1965
10. Pridham, T. G. & D. Gottlieb: The utilization of carbon compounds by some actinomycetales as an aid for species determination. J. Bacteriol. 56: 107-114, 1948
11. Marsh, M.; S. Schmid, H. Kern, E. Harms, P. Male, I. Mellman & A. Helenius: Rapid analytical and preparative isolation of functional endosomes by free flow electrophoresis. J. Cell Biol. 104: 875-886, 1987
12. Schmid, S. L.; R. Fuchs, P. Male & I. Mellman: Two distinct subpopulations of endosomes involved in membrane recycling and transport to lysosomes. Cell 52: 73-83, 1988
13. Schneider, D. L. & J. Chin: Preparation and acidification activity of lysosomes and endosomal membranes. Methods in Enzymol. 157: 591-594, 1988
14. Moriyama, Y.; T. Takano & S. Ohkuma: Proton translocating ATPase in lysosomal membrane ghosts. Evidence that alkaline Mg2+-ATPase acts as a proton pump. J. Biochem. 95: 995-1007, 1984
15. Bowman, E. J.; A. Siebers & K. Altendorf: Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc. Natl. Acad. Sci. U.S.A. 85: 7972-7976, 1988